Journal of Parenteral and Enteral Nutrition最新文献

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Effects of parenteral nutrition supplemented with beta-hydroxy-beta-methylbutyrate on gut-associated lymphoid tissue and morphology in mice 补充β-羟基-β-甲基丁酸的肠外营养对小鼠肠道相关淋巴组织和形态的影响
IF 3.2 3区 医学
Journal of Parenteral and Enteral Nutrition Pub Date : 2024-09-20 DOI: 10.1002/jpen.2686
Haruka Takayama RD, PhD, Kazuhiko Fukatsu MD, PhD, Midori Noguchi BA, Kazuya Takahashi MD, PhD, Ayako Watkins RD, PhD, Nana Matsumoto RD, MS, Tomonori Narita MD, Satoshi Murakoshi MD, PhD
{"title":"Effects of parenteral nutrition supplemented with beta-hydroxy-beta-methylbutyrate on gut-associated lymphoid tissue and morphology in mice","authors":"Haruka Takayama RD, PhD,&nbsp;Kazuhiko Fukatsu MD, PhD,&nbsp;Midori Noguchi BA,&nbsp;Kazuya Takahashi MD, PhD,&nbsp;Ayako Watkins RD, PhD,&nbsp;Nana Matsumoto RD, MS,&nbsp;Tomonori Narita MD,&nbsp;Satoshi Murakoshi MD, PhD","doi":"10.1002/jpen.2686","DOIUrl":"10.1002/jpen.2686","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Parenteral nutrition (PN) without enteral nutrition (EN) leads to marked atrophy of gut-associated lymphoid tissue (GALT), causing mucosal defense failure in both the gut and the extraintestinal mucosal system. We evaluated the effects of beta-hydroxy-beta-methylbutyrate (HMB) on GALT and gut morphology in PN-fed mice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Experiment 1: male Institute of Cancer Research mice were assigned to the Chow (<i>n</i> = 12), Control (standard PN: <i>n</i> = 10), or H600 and H2000 (PN containing 600 mg/kg or H2000 mg/kg body weight of Ca-HMB: <i>n</i> = 12 and 10, respectively) groups. After 5 days of dietary manipulation, all mice were killed and the whole small intestine was harvested. GALT lymphocyte cell numbers and phenotypes of Peyer patch (PP), intraepithelial space, and lamina propria lymphocytes were evaluated. Experiment 2: 47 mice (Chow: <i>n</i> = 12; Control: <i>n</i> = 14; H600: <i>n</i> = 11; and H2000: <i>n</i> = 10) were fed for 5 days as in experiment 1. Proliferation and apoptosis of gut immune cells and mucosa, and protein expressions (mammalian target of rapamycin [mTOR], caspase-3, and Bcl2) were evaluated in the small intestine.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Compared with the Controls, the Chow and HMB groups showed significantly higher PP cell numbers, prevented gut mucosal atrophy, inhibited apoptosis of gut cells, and increased their proliferation in association with increased mTOR activity and Bcl2 expression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>HMB-supplemented PN is a potentially novel method of preserving GALT mass and gut morphology in the absence of EN.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"48 8","pages":"927-939"},"PeriodicalIF":3.2,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intravenous tigecycline with selected multichamber bag parenteral nutrition: A compatibility study 静脉注射替加环素与精选多室袋肠外营养:兼容性研究
IF 3.2 3区 医学
Journal of Parenteral and Enteral Nutrition Pub Date : 2024-09-10 DOI: 10.1002/jpen.2683
Katarzyna Dettlaff PhD, Julia Guzińska MSc, Pharm, Marta Klimaszewska MSc, Pharm, Katarzyna Dominiak MSc, Pharm, Anna Jelińska PhD
{"title":"Intravenous tigecycline with selected multichamber bag parenteral nutrition: A compatibility study","authors":"Katarzyna Dettlaff PhD,&nbsp;Julia Guzińska MSc, Pharm,&nbsp;Marta Klimaszewska MSc, Pharm,&nbsp;Katarzyna Dominiak MSc, Pharm,&nbsp;Anna Jelińska PhD","doi":"10.1002/jpen.2683","DOIUrl":"10.1002/jpen.2683","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Tigecycline is widely used to treat infections in intensive care units. Drugs often need to be delivered to critically ill patients feeding by parenteral nutrition (PN). Before two preparations are administered in the same infusion line, the safety of this combination should be established. The objective of this study was to determine the compatibility of tigecycline with selected multichamber bag PN (MCB-PN).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Tigecycline was diluted in 0.9% sodium chloride solution and 5% glucose solution to obtain two 0.5 mg/ml solutions. Then the solutions were combined with selected MCB-PN in appropriate proportions. The samples were visually assessed, and pH, osmolality, turbidity, particle size, and zeta potential were measured. These measurements were made immediately after combining the solutions and after 4 h of storage at 23°C ± 1°C.