Journal of neuroimmunology最新文献

Correspondence: Electroconvulsive therapy in N-methyl-D-aspartate receptor encephalitis. 通讯：N-甲基-D-天冬氨酸受体脑炎的电休克疗法。

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2025-01-15 Epub Date: 2024-07-20 DOI: 10.1016/j.jneuroim.2024.578404

Jonathan Reed Komisar, Sohag Sanghani, Grace Thrall, Leonardo V Lopez, Khyati Brahmbhatt, Stanley Brewer, Jacob Feigal, James Luccarelli, Nasuh Malas, Dennis Popeo, Joshua Ryan Smith, Chase Samsel, D Catherine Fuchs, GenaLynne C Mooneyham

引用次数: 0

Pure spinal multiple sclerosis: A case series of a possible new entity. 临时切除：纯脊髓型多发性硬化症：一个可能的新病例系列。

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2025-01-15 Epub Date: 2024-08-08 DOI: 10.1016/j.jneuroim.2024.578429

Masoud Etemadifar, Seyyed-Ali Alaei, Nahad Sedaghat, Amir Hossein Ghandehari, Ahmadreza Dehghani, Zahra-Sadat Mirian, Mahdi Norouzi, Mohammadreza Etemadifar, Mehri Salari

{"title":"Pure spinal multiple sclerosis: A case series of a possible new entity.","authors":"Masoud Etemadifar, Seyyed-Ali Alaei, Nahad Sedaghat, Amir Hossein Ghandehari, Ahmadreza Dehghani, Zahra-Sadat Mirian, Mahdi Norouzi, Mohammadreza Etemadifar, Mehri Salari","doi":"10.1016/j.jneuroim.2024.578429","DOIUrl":"10.1016/j.jneuroim.2024.578429","url":null,"abstract":"Background: Recent literature describes a condition similar to multiple sclerosis (MS) but with demyelinating lesions limited to the spinal cord. This condition, referred to as \"pure spinal\" MS, might benefit from disease-modifying treatment (DMT).Methods: We screened the medical records of approximately 8000 patients with demyelinating diseases at the Isfahan MS clinic in Iran. Criteria for inclusion in the case series were adults with a demyelinating disease limited to the spinal cord, positive oligoclonal IgG bands in cerebrospinal fluid (CSF), and negative results for other potential diagnoses.Results: Seven people with pure spinal MS were identified (all women, mean age [SD]: 40.14 [6.17] years at the first visit, mean follow-up duration [SD]: 98 [39.41] months). Two had a family history of conventional MS in their siblings. All patients exhibited lower limb weakness and tested negative for anti-MOG and anti-AQP4 antibodies. They experienced relapsing-remitting partial myelitis, with new spinal cord lesions on MRI but no extraspinal CNS lesions. DMT significantly reduced relapse rates in all patients, and two showed no increase in EDSS scores.Conclusion: Pure spinal MS might be an atypical form of MS. Those affected may benefit from DMT; therefore, further investigation and consideration in the upcoming revisions of the McDonald criteria are recommended.","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":" ","pages":"578429"},"PeriodicalIF":2.9,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A 7-year-old with new-onset seizures, behavior disturbance, and encephalitis.

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-12-30 DOI: 10.1016/j.jneuroim.2024.578520

MaryGlen V Stanich, Trevor Memmott, Taumoha Ghosh, Melissa A Wright

引用次数: 0

Corrigendum to "Elevated frequencies of activated memory B cells in multiple sclerosis are reset to healthy control levels are B cell depletion with Ocrelizumab" [J. Neuroimmunol. 339:578502 (2024)].

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-12-27 DOI: 10.1016/j.jneuroim.2024.578519

Cody J Gurski, Zivar Hajiyeva, Anthony J Veltri, Kaylan Fenton, Samantha O'Dell, Ahmed Z Obeidat, Bonnie N Dittel

引用次数: 0

Vitamin C co-administration with artemether-lumefantrine abrogates chronic stress exacerbated Plasmodium berghei-induced sickness behaviour, inflammatory and oxidative stress responses in mice.

