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The effect of long standing chronic mechanical irritation on the tongue of rats. 长期慢性机械刺激对大鼠舌头的影响。
Journal of oral pathology Pub Date : 1976-09-01 DOI: 10.1111/j.1600-0714.1976.tb01777.x
A Shteyer, S Greenman, J Lewin-Epstein
{"title":"The effect of long standing chronic mechanical irritation on the tongue of rats.","authors":"A Shteyer,&nbsp;S Greenman,&nbsp;J Lewin-Epstein","doi":"10.1111/j.1600-0714.1976.tb01777.x","DOIUrl":"https://doi.org/10.1111/j.1600-0714.1976.tb01777.x","url":null,"abstract":"<p><p>The effect of long standing mechanical irritation of the tongue was studied in 100 young rats. This was effected by the protruding end of a twisted wire, ligated around the lower first molar and directed toward the later-ventral aspect of the tongue on one side, while the other side served as control. Groups of rats were killed after 3, 6, 9 and 12 months and the tongues were examined grossly and microscopically. Fibrous hyperplasia was observed in 48% of tongues in the 3-month group and increased to 79% in the 12-month group. Microscopically, epithelial changes were noted which included ulceration acanthosis and hyperkeratosis. In no instance was dyskeratosis or any other malignant change noted.</p>","PeriodicalId":16672,"journal":{"name":"Journal of oral pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1976-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0714.1976.tb01777.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12010686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Granular cell peripheral odontogenic fibroma. 颗粒细胞外周牙源性纤维瘤。
Journal of oral pathology Pub Date : 1976-09-01 DOI: 10.1111/j.1600-0714.1976.tb01778.x
J F Lownie, M Altini, M Shear
{"title":"Granular cell peripheral odontogenic fibroma.","authors":"J F Lownie,&nbsp;M Altini,&nbsp;M Shear","doi":"10.1111/j.1600-0714.1976.tb01778.x","DOIUrl":"https://doi.org/10.1111/j.1600-0714.1976.tb01778.x","url":null,"abstract":"<p><p>A case of a peripheral odontogenic fibroma which contained aggregates of large granular cells is reported. These granular cells are similar to those previously described in the granular cell myoblastoma, congenital epulis and the granular cell ameloblastic fibroma. Deep extensions of the basal layer of overlying gingival epithelium, in double-strand fashion, are frequently observed in peripheral odontogenic fibromas. These strands closely resemble those seen in the tumor itself. On this basis, and as similar basal cell prolongations are seen in otherjaw lesions, it is postulated that residual ectomesenchymal influence may be responsible for inducing the basal cell proliferations in a similar manner to that which occurs during early embryonic dental development. This, it is suggested, might possibly be the histogenesis of the odontogenic epithelial strands in the peripheral odontogenic fibroma.</p>","PeriodicalId":16672,"journal":{"name":"Journal of oral pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1976-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0714.1976.tb01778.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12010687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 34
Sclerotic masses in the mandible of a patient with familial polyposis of the colon. 家族性结肠息肉病患者的下颌骨硬化肿块。
Journal of oral pathology Pub Date : 1976-09-01 DOI: 10.1111/j.1600-0714.1976.tb01779.x
K Ooya, H Yamamoto, K M Lay
{"title":"Sclerotic masses in the mandible of a patient with familial polyposis of the colon.","authors":"K Ooya,&nbsp;H Yamamoto,&nbsp;K M Lay","doi":"10.1111/j.1600-0714.1976.tb01779.x","DOIUrl":"https://doi.org/10.1111/j.1600-0714.1976.tb01779.x","url":null,"abstract":"","PeriodicalId":16672,"journal":{"name":"Journal of oral pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1976-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0714.1976.tb01779.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12010688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
In memoriam David Farrar Mitchell, BS, DDS, PHD December 15, 1918-July 17, 1975. 纪念大卫·法拉尔·米切尔，学士，DDS，博士1918年12月15日- 1975年7月17日。
Journal of oral pathology Pub Date : 1976-07-01
G Yamane
