Journal of neuroimmunology最新文献_第2页

A complex and severe encephalitis associated with four co-existing neuronal cell-surface autoantibodies.

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-12-03 DOI: 10.1016/j.jneuroim.2024.578501

Michael Gilligan, Luke O'Donnell, Andrew Westbrook, Niall Tubridy, Sean 'o Riordan, Christopher McGuigan, Sean Connolly, Michael Farrell, Patrick Waters, Sarosh R Irani, Justin A Kinsella

{"title":"A complex and severe encephalitis associated with four co-existing neuronal cell-surface autoantibodies.","authors":"Michael Gilligan, Luke O'Donnell, Andrew Westbrook, Niall Tubridy, Sean 'o Riordan, Christopher McGuigan, Sean Connolly, Michael Farrell, Patrick Waters, Sarosh R Irani, Justin A Kinsella","doi":"10.1016/j.jneuroim.2024.578501","DOIUrl":"https://doi.org/10.1016/j.jneuroim.2024.578501","url":null,"abstract":"<p><p>Many forms of autoimmune encephalitis are mediated by neuronal cell-surface directed autoantibodies. The co-occurrence of four neuronal cell-surface antibodies in a single patient is exceptionally rare. We report a patient who had a severe encephalitis associated with antibodies to NMDA, Glycine, GABA<sub>A</sub> and GABA<sub>B</sub> receptors. Case: A 28-year-old man on tacrolimus presented with a first seizure. Thereafter, he developed confusion, cerebellar signs, opsoclonus, neuromyotonia and medication-refractory seizures. CSF sampling revealed 826 white cells and NMDA, glycine and GABA<sub>B</sub> receptor antibodies: all were also detected in serum along with additional GABA<sub>A</sub> receptor antibodies. Neural antibodies were detected using fixed (NMDA, GABA<sub>A</sub>, GABA<sub>B</sub> receptor) or live (glycine receptor) cell-based assays at Oxford Neuroimmunology Laboratory, Oxford, UK. MRI brain demonstrated cerebellar leptomeningeal enhancement and a hyperintense lesion in the cerebellar vermis. EEG revealed extreme delta brush and needle EMG confirmed neuromyotonia. No underlying malignancy was detected. Methylprednisolone, IVIG, Rituximab, therapeutic plasma exchange, cyclophosphamide and bortezomib were administered sequentially, with minimal clinical improvement. Death secondary to respiratory sepsis occurred on the 714th hospital day. Postmortem revealed pan-cerebellar atrophy with Purkinje cell loss; dentate nucleus ganglionopathy, and thoracolumbar cord myelopathy. In summary, the detection of multiple neuronal cell-surface antibodies in autoimmune encephalitis is unusual and may result in a complex overlap syndrome with a poor response to immunotherapy.</p>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"399 ","pages":"578501"},"PeriodicalIF":2.9,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elevated frequencies of activated memory B cells in multiple sclerosis are reset to healthy control levels after B cell depletion with Ocrelizumab.

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-12-02 DOI: 10.1016/j.jneuroim.2024.578502

Cody J Gurski, Zivar Hajiyeva, Anthony J Veltri, Kaylan Fenton, Samantha O'Dell, Ahmed Z Obeidat, Bonnie N Dittel

{"title":"Elevated frequencies of activated memory B cells in multiple sclerosis are reset to healthy control levels after B cell depletion with Ocrelizumab.","authors":"Cody J Gurski, Zivar Hajiyeva, Anthony J Veltri, Kaylan Fenton, Samantha O'Dell, Ahmed Z Obeidat, Bonnie N Dittel","doi":"10.1016/j.jneuroim.2024.578502","DOIUrl":"10.1016/j.jneuroim.2024.578502","url":null,"abstract":"<p><p>In multiple sclerosis (MS) the B cell depleting drug ocrelizumab has shown high efficacy in reducing inflammatory activity. Its mechanism of action is unclear due to B cell subset complexity and unknown roles in pathogenesis. Here, we comprehensively phenotyped and quantitated peripheral blood B cell subsets before and after ocrelizumab infusion to gain insight into the fate of B cell subsets with pathogenic potential. Peripheral blood B cells were collected from treatment naïve patients at baseline and months one, three, and six following the first course of ocrelizumab treatment; at 6 months following the second treatment cycle; ∼14 months following their last infusion; and from healthy controls. Flow cytometry combined with cluster analysis was used to track depletion and repletion of naïve, memory, and antibody secreting cells. By month one, naïve B cells were depleted, but a small subset of memory B cells were retained with no depletion of antibody secreting cells. Uniform manifold approximation and projection for dimension reduction analysis of flow cytometry data revealed two non-class switched naïve clusters and two class switched memory clusters. One class switched cluster was activated in MS patients but largely absent in healthy controls. Both memory B cell subsets underwent depletion after a single six-month course of ocrelizumab treatment after which their proportions were reset to heathy control levels. These observations suggest that activated class-switched memory B cells could serve as a biomarker of recent or ongoing MS disease activity to guide redosing.</p>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"399 ","pages":"578502"},"PeriodicalIF":2.9,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic g-CSF increases the neutrophil-lymphocyte ratio and decreases plasma corticosterone concentrations in Peromyscus maniculatus without impacting compulsive-like stereotypy 慢性 g-CSF 可提高中性粒细胞-淋巴细胞比率，降低啮齿类动物血浆皮质酮浓度，但不会影响强迫性刻板行为

