Journal of neuroimmunology最新文献_第2页

Correspondence: Electroconvulsive therapy in N-methyl-D-aspartate receptor encephalitis 通讯：N-甲基-D-天冬氨酸受体脑炎的电休克疗法。

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2025-01-15 DOI: 10.1016/j.jneuroim.2024.578404

Jonathan Reed Komisar , Sohag Sanghani , Grace Thrall , Leonardo V. Lopez , Khyati Brahmbhatt , Stanley Brewer , Jacob Feigal , James Luccarelli , Nasuh Malas , Dennis Popeo , Joshua Ryan Smith , Chase Samsel , D. Catherine Fuchs , GenaLynne C. Mooneyham

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Pure spinal multiple sclerosis: A case series of a possible new entity 临时切除：纯脊髓型多发性硬化症：一个可能的新病例系列。

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2025-01-15 DOI: 10.1016/j.jneuroim.2024.578429

Masoud Etemadifar , Seyyed-Ali Alaei , Nahad Sedaghat , Amir Hossein Ghandehari , Ahmadreza Dehghani , Zahra-sadat Mirian , Mahdi Norouzi , Mohammadreza Etemadifar , Mehri Salari

{"title":"Pure spinal multiple sclerosis: A case series of a possible new entity","authors":"Masoud Etemadifar , Seyyed-Ali Alaei , Nahad Sedaghat , Amir Hossein Ghandehari , Ahmadreza Dehghani , Zahra-sadat Mirian , Mahdi Norouzi , Mohammadreza Etemadifar , Mehri Salari","doi":"10.1016/j.jneuroim.2024.578429","DOIUrl":"10.1016/j.jneuroim.2024.578429","url":null,"abstract":"<div><h3>Background</h3><div>Recent literature describes a condition similar to multiple sclerosis (MS) but with demyelinating lesions limited to the spinal cord. This condition, referred to as “pure spinal” MS, might benefit from disease-modifying treatment (DMT).</div></div><div><h3>Methods</h3><div>We screened the medical records of approximately 8000 patients with demyelinating diseases at the Isfahan MS clinic in Iran. Criteria for inclusion in the case series were adults with a demyelinating disease limited to the spinal cord, positive oligoclonal IgG bands in cerebrospinal fluid (CSF), and negative results for other potential diagnoses.</div></div><div><h3>Results</h3><div>Seven people with pure spinal MS were identified (all women, mean age [SD]: 40.14 [6.17] years at the first visit, mean follow-up duration [SD]: 98 [39.41] months). Two had a family history of conventional MS in their siblings. All patients exhibited lower limb weakness and tested negative for anti-MOG and anti-AQP4 antibodies. They experienced relapsing-remitting partial myelitis, with new spinal cord lesions on MRI but no extraspinal CNS lesions. DMT significantly reduced relapse rates in all patients, and two showed no increase in EDSS scores.</div></div><div><h3>Conclusion</h3><div>Pure spinal MS might be an atypical form of MS. Those affected may benefit from DMT; therefore, further investigation and consideration in the upcoming revisions of the McDonald criteria are recommended.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"398 ","pages":"Article 578429"},"PeriodicalIF":2.9,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seasonal variation in myasthenia gravis incidence 重症肌无力发病率的季节变化。

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2025-01-09 DOI: 10.1016/j.jneuroim.2025.578524

Silvia Falso , Pietro Zara , Sofia Marini , Mariangela Puci , Eleonora Sabatelli , Giovanni Sotgiu , Martina Marini , Gregorio Spagni , Amelia Evoli , Paolo Solla , Raffaele Iorio , Elia Sechi

