Journal of neuroimmunology最新文献

{"title":"Corrigendum to “Cerebrospinal fluid soluble CD27 is associated with CD8+ T cells, B cells and biomarkers of B cell activity in relapsing-remitting multiple sclerosis” [Journal of neuroimmunology vol. 381 (2023): 578128]","authors":"Sahla El Mahdaoui , Signe Refstrup Husted , Malene Bredahl Hansen , Stefan Cobanovic , Mie Reith Mahler , Sophie Buhelt , Marina Rode von Essen , Finn Sellebjerg , Jeppe Romme Christensen","doi":"10.1016/j.jneuroim.2025.578607","DOIUrl":"10.1016/j.jneuroim.2025.578607","url":null,"abstract":"","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"403 ","pages":"Article 578607"},"PeriodicalIF":2.9,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An enjoyable career in science","authors":"Maria Staykova","doi":"10.1016/j.jneuroim.2025.578612","DOIUrl":"10.1016/j.jneuroim.2025.578612","url":null,"abstract":"","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"404 ","pages":"Article 578612"},"PeriodicalIF":2.9,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143816783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autoantigen and IL-2 activated CD4+CD25+T regulatory cells are induced to express CD8 and are autoantigen specific in inhibiting experimental autoimmune encephalomyelitis","authors":"Giang T. Tran ,&nbsp;Sukhandep Bedi ,&nbsp;Prateek Rakesh ,&nbsp;Nirupama D. Verma ,&nbsp;Nicole Carter ,&nbsp;Catherine M. Robinson ,&nbsp;Ranje Al-Atiyah ,&nbsp;Bruce M. Hall ,&nbsp;Suzanne J. Hodgkinson","doi":"10.1016/j.jneuroim.2025.578611","DOIUrl":"10.1016/j.jneuroim.2025.578611","url":null,"abstract":"<div><div>Experimental autoimmune encephalomyelitis (EAE) induced by immunization with myelin basic protein (MBP) is a self-limiting disease model of multiple sclerosis. CD4⁺CD25⁺Foxp3⁺T cells play a role in limiting autoimmune disease but treatment with antigen naïve CD4⁺CD25⁺ cells does not reduce EAE.</div><div>This study examined if in vitro activation by MBP and rIL-2 induced CD4⁺CD25⁺Foxp3⁺ cells that could inhibit EAE. Culture of CD4⁺CD8^-CD25⁺cells from naïve rats with MBP and rIL-2 induced activated Treg that reduced the severity of clinical EAE and infiltration of CD8⁺T cells and macrophage into brain stem. CD4⁺CD25⁺T cells activated by an irrelevant autoantigen and rIL-2 did not suppress EAE. Resting CD4⁺CD25⁺T cells activated by autoantigen and rIL-2 have mRNA for <em>Infgr, Il12rb2, Il5</em> but not <em>Tbet, Gata3, Ilr5ra</em> or <em>Ifng.</em> These changes in mRNA expression are the markers of Ts1 cells.</div><div>A proportion of CD4⁺CD8^-CD25⁺ cells activated by MBP/rIL-2 were induced to express CD8α, CD8β and CD62L. Depletion of CD4⁺CD8α⁺CD25⁺ cells removed the capacity of MBP and rIL-2 activated CD4⁺CD25⁺T cells to suppress EAE.</div><div>This study demonstrated that in vitro activation of CD4⁺CD8^-CD25⁺ cells by MBP/rIL-2 induced relevant antigen-specific Treg within days, which expressed CD8α, CD8β and CD62L with a Ts1 phenotype and that had greater potency than freshly isolated antigen naive CD4⁺CD25⁺Treg in suppressing clinical severity of EAE and immune inflammation in CNS. These findings may guide development of antigen-specific Treg for therapy.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"404 ","pages":"Article 578611"},"PeriodicalIF":2.9,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kinetics of serum NFL and GFAP and changes in cognitive functions, in MS patients treated with repeated administrations of autologous mesenchymal stem cells (MSC-NG01)","authors":"Panayiota Petrou,&nbsp;Ibrahim Kassis,&nbsp;Yarden Levi,&nbsp;Nour Yaghmour,&nbsp;Tehila Epstein,&nbsp;Ariel Ginzberg,&nbsp;Dimitrios Karussis","doi":"10.1016/j.jneuroim.2025.578613","DOIUrl":"10.1016/j.jneuroim.2025.578613","url":null,"abstract":"<div><h3>Background</h3><div>Intrathecal injection (IT) of autologous mesenchymal stem cells (MSC) showed robust beneficial effects a previous randomized study from our center, in patients with progressive multiple sclerosis (MS) (<span><span>NCT02166021</span><svg><path></path></svg></span>). We evaluated here the effect of repeated MSC-NG01 transplantations on serum biomarkers of neuroinflammation and neurodegeneration, namely, neurofilaments light chains (NFL) and glial fibrillary acidic protein (GFAP), in an open-label extension trial.</div></div><div><h3>Methods</h3><div>23 patients with progressive types of MS, who participated in the <span><span>NCT02166021</span><svg><path></path></svg></span>-trial, were included. Patients were treated with 2–3 intrathecal injections of MSC-NG01 and followed up for a period of &gt;12 months. Safety/tolerability and various efficacy measurements, including EDSS/FS, timed 25-ft (T25FW) walking, cognitive functions, and serum levels of the biomarkers NFL and GFAP, were assessed.