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-11-25 DOI: 10.1016/j.jneuroim.2024.578490

J.P. Strydom, Linda Brand, Francois P. Viljoen, De Wet Wolmarans

{"title":"Chronic g-CSF increases the neutrophil-lymphocyte ratio and decreases plasma corticosterone concentrations in Peromyscus maniculatus without impacting compulsive-like stereotypy","authors":"J.P. Strydom, Linda Brand, Francois P. Viljoen, De Wet Wolmarans","doi":"10.1016/j.jneuroim.2024.578490","DOIUrl":"10.1016/j.jneuroim.2024.578490","url":null,"abstract":"<div><div>Increasing evidence points to brain-immune mechanisms underlying conditions characterized by neurocognitive rigidity. However, causal evidence remains elusive. Thus, the present work first aimed to investigate the naturalistic associations between rigid motor stereotypy and non-specific markers of systemic inflammation, i.e., the neutrophil-lymphocyte ratio (NLR) and plasma corticosterone concentrations in deer mice. We then explored causal immune-brain interactions by bolstering the NLR, using the recombinant human granulocyte colony-stimulating factor (g-CSF), i.e., pegfilgrastim (Peg). One-hundred and twenty (120) 3-week-old deer mice (both sexes) were exposed to nine weekly injections with normal water for injection or Peg (<em>n</em> = 60 per group) and then assessed for stereotypical expression. Stereotypical behaviour, the NLR, and plasma corticosterone were then measured. Our findings show that 1) NLR and plasma corticosterone concentrations do not predict stereotypical expression and 2) chronic Peg exposure significantly increased the NLR and decreased the plasma corticosterone concentration in mice of both sexes, without impacting stereotypical expression. While valuable findings related to the relationship between exogenous NLR manipulation and immune system functioning were highlighted, continued investigation will be necessary to further explore whether spontaneous stereotypy in deer mice may be associated with immune-inflammatory involvement.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"398 ","pages":"Article 578490"},"PeriodicalIF":2.9,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of the immune system in Parkinson's disease pathogenesis: A focus on Th17 cells - A systematic review and meta-analysis 免疫系统在帕金森病发病机制中的作用：聚焦Th17细胞--系统综述与荟萃分析。

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-11-17 DOI: 10.1016/j.jneuroim.2024.578484

Zihan Jiang , Honghao Huang , Yiqun Chen , Haobo Xie , Yangguang Lu , Yaoyin Ge , Ruotong Yao , Lingsheng Wang , Zihao Wu , Yiran Bu , Guangyong Chen , Dehao Yang

