长期慢性机械刺激对大鼠舌头的影响。

A Shteyer, S Greenman, J Lewin-Epstein
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引用次数: 2

摘要

在100只幼鼠身上研究了长期机械刺激舌头的效果。这是通过一根扭曲的金属丝的突出末端来实现的,这根金属丝缠绕在下颌第一磨牙周围,并在一侧指向舌头的后腹侧,而另一侧则作为控制。各组大鼠分别于3、6、9和12个月后处死,对其舌头进行肉眼和显微镜检查。纤维增生在3个月组中出现48%,在12个月组中增加到79%。镜下可见上皮改变,包括溃疡、棘层增生和角化过度。没有发现角化不良或任何其他恶性变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The effect of long standing chronic mechanical irritation on the tongue of rats.

The effect of long standing mechanical irritation of the tongue was studied in 100 young rats. This was effected by the protruding end of a twisted wire, ligated around the lower first molar and directed toward the later-ventral aspect of the tongue on one side, while the other side served as control. Groups of rats were killed after 3, 6, 9 and 12 months and the tongues were examined grossly and microscopically. Fibrous hyperplasia was observed in 48% of tongues in the 3-month group and increased to 79% in the 12-month group. Microscopically, epithelial changes were noted which included ulceration acanthosis and hyperkeratosis. In no instance was dyskeratosis or any other malignant change noted.

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