{"title":"In memoriam David Farrar Mitchell, BS, DDS, PHD December 15, 1918-July 17, 1975.","authors":"G Yamane","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":16672,"journal":{"name":"Journal of oral pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1976-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12007305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The relation of the clinical picture to the histopathology of snuff dipper"s lesions in a Swedish population. 瑞典人鼻烟壶病变的临床表现与组织病理学的关系。
Journal of oral pathology Pub Date : 1976-07-01
T Axéll, H Mörnstad, B Sundström
{"title":"The relation of the clinical picture to the histopathology of snuff dipper\"s lesions in a Swedish population.","authors":"T Axéll, H Mörnstad, B Sundström","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The relation of the clinical picture of snuff dipper's lesions to the histopathological appearance was studied in 114 male dippers aged 20-88 years. Histological study revealed increased epithelial thickness, a vacuolated surface layer with wavelike, eosinophilic spikes directed toward the surface having a narrow, eosinophilic band as a demarcation toward the prickle cell layer, acanthosis, and a slight inflammatory reaction. Thirteen cases showed an increased number of eosinophilic granulocytes, and nine cases contained amorphous, weakly eosinophilic areas in the connective tissue papillae. No epithelial dysplasia was observed. Increased epithelial thicknees, especially the presence of a vacuolated surface layer, was the only histologic feature that could be correlated with the severity of clinical appearance of the lesions. Deeply located changes, like inflammation and amorphous areas, however, were not reflected in the clinical grading of the lesions.</p>","PeriodicalId":16672,"journal":{"name":"Journal of oral pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1976-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12006919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dinitrochlorobenzene contact hypersensitivity in the hamster cheek pouch. 二硝基氯苯接触性超敏反应在仓鼠颊袋。
Journal of oral pathology Pub Date : 1976-05-01 DOI: 10.1111/j.1600-0714.1976.tb01762.x
A R Mohammad, H H Mincer
{"title":"Dinitrochlorobenzene contact hypersensitivity in the hamster cheek pouch.","authors":"A R Mohammad,&nbsp;H H Mincer","doi":"10.1111/j.1600-0714.1976.tb01762.x","DOIUrl":"https://doi.org/10.1111/j.1600-0714.1976.tb01762.x","url":null,"abstract":"<p><p>Stimulation of cell mediated immunity has been reported to be effective in bringing about clinical regression of carcinomas. The purpose of this pilot study was to investigate the possibility of introducing cell mediated immunity into an experimental animal-chemical carcinogenesis system (dimethylbenzanthracene-hamster cheek pouch) to serve as a model for the study of immunotherapy of oral cancer in humans. Contact hypersensitivity to dinitrochlorobenzene (DNCB) was induced in 17 Syrian hamsters via the abdominal skin. After secondary application of the allergen to the cheek pouch, local gross and histologic characteristics indicative of delayed hypersensitivity were observed. Control animals that had received only a primary or a secondary challenge with DNCB essentially showed no change. This study demonstrates that the buccal pouch of the Syrian hamster is capable of manifesting contact hypersensitivity to DNCB.</p>","PeriodicalId":16672,"journal":{"name":"Journal of oral pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1976-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0714.1976.tb01762.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12005320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
The periodontal disease process. 牙周病的过程。
Journal of oral pathology Pub Date : 1976-05-01 DOI: 10.1111/j.1600-0714.1976.tb01763.x
W R Grigsby, C B Sabiston
{"title":"The periodontal disease process.","authors":"W R Grigsby,&nbsp;C B Sabiston","doi":"10.1111/j.1600-0714.1976.tb01763.x","DOIUrl":"https://doi.org/10.1111/j.1600-0714.1976.tb01763.x","url":null,"abstract":"","PeriodicalId":16672,"journal":{"name":"Journal of oral pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1976-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0714.1976.tb01763.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11229650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Lanthanum staining of cell surface and junctional complexes in normal and malignant human oral mucosa. 正常和恶性人口腔黏膜细胞表面及连接复合物的镧染色。
Journal of oral pathology Pub Date : 1975-11-01 DOI: 10.1111/j.1600-0714.1975.tb01863.x
M S Palekar, S M Sirsat