{"title":"The role of the immune system in Parkinson's disease pathogenesis: A focus on Th17 cells - A systematic review and meta-analysis","authors":"Zihan Jiang , Honghao Huang , Yiqun Chen , Haobo Xie , Yangguang Lu , Yaoyin Ge , Ruotong Yao , Lingsheng Wang , Zihao Wu , Yiran Bu , Guangyong Chen , Dehao Yang","doi":"10.1016/j.jneuroim.2024.578484","DOIUrl":"10.1016/j.jneuroim.2024.578484","url":null,"abstract":"<div><h3>Background</h3><div>Parkinson's disease (PD) has been linked to T helper 17 (Th17) cells in prior investigations, but the evidence remains inconclusive. To gain a deeper understanding of this potential connection, we conducted a systematic review and meta-analysis.</div></div><div><h3>Methods</h3><div>A comprehensive search for relevant studies published up to July 8, 2023, was performed across PubMed, EMBASE, and Cochrane Library databases. A random-effect model was employed to synthesize effect sizes and their corresponding 95 % confidence intervals (CIs). Leave-one-out sensitivity analysis and funnel plots with trim-and-fill were utilized to assess the combined results' robustness.</div></div><div><h3>Results</h3><div>Thirteen studies were ultimately included in the meta-analysis. Pooled effect sizes indicated a significantly higher percentage of Th17 cells in PD patients (Standardized Mean Difference [SMD] = 1.00, 95 % CI 0.30–1.71). Notably, Th17 cell levels were more elevated in Asian PD patients (SMD = 1.33, 95 % CI 0.31–2.35). Additionally, the percentage of Th17 cells positively correlated with Movement Disorder Society Unified Parkinson's Disease Rating Scale-III (UPDRS-III) scores (<em>r</em> = 0.22, 95 % CI 0.01–0.41), indicating a link to motor dysfunction. Conversely, a negative correlation was observed with Cognitive function scale scores (<em>r</em> = − 0.27, 95 % CI -0.47–-0.04), suggesting a potential association with cognitive decline.</div></div><div><h3>Conclusions</h3><div>This study revealed a positive association between Th17 cells and PD, with PD patients exhibiting elevated Th17 levels. Furthermore, the percentage of Th17 cells correlated with motor and cognitive impairments in PD patients.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"398 ","pages":"Article 578484"},"PeriodicalIF":2.9,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune cell-enriched single-cell RNA sequencing unveils the interplay between infiltrated CD8+ T resident memory cells and choroid plexus epithelial cells in Alzheimer's disease 免疫细胞富集单细胞 RNA 测序揭示了阿尔茨海默病中浸润的 CD8+ T 常驻记忆细胞与脉络丛上皮细胞之间的相互作用。

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-11-17 DOI: 10.1016/j.jneuroim.2024.578488

Seong-Jun Kang , Yong-Hee Kim , Thuy Nguyen-Phuong , Yijoon Kim , Jin-Mi Oh , Jae-chun Go , DaeSik Kim , Chung-Gyu Park , Hyunsu Lee , Hyun Je Kim

{"title":"Immune cell-enriched single-cell RNA sequencing unveils the interplay between infiltrated CD8+ T resident memory cells and choroid plexus epithelial cells in Alzheimer's disease","authors":"Seong-Jun Kang , Yong-Hee Kim , Thuy Nguyen-Phuong , Yijoon Kim , Jin-Mi Oh , Jae-chun Go , DaeSik Kim , Chung-Gyu Park , Hyunsu Lee , Hyun Je Kim","doi":"10.1016/j.jneuroim.2024.578488","DOIUrl":"10.1016/j.jneuroim.2024.578488","url":null,"abstract":"<div><div>Alzheimer's disease (AD) is a progressive neurological disorder and the leading cause of dementia. Despite significant efforts, treatment strategies targeting amyloid-β have been less successful than anticipated. Recently, the role of neuroinflammation and adaptive immune response in AD pathogenesis has gained attention. Here, we performed immune cell-enriched single-cell RNA sequencing of brain parenchymal cells from 12-month-old 5xFAD, an AD mouse model. We analyzed 11,587 single cells and found distinct differences in T cell and choroid plexus cell populations between 5xFAD mouse and littermate control. Subsequent sub-clustering of T cells in the 5xFAD mouse revealed distinct subtypes, with CD8<sup>+</sup> resident memory T cells (T<sub>RM</sub>) being the most prevalent T cell type. In addition, we observed an increase in T cell exhaustion markers, including <em>Pdcd1, Ctla4, and Havcr2</em>, with a particularly significant elevation of PD-1 and TIM-3 in CD8<sup>+</sup> T<sub>RM</sub> in 5xFAD mouse. Furthermore, choroid plexus (ChP) epithelial cells showed altered gene expression patterns, with higher expression of MHC class I and Type I IFN-stimulated genes in 5xFAD mouse compared to the control mouse, suggesting an association with clonal expansion of AD-specific T cells in the brain. Through single-cell RNA sequencing (scRNA-seq) analysis, our study highlights the potential role of resident memory CD8<sup>+</sup> T cell and their possible interactions with ChP epithelial cells. This study provides an exploration of the brain microenvironment landscape in AD, revealing critical insights into its underlying mechanisms.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"398 ","pages":"Article 578488"},"PeriodicalIF":2.9,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142687200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retinoic acid modulates peripheral blood helper innate lymphoid cell composition in vitro in patients with multiple sclerosis 维甲酸可调节多发性硬化症患者体外外周血辅助性先天性淋巴细胞的组成。

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-11-17 DOI: 10.1016/j.jneuroim.2024.578489

Altuğ Özkoşar , Fatma Betül Öktelik , Metin Yusuf Gelmez , Sevda Öztürk Erden , Tuncay Gündüz , Murat Kürtüncü , Günnur Deniz , Suzan Çınar

引用次数: 0

Silencing of circular RNA PTP4A2 ameliorates depressive-like behaviors by inhibiting microglia activation in mice 通过抑制小鼠小胶质细胞的激活，沉默环状 RNA PTP4A2 可改善抑郁样行为。

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-11-13 DOI: 10.1016/j.jneuroim.2024.578486

Han Zhang, Xiang Chen, Jialu Qian

{"title":"Silencing of circular RNA PTP4A2 ameliorates depressive-like behaviors by inhibiting microglia activation in mice","authors":"Han Zhang, Xiang Chen, Jialu Qian","doi":"10.1016/j.jneuroim.2024.578486","DOIUrl":"10.1016/j.jneuroim.2024.578486","url":null,"abstract":"<div><div>Major depressive disorder (MDD) is a prevalent mental illness and showed a strong link with inflammation. Microglia, as the main resident immune cells, play an important role in the occurrence and development of depression. Circular RNA PTP4A2 (circPTP4A2) was highly expressed in microglia inflammation induced by oxygen glucose deprivation/reperfusion. However, whether circPTP4A2 involves in microglia inflammation in MDD is not clear. Here, chronic unpredictable stress (CUS) induced depressive behaviors and microglia activation in mouse hippocampus, accompanied by the elevated expression of circPTP4A2. Knockdown circPTP4A2 in mouse hippocampus ameliorated depressive-like behaviors and microglia activation. Moreover, CUS promoted phosphorylation of ERK, JNK and P38 in mouse hippocampus as same as LPS-exposed BV2 microglia. Only P38 phosphorylation was inhibited by circPTP4A2 knockdown in the hippocampus. P38 inhibitor, sb203580, repressed circPTP4A2 overexpression-induced inflammatory reaction in BV2 cells. These findings suggest that circPTP4A2 promotes depressive-like behaviors and microglia activation via P38 phosphorylation.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"397 ","pages":"Article 578486"},"PeriodicalIF":2.9,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pre-existing Lambert-Eaton Myasthenic Syndrome and Scleroderma in a Patient with Neuroendocrine Carcinoma Undergoing Immune Checkpoint Inhibitor Cancer Immunotherapy 接受免疫检查点抑制剂癌症免疫疗法的神经内分泌癌患者原有的兰伯特-伊顿氏肌萎缩综合征和硬皮病

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-11-12 DOI: 10.1016/j.jneuroim.2024.578485

Nisa Vorasoot , Thorvardur R. Halfdanarson , Nicolas N. Madigan , Divyanshu Dubey , Uma Thanarajasingam , Anastasia Zekeridou

{"title":"Pre-existing Lambert-Eaton Myasthenic Syndrome and Scleroderma in a Patient with Neuroendocrine Carcinoma Undergoing Immune Checkpoint Inhibitor Cancer Immunotherapy","authors":"Nisa Vorasoot , Thorvardur R. Halfdanarson , Nicolas N. Madigan , Divyanshu Dubey , Uma Thanarajasingam , Anastasia Zekeridou","doi":"10.1016/j.jneuroim.2024.578485","DOIUrl":"10.1016/j.jneuroim.2024.578485","url":null,"abstract":"<div><h3>Introduction</h3><div>Paraneoplastic neurological syndromes (PNS) can worsen with immune checkpoint inhibitor (ICI) cancer immunotherapy.</div></div><div><h3>Case report</h3><div>A 66-year-old female with paraneoplastic Lambert-Eaton Myasthenic Syndrome (LEMS), which led to the diagnosis of metastatic neuroendocrine carcinoma, was treated with intravenous immune globulin (IVIg) (with minimal response), chemotherapy, and radiation, resulting in neurological improvement. However, sclerodermatous changes developed after a year. Due to cancer progression, dual ICI therapy was initiated, and the patient remained stable for eight months until the progression of both LEMS and cancer, ultimately leading to death.</div></div><div><h3>Discussion</h3><div>This case highlights the challenges of managing pre-existing PNS during ICI therapy, emphasizing the need for a multidisciplinary approach and the consideration of unusual clinical presentations in therapeutic decision-making.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"398 ","pages":"Article 578485"},"PeriodicalIF":2.9,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MOGAD presenting as fulminant intracranial hypertension 表现为暴发性颅内高压的 MOGAD。

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-11-10 DOI: 10.1016/j.jneuroim.2024.578487

Sai Nagaratnam , Amardeep Gill , Niroshan Jeyakumar , Shuo Xi , Ming-Wei Lin , Andrew Martin , Winny Varikatt , Michael W.K. Fong , Hugo Morales-Briceno

{"title":"MOGAD presenting as fulminant intracranial hypertension","authors":"Sai Nagaratnam , Amardeep Gill , Niroshan Jeyakumar , Shuo Xi , Ming-Wei Lin , Andrew Martin , Winny Varikatt , Michael W.K. Fong , Hugo Morales-Briceno","doi":"10.1016/j.jneuroim.2024.578487","DOIUrl":"10.1016/j.jneuroim.2024.578487","url":null,"abstract":"<div><h3>Objectives</h3><div>Myelin oligodendrocyte glycoprotein antibody disease (MOGAD) has an expanding phenotype. We describe two cases of MOGAD with associated severe intracranial hypertension.</div><div>Case 1: A 21-year-old male presented with diffuse cortical encephalitis and intracranial hypertension with both serum and CSF MOG antibody positivity. Initial brain CT scan was normal but subsequent demyelination was evident on MRI. Case 2: A 44-year-old female presented with a progressive brainstem encephalitis and intracranial hypertension and normal MRI, with later development of subcortical demyelination which was confirmed on brain biopsy. CSF-restricted MOG antibody was detected following the biopsy results.</div></div><div><h3>Results</h3><div>Both patients presented with clinical features of severe intracranial hypertension requiring surgical management followed by immunosuppressive therapy (methylprednisone and plasma exchange; and intravenous immunoglobulin and plasma exchange) leading to clinical improvement.</div></div><div><h3>Discussion</h3><div>MOGAD should be in the differential diagnosis of acute severe intracranial hypertension even in the absence of demyelination on initial neuroimaging. Clinicians should be alert of this syndrome that requires combined management of intracranial pressure in addition to early and intensive immunotherapy.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"397 ","pages":"Article 578487"},"PeriodicalIF":2.9,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Minocycline inhibits microglial activation in the CA1 hippocampal region and prevents long-term cognitive sequel after experimental cerebral malaria 米诺环素可抑制 CA1 海马区的小胶质细胞活化并预防实验性脑疟疾后的长期认知后遗症

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-10-29 DOI: 10.1016/j.jneuroim.2024.578480

E.T. Moreira , M.P. Lourenço , T. Cunha-Fernandes , T.I. Silva , L.D. Siqueira , H.C. Castro-Faria-Neto , P.A. Reis

{"title":"Minocycline inhibits microglial activation in the CA1 hippocampal region and prevents long-term cognitive sequel after experimental cerebral malaria","authors":"E.T. Moreira , M.P. Lourenço , T. Cunha-Fernandes , T.I. Silva , L.D. Siqueira , H.C. Castro-Faria-Neto , P.A. Reis","doi":"10.1016/j.jneuroim.2024.578480","DOIUrl":"10.1016/j.jneuroim.2024.578480","url":null,"abstract":"<div><div>Cerebral malaria is the worst complication of malaria infection, has a high mortality rate, and may cause different neurodysfunctions, including cognitive decline. Neuroinflammation is an important cause of cognitive damage in neurodegenerative diseases, and microglial cells can be activated in a disease-associated profile leading to tissue damage and neuronal death. Here, we demonstrated that treatment with minocycline reduced blood-brain barrier breakdown and modulated ICAM1 mRNA expression; reduced proinflammatory cytokines, such as TNF-α, IL-1β, IFN-γ, and IL-6; and prevented long-term cognitive decline in contextual and aversive memory tasks. Taken together, our data suggest that microglial cells are activated during experimental cerebral malaria, leading to neuroinflammatory events that end up in cognitive damage. In addition, pharmacological modulation of microglial activation, by drugs such as minocycline may be an important therapeutic strategy in the prevention of long-term memory impairment.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"397 ","pages":"Article 578480"},"PeriodicalIF":2.9,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142586463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0