</div></div><div><h3>Results</h3><div>Serum levels of NFL and GFAP showed a gradual and consistent reduction after the intrathecal treatments with MSC-NG01, in multiple measurements. The mean NFL reduction at last observation after one year was 33.2 % (<em>p</em> &lt; 0.001, Wilcoxon-paired test). Serum levels of GFAP were reduced in all tested patients (<em>p</em> &lt; 0.0004, Wilcoxon-paired test). A significant improvement was observed in T25-FW and in the sum of all functional systems (FS) at the final visit of 12 months. SDMT cognitive test was also improved by a mean of &gt;3 degrees (<em>p</em> = 0.0008).</div></div><div><h3>Conclusion</h3><div>Treatment of progressive MS patients with IT injections of autologous MSC-NG01 induced a reduction in both NFL and GFAP biomarkers levels, paralleled by beneficial effects on cognition, neurological functional tests and quality of life. These data indicate significant effects of MSC-transplantation on neurodegeneration and neuroinflammation.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"403 ","pages":"Article 578613"},"PeriodicalIF":2.9,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143817240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiome depletion modulates cocaine-induced behavioral and transcriptional responses in female mice","authors":"Yesha A. Dave ,&nbsp;Marta Koperska ,&nbsp;Kelsey E. Lucerne ,&nbsp;Ava L. Shipman ,&nbsp;Sharon M. Zeldin ,&nbsp;Aya Osman ,&nbsp;Rebecca S. Hofford ,&nbsp;Drew D. Kiraly","doi":"10.1016/j.jneuroim.2025.578609","DOIUrl":"10.1016/j.jneuroim.2025.578609","url":null,"abstract":"<div><div>Cocaine use disorder is a chronic relapsing condition with no FDA-approved biological treatments. The gut microbiome has emerged as a key modulator of neurobehavioral responses to drugs of abuse, yet its role in female animals has been under studied. Here, we investigated the effects of gut microbiome depletion on cocaine-induced behavioral and transcriptional responses in female mice. Adult female C57BL/6 J mice were treated with a non-absorbable oral antibiotic (Abx) cocktail for two weeks to deplete the gut microbiome, followed by behavioral assays assessing locomotor sensitization and conditioned place preference (CPP) to cocaine. Abx-treated females displayed reduced locomotor sensitization and a shifted CPP dose-response curve, characterized by attenuated preference at higher cocaine doses. Transcriptional analysis of the nucleus accumbens (NAc) revealed that microbiome depletion suppressed cocaine-induced expression of immediate early genes (<em>c-Fos</em>, <em>FosB</em>, <em>Nr4a1</em>, <em>Egr4</em>) and altered dopamine-related (<em>Drd1</em>) and microglial (<em>Cx3cr1</em>) markers. These findings contrast with prior studies in males, where microbiome depletion enhanced cocaine-induced behavioral plasticity. The observed effects suggest distinct gut-brain signaling as an important contributor to cocaine reinforcement and neuroadaptations in females. This study provides novel insights into microbiome regulation of addiction-relevant behaviors and highlights the necessity of sex-specific investigations in neuropsychiatric disorders. Further research is needed to elucidate the molecular pathways linking gut dysbiosis to substance use vulnerability in females.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"403 ","pages":"Article 578609"},"PeriodicalIF":2.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143820779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific immune-biological profiles in Parkinson's disease","authors":"Roberta Bovenzi ,&nbsp;Matteo Conti ,&nbsp;Clara Simonetta ,&nbsp;Jacopo Bissacco ,&nbsp;Davide Mascioli ,&nbsp;Maria Mancini ,&nbsp;Veronica Buttarazzi ,&nbsp;Federica Veltri ,&nbsp;Giulia Maria Sancesario ,&nbsp;Silvio Bagetta ,&nbsp;Francesca D'Amaro ,&nbsp;Massimo Pieri ,&nbsp;Rocco Cerroni ,&nbsp;Claudio Liguori ,&nbsp;Valerio Chiurchiù ,&nbsp;Mariangela Pierantozzi ,&nbsp;Alessandro Stefani ,&nbsp;Nicola Biagio Mercuri ,&nbsp;Tommaso Schirinzi","doi":"10.1016/j.jneuroim.2025.578610","DOIUrl":"10.1016/j.jneuroim.2025.578610","url":null,"abstract":"<div><div>Depending on age, both the risk and characteristics of Parkinson's disease (PD) differ between the sexes. The immune system might have a role; however, human-based evidence remains scarce. Here, we investigated the relationship between peripheral immune cellular composition and the clinical-biological sexual dimorphism of PD. The leukocyte population count (neutrophils, lymphocytes, monocytes, eosinophils, and basophils), the neutrophil-to-lymphocyte ratio (NLR), and the monocytes-to-lymphocytes ratio (MLR) were collected and compared in 117 PD patients and 86 controls (CTLs), and then related to blood levels of sex hormones, CSF markers of