Journal of neuroimmunology最新文献_第6页

NOD-like receptor protein 3 inhibition by MCC950 improves the cognitive function of rats with sepsis-associated encephalopathy

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2025-01-06 DOI: 10.1016/j.jneuroim.2024.578517

Li Zhang , Long Ma , Yi Wang , Xiang Li , Yanjie Yang , Ling Yang , Xiangyou Yu

{"title":"NOD-like receptor protein 3 inhibition by MCC950 improves the cognitive function of rats with sepsis-associated encephalopathy","authors":"Li Zhang , Long Ma , Yi Wang , Xiang Li , Yanjie Yang , Ling Yang , Xiangyou Yu","doi":"10.1016/j.jneuroim.2024.578517","DOIUrl":"10.1016/j.jneuroim.2024.578517","url":null,"abstract":"<div><div>This study aimed to investigate the effects of MCC950 in a rat model of sepsis-associated encephalopathy (SAE). Adult male rats were randomly assigned to 12 groups according to the surgery or treatment received and evaluation times. The SAE model was established using the cecal ligation and puncture (CLP) method. Intraperitoneal injections of normal saline (10 mL/kg) or MCC950 (10 mg/kg) were administered 30 min pre-surgery and daily post-surgery. Changes in survival rates, weight loss, and heart rate were assessed at four time points, and neurobehavioral changes were evaluated using the composite neural reflex function scores, light/dark box test, and open-field test (OFT). Compared with the SAE group, the SAE + MCC950 group had significantly higher survival rates (<em>P</em> < 0.05), lower postoperative weight loss rates (P < 0.05), and higher neurological function scores (<em>P</em> < 0.05); the SAE + MCC950 group also traveled further and crossed the central area more frequently in the OFT (<em>P</em> < 0.05), spent more time in the light compartment at different time points (<em>P</em> < 0.05), and exhibited a lower heart rate at different time points (P < 0.05). MCC950 treatment significantly improved cognitive function and related indices in the SAE rats.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"400 ","pages":"Article 578517"},"PeriodicalIF":2.9,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebrospinal fluid biomarkers associated with neurofilament light levels: A study in HIV disease

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2025-01-06 DOI: 10.1016/j.jneuroim.2025.578521

Enrico Ripamonti , Magnus Gisslén , Lars Hagberg , Pradeepthi Bathala , Shraddha Kale , Martin Stengelin , George Sigal , Jacob Wohlstadter , Henrik Zetterberg , Richard Price

{"title":"Cerebrospinal fluid biomarkers associated with neurofilament light levels: A study in HIV disease","authors":"Enrico Ripamonti , Magnus Gisslén , Lars Hagberg , Pradeepthi Bathala , Shraddha Kale , Martin Stengelin , George Sigal , Jacob Wohlstadter , Henrik Zetterberg , Richard Price","doi":"10.1016/j.jneuroim.2025.578521","DOIUrl":"10.1016/j.jneuroim.2025.578521","url":null,"abstract":"<div><h3>Background</h3><div>A retrospective study was conducted in people with HIV (PWH) to explore potential cerebrospinal fluid (CSF) biomarkers linked to CSF neurofilament light levels (NfL), indicative of neuronal injury.</div></div><div><h3>Methods</h3><div>A sample of 168 participants was tested, including 43 HIV-negative controls and PWH who were classified into subgroups based on HIV and treatment status. Twenty CSF protein biomarkers were analyzed for their association with CSF NfL concentrations using a linear regression forward selection strategy, adjusted for age and sex. Regression trees were utilized to visualize feature relationships.</div></div><div><h3>Results</h3><div>Age-adjusted average concentrations of CSF NfL ranged from 427 pg/mL (SD = 190) in HIV- participants to 6456 pg/mL (SD = 46,024) in participants with HIV-associated dementia. Significant associations were found between specific biomarkers and CSF NfL levels in different participant subgroups. Noteworthy findings included correlations between CSF t-tau, CSF MCP-1, CSF TNF-α, and albumin ratio with CSF NfL levels in untreated PWH, and CSF IL-21 with CSF NfL in treated, virally suppressed PWH. Association between age and CSF NfL concentrations was a general finding.</div></div><div><h3>Conclusion</h3><div>We identified specific CSF biomarkers, including CSF t-tau protein, CSF MCP-1, and CSF TNF-α that associated with CSF NfL concentrations in untreated PWH and CSF IL-21 that associated with CSF NfL in PWH with effective treatment, shedding light on neuroinflammatory processes which may underlie HIV-related neuronal injury and the impact of antiviral therapy. Further investigations are needed to validate if elevated CSF IL-21 concentrations persist during long-term treatment, and if particular drug combinations are optimal for decreasing inflammatory latency.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"400 ","pages":"Article 578521"},"PeriodicalIF":2.9,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143305167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A 7-year-old with new-onset seizures, behavior disturbance, and encephalitis 7岁，新发癫痫，行为障碍，脑炎。

