Journal of neuroimmunology最新文献_第5页

A ferroptosis-associated prognostic model correlated with immune landscape and radiotherapy response in low-grade gliomas (LGGs) 与低级别胶质瘤（LGGs）免疫状况和放疗反应相关的铁蛋白沉积预后模型。

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-09-02 DOI: 10.1016/j.jneuroim.2024.578444

Zhaoming Zhou , Jing Liao , Yinghui Wang , Meijuan Zhou

{"title":"A ferroptosis-associated prognostic model correlated with immune landscape and radiotherapy response in low-grade gliomas (LGGs)","authors":"Zhaoming Zhou , Jing Liao , Yinghui Wang , Meijuan Zhou","doi":"10.1016/j.jneuroim.2024.578444","DOIUrl":"10.1016/j.jneuroim.2024.578444","url":null,"abstract":"<div><div>Despite receiving comprehensive treatment, the prognosis for low-grade gliomas (LGGs) patients varies considerably. Recent studies have focused extensively on ferroptosis, across a range of tumor types. Nevertheless, methodologies to evaluate the efficacy of radiotherapy for LGGs, from the perspective of ferroptosis-related genes (FRGs), remain strikingly rare. In this study, we conducted a retrospective study on the transcriptional profiles of LGG patients from the public databases and a local cohort. An FRG model was developed and validated, exhibits heightened robustness when contrasted with the traditional ssGSEA model. Patients demonstrating higher FRG scores were identified as a high-risk group, displaying a worse prognosis. By incorporating the FRG score alongside other prognosis-associated clinical indicators, we formulated an enhanced nomogram to achieve a higher level of prediction performance. Additionally, among LGG patients receiving radiotherapy, a poorer prognosis was observed in the high-risk group. Further investigation revealed that samples from the high-risk group generally exhibit a TME in an immuno-suppressive state. Collectively, we developed an FRG model and a robust nomogram for LGG prognostication. This study suggests that a high FRG score, indicative of an immunosuppressive TME, could potentially lead to a less favorable prognosis for certain LGG patients receiving radiotherapy.</div></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"396 ","pages":"Article 578444"},"PeriodicalIF":2.9,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Discordance of reported multiple sclerosis clinical course amongst patients and providers 患者和医疗服务提供者报告的多发性硬化症临床病程不一致

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-08-29 DOI: 10.1016/j.jneuroim.2024.578443

Albert Aboseif , Moein Amin , Gabrielle Macaron , Daniel Ontaneda

{"title":"Discordance of reported multiple sclerosis clinical course amongst patients and providers","authors":"Albert Aboseif , Moein Amin , Gabrielle Macaron , Daniel Ontaneda","doi":"10.1016/j.jneuroim.2024.578443","DOIUrl":"10.1016/j.jneuroim.2024.578443","url":null,"abstract":"<div><h3>Background</h3><p>Effective communication between providers and people with multiple sclerosis (pwMS) is essential.</p></div><div><h3>Objectives</h3><p>To determine the level of concordance between provider- and pwMS-reported disease course.</p></div><div><h3>Methods</h3><p>Patient encounters from December 2015 through April 2020 were retrospectively reviewed for MS disease course self-reported by the patient and separately documented by the provider at each visit. The proportion of agreement was compared across disease course Cohen's kappa, and subsequently stratified by sex, race, and level education.</p></div><div><h3>Results</h3><p>Across 1335 encounters, the proportion of disease course agreement varied. Compared with RRMS, there was statistically significant difference across all other disease courses. Overall concordance between providers and pwMS was 64 % with a Cohen's kappa of 0.312. Concordance was higher amongst female patients, black patients, and patients with a higher level of education (>14 years).</p></div><div><h3>Conclusion</h3><p>Overall agreement on MS disease course amongst patients and providers was suboptimal. A concerted effort to understand these discrepancies is needed.</p></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"395 ","pages":"Article 578443"},"PeriodicalIF":2.9,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142089350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

JAK inhibition in Down Syndrome Regression Disorder 抑制 JAK 在唐氏综合征回归障碍中的作用

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-08-22 DOI: 10.1016/j.jneuroim.2024.578442