{"title":"Seasonal variation in myasthenia gravis incidence","authors":"Silvia Falso , Pietro Zara , Sofia Marini , Mariangela Puci , Eleonora Sabatelli , Giovanni Sotgiu , Martina Marini , Gregorio Spagni , Amelia Evoli , Paolo Solla , Raffaele Iorio , Elia Sechi","doi":"10.1016/j.jneuroim.2025.578524","DOIUrl":"10.1016/j.jneuroim.2025.578524","url":null,"abstract":"<div><h3>Introduction</h3><div>Environmental factors may contribute to myasthenia gravis (MG) development, sometimes with seasonal patterns of exposure. However, whether seasonality has an impact on MG incidence remains unclear. We aimed to investigate the association between seasonality and MG onset.</div></div><div><h3>Methods</h3><div>We reviewed data of MG patients with acetylcholine receptor (AChR)-IgG and disease onset between January 2010–December 2019, from two Italian cohorts: 1) an hospital-based cohort and 2) a population-based cohort. MG cases were assigned to four season-trimesters based on month of onset to determine seasonal association with MG incidence.</div></div><div><h3>Results</h3><div>We enrolled 316 patients:214 in the hospital-based and 102 in the population-based cohort. Median age at onset was 66 years (range, 8–92); Female accounted for 41.1 %. The median number of new MG cases per season-trimester was significantly higher in summer than other trimesters <em>(p</em> <em>=</em> <em>0.009),</em> and associated with higher environmental temperatures.</div></div><div><h3>Discussion</h3><div>Our findings suggest that MG onset may be more common in summer and at higher environmental temperatures. Identifying the determinants of this association may improve our understanding of disease pathophysiology.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"399 ","pages":"Article 578524"},"PeriodicalIF":2.9,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the Editor Regarding “Spinocerebellar ataxia masquerading as multiple sclerosis, a case report” 致编辑的信关于“脊髓小脑共济失调伪装成多发性硬化症，一例报告”。

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2025-01-09 DOI: 10.1016/j.jneuroim.2025.578523

Bade Gulec , Elif Everest , Ugur Uygunoglu

引用次数: 0

Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) as a cause of new-onset refractory status epilepticus (NORSE): Case report and review of literature 髓鞘少突胶质细胞糖蛋白抗体相关疾病（MOGAD）作为新发难治性癫痫持续状态（NORSE）的原因：病例报告和文献回顾

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2025-01-08 DOI: 10.1016/j.jneuroim.2025.578522

Abhishek Vaingankar , Ayush Agarwal , Divyani Garg , Pranjal Gupta , Ajay Garg , Divya M. Radhakrishnan , Awadh K. Pandit , Achal Kumar Srivastava

引用次数: 0

NOD-like receptor protein 3 inhibition by MCC950 improves the cognitive function of rats with sepsis-associated encephalopathy

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2025-01-06 DOI: 10.1016/j.jneuroim.2024.578517

Li Zhang , Long Ma , Yi Wang , Xiang Li , Yanjie Yang , Ling Yang , Xiangyou Yu

{"title":"NOD-like receptor protein 3 inhibition by MCC950 improves the cognitive function of rats with sepsis-associated encephalopathy","authors":"Li Zhang , Long Ma , Yi Wang , Xiang Li , Yanjie Yang , Ling Yang , Xiangyou Yu","doi":"10.1016/j.jneuroim.2024.578517","DOIUrl":"10.1016/j.jneuroim.2024.578517","url":null,"abstract":"<div><div>This study aimed to investigate the effects of MCC950 in a rat model of sepsis-associated encephalopathy (SAE). Adult male rats were randomly assigned to 12 groups according to the surgery or treatment received and evaluation times. The SAE model was established using the cecal ligation and puncture (CLP) method. Intraperitoneal injections of normal saline (10 mL/kg) or MCC950 (10 mg/kg) were administered 30 min pre-surgery and daily post-surgery. Changes in survival rates, weight loss, and heart rate were assessed at four time points, and neurobehavioral changes were evaluated using the composite neural reflex function scores, light/dark box test, and open-field test (OFT). Compared with the SAE group, the SAE + MCC950 group had significantly higher survival rates (<em>P</em> < 0.05), lower postoperative weight loss rates (P < 0.05), and higher neurological function scores (<em>P</em> < 0.05); the SAE + MCC950 group also traveled further and crossed the central area more frequently in the OFT (<em>P</em> < 0.05), spent more time in the light compartment at different time points (<em>P</em> < 0.05), and exhibited a lower heart rate at different time points (P < 0.05). MCC950 treatment significantly improved cognitive function and related indices in the SAE rats.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"400 ","pages":"Article 578517"},"PeriodicalIF":2.9,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebrospinal fluid biomarkers associated with neurofilament light levels: A study in HIV disease

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2025-01-06 DOI: 10.1016/j.jneuroim.2025.578521