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-12-30 DOI: 10.1016/j.jneuroim.2024.578520

MaryGlen V. Stanich , Trevor Memmott , Taumoha Ghosh , Melissa A. Wright

引用次数: 0

Corrigendum to “Elevated frequencies of activated memory B cells in multiple sclerosis are reset to healthy control levels are B cell depletion with Ocrelizumab” [J. Neuroimmunol. 339:578502 (2024)] “激活记忆B细胞频率升高在多发性硬化症中被重置到健康控制水平是奥克雷单抗的B细胞消耗”的更正[J]。中国生物医学工程学报[j].中国生物医学工程学报。

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-12-27 DOI: 10.1016/j.jneuroim.2024.578519

Cody J. Gurski , Zivar Hajiyeva , Anthony J. Veltri , Kaylan Fenton , Samantha O'Dell , Ahmed Z. Obeidat , Bonnie N. Dittel

引用次数: 0

Vitamin C co-administration with artemether-lumefantrine abrogates chronic stress exacerbated Plasmodium berghei-induced sickness behaviour, inflammatory and oxidative stress responses in mice 维生素C与蒿甲醚-氨芳碱联合使用可消除小鼠慢性应激加剧的伯氏疟原虫引起的疾病行为、炎症和氧化应激反应。

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-12-20 DOI: 10.1016/j.jneuroim.2024.578518

Kehinde Joshua Ogundeyi , Abayomi Mayowa Ajayi , Ololade Justina Oduyomi , Stella Afolakemi Adeyemo , Mary O. Ologe , Olusegun George Ademowo

引用次数: 0

IgLON5 autoimmunity secondary to immune checkpoint inhibitor 免疫检查点抑制剂继发的IgLON5自身免疫。

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-12-16 DOI: 10.1016/j.jneuroim.2024.578516

Christopher Itoh , Grace Swart , Erik St. Louis , Manish Gandhi , Divyanshu Dubey

引用次数: 0

Guhong injection attenuates brain injury and promotes neuroprotection after acute ischemic stroke 骨红注射液可减轻急性缺血性脑卒中后脑损伤，促进神经保护。

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-12-15 DOI: 10.1016/j.jneuroim.2024.578515

Xiaoshan Du , Zhihui Qi , Yulin Li, Siting Wu, Fang Zhang, Zhiguo Li, Jingshan Chen

{"title":"Guhong injection attenuates brain injury and promotes neuroprotection after acute ischemic stroke","authors":"Xiaoshan Du , Zhihui Qi , Yulin Li, Siting Wu, Fang Zhang, Zhiguo Li, Jingshan Chen","doi":"10.1016/j.jneuroim.2024.578515","DOIUrl":"10.1016/j.jneuroim.2024.578515","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Guhong injection (GHI) has multiple components and generates diverse effects, and is mainly used in the treatment of acute ischemic stroke (AIS). The purpose of this study is to explore the multiple effects of GHI in AIS models in mice and the mechanism how they work together to affect the stroke outcome.</div></div><div><h3>Methods</h3><div>Middle cerebral artery occlusion (MCAO) and photothrombotic stroke models were established with GHI or vehicle. Neurological function assessment including the Modified Neurological Severity Score (mNSS) and rota-rod test, and relative cerebral blood flow were monitored at day 1 and day 3 after model establishment. Flow cytometry, 2, 3, 5-Triphenyltetrazolium chloride (TTC) staining, histology and immunofluorescence, Western blotting (WB) assay were performed at day 3.</div></div><div><h3>Results</h3><div>The mean mNSS score was lower and the latency to falling off the rota-rod was prolonged at day 3 in the GHI group. GHI reduced the relative infarct volume and increased the relative cerebral blood flow. The histopathological damage of ischemic core was significantly ameliorated in the GHI group. GHI decreased the Caspase-3<sup>+</sup> cells and increased the MAP-2<sup>+</sup> and Claudin-5<sup>+</sup> cells. GHI increased the expression of Bcl-2 and the ratio of Bcl-2/Bax, and decreased the expression levels of Bax, Caspase-3 and Cleaved-Caspased-3. GHI reduced the microglia, decreased the IL-6 positive cells, TNF-α positive cells and increased TGF-β1 positive cells.</div></div><div><h3>Conclusions</h3><div>GHI alleviated brain injury and neurological deficits through improving cerebral blood circulation, attenuating neuronal apoptosis, reducing the disruption of blood-brain barrier (BBB) and decreasing neuroinflammation in MCAO and photothrombotic stroke models in mice. GHI has certain neuroprotective function to be applied to clinical use.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"399 ","pages":"Article 578515"},"PeriodicalIF":2.9,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the immunomodulatory effects of sertraline: Cytokine modulation and signaling pathway dynamics 探索舍曲林的免疫调节作用：细胞因子调节和信号通路动力学。

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-12-14 DOI: 10.1016/j.jneuroim.2024.578514