Angela L. Rachubinski , Lina R. Patel , Elise M. Sannar , Ryan M. Kammeyer , Jessica Sanders , Belinda A. Enriquez-Estrada , Kayleigh R. Worek , Deborah J. Fidler , Jonathan D. Santoro , Joaquin M. Espinosa

引用次数: 0

Conventional dendritic cells are more activated in the hyperplastic Thymus of myasthenia gravis patients 肌无力患者增生的胸腺中传统树突状细胞更活跃

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-08-20 DOI: 10.1016/j.jneuroim.2024.578441

Pei Chen , Jiaxin Chen , Hao Huang , Weibin Liu

{"title":"Conventional dendritic cells are more activated in the hyperplastic Thymus of myasthenia gravis patients","authors":"Pei Chen , Jiaxin Chen , Hao Huang , Weibin Liu","doi":"10.1016/j.jneuroim.2024.578441","DOIUrl":"10.1016/j.jneuroim.2024.578441","url":null,"abstract":"<div><h3>Introduction</h3><p>Dendritic cells (DCs) are crucial to form ectopic germinal centers (GCs) in the hyperplastic thymus (HT), which are typically found in anti-acetylcholine receptor autoantibody-positive myasthenia gravis (MG) patients. However, the characteristics of such DCs in the HT and their roles in thymic hyperplasia formation remain unclear.</p></div><div><h3>Methods</h3><p>We collected thymic tissue from MG patients and patients who underwent cardiac surgery. The tissues were cut into sections for immunohistochemistry and immunofluorescence or digested into a single cell suspension for flow cytometry.</p></div><div><h3>Results</h3><p>In addition to formation of ectopic GCs, we found that the proportion of the medulla in the thymic parenchyma was higher than that in the cortex (area<sub>cortex</sub>/area<sub>medulla</sub>, 1.279 vs. 0.6576) in the HT of MG patients. The density of conventional dendritic cells (cDCs) in the HT was 131 ± 64.36 per mm<sup>2</sup>, whereas in normal thymic tissue, the density was 59.17 ± 22.54 per mm<sup>2</sup>. The more abundant cDCs expressed co-stimulatory molecules (CD80 and CD86) strongly. Moreover, the more abundant subset was mainly CD141+ DCs (cDC1s), accounting for an increase from 15% to 29%. However, these increased cDC1s appeared to be unrelated to Hassall's corpuscles and ectopic GCs.</p></div><div><h3>Conclusion</h3><p>Thymic hyperplasia in MG patients is manifested as an increase in the proportion of the thymic medulla accompanied by increases in the density and functional activation as well as changes in the subset composition of cDCs.</p></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"395 ","pages":"Article 578441"},"PeriodicalIF":2.9,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142095625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-intensity intermittent exercise increases serum levels of chitinase 3-like protein-1 and matrix metalloproteinase-9 in persons with multiple sclerosis 高强度间歇运动可提高多发性硬化症患者血清中几丁质酶 3 样蛋白-1 和基质金属蛋白酶-9 的水平

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-08-20 DOI: 10.1016/j.jneuroim.2024.578434

Furkan Bilek , Zubeyde Ercan , Gulnihal Deniz , Sinem Ozgul , Caner Feyzi Demir

引用次数: 0

Microglial-mediated immune mechanisms in autoimmune uveitis: Elucidating pathogenic pathways and targeted therapeutics 自身免疫性葡萄膜炎中小胶质细胞介导的免疫机制：阐明致病途径和靶向疗法

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-08-14 DOI: 10.1016/j.jneuroim.2024.578433

Monika Sharma , Pankaj Pal , Sukesh Kumar Gupta , Mrugendra B. Potdar , Aarti V. Belgamwar

