Journal of neuroimmunology最新文献

{"title":"Sexual dimorphism of hypothalamic serotonin release during systemic inflammation: Role of endothelin-1","authors":"Regina Azevedo Costa ,&nbsp;Jefferson Angulski Amatnecks ,&nbsp;Gisele de Oliveira Guaita ,&nbsp;Cristina Aparecida Jark Stern ,&nbsp;Luiz Guilherme Siqueira Branco ,&nbsp;Aleksander Roberto Zampronio","doi":"10.1016/j.jneuroim.2024.578427","DOIUrl":"10.1016/j.jneuroim.2024.578427","url":null,"abstract":"<div><p>The hypothalamus receives serotonergic projections from the raphe nucleus in a sex-specific manner. During systemic inflammation, hypothalamic levels of serotonin (5-hydroxytryptamine [5-HT]) decrease in male rats. The present study evaluated the involvement of endothelin-1 (ET-1) in the febrile response, hypolocomotion, and changes in hypothalamic 5-HT levels during systemic inflammation in male and female rats. An intraperitoneal injection of lipopolysaccharide (LPS) induced a febrile response and hypolocomotion in both male and female rats. However, although LPS reduced hypothalamic levels of 5-HT and its metabolite 5-hydroxyindol acetic acid (5-HIAA) in male rats, it increased these levels in female rats. An intracerebroventricular injection of the endothelin-B receptor antagonist BQ788 significantly reduced LPS-induced fever and hypolocomotion and changes in hypothalamic 5-HT and 5-HIAA levels in both male and female rats. The i.c.v. administration of ET-1 induced a significant fever and hypolocomotion, but reduced the hypothalamic levels of 5-HT and 5-HIAA in both males and females. These results suggest an important sexual dimorphism during systemic inflammation regarding the release of 5-HT in the hypothalamus. Moreover, ET-1 arises as an important mediator involved in the changes in hypothalamic 5-HT levels in both male and female rats.</p></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"394 ","pages":"Article 578427"},"PeriodicalIF":2.9,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probiotics-regulated lithocholic acid suppressed B-cell differentiation in neuromyelitis optica spectrum disorder","authors":"Xi Cheng ,&nbsp;Chunping Cui ,&nbsp;Shishi Shen ,&nbsp;Zhibin Li ,&nbsp;Yipeng Zhao ,&nbsp;Caixia Li ,&nbsp;Allan G. Kermode ,&nbsp;Xiaonan Zhong ,&nbsp;Wei Qiu","doi":"10.1016/j.jneuroim.2024.578422","DOIUrl":"10.1016/j.jneuroim.2024.578422","url":null,"abstract":"<div><p>Intestinal microbes play a crucial role in gut health and the immune-mediated central nervous system through the “gut-brain” axis. However, probiotic safety and efficacy in Neuromyelitis optica spectrum disorder (NMOSD) are not well-explored. A pilot clinic trial for NMOSD with probiotic intervention revealed alterations in the microbiota (increased A<em>naerostipes, Bacteroides</em>; decreased <em>Granulicatella, Streptococcus, Rothia</em>). Metabolite analysis showed elevated 2-methylbutyric and isobutyric acids, reduced lithocholic acid (LCA), and glycodeoxycholic acid (GDCA). Immune markers Interleukin (IL-7), vascular endothelial growth factor (VEGF-A), and B lymphocyte chemoattractant (BLC) decreased, while plasma cells and transitional B cells increased post-probiotics, suggesting potential immunomodulatory effects on NMOSD.</p></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"395 ","pages":"Article 578422"},"PeriodicalIF":2.9,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142045091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age and sex-dependent gut alterations in mice induced by neonatal immune activation with lipopolysaccharide","authors":"Nayana Soares Gomes ,&nbsp;Natália Gindri Fiorenza ,&nbsp;Carlos Eduardo da Silva Monteiro ,&nbsp;Francisca Géssica Oliveira Silva ,&nbsp;Raimunda das Candeias ,&nbsp;Lucas Calixto Saldanha ,&nbsp;Suellen Monike do Vale Sabino ,&nbsp;Hoanna Izabely Rego Castro ,&nbsp;Pedro Marcos Gomes Soares ,&nbsp;Danielle S. Macêdo","doi":"10.1016/j.jneuroim.2024.578424","DOIUrl":"10.1016/j.jneuroim.2024.578424","url":null,"abstract":"<div><p>Neonatal immune activation (NIA) through exposure to lipopolysaccharide (LPS) induces