Harika Topal Önal , Derya Yetkin , Furkan Ayaz

{"title":"Exploring the immunomodulatory effects of sertraline: Cytokine modulation and signaling pathway dynamics","authors":"Harika Topal Önal , Derya Yetkin , Furkan Ayaz","doi":"10.1016/j.jneuroim.2024.578514","DOIUrl":"10.1016/j.jneuroim.2024.578514","url":null,"abstract":"<div><div>This study explores the nuanced immunomodulatory effects of sertraline, which is widely used in the treatment of major depression, obsessive-compulsive disorder, and anxiety in adults and children. Recent investigations have emphasized the intricate interplay between depression and the body's inflammatory response. This has sparked an exploration into the impact of sertraline on the immune system, an area that still awaits comprehensive exploration.</div><div>Our research methodically examines the influence of sertraline on the levels of cytokines (TNF-a, IL-6, IL-12p40, GM-CSF) in the macrophage cell line J774.2. This analysis is conducted under conditions with and without the lipopolysaccharide (LPS) danger signal. To enhance specificity, sertraline's effects are juxtaposed with those of salicylic acid, a known anti-inflammatory agent. Furthermore, a comprehensive exploration of sertraline's impact on the intracellular signaling pathways regulated phosphoinositide-3-kinase (PI3K) and the p38 pathway is the third major signaling cassettes of the mitogen-activated protein kinase (MAPK) signaling is presented.</div><div>The outcomes of our study unveil distinctive patterns in sertraline's modulation of cytokine levels within macrophage cells. Under the influence of the LPS danger signal, sertraline exhibits immunostimulatory characteristics, contrasting with its ability to suppress GM-CSF cytokine levels, even in the presence of LPS. Notably, the p38 pathway portrays a pro-inflammatory role for sertraline, while inhibiting the PI3K signaling pathway highlights its anti-inflammatory attributes. These findings contribute novel insights into the intricate interplay between sertraline and the immune system.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"399 ","pages":"Article 578514"},"PeriodicalIF":2.9,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic development towards T follicular helper cells as a molecular target in myasthenia gravis disease T滤泡辅助细胞作为重症肌无力疾病分子靶点的治疗进展。

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-12-05 DOI: 10.1016/j.jneuroim.2024.578503

J.J. Hernández Ruiz, A.M.C. Romero Malacara, L.A. López Mota, M.J. Pérez Guzmán

引用次数: 0

Quantitative assessment of thalamic damage and serum neurofilament light chain in relapsing-remitting multiple sclerosis 复发-缓解型多发性硬化症丘脑损伤及血清神经丝轻链定量评价。

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-12-04 DOI: 10.1016/j.jneuroim.2024.578504

Yan Liang , Jing Huang , Xiyue Zhang , Fang Xu , Chunrui Bo , Ming Lin , Xinmei Wen

{"title":"Quantitative assessment of thalamic damage and serum neurofilament light chain in relapsing-remitting multiple sclerosis","authors":"Yan Liang , Jing Huang , Xiyue Zhang , Fang Xu , Chunrui Bo , Ming Lin , Xinmei Wen","doi":"10.1016/j.jneuroim.2024.578504","DOIUrl":"10.1016/j.jneuroim.2024.578504","url":null,"abstract":"<div><h3>Background</h3><div>The study assessed group differences in the thalamus microstructural parameters among healthy individuals and relapsing-remitting multiple sclerosis (RRMS) patients and examined the relationship between quantitative MRI (qMRI) parameters and neurological scores, T2 lesion load, and serum neurofilament light chain (sNfL) levels.</div></div><div><h3>Methods</h3><div>A total of 30 patients with RRMS and 26 age- and sex-matched healthy controls were recruited in this study. The qMRI images were obtained from these individuals. T2 lesion load, thalamic volume, and parameters of thalamic subnuclei were estimated. The neurological functions of participants were assessed using a battery of tests. sNfL concentrations were measured using the single molecule array (SIMOA) technique.</div></div><div><h3>Results</h3><div>T2 relaxometry in the whole thalamus and its subnuclei were increased, and showed an apparent correlation with T2 lesion load and the severity of MS (EDSS, MSSS, 9HPT, T25FW, SDMT). T1 variability was prolonged in most thalamic subnuclei, and it was correlated with the severity of MS (EDSS, 9HPT, SDMT). Thalamic volumetric parameters of MS patients were smaller than those of healthy controls (<em>p</em> < 0.001) and showed an apparent correlation with MS severity. Surprisingly, sNfL levels showed no correlation with T2 relaxometry, T1 variability, or thalamic volumetric parameters.</div></div><div><h3>Conclusion</h3><div>Quantitative synthetic MRI, especially, the metric T2 relaxation times provides a surrogate parameter for assessing underlying thalamic and subnuclei damage in the RRMS group. Integrating structural and quantitative MRI allows a better assessment of the neurodegeneration in the normal-appearing thalamus of RRMS.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"399 ","pages":"Article 578504"},"PeriodicalIF":2.9,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0