{"title":"Microglial-mediated immune mechanisms in autoimmune uveitis: Elucidating pathogenic pathways and targeted therapeutics","authors":"Monika Sharma , Pankaj Pal , Sukesh Kumar Gupta , Mrugendra B. Potdar , Aarti V. Belgamwar","doi":"10.1016/j.jneuroim.2024.578433","DOIUrl":"10.1016/j.jneuroim.2024.578433","url":null,"abstract":"<div><p>This review offers a comprehensive examination of the role of microglia in the pathogenesis of autoimmune uveitis, an inflammatory eye disease with significant potential for vision impairment. Central to our discussion is the dual nature of microglial cells, which act as both protectors and potential perpetrators in the immune surveillance of the retina. We explore the mechanisms of microglial activation, highlighting the key signaling pathways involved, such as NF-κB, JAK/STAT, MAPK, and PI3K/Akt. The review also delves into the genetic and environmental factors influencing microglial behavior, underscoring their complex interaction in disease manifestation. Advanced imaging techniques and emerging biomarkers for microglial activation, pivotal in diagnosing and monitoring the disease, are critically assessed. Additionally, we discuss current and novel therapeutic strategies targeting microglial activity, emphasizing the shift towards more precise and personalized interventions. This article aims to provide a nuanced understanding of microglial dynamics in autoimmune uveitis, offering insights into potential avenues for effective treatment and management.</p></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"395 ","pages":"Article 578433"},"PeriodicalIF":2.9,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142011491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fibrinolysis associated proteins and lipopolysaccharide bioactivity in plasma and cerebrospinal fluid in multiple sclerosis 多发性硬化症患者血浆和脑脊液中的纤溶相关蛋白和脂多糖生物活性

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-08-12 DOI: 10.1016/j.jneuroim.2024.578432

Joonas Lehikoinen , Tomas Strandin , Jukka Parantainen , Katariina Nurmi , Kari K. Eklund , Francisco J. Rivera , Antti Vaheri , Pentti J. Tienari

引用次数: 0

Efgartigimod as a fast-acting add-on therapy in manifest and impending myasthenic crisis: A single-center case series 依夫加替莫德作为一种快速起效的附加疗法，可用于显性和即将发生的肌无力危象：单中心病例系列

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-08-10 DOI: 10.1016/j.jneuroim.2024.578431

Ye Hong , Lin Gao , Shi-Qi Huang , Shen Liu , Shuai Feng , Yu-Bao Chen , Teng Jiang , Jian-Quan Shi , Hong-Dong Zhao

{"title":"Efgartigimod as a fast-acting add-on therapy in manifest and impending myasthenic crisis: A single-center case series","authors":"Ye Hong , Lin Gao , Shi-Qi Huang , Shen Liu , Shuai Feng , Yu-Bao Chen , Teng Jiang , Jian-Quan Shi , Hong-Dong Zhao","doi":"10.1016/j.jneuroim.2024.578431","DOIUrl":"10.1016/j.jneuroim.2024.578431","url":null,"abstract":"<div><p>Efgartigimod was the first-in-class neonatal Fc receptor antagonist approved for the treatment of acetylcholine receptor antibody positive (AChR+), Myasthenia Gravis Foundation of America (MGFA) Class II-IV generalized myasthenia gravis (gMG) patients. As a novel therapy, the clinical experiences are still lacking, especially for the use of efgartigimod in manifest and impending myasthenic crisis (IMC). We reported three AChR+, gMG patients, two with myasthenic crisis (MC) and one with IMC, treated with efgartigimod. MGFA class, MG-Activity of Daily Living score (MG-ADL), Quantitative MG score (QMG), and Muscle Research Council sum score (MRC), concentration of anti-AChR antibody, IgG, globulin, and albumin, subsets of T and B lymphocyte were evaluated or measured before, during and after efgartigimod treatment. All patients showed fast and robust response to efgartigimod with marked improvement in MGFA, MG-ADL, QMG, and MRC scores. Patient 1 did not respond effectively to IVIg but was successfully rescued by add-on efgartigimod. She extubated at 7 days after the first infusion and got rid of NIV after 14-days treatment. Patient 2 and patient 3 directly used efgartigimod when symptoms were not ameliorated by adjusting of oral drugs. Patient 2 wean from BiPAP at seven days after the first infusion. Patient 3 in IMC status, overcame the severe dysphagia at three days after the first infusion. Clinical symptoms continued to improve 1–2 weeks after discharge. Concentration of anti-AChR antibody, IgG and globulin were remarkably reduced by efgartigimod treatment. Our study supported that efgartigimod could act as a fast-acting rescue therapy for patients with MC or IMC. Larger studies from multicenter are required to provide further evidence.</p></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"395 ","pages":"Article 578431"},"PeriodicalIF":2.9,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141978494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IT-DEX and B cell depletion in a child with anti-GAD 65 autoimmune encephalitis presenting as NORSE: A case report IT-DEX 和 B 细胞耗竭治疗一名表现为 NORSE 的抗 GAD 65 自身免疫性脑炎患儿：病例报告。