adult behavioral changes in rodents that resemble symptoms of developmental disorders, such as autism spectrum disorder. The neonatal timing of LPS exposure appears to play a crucial role in determining the nature and extent of long-term changes. This study aims to explore whether a 3-day LPS-NIA triggers sex- and age-related changes in gut function, potentially linking LPS-NIA to gastrointestinal dysfunction. Male and female Swiss mice received intraperitoneal injections of LPS or saline on postnatal days (PN) 3, 5, and 7. At PN35 (juvenile) and PN70 (adult), gut inflammation and oxidative stress were evaluated in addition to assessments of working memory, depressive-like symptoms, sociability, and repetitive behavior. Gut examination showed elevated C-X-C motif chemokine receptor 3 (CXCR3) in LPS-NIA mice, while MyD88 and Zonulin expressions were significantly higher only in adult LPS-NIA females. Interleukin (IL)-23 expression increased in juvenile and adult male and juvenile female LPS-NIA mice. Oxidative changes included decreased duodenal reduced glutathione (GSH) in juvenile females and ileal GSH in adult females exposed to LPS-NIA. Regarding behavioral alterations, adult LPS-NIA females exhibited depressive-like behavior. Working memory deficits were observed across all LPS-NIA groups. Only juvenile LPS-NIA females increased grooming, while rearing was higher in adult LPS-NIA mice of both sexes. The findings imply that LPS-NIA impacts intestinal barrier function and causes gut inflammatory alterations that are sex- and age-specific. These findings pave the way for exploring potential mechanisms that could contribute to LPS-induced gastrointestinal disturbances among individuals with ASD.</p></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"395 ","pages":"Article 578424"},"PeriodicalIF":2.9,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteomics analysis of immune response-related proteins in Guillain-Barré Syndrome (GBS) and Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)","authors":"Yu-Jing Li ,&nbsp;Xue-Yu Zhang ,&nbsp;Wen-Jun Zhang ,&nbsp;Ya-Li Han ,&nbsp;Min-Shu Li ,&nbsp;Jian-Li Zhao ,&nbsp;Jie Wu ,&nbsp;Xiao-Wen Li ,&nbsp;Jing Xu ,&nbsp;Fu-Dong Shi","doi":"10.1016/j.jneuroim.2024.578423","DOIUrl":"10.1016/j.jneuroim.2024.578423","url":null,"abstract":"<div><p>The objective is to characterize differentially expressed proteins (DEPs) in Guillain-Barré Syndrome (GBS) and Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) through high-throughput analysis. Sera from 11 healthy controls (HCs), 21 GBS and 19 CIDP patients were subjected to Olink Proteomics Analysis. In the comparison between CIDP and GBS groups, up-regulation of ITM2A and down-regulation of NTF4 were observed. Comparing GBS with HCs revealed 18 up-regulated and 4 down-regulated proteins. Comparing CIDP with the HCs identified 15 up-regulated and 4 down-regulated proteins. Additionally, the correlation between clinical characteristics and DEPs were uncovered. In conclusion, the DEPs have significant potential to advance our understanding of the pathogenesis in these debilitating neurological disorders.</p></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"394 ","pages":"Article 578423"},"PeriodicalIF":2.9,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141795814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infections and neurodegenerative diseases: A complex, still enigmatic connection","authors":"Francesca Aloisi ,&nbsp;Giovanna De Chiara","doi":"10.1016/j.jneuroim.2024.578412","DOIUrl":"10.1016/j.jneuroim.2024.578412","url":null,"abstract":"","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"394 ","pages":"Article 578412"},"PeriodicalIF":2.9,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141796026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the causal role of immune cells in vascular dementia: A bidirectional mendelian randomization study","authors":"Ze Chang ,&nbsp;Yuli Hu ,&nbsp;Xiao Liang ,&nbsp;Lina Miao ,&nbsp;Xiansu Chi ,&nbsp;Xie Wang ,&nbsp;Hong Chen ,&nbsp;Hongxi Liu ,&nbsp;Longtao Liu ,&nbsp;Yunling Zhang ,&nbsp;Zhenyun Han","doi":"10.1016/j.jneuroim.2024.578409","DOIUrl":"10.1016/j.jneuroim.2024.578409","url":null,"abstract":"<div><h3>Background</h3><p>The aim of this study was to explore the causal association between immune cells and VaD based on a two-sample bidirectional Mendelian randomization study.