{"title":"Lanthanum staining of cell surface and junctional complexes in normal and malignant human oral mucosa.","authors":"M S Palekar,&nbsp;S M Sirsat","doi":"10.1111/j.1600-0714.1975.tb01863.x","DOIUrl":"https://doi.org/10.1111/j.1600-0714.1975.tb01863.x","url":null,"abstract":"<p><p>Biopsies from normal and malignant human oral epithelium were studied electron histochemically using lanthanum nitrate for a selective demonstration of junctional complexes at the plasma membrane of adjacent cells. The heavy metal complex was found to settle irregularly, sometimes in intimate proximity to the epithelial cell, in areas corresponding to the glycocalyx, gap junctions, desmosomes and nonspecific contact areas. Tight junctions were rarely seen. The lack of these morphological adhesive areas, the desosomal detachment seen between cancer cells and the increased lanthanum-positive cell surface may be possible factors responsible for the dissociation of oral malignant cells.</p>","PeriodicalId":16672,"journal":{"name":"Journal of oral pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1975-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0714.1975.tb01863.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11277799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Ultrastructural observations of the oral mucosa in Anderson-Fabry disease. 安德森-法布里病口腔黏膜超微结构观察。
Journal of oral pathology Pub Date : 1975-11-01
H O Archard, H P Brindley
{"title":"Ultrastructural observations of the oral mucosa in Anderson-Fabry disease.","authors":"H O Archard,&nbsp;H P Brindley","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Electron microscopic study of oral mucosa from a patient with Anderson-Fabry disease (glycosphingolipid lipidosis) revealed lamellar and membranous osmiophilic intracytoplasmic inclusions having a periodicity of 4.5 nanometers. These were observed chiefly in reticulo-endothelial cells as membrane bound and occasionally unbound bodies. They could also be observed within the cytoplasm of squamous epithelial cells, particularly of the stratum germinativum. Morphologic features in endothelial and epithelial cells are described.</p>","PeriodicalId":16672,"journal":{"name":"Journal of oral pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1975-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12001611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrastructural characteristics of mast cells from a canine mastocytoma maintained in vitro. 体外维持犬肥大细胞瘤肥大细胞的超微结构特征。
Journal of oral pathology Pub Date : 1975-11-01 DOI: 10.1111/j.1600-0714.1975.tb01864.x
C M Cobb, H Birkedal-Hansen, F R Denys
{"title":"Ultrastructural characteristics of mast cells from a canine mastocytoma maintained in vitro.","authors":"C M Cobb,&nbsp;H Birkedal-Hansen,&nbsp;F R Denys","doi":"10.1111/j.1600-0714.1975.tb01864.x","DOIUrl":"https://doi.org/10.1111/j.1600-0714.1975.tb01864.x","url":null,"abstract":"<p><p>Mast cells obtained from a canine mastocytoma were maintained in cell culture for a period of 11 weeks. Samples of these cells were harvested for electron microscopic examination after 9 weeks in vitro. Although the overall morphologic appearance was sufficient to allow their identification as mast cells, the tumor cells differed in several respects from descriptions of normal tissue mast cells. In contrast to normal tissue mast cells, the tumor cells exhibited peripheral accumulations of microfilaments, randomly dispersed microtubules, and small clusters of smooth endoplasmic reticulum. The tumor mast cells also presented three different granule types: spherical granules with an amorphous and electron dense matrix; irregularly shaped granules possessing a limiting external membrane and an internal matrix containing laminated and/or coiled structures; and granules containing loosely coiled, unorganized membrane structures similar in appearance to myelin whorls. The canine mastocytoma is an excellent source of mast cells as they can be obtained in large numbers without contamination by extraneous cell types and the cells can be maintained in vitro for extended periods of time.</p>","PeriodicalId":16672,"journal":{"name":"Journal of oral pathology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1975-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1600-0714.1975.tb01864.x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12001608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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