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-12-20 DOI: 10.1016/j.jneuroim.2024.578518

Kehinde Joshua Ogundeyi, Abayomi Mayowa Ajayi, Ololade Justina Oduyomi, Stella Afolakemi Adeyemo, Mary O Ologe, Olusegun George Ademowo

引用次数: 0

IgLON5 autoimmunity secondary to immune checkpoint inhibitor.

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-12-16 DOI: 10.1016/j.jneuroim.2024.578516

Christopher Itoh, Grace Swart, Erik St Louis, Manish Gandhi, Divyanshu Dubey

引用次数: 0

Guhong injection attenuates brain injury and promotes neuroprotection after acute ischemic stroke.

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-12-15 DOI: 10.1016/j.jneuroim.2024.578515

Xiaoshan Du, Zhihui Qi, Yulin Li, Siting Wu, Fang Zhang, Zhiguo Li, Jingshan Chen

{"title":"Guhong injection attenuates brain injury and promotes neuroprotection after acute ischemic stroke.","authors":"Xiaoshan Du, Zhihui Qi, Yulin Li, Siting Wu, Fang Zhang, Zhiguo Li, Jingshan Chen","doi":"10.1016/j.jneuroim.2024.578515","DOIUrl":"https://doi.org/10.1016/j.jneuroim.2024.578515","url":null,"abstract":"Background and objectives: Guhong injection (GHI) has multiple components and generates diverse effects, and is mainly used in the treatment of acute ischemic stroke (AIS). The purpose of this study is to explore the multiple effects of GHI in AIS models in mice and the mechanism how they work together to affect the stroke outcome.Methods: Middle cerebral artery occlusion (MCAO) and photothrombotic stroke models were established with GHI or vehicle. Neurological function assessment including the Modified Neurological Severity Score (mNSS) and rota-rod test, and relative cerebral blood flow were monitored at day 1 and day 3 after model establishment. Flow cytometry, 2, 3, 5-Triphenyltetrazolium chloride (TTC) staining, histology and immunofluorescence, Western blotting (WB) assay were performed at day 3.Results: The mean mNSS score was lower and the latency to falling off the rota-rod was prolonged at day 3 in the GHI group. GHI reduced the relative infarct volume and increased the relative cerebral blood flow. The histopathological damage of ischemic core was significantly ameliorated in the GHI group. GHI decreased the Caspase-3+ cells and increased the MAP-2+ and Claudin-5+ cells. GHI increased the expression of Bcl-2 and the ratio of Bcl-2/Bax, and decreased the expression levels of Bax, Caspase-3 and Cleaved-Caspased-3. GHI reduced the microglia, decreased the IL-6 positive cells, TNF-α positive cells and increased TGF-β1 positive cells.Conclusions: GHI alleviated brain injury and neurological deficits through improving cerebral blood circulation, attenuating neuronal apoptosis, reducing the disruption of blood-brain barrier (BBB) and decreasing neuroinflammation in MCAO and photothrombotic stroke models in mice. GHI has certain neuroprotective function to be applied to clinical use.","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"399 ","pages":"578515"},"PeriodicalIF":2.9,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the immunomodulatory effects of sertraline: Cytokine modulation and signaling pathway dynamics.

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-12-14 DOI: 10.1016/j.jneuroim.2024.578514