</p></div><div><h3>Methods</h3><p>Bidirectional two-sample MR analyses based on pooled datasets from publicly available genome-wide association studies were performed using inverse variance weighted (IVW), weighted median (WE), and MR–Egger regressions to evaluate the causal relationships between immune cells and vascular dementia. Heterogeneity was assessed using Cochran's Q statistic. The reliability of the MR analysis results was verified by using the MR-PRESSO method for outlier detection, the MR–Egger method for horizontal multivariate analysis, and the leave-one-out method for sensitivity analysis.</p></div><div><h3>Results</h3><p>Specifically, 27 immunophenotypes were associated with VaD pathogenesis, including Sw mem %lymphocyte (<em>P</em> = 0.043), CD38 on CD20- (<em>P</em> = 0.039), CD11c⁺ monocyte AC (<em>P</em> = 0.024), DC AC (<em>P</em> = 0.002), CCR2 on CD62L⁺ myeloid DC (<em>P</em> = 0.039), Resting Treg %CD4 (<em>P</em> = 0.042), Activated &amp; resting Treg %CD4⁺ (<em>P</em> = 0.038), CD28⁺ CD45RA⁻ CD8br %CD8br (<em>P</em> = 0.047), NK %CD3⁻ lymphocyte (<em>P</em> = 0.042), CD45 on B cell (<em>P</em> = 0.029), FSC-A on NKT (<em>P</em> = 0.033), CD45 on CD33br HLA DR⁺ CD14⁻ (<em>P</em> = 0.039) were significantly correlated with increased VaD risk. Additionally, four immune phenotypes, namely, CD19 on CD20⁻, Resting Treg %CD4, Activated &amp; resting Treg %CD4⁺, and CD11c⁺ monocyte AC, showed bidirectional effects on VaD.</p></div><div><h3>Conclusions</h3><p>MR analysis revealed potential causal relationships between certain immune cells and VaD. Our preliminary exploration through immune cell infiltration analysis highlights the significant value of immune cells in VaD. Therefore, this study may provide a new perspective for the prevention and treatment of VaD.</p></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"394 ","pages":"Article 578409"},"PeriodicalIF":2.9,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141846412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-contactin-associated protein 1 antibody-positive nodopathy presenting with central nervous system symptoms","authors":"Yasuko Mori ,&nbsp;Nobuaki Yoshikura ,&nbsp;Yuki Fukami ,&nbsp;Akira Takekoshi ,&nbsp;Akio Kimura ,&nbsp;Masahisa Katsuno ,&nbsp;Takayoshi Shimohata","doi":"10.1016/j.jneuroim.2024.578420","DOIUrl":"10.1016/j.jneuroim.2024.578420","url":null,"abstract":"<div><p>Contactin-associated protein 1 (Caspr1) is widespread in both the peripheral and central nervous systems (CNS). However, anti-Caspr1 antibody-positive nodopathy associated with CNS symptoms has not previously been reported. In this case, a 69-year-old man presented with polyneuropathy and memory loss. The patient had negative myoclonus, positive myoclonus, and pseudoathetosis in the upper limbs, and we detected anti-Caspr1 antibodies in the serum and cerebrospinal fluid. Therefore, anti-Caspr1 nodopathy was diagnosed. After rituximab treatment, all symptoms of polyneuropathy, involuntary movements, and memory impairment improved. In conclusion, anti-Caspr1 antibodies might also affect the CNS; therefore, CNS symptoms of anti-Caspr1 nodopathy require attention.