与抗gaba - b和抗hu抗体相关的多灶性副肿瘤脑炎，表现为癫痫持续状态和部分持续性癫痫：扩大临床放射谱

IF 2.9 4区医学 Q3 IMMUNOLOGY

Journal of neuroimmunology Pub Date : 2025-05-04 DOI:10.1016/j.jneuroim.2025.578634

Veronica Viola , Gian Maria Asioli , Lorenzo Ferri , Simone Rossi , Elisa Andrini , Elisabetta Pierucci , Giuseppe Lamberti , Luisa Sambati , Rita Rinaldi , Francesca Bisulli , Luca Spinardi , Maria Guarino

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引用次数: 0

摘要

副肿瘤神经综合征（PNSs）是远处肿瘤的免疫介导效应，通常含有抗神经元抗体。这些抗体可能直接针对细胞内或细胞表面抗原，并且与每种抗体相关的临床图像通常是模式化的。PNSs伴抗细胞内和抗表面神经元抗原的临床和影像学表现尚不清楚。本病例报告描述了一例独特的小细胞肺癌患者，同时携带抗gababr和抗hu抗体，表现为多灶性脑炎，表现为癫痫持续状态和部分持续性癫痫。

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Multifocal paraneoplastic encephalitis associated with anti-GABA-B and anti-Hu antibodies manifesting with status epilepticus and epilepsia partialis continua: Expanding the clinical-radiological spectrum

Paraneoplastic neurological syndromes (PNSs) are immune-mediated effects of remote cancer, which often harbor anti-neuronal antibodies. These antibodies may direct toward intracellular or cell-surface antigens and the clinical picture associated with each antibody is often stereotyped. Little is known about clinical and radiological manifestations of PNSs with co-occurring anti-intracellular and anti-surface neuronal antigens. This case report describes a unique case of a patient with small cell lung cancer harboring both anti-GABABR and anti-Hu antibodies who presented with multifocal encephalitis, manifesting with status epilepticus and epilepsia partialis continua.

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来源期刊

Journal of neuroimmunology 医学-免疫学

CiteScore

6.10

自引率

3.00%

发文量

154

审稿时长

37 days

期刊介绍： The Journal of Neuroimmunology affords a forum for the publication of works applying immunologic methodology to the furtherance of the neurological sciences. Studies on all branches of the neurosciences, particularly fundamental and applied neurobiology, neurology, neuropathology, neurochemistry, neurovirology, neuroendocrinology, neuromuscular research, neuropharmacology and psychology, which involve either immunologic methodology (e.g. immunocytochemistry) or fundamental immunology (e.g. antibody and lymphocyte assays), are considered for publication.