Harika Topal Önal, Derya Yetkin, Furkan Ayaz

{"title":"Exploring the immunomodulatory effects of sertraline: Cytokine modulation and signaling pathway dynamics.","authors":"Harika Topal Önal, Derya Yetkin, Furkan Ayaz","doi":"10.1016/j.jneuroim.2024.578514","DOIUrl":"https://doi.org/10.1016/j.jneuroim.2024.578514","url":null,"abstract":"This study explores the nuanced immunomodulatory effects of sertraline, which is widely used in the treatment of major depression, obsessive-compulsive disorder, and anxiety in adults and children. Recent investigations have emphasized the intricate interplay between depression and the body's inflammatory response. This has sparked an exploration into the impact of sertraline on the immune system, an area that still awaits comprehensive exploration. Our research methodically examines the influence of sertraline on the levels of cytokines (TNF-a, IL-6, IL-12p40, GM-CSF) in the macrophage cell line J774.2. This analysis is conducted under conditions with and without the lipopolysaccharide (LPS) danger signal. To enhance specificity, sertraline's effects are juxtaposed with those of salicylic acid, a known anti-inflammatory agent. Furthermore, a comprehensive exploration of sertraline's impact on the intracellular signaling pathways regulated phosphoinositide-3-kinase (PI3K) and the p38 pathway is the third major signaling cassettes of the mitogen-activated protein kinase (MAPK) signaling is presented. The outcomes of our study unveil distinctive patterns in sertraline's modulation of cytokine levels within macrophage cells. Under the influence of the LPS danger signal, sertraline exhibits immunostimulatory characteristics, contrasting with its ability to suppress GM-CSF cytokine levels, even in the presence of LPS. Notably, the p38 pathway portrays a pro-inflammatory role for sertraline, while inhibiting the PI3K signaling pathway highlights its anti-inflammatory attributes. These findings contribute novel insights into the intricate interplay between sertraline and the immune system.","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"399 ","pages":"578514"},"PeriodicalIF":2.9,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic development towards T follicular helper cells as a molecular target in myasthenia gravis disease.

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-12-05 DOI: 10.1016/j.jneuroim.2024.578503

J J Hernández Ruiz, A M C Romero Malacara, L A López Mota, M J Pérez Guzmán

引用次数: 0

Quantitative assessment of thalamic damage and serum neurofilament light chain in relapsing-remitting multiple sclerosis.

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-12-04 DOI: 10.1016/j.jneuroim.2024.578504

Yan Liang, Jing Huang, Xiyue Zhang, Fang Xu, Chunrui Bo, Ming Lin, Xinmei Wen

{"title":"Quantitative assessment of thalamic damage and serum neurofilament light chain in relapsing-remitting multiple sclerosis.","authors":"Yan Liang, Jing Huang, Xiyue Zhang, Fang Xu, Chunrui Bo, Ming Lin, Xinmei Wen","doi":"10.1016/j.jneuroim.2024.578504","DOIUrl":"https://doi.org/10.1016/j.jneuroim.2024.578504","url":null,"abstract":"Background: The study assessed group differences in the thalamus microstructural parameters among healthy individuals and relapsing-remitting multiple sclerosis (RRMS) patients and examined the relationship between quantitative MRI (qMRI) parameters and neurological scores, T2 lesion load, and serum neurofilament light chain (sNfL) levels.Methods: A total of 30 patients with RRMS and 26 age- and sex-matched healthy controls were recruited in this study. The qMRI images were obtained from these individuals. T2 lesion load, thalamic volume, and parameters of thalamic subnuclei were estimated. The neurological functions of participants were assessed using a battery of tests. sNfL concentrations were measured using the single molecule array (SIMOA) technique.Results: T2 relaxometry in the whole thalamus and its subnuclei were increased, and showed an apparent correlation with T2 lesion load and the severity of MS (EDSS, MSSS, 9HPT, T25FW, SDMT). T1 variability was prolonged in most thalamic subnuclei, and it was correlated with the severity of MS (EDSS, 9HPT, SDMT). Thalamic volumetric parameters of MS patients were smaller than those of healthy controls (p < 0.001) and showed an apparent correlation with MS severity. Surprisingly, sNfL levels showed no correlation with T2 relaxometry, T1 variability, or thalamic volumetric parameters.Conclusion: Quantitative synthetic MRI, especially, the metric T2 relaxation times provides a surrogate parameter for assessing underlying thalamic and subnuclei damage in the RRMS group. Integrating structural and quantitative MRI allows a better assessment of the neurodegeneration in the normal-appearing thalamus of RRMS.","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"399 ","pages":"578504"},"PeriodicalIF":2.9,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0