</p></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"394 ","pages":"Article 578420"},"PeriodicalIF":2.9,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141849304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune-regulating effect of oxytocin and its association with the hypothalamic-pituitary axes","authors":"Tong Li ,&nbsp;Yun-Hao Jiang ,&nbsp;Xiaoran Wang ,&nbsp;Dan Hou ,&nbsp;Shu-Wei Jia ,&nbsp;Yu-Feng Wang","doi":"10.1016/j.jneuroim.2024.578419","DOIUrl":"10.1016/j.jneuroim.2024.578419","url":null,"abstract":"<div><p>Oxytocin can regulate immunological activity directly or indirectly; however, immunological functions and mechanisms of oxytocin actions under chronic stress like cesarean delivery (CD) are poorly understood. Our study found that abnormal oxytocin production and secretion in CD rats caused atrophy of thymic tissues. Neurotoxin kainic acid microinjected into the dorsolateral supraoptic nucleus in male rats selectively reduced hypothalamic oxytocin levels, increased corticotrophin-releasing hormone and plasma interleukin-1β while reducing plasma oxytocin, thyroxine and testosterone levels and causing atrophy of immune tissues. Thus, plasma oxytocin is essential for immunological homeostasis, which involves oxytocin facilitation of thyroid hormone and sex steroid secretion.</p></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"394 ","pages":"Article 578419"},"PeriodicalIF":2.9,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141842463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Niacin produces an inconsistent treatment response in the EAE model of multiple sclerosis","authors":"Emily C. Wuerch ,&nbsp;Reza Mirzaei ,&nbsp;V. Wee Yong","doi":"10.1016/j.jneuroim.2024.578421","DOIUrl":"10.1016/j.jneuroim.2024.578421","url":null,"abstract":"<div><p>Niacin was found in the lysolecithin model of multiple sclerosis (MS) to promote the phagocytic clearance of debris and enhance remyelination. Lysolecithin lesions have prominent microglia/macrophages but lack lymphocytes that populate plaques of MS or its experimental autoimmune encephalomyelitis (EAE) model. Thus, the current study assessed the efficacy of niacin in EAE. We found that niacin inconsistently affects EAE clinical score, and largely does not ameliorate neuropathology. In culture, niacin enhances phagocytosis by macrophages, but does not reduce T cell proliferation. We suggest that studies of niacin for potential remyelination in MS should include a therapeutic that targets adaptive immunity.</p></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"394 ","pages":"Article 578421"},"PeriodicalIF":2.9,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0165572824001401/pdfft?md5=42e99a44411fdbc678cc66569ef6d484&pid=1-s2.0-S0165572824001401-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141846714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel model of multiple sclerosis induced by EBV-like virus generates a unique B cell population","authors":"Joshua L. Deffenbaugh ,&nbsp;Kyeong-Joo Jung ,&nbsp;Shawn P. Murphy ,&nbsp;Yue Liu ,&nbsp;Christina N. Rau ,&nbsp;Cora L. Petersen-Cherubini ,&nbsp;Patrick L. Collins ,&nbsp;Dongjun Chung ,&nbsp;Amy E. Lovett-Racke","doi":"10.1016/j.jneuroim.2024.578408","DOIUrl":"10.1016/j.jneuroim.2024.578408","url":null,"abstract":"<div><p>Epstein-Barr virus (EBV) is deemed a necessary, yet insufficient factor in the development of multiple sclerosis (MS). In this study, myelin basic protein-specific transgenic T cell receptor mice were infected with murid gammaherpesvirus 68 virus (MHV68), an EBV-like virus that infects mice, resulting in the onset neurological deficits at a significantly higher frequency than influenza or mock-infected mice. MHV68 infected mice exhibited signs including optic neuritis and ataxia which are frequently observed in MS patients but not in experimental autoimmune encephalomyelitis mice. MHV68-infected mice exhibited increased focal immune cell infiltration in the central nervous system. Single cell RNA sequencing identified the emergence of a population of B cells that express genes associated with antigen presentation and costimulation, indicating that gammaherpesvirus infection drives a distinct, pro-inflammatory transcriptional program in B cells that may promote autoreactive T cell responses in MS.</p></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"394 ","pages":"Article 578408"},"PeriodicalIF":2.9,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0165572824001279/pdfft?md5=af5b53f47d01b4f9e6299cf1ecdc7ed0&pid=1-s2.0-S0165572824001279-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141848499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}