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-08-08 DOI: 10.1016/j.jneuroim.2024.578430

Jonathan M. Yarimi , Alexander J. Sandweiss , Karla P. Salazar , Chrissie Massrey , Alexander Ankar , Eyal Muscal , Yi-Chen Lai , Jon A. Cokley , Daniel Davila-Williams , Nikita M. Shukla , Kristen S. Fisher

引用次数: 0

Evaluating the complement C1q levels in serum and cerebrospinal fluid in multiple sclerosis patients: Could it serve as a valuable marker in clinical practice? 评估多发性硬化症患者血清和脑脊液中的补体 C1q 水平：它能作为临床实践中的重要标记物吗？

IF 2.9 4区医学

Journal of neuroimmunology Pub Date : 2024-08-03 DOI: 10.1016/j.jneuroim.2024.578428

Jordi Tortosa-Carreres , Laura Cubas-Núñez , Mónica Piqueras , Jéssica Castillo-Villalba , Carlos Quintanilla-Bordàs , Ana Quiroga-Varela , Noelia Villarrubia , Enric Monreal , Gary Álvarez , Raquel Gasque-Rubio , Lorena Forés-Toribio , Sara Carratalà-Boscà , Celia Lucas , María T. Sanz , Lluís Ramió-Torrentà , Luisa María Villar , Bonaventura Casanova , Begoña Laiz , Francisco Carlos Pérez-Miralles

{"title":"Evaluating the complement C1q levels in serum and cerebrospinal fluid in multiple sclerosis patients: Could it serve as a valuable marker in clinical practice?","authors":"Jordi Tortosa-Carreres , Laura Cubas-Núñez , Mónica Piqueras , Jéssica Castillo-Villalba , Carlos Quintanilla-Bordàs , Ana Quiroga-Varela , Noelia Villarrubia , Enric Monreal , Gary Álvarez , Raquel Gasque-Rubio , Lorena Forés-Toribio , Sara Carratalà-Boscà , Celia Lucas , María T. Sanz , Lluís Ramió-Torrentà , Luisa María Villar , Bonaventura Casanova , Begoña Laiz , Francisco Carlos Pérez-Miralles","doi":"10.1016/j.jneuroim.2024.578428","DOIUrl":"10.1016/j.jneuroim.2024.578428","url":null,"abstract":"<div><p>Immunohistochemical studies have identified complement component C1q in MS lesions. We aimed to compare serum (sC1q) and CSF (csfC1q) levels in a large cohort of MS patients (pwMS) (<em>n</em> = 222) with those of healthy controls (HC, <em>n</em> = 52), individuals with other immune (IND, <em>n</em> = 14), and non-immune neurological disorders (nIND, <em>n</em> = 15), and to analyze their correlation with other biomarkers.</p><p>pwMS were divided into three series based on their origin. CSF samples were unavailable for HC. All three pwMS cohorts had lower sC1q levels compared to HC and IND. csfC1q was higher in one pwMS cohort, with a trend in another, and correlated with IgG, Free Kappa Light Chains, GFAP, and Chitinase-3 Like Protein-1 in CSF. Our findings suggest a significant role for C1q in MS pathophysiology, potentially serving as a biomarker for disease identification.</p></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"394 ","pages":"Article 578428"},"PeriodicalIF":2.9,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141913044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0