自身免疫性胃炎伴亚急性合并脊髓变性的双滤过血浆置换1例

IF 2.9 4区医学 Q3 IMMUNOLOGY

Journal of neuroimmunology Pub Date : 2025-04-14 DOI:10.1016/j.jneuroim.2025.578618

Qiuju Li , Bin Liu , Yangtai Guan, Yuhui Wang

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引用次数: 0

摘要

自身免疫性胃炎（AIG）的特征是胃壁细胞的破坏，导致维生素B12缺乏，并可能导致亚急性脊髓联合变性（SCD）。我们报告了一例61岁的AIG男性患者，他发展为SCD，并接受了三次双滤过血浆置换（DFPP），导致自身抗体滴度显著降低，神经系统症状得到改善。DFPP在治疗AIG合并SCD方面表现出疗效，通过快速降低自身抗体水平，提供比传统疗法更快的临床反应。该病例强调了早期诊断和干预对预防不可逆神经损伤的重要性，提示DFPP作为AIG合并SCD的一种有希望的辅助治疗方法，值得进一步研究其在自身免疫性疾病中的机制和应用。

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Double filtration plasmapheresis in autoimmune gastritis with subacute combined degeneration of the spinal cord: A case report

Autoimmune gastritis (AIG) is characterized by the destruction of gastric parietal cells, leading to vitamin B12 deficiency and potentially causing subacute combined degeneration of the spinal cord (SCD). We present a case of a 61-year-old male with AIG who developed SCD and underwent three sessions of double filtration plasmapheresis (DFPP), resulting in significant reduction of autoantibody titers and improvement in neurological symptoms. DFPP demonstrated efficacy in treating AIG complicated by SCD, offering potentially faster clinical response than conventional therapies by rapidly reducing autoantibody levels. This case underscores the importance of early diagnosis and intervention in preventing irreversible neurological damage, suggesting DFPP as a promising adjunctive treatment for AIG with SCD and warranting further investigation into its mechanisms and applications in autoimmune diseases.

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来源期刊

Journal of neuroimmunology 医学-免疫学

CiteScore

6.10

自引率

3.00%

发文量

154

审稿时长

37 days

期刊介绍： The Journal of Neuroimmunology affords a forum for the publication of works applying immunologic methodology to the furtherance of the neurological sciences. Studies on all branches of the neurosciences, particularly fundamental and applied neurobiology, neurology, neuropathology, neurochemistry, neurovirology, neuroendocrinology, neuromuscular research, neuropharmacology and psychology, which involve either immunologic methodology (e.g. immunocytochemistry) or fundamental immunology (e.g. antibody and lymphocyte assays), are considered for publication.