neurodegeneration (α-synuclein, amyloid-β-42, amyloid-β-40, total tau, and phosphorylated-181-tau), and clinical features in male and female PD patients. Finally, a cluster analysis based on the three main leukocyte populations (neutrophils, lymphocytes, monocytes) was performed for the entire PD cohort. Male PD patients had lower lymphocyte counts and higher NLR than male CTLs. Females with PD had lower monocyte counts, NLR, and MLR than males with PD. Lymphocyte counts correlated with cognition in male, but not female, PD patients. Finally, two clusters of peripheral immune cellular composition were identified: the “high peripheral inflammation” one, mostly comprising male patients, with worse clinical features and greater central α-synuclein burden, and the “low peripheral inflammation cluster”, which mainly comprised female patients, with milder clinical features and lower central synucleinopathy. In conclusion, the peripheral immune pattern entails sex-specific clinical-biological profiles in PD. Moreover, systemic inflammation clusters with sex, sexual hormones, clinical features, and central synucleinopathy in PD, supporting the relevance of immunity in sexual dimorphism of the disease.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"403 ","pages":"Article 578610"},"PeriodicalIF":2.9,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143800372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and immunotherapy efficacy in autoimmune-associated benign epilepsy with centrotemporal spikes: A prospective cohort study","authors":"Zhijie Zhang ,&nbsp;Jing Wu ,&nbsp;Danfeng Xu,&nbsp;Shengnan Zhao,&nbsp;Di Lian,&nbsp;Dandan Zhang,&nbsp;Ling Li","doi":"10.1016/j.jneuroim.2025.578603","DOIUrl":"10.1016/j.jneuroim.2025.578603","url":null,"abstract":"<div><h3>Introduction</h3><div>Benign Epilepsy with Centrotemporal Spikes (BECTS) is the most common form of focal epilepsy in pediatric patients. In clinical practice, immune dysregulation and neuroinflammation have been observed in a subset of patients with BECTS harboring latent Herpesviridae infections, including the Epstein-Barr Virus (EBV) and Human Cytomegalovirus (CMV). Therefore, the present study aimed to explore the correlation between clinical characteristics and immune dysregulation in autoimmunity-associated BECTS and latent viral or Mycoplasma infections.</div></div><div><h3>Method</h3><div>Fourteen pediatric patients diagnosed with autoimmunity-associated BECTS were prospectively enrolled and underwent assessment of their presentations and etiological and immunological indicators. Further, we evaluated the effectiveness and safety of specific immune therapies (intravenous methylprednisolone and/or intravenous immunoglobulin). Therapy efficacy was determined by a reduction in Rolandic spikes on electroencephalogram recordings and seizure frequency. Potential risk factors were assessed through a retrospective comparative analysis with a control group comprising 46 patients diagnosed with cryptogenic BECTS.</div></div><div><h3>Result</h3><div>The autoimmunity-associated BECTS cohort demonstrated a higher likelihood of cognitive impairment, ADHD, psychiatric symptoms, and atypical BECTS; required a greater number of anti-seizure medications (ASMs); and experienced longer delays from symptom onset to hospital admission. The prevalence of CMV infection was also found to be significantly higher in the autoimmune disease group than in the control group. Elevated levels of IL-6, IgG, and Complement C3 were observed in the sera of both infected and non-infected children with BECTS. Atypical BECTS and Bilateral Rolandic spikes in EEG were identified as key risk factors for autoimmunity-associated BECTS. Following immunotherapy (intravenous methylprednisolone and/or intravenous immunoglobulin), a substantial reduction in seizure frequency and accumulated spike-wave index (AccSWI) was observed.</div></div><div><h3>Conclusion</h3><div>These findings support the hypothesis that autoimmune mechanisms contribute to the pathogenesis of selected BECTS cases. Latent viral infections such as CMV may serve as potential triggers. Atypical presentations of BECTS, with Bilateral Rolandic spikes in EEG, indicate the possibility of an autoimmune-associated trigger. Immunotherapy appears to offer therapeutic benefits to patients with autoimmunity-associated BECTS.</div></div><div><h3>Clinical trial registration</h3><div>This single-center, longitudinal observational study (XH-16-029/<span><span>NCT02969213</span><svg><path></path></svg></span>) included pediatric patients diagnosed with epilepsy.