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>It was determined that the pH values of the mixtures after combining with tigecycline changed by ≤0.1 unit. An increase in zeta potential was recorded, excluding one combination of tigecycline with the mixture. For all samples tested, the particle size distribution was within the acceptable range immediately after combination and after 4 h of storage. The difference in osmolality did not exceed ±3%, whereas the zeta potential decreased for only one combination. The turbidity of none of the samples exceeded a critical value.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The physical compatibility of the tigecycline with five MCB-PN was proved. They can therefore be administered to patients in one infusion line using the Y-site.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"48 8","pages":"990-997"},"PeriodicalIF":3.2,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142227880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
JPEN Journal Club 87. The subgroup paradox JPEN 期刊俱乐部 87。子群悖论
IF 3.2 3区 医学
Journal of Parenteral and Enteral Nutrition Pub Date : 2024-09-07 DOI: 10.1002/jpen.2684
Ronald L. Koretz MD
{"title":"JPEN Journal Club 87. The subgroup paradox","authors":"Ronald L. Koretz MD","doi":"10.1002/jpen.2684","DOIUrl":"10.1002/jpen.2684","url":null,"abstract":"","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"49 2","pages":"267-269"},"PeriodicalIF":3.2,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142145829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serial transverse enteroplasty in adults with parenteral nutrition dependence: A case series 对依赖肠外营养的成人进行连续横向肠成形术:病例系列。
IF 3.2 3区 医学
Journal of Parenteral and Enteral Nutrition Pub Date : 2024-09-02 DOI: 10.1002/jpen.2682
Eli Mlaver MD, MSc, Savannah R. Smith MD, Abraham J. Matar MD, Vivian M. Zhao PharmD, Rachel Leong PharmD, Jyotirmay Sharma MD, Jahnavi K. Srinivasan MD, John R. Galloway MD
{"title":"Serial transverse enteroplasty in adults with parenteral nutrition dependence: A case series","authors":"Eli Mlaver MD, MSc,&nbsp;Savannah R. Smith MD,&nbsp;Abraham J. Matar MD,&nbsp;Vivian M. Zhao PharmD,&nbsp;Rachel Leong PharmD,&nbsp;Jyotirmay Sharma MD,&nbsp;Jahnavi K. Srinivasan MD,&nbsp;John R. Galloway MD","doi":"10.1002/jpen.2682","DOIUrl":"10.1002/jpen.2682","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Serial transverse enteroplasty is used to treat patients with chronic intestinal failure owing to short bowel syndrome. Current literature lacks discussion of its role for other etiologies of intestinal failure and its impact on adult patients' nutrition support needs and quality of life.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We performed a case series on adults with parenteral nutrition (PN) dependence who underwent serial transverse enteroplasty at Emory University Hospital, a quaternary referral center between 2011 and 2022. Data collected included demographics, operative technique, and preoperative and postoperative PN requirements. A phone survey was administered to evaluate the impact of PN and the operation on quality of life.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Ten patients underwent the procedure of interest during the study period. Indications included short bowel syndrome following multiple abdominal operations or intra-abdominal catastrophe and chronic partial bowel obstruction with dysmotility. Bowel length increased by a median of 83%. All patients were discharged home after a median hospital stay of 21 days. At 1-year follow-up, survival was 100%, two (20%) patients fully weaned from PN, three others (30%) reduced PN frequency, and six (60%) decreased their daily parenteral energy requirement. Two additional patients fully weaned from PN by 18 months postoperatively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This represents one of the largest case series of serial transverse enteroplasty in adults. Small intestinal length nearly doubled, and PN dependence was reduced in most patients. Given the low morbidity and good quality of life observed in this series, this procedure should be more widely investigated for patients with chronic intestinal failure.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"48 8","pages":"965-973"},"PeriodicalIF":3.2,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Propyl acetate protects intestinal barrier during parenteral nutrition in mice and Caco-2 cells 醋酸丙酯在小鼠和 Caco-2 细胞肠外营养过程中保护肠道屏障。
IF 3.2 3区 医学
Journal of Parenteral and Enteral Nutrition Pub Date : 2024-08-26 DOI: 10.1002/jpen.2681
Jiwei Wang PhD, Jing Du MS, Xiaomei Gou MS, Yong Huang MS, Jixin He MS, Xiaoyun Lu MS, Ming Xie MD
{"title":"Propyl acetate protects intestinal barrier during parenteral nutrition in mice and Caco-2 cells","authors":"Jiwei Wang PhD,&nbsp;Jing Du MS,&nbsp;Xiaomei Gou MS,&nbsp;Yong Huang MS,&nbsp;Jixin He MS,&nbsp;Xiaoyun Lu MS,&nbsp;Ming Xie MD","doi":"10.1002/jpen.2681","DOIUrl":"10.1002/jpen.2681","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Gut microbiota dysbiosis induces intestinal barrier damage during parenteral nutrition (PN). However, the underlying mechanisms remain unclear. This study aimed to investigate gut microbiota dysbiosis, luminal short-chain fatty acids, and autophagy in a mouse model and how these short-chain fatty acids regulate autophagy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Eight-week-old male specific-pathogen–free mice were randomly divided into a Chow group (standard diet and intravenous normal saline infusion) and a PN group (continuous infusion of PN nutrient solution) for 7 days. Caco-2 cells were also treated with intestinal rinse solutions from Chow and PN mouse models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Compared with the Chow group, the PN group exhibited increased Proteobacteria and decreased Firmicutes, correlating with decreased propyl acetate. In the PN group, intestinal tissue exhibited elevated adenosine monophosphate–activated protein kinase (AMPK) phosphorylation, LC3II protein levels, and <i>Atg3</i> and <i>Atg7</i> messenger RNA levels. P62 protein levels were decreased, indicating an increase of autophagy flux in the PN group. In the Caco-2 cell model, cells treated with PN solution plus propyl acetate exhibited increased Claudin-1 and occluding along with decreased interleukin-6 and tumor necrosis factor α compared with those treated with PN solution alone. Propyl acetate addition inhibited the AMPK–mammalian target of rapamycin (mTOR) pathway, mitigating the excessive autophagy induced by the PN intestinal rinse solution in Caco-2 cells.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>PN led to a significant reduction in propyl acetate levels in the intestine, excessive activation of autophagy, and barrier dysfunction. Propyl acetate inhibited excessive autophagy via the AMPK/mTOR signaling pathway and protected the intestinal barrier during PN.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"48 8","pages":"917-926"},"PeriodicalIF":3.2,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Caregiver burden and eating-related guilt during dysphagia rehabilitation: A descriptive cross-sectional time series study 吞咽困难康复期间照顾者的负担和与进食有关的内疚感:一项描述性横断面时间序列研究。
IF 3.2 3区 医学
Journal of Parenteral and Enteral Nutrition Pub Date : 2024-08-22 DOI: 10.1002/jpen.2679
Hiroko Mori MPH, PhD, Ayako Nakane DDS, Yuri Yokota PhD, Haruka Tohara DDS, PhD, Takeo Nakayama MPH, PhD
{"title":"Caregiver burden and eating-related guilt during dysphagia rehabilitation: A descriptive cross-sectional time series study","authors":"Hiroko Mori MPH, PhD,&nbsp;Ayako Nakane DDS,&nbsp;Yuri Yokota PhD,&nbsp;Haruka Tohara DDS, PhD,&nbsp;Takeo Nakayama MPH, PhD","doi":"10.1002/jpen.2679","DOIUrl":"10.1002/jpen.2679","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Caregivers of patients with chronic dysphasia experience stress and guilt regarding their eating behaviors. Dysphagia rehabilitation, including minimal oral intake with tube feeding, may be vital for caregivers. This study investigated the effects of dysphagia rehabilitation on caregiver well-being and attitudes toward eating assistance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cross-sectional questionnaire study was conducted at two dental university hospitals on caregivers of homebound patients with dysphagia undergoing rehabilitation. Caregivers' experiences, with an emphasis on guilt and psychological status, were assessed using the Apathy Scale and Patient Health Questionnaire-5 Depression Scale. Patients were evaluated at the time