Journal of neuroimmunology最新文献

Corrigendum to “Novel model of multiple sclerosis induced by EBV-like virus generate a unique B cell population” [Journal of Neuroimmunology volume 394 (2024) 578408] “由ebv样病毒诱导的多发性硬化症的新模型产生独特的B细胞群”的勘误表[Journal of Neuroimmunology卷394 (2024)578408]

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2025-04-29 DOI: 10.1016/j.jneuroim.2025.578625

J.L. Deffenbaugh , K.-J. Jung , S.P. Murphy , Y. Liu , C.N. Rau , C. Petersen-Cherubini , P.L. Collins , D. Chung , A.E. Lovett-Racke

引用次数: 0

Identification of shared pathophysiological molecules of major psychiatric disorders: A comprehensive analysis of serum immune complex antigens before and after electroconvulsive therapy 鉴定主要精神疾病的共同病理生理分子：电休克治疗前后血清免疫复合物抗原的综合分析

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2025-04-25 DOI: 10.1016/j.jneuroim.2025.578623

Yuki Jimbayashi Kutsuna , Nozomi Aibara , Junya Hashizume , Wataru Omori , Mami Okada-Tsuchioka , Naoto Kajitani , Mikiro Nakashima , Atsushi Kawakami , Kaname Ohyama , Minoru Takebayashi

{"title":"Identification of shared pathophysiological molecules of major psychiatric disorders: A comprehensive analysis of serum immune complex antigens before and after electroconvulsive therapy","authors":"Yuki Jimbayashi Kutsuna , Nozomi Aibara , Junya Hashizume , Wataru Omori , Mami Okada-Tsuchioka , Naoto Kajitani , Mikiro Nakashima , Atsushi Kawakami , Kaname Ohyama , Minoru Takebayashi","doi":"10.1016/j.jneuroim.2025.578623","DOIUrl":"10.1016/j.jneuroim.2025.578623","url":null,"abstract":"<div><div>Recent studies indicate common inflammatory findings have been identified in peripheral blood in patients with major psychiatric disorders, including schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD). Electroconvulsive therapy (ECT) frequently improves both severe symptoms and inflammatory markers in these conditions. However, the shared inflammatory mechanisms underlying these disorders, and thus, reliable biomarkers remain unclear. We hypothesized that the activation of immune complexes (ICs) contributes to inflammatory pathogenesis of these disorders. Using immune complexome analysis, we examined antigens forming ICs (IC-antigens) in the serum of patients with SCZ, BD, and MDD (<em>n</em> = 60) before and after ECT. Our analysis showed that although the overall quantity of ICs did not change before and after ECT, four proteins significantly decreased following ECT. These proteins were DENN domain-containing protein 1C (DENND1C), double-stranded RNA-specific editase 1 (ADARB1), perilipin-4, and coagulation factor XI, which were all consistently detected as IC-antigens across patient groups. Notably, DENND1C, ADARB1, and perilipin-4 were specific to psychiatric patients and absent in healthy controls. The abundance of these IC-antigens significantly correlated with psychiatric symptom scores, with DENND1C showing a particularly strong correlation with total symptom scores across all three disorders. These findings suggest that DENND1C may contribute to the shared pathophysiology of SCZ, BD, and MDD through antigenization or IC formation. This highlights its potential as a biomarker for ECT treatment availability and diagnostic/treatment efficacy monitoring.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"405 ","pages":"Article 578623"},"PeriodicalIF":2.9,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seropositivity rate of IGLON 5– A retrospective laboratory based study from India IGLON 5血清阳性率——印度回顾性实验室研究

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2025-04-24 DOI: 10.1016/j.jneuroim.2025.578624

Meena Thevarkalam , Annamma Mathai , Suprabha Panicker , Nandana Sajith , Sudheeran Kannoth , Anandkumar Anandakuttan , Dipanjan Chakraborty

{"title":"Seropositivity rate of IGLON 5– A retrospective laboratory based study from India","authors":"Meena Thevarkalam , Annamma Mathai , Suprabha Panicker , Nandana Sajith , Sudheeran Kannoth , Anandkumar Anandakuttan , Dipanjan Chakraborty","doi":"10.1016/j.jneuroim.2025.578624","DOIUrl":"10.1016/j.jneuroim.2025.578624","url":null,"abstract":"<div><h3>Objective</h3><div>IgLON 5 disease is a rare immune mediated tauopathy and its prevalence in India is unknown. Our aim was to determine the rate of seropositivity of anti IgLON 5 antibodies in our study population.</div></div><div><h3>Methods</h3><div>Retrospective study done between February 2022 and December 2023 at the Neuroimmunology laboratory of Amrita Institute of Medical Sciences, Kochi, Kerala, India. Patients who underwent IgLON 5 testing were identified from laboratory records and their details extracted.</div></div><div><h3>Results</h3><div>Out of a total of 1027 patients tested for IgLON 5, 33 were positive for anti IgLON 5 antibody. [Mean age - 63.45±9.59 years; males −21]. Twenty-six cases were positive in serum, 4 in cerebrospinal fluid and 3 in both serum and CSF. The rate of seropositivity of IgLON 5 in this study population was 3.21 %.</div></div><div><h3>Discussion</h3><div>This laboratory study shows an increased seropositivity rate of IgLON 5 disease in India. Genetic predisposition could be a potential explanation. Population based studies and genetic studies will be required to ascertain this. However, this brief report points at the need for increased awareness among clinicians regarding IgLON 5 disease, as it is more common in our population.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"404 ","pages":"Article 578624"},"PeriodicalIF":2.9,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oligoclonal IgM band patterns in multiple sclerosis: A two-center study 多发性硬化症的寡克隆IgM条带模式：一项双中心研究

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2025-04-22 DOI: 10.1016/j.jneuroim.2025.578622

Francesco Masi , Sabrina Al Qudsi , Davide Visigalli , Elisabetta Zardini , Elisabetta Capello , Luca Pio Dicembre , Elena Colombo , Antonio Uccelli , Matteo Gastaldi , Matilde Inglese , Diego Franciotta

{"title":"Oligoclonal IgM band patterns in multiple sclerosis: A two-center study","authors":"Francesco Masi , Sabrina Al Qudsi , Davide Visigalli , Elisabetta Zardini , Elisabetta Capello , Luca Pio Dicembre , Elena Colombo , Antonio Uccelli , Matteo Gastaldi , Matilde Inglese , Diego Franciotta","doi":"10.1016/j.jneuroim.2025.578622","DOIUrl":"10.1016/j.jneuroim.2025.578622","url":null,"abstract":"<div><h3>Background</h3><div>Cerebrospinal fluid (CSF) oligoclonal IgM bands (OCMBs) have been suggested as prognostic biomarkers in MS, but serum OCMBs meaning is still uncertain.</div></div><div><h3>Objectives</h3><div>We aimed to assess frequency and clinical relevance of all OCMB patterns.</div></div><div><h3>Methods</h3><div>In this retrospective cohort study, 136 paired sera-CSF from consecutive persons with MS (pwMS) were tested in 2 centers for OCMBs using isoelectric focusing-immunoblotting. Active disease was defined as clinical or radiological relapse occurring during two-year follow-up. Predictors of active disease were analyzed with logistic regressions and Kaplan-Meier survival curves.</div></div><div><h3>Results</h3><div>OCMBs were found in 6.6 % of pwMS as unique-to-CSF (pattern #2), and in 20.6 % as identical in serum-CSF (pattern #4), without between-cohort difference. Active disease was more frequent in those with pattern #2 (88.9 %) and #4 (64.3 %) than in those OCMB-negative (33.3 %, <em>p</em> < 0.001). In multivariate analysis, pattern #2 (OR: 15.9; 95 % CI [1.8–136]), and pattern #4 (OR: 3.3 95 % CI [1.3–8.3]) were independent predictors of active disease. In survival analysis, pattern #2 (<em>p</em> < 0.001) and #4 (<em>p</em> = 0.017) predicted radiological relapses.</div></div><div><h3>Conclusions</h3><div>Our data confirm that CSF OCMB marks poor prognosis in MS. However, both OCMB pattern #4 and pattern #2, with different strength prediction, might be useful to stratify pwMS deserving more aggressive treatments, although the stratification could be achieved in the near future with more standardized and easily measurable biomarkers (e.g., serum neurofilaments).</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"404 ","pages":"Article 578622"},"PeriodicalIF":2.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elevated serum levels of IL-10 family and IL-12 family cytokines in myasthenia gravis 重症肌无力患者血清IL-10家族和IL-12家族细胞因子水平升高

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2025-04-22 DOI: 10.1016/j.jneuroim.2025.578621

Yosuke Onishi , Akiyuki Uzawa , Manato Yasuda , Hiroyuki Akamine , Etsuko Ogaya , Hideo Handa , Yukiko Ozawa , Satoshi Kuwabara

{"title":"Elevated serum levels of IL-10 family and IL-12 family cytokines in myasthenia gravis","authors":"Yosuke Onishi , Akiyuki Uzawa , Manato Yasuda , Hiroyuki Akamine , Etsuko Ogaya , Hideo Handa , Yukiko Ozawa , Satoshi Kuwabara","doi":"10.1016/j.jneuroim.2025.578621","DOIUrl":"10.1016/j.jneuroim.2025.578621","url":null,"abstract":"<div><h3>Background</h3><div>IL-10 and IL-12 family cytokines play important roles in various immunological diseases. This study identified a relationship between IL-10 and IL-12 family cytokines and the pathogenesis of myasthenia gravis (MG).</div></div><div><h3>Methods</h3><div>We measured IL-10 and IL-12 family cytokines levels in 25 treatment-naive MG patients with acetylcholine receptor (AChR) antibodies and 28 controls and examined their relationships with clinical parameters.</div></div><div><h3>Results</h3><div>Serum levels of IL-10, IL-12p40, IL-12p70, IL-20, IL-22, IL-26, IL-28A, IL-29, and IL-35 were significantly higher in MG group than in control group. Among these, IL-20, IL-26, IL-28A, and IL-29 levels decreased after immunotherapy. AChR antibody titers were negatively correlated with levels of IL-12p40, IL-22, and IL-26. Scores on the MG activities of daily living (MG-ADL) scale were negatively correlated with IL-20 levels.</div></div><div><h3>Conclusion</h3><div>Serum levels of IL-10 and IL-12 family cytokines were elevated in MG. In particular, IL-12p40, IL-20, IL-22, and IL-26 levels might be potential disease biomarkers in MG patients.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"404 ","pages":"Article 578621"},"PeriodicalIF":2.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Double filtration plasmapheresis in autoimmune gastritis with subacute combined degeneration of the spinal cord: A case report 自身免疫性胃炎伴亚急性合并脊髓变性的双滤过血浆置换1例

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2025-04-14 DOI: 10.1016/j.jneuroim.2025.578618

Qiuju Li , Bin Liu , Yangtai Guan, Yuhui Wang

引用次数: 0

Associations between serum levels of alpha-calcitonin gene-related peptide and clinical features of neuromyelitis optica spectrum disorders 血清α -降钙素基因相关肽水平与视神经脊髓炎谱系障碍临床特征的关系

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2025-04-13 DOI: 10.1016/j.jneuroim.2025.578615

Yuka Inoue , Takayuki Fujii , Kaoru Yoshida Kashu , Mitsuru Watanabe , Katsuhisa Masaki , Eizo Tanaka , Yuu-ichi Kira , Hajime Takeuchi , Ken Yamaura , Noriko Isobe

{"title":"Associations between serum levels of alpha-calcitonin gene-related peptide and clinical features of neuromyelitis optica spectrum disorders","authors":"Yuka Inoue , Takayuki Fujii , Kaoru Yoshida Kashu , Mitsuru Watanabe , Katsuhisa Masaki , Eizo Tanaka , Yuu-ichi Kira , Hajime Takeuchi , Ken Yamaura , Noriko Isobe","doi":"10.1016/j.jneuroim.2025.578615","DOIUrl":"10.1016/j.jneuroim.2025.578615","url":null,"abstract":"<div><div>Neuromyelitis optica spectrum disorders (NMOSD) are characterized by severe inflammation-mediated astrocytopathy in the central nervous system. Neuropathic pain (NP) is highly prevalent among patients with NMOSD, and significantly impairs their quality of life. Alpha-calcitonin gene-related peptide (α-CGRP) is a neuropeptide related to pain and neuroinflammation in the central and peripheral nerves; however, the involvement of α-CGRP in NMOSD pathophysiology remains unexplored. Here, we measured serum levels of α-CGRP in 33 patients with NMOSD and 36 healthy controls by enzyme-linked immunosorbent assay to clarify associations between serum α-CGRP levels and clinical NMOSD features, including NP. The NMOSD patients showed significantly higher serum α-CGRP levels than healthy controls [median (interquartile range), ng/mL; 1.89 (1.66–2.39) vs 1.54 (1.34–1.87), <em>p</em> = 0.008]. NMOSD patients with sensory or bowel and bladder dysfunction had elevated serum α-CGRP levels compared with those without [2.02 (1.76–2.80) vs 1.76 (1.44–1.95), <em>p</em> = 0.049; 2.19 (1.96–2.86) vs 1.71 (1.40–1.90), <em>p</em> < 0.001, respectively]. Serum α-CGRP levels were higher in NMOSD patients with neuropathic pain than in those without [2.00 (1.71–2.76) vs 1.78 (1.51–1.97), <em>p</em> = 0.120]. NMOSD patients with spinal cord lesions on magnetic resonance imaging showed significantly higher serum α-CGRP levels compared with those without [2.02 (1.73–2.83) vs 1.73 (1.36–1.87), <em>p</em> = 0.044]. These findings indicate an association between α-CGRP and NMOSD pathophysiological status, especially sensory and bowel and bladder dysfunction derived from spinal cord lesions.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"404 ","pages":"Article 578615"},"PeriodicalIF":2.9,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143844106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune cells in dorsal root ganglia are associated with pruritus in a mouse model of allergic contact dermatitis and co-culture study 小鼠变应性接触性皮炎模型中背根神经节免疫细胞与瘙痒的关系及共培养研究

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2025-04-12 DOI: 10.1016/j.jneuroim.2025.578617

Tichakorn Singto , Alisa Sergeeva , Viviane Filor , Jonathan Vidak , Burkhard Kleuser , Vitaly Belik , Fabian Schumacher , Wolfgang Bäumer

{"title":"Immune cells in dorsal root ganglia are associated with pruritus in a mouse model of allergic contact dermatitis and co-culture study","authors":"Tichakorn Singto , Alisa Sergeeva , Viviane Filor , Jonathan Vidak , Burkhard Kleuser , Vitaly Belik , Fabian Schumacher , Wolfgang Bäumer","doi":"10.1016/j.jneuroim.2025.578617","DOIUrl":"10.1016/j.jneuroim.2025.578617","url":null,"abstract":"<div><div>The interaction between the neuroimmune system plays a crucial role in itch sensation, yet most research has focused on immune cells within the skin. Our study seeks to explore the presence and functions of immune cells within the dorsal root ganglia (DRG) in the context of allergic contact dermatitis (ACD). Immunofluorescence and histological staining techniques were employed to identify immune cells, including T-cells, basophils, mast cells, and dendritic cells (DCs), within the DRG of BALB/c mice sensitized and challenged with toluene diisocyanate (TDI). Our findings revealed an increase in mast cells and DCs within the DRG under ACD condition. Additionally, when DRG neurons were cultured with mast cells, a higher proportion of neurons exhibited responses to non-histaminergic pruritogens compared to neurons cultured alone. This suggests that mast cells may contribute to heightened sensitivity to non-histaminergic pruritogens. Furthermore, we conducted transcriptomic analysis of DCs within the DRG using RNA sequencing, followed by pathway enrichment analysis. Our analysis revealed that sorted DCs are implicated in immune responses, inflammation, and itch, with notable upregulation of Cathepsin S (<em>Ctss</em>) and sphingosine-1-phosphate (S1P) phosphatase 2 (<em>Sgpp2</em>). Subsequent functional experiments targeting CTSS in co-culture studies validated suppressed response to pruritogen and agonists of TRPA1 and TRPV1, indicating a potential role in peripheral sensitization. Additionally, the co-culture study indicated that the neuroimmune interaction between DCs and DRG neurons might involve S1P metabolism and S1P receptor signaling. In conclusion, targeting DCs and exploring the non-histaminergic functions of mast cells within the DRG, holds promise as novel targets for treating pruritus.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"404 ","pages":"Article 578617"},"PeriodicalIF":2.9,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143839207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autoantibody-mediated disorders of the central and peripheral nervous system: Overview Infection 自身抗体介导的中枢和周围神经系统疾病：概述感染

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2025-04-11 DOI: 10.1016/j.jneuroim.2025.578616

Yury Zharikov , Anna Shitova , Polina Melnikova , Ilya Voloshin , Maria Orliuk , Anna Olsufieva , André Pontes-Silva , Tatiana Zharikova

引用次数: 0

Corrigendum to “Cerebrospinal fluid soluble CD27 is associated with CD8+ T cells, B cells and biomarkers of B cell activity in relapsing-remitting multiple sclerosis” [Journal of neuroimmunology vol. 381 (2023): 578128] “脑脊液可溶性CD27与复发缓解型多发性硬化症中CD8+ T细胞、B细胞和B细胞活性生物标志物相关”的勘误表[Journal of neuroimmunology vol. 381 (2023): 578128]

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2025-04-10 DOI: 10.1016/j.jneuroim.2025.578607

Sahla El Mahdaoui , Signe Refstrup Husted , Malene Bredahl Hansen , Stefan Cobanovic , Mie Reith Mahler , Sophie Buhelt , Marina Rode von Essen , Finn Sellebjerg , Jeppe Romme Christensen

引用次数: 0