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"404 ","pages":"Article 578603"},"PeriodicalIF":2.9,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143807925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rasmussen encephalitis and localized scleroderma of the lower limb: Another piece of the puzzle. A case-report and literature review with individual participant data","authors":"Adolfo Mazzeo ,&nbsp;Emanuele Cerulli Irelli ,&nbsp;Alessandra Morano ,&nbsp;Pierpaolo Quarato ,&nbsp;Giancarlo Di Gennaro ,&nbsp;Carlo Di Bonaventura","doi":"10.1016/j.jneuroim.2025.578608","DOIUrl":"10.1016/j.jneuroim.2025.578608","url":null,"abstract":"<div><div>The co-occurrence of Rasmussen encephalitis (RE) and localized scleroderma (LS) is rare and poorly known. We describe the unique case of a 23-year-old patient with late-onset RE of the right hemisphere, emerging 15 years following LS of the left lower limb exclusively.</div><div>Furthermore, through a systematic review of existing literature, we delineate distinct characteristics of RE concomitant with LS: a delayed onset compared to classical RE cases; its occurrence either preceding or succeeding LS; and the variable involvement of the ipsilateral or contralateral hemisphere to the affected craniofacial skin. These findings might provide some hints regarding the interplay between these two conditions.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"404 ","pages":"Article 578608"},"PeriodicalIF":2.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nitric oxide and experimental autoimmune encephalomyelitis review","authors":"Maria Staykova,&nbsp;Anne Bruestle","doi":"10.1016/j.jneuroim.2025.578586","DOIUrl":"10.1016/j.jneuroim.2025.578586","url":null,"abstract":"<div><div>Immunisation with neuroantigen in complete Freund's adjuvant (CFA) results in a range from severe experimental autoimmune encephalomyelitis (EAE) to no EAE in various strains and sexes of rodents. When CFA was substituted for carbonyl iron, all were EAE-susceptible. One of the differences between the two adjuvants was the strong induction of inducible nitric oxide synthase in EAE-resistant strains by CFA.</div><div>The questions discussed in this review are:</div><div>1/ Could exaggerated production of nitric oxide protect against development of autoimmunity?</div><div>2/ Could non-susceptible strains be rendered susceptible to EAE by interfering with NO levels during the inductive phase?</div><div>3/ Could susceptible strains be rendered resistant to EAE by interfering with NO levels during the inductive phase?</div><div>The answer to the three questions is “yes” and one of the reasons is the NO-induced actin polarization in the encephalitogenic T cells leading to their reduced trans-endothelial migration.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"404 ","pages":"Article 578586"},"PeriodicalIF":2.9,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143821176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MOGAD optic neuritis after mild head/orbital trauma in six children","authors":"Alexander J. Sandweiss ,&nbsp;Jonathan Rosen ,&nbsp;Chaitanya Aduru ,&nbsp;Akansha Chandrasekar ,&nbsp;Kyla Blasingame ,&nbsp;Madhuri Chilakapati ,&nbsp;Rod Foroozan ,&nbsp;Jonathan M. Yarimi","doi":"10.1016/j.jneuroim.2025.578605","DOIUrl":"10.1016/j.jneuroim.2025.578605","url":null,"abstract":"<div><div>Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a potential cause of optic neuritis (ON). Its triggers and etiologies are not completely understood. We describe a novel clinical observation in six young patients with MOGAD-ON in the setting of strikingly parallel histories of mild head/orbital trauma. This is a single-center retrospective case series of six young patients and age-matched isolated MOGAD-ON controls. We present data both individually (de-identified, only the six trauma-associated cases) and in aggregate. Averages are presented as the arithmetic mean +/− SEM. 6/27 patients with MOGAD-ON, (3/6 female), between 8 and 18 years old presented with ON 5.5 days after mild head trauma. Four patients developed ON ipsilateral to their unilateral head trauma while two developed bilateral ON following midline head trauma. All patients tested positive for serum anti-MOG antibodies upon ON workup. They all received intravenous corticosteroids with rapid improvement in symptoms (5.5 weeks to full visual recovery) and none have since relapsed. No other patients with MOGAD-ON experienced preceding head trauma, and all patients in the control group were asked about trauma upon assessment of the history. Head trauma may serve as an inciting event in the presentation and diagnosis of MOGAD-ON. This novel observation provides a potential pathophysiologic mechanism independent of infectious triggers, although we cannot determine if these patients were already predisposed towards MOGAD-ON.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"404 ","pages":"Article 578605"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}