Enrico Ripamonti , Magnus Gisslén , Lars Hagberg , Pradeepthi Bathala , Shraddha Kale , Martin Stengelin , George Sigal , Jacob Wohlstadter , Henrik Zetterberg , Richard Price

{"title":"Cerebrospinal fluid biomarkers associated with neurofilament light levels: A study in HIV disease","authors":"Enrico Ripamonti , Magnus Gisslén , Lars Hagberg , Pradeepthi Bathala , Shraddha Kale , Martin Stengelin , George Sigal , Jacob Wohlstadter , Henrik Zetterberg , Richard Price","doi":"10.1016/j.jneuroim.2025.578521","DOIUrl":"10.1016/j.jneuroim.2025.578521","url":null,"abstract":"<div><h3>Background</h3><div>A retrospective study was conducted in people with HIV (PWH) to explore potential cerebrospinal fluid (CSF) biomarkers linked to CSF neurofilament light levels (NfL), indicative of neuronal injury.</div></div><div><h3>Methods</h3><div>A sample of 168 participants was tested, including 43 HIV-negative controls and PWH who were classified into subgroups based on HIV and treatment status. Twenty CSF protein biomarkers were analyzed for their association with CSF NfL concentrations using a linear regression forward selection strategy, adjusted for age and sex. Regression trees were utilized to visualize feature relationships.</div></div><div><h3>Results</h3><div>Age-adjusted average concentrations of CSF NfL ranged from 427 pg/mL (SD = 190) in HIV- participants to 6456 pg/mL (SD = 46,024) in participants with HIV-associated dementia. Significant associations were found between specific biomarkers and CSF NfL levels in different participant subgroups. Noteworthy findings included correlations between CSF t-tau, CSF MCP-1, CSF TNF-α, and albumin ratio with CSF NfL levels in untreated PWH, and CSF IL-21 with CSF NfL in treated, virally suppressed PWH. Association between age and CSF NfL concentrations was a general finding.</div></div><div><h3>Conclusion</h3><div>We identified specific CSF biomarkers, including CSF t-tau protein, CSF MCP-1, and CSF TNF-α that associated with CSF NfL concentrations in untreated PWH and CSF IL-21 that associated with CSF NfL in PWH with effective treatment, shedding light on neuroinflammatory processes which may underlie HIV-related neuronal injury and the impact of antiviral therapy. Further investigations are needed to validate if elevated CSF IL-21 concentrations persist during long-term treatment, and if particular drug combinations are optimal for decreasing inflammatory latency.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"400 ","pages":"Article 578521"},"PeriodicalIF":2.9,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143305167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A 7-year-old with new-onset seizures, behavior disturbance, and encephalitis 7岁，新发癫痫，行为障碍，脑炎。

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-12-30 DOI: 10.1016/j.jneuroim.2024.578520

MaryGlen V. Stanich , Trevor Memmott , Taumoha Ghosh , Melissa A. Wright

引用次数: 0

Corrigendum to “Elevated frequencies of activated memory B cells in multiple sclerosis are reset to healthy control levels are B cell depletion with Ocrelizumab” [J. Neuroimmunol. 339:578502 (2024)] “激活记忆B细胞频率升高在多发性硬化症中被重置到健康控制水平是奥克雷单抗的B细胞消耗”的更正[J]。中国生物医学工程学报[j].中国生物医学工程学报。

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-12-27 DOI: 10.1016/j.jneuroim.2024.578519

Cody J. Gurski , Zivar Hajiyeva , Anthony J. Veltri , Kaylan Fenton , Samantha O'Dell , Ahmed Z. Obeidat , Bonnie N. Dittel

引用次数: 0

Vitamin C co-administration with artemether-lumefantrine abrogates chronic stress exacerbated Plasmodium berghei-induced sickness behaviour, inflammatory and oxidative stress responses in mice 维生素C与蒿甲醚-氨芳碱联合使用可消除小鼠慢性应激加剧的伯氏疟原虫引起的疾病行为、炎症和氧化应激反应。

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-12-20 DOI: 10.1016/j.jneuroim.2024.578518

Kehinde Joshua Ogundeyi , Abayomi Mayowa Ajayi , Ololade Justina Oduyomi , Stella Afolakemi Adeyemo , Mary O. Ologe , Olusegun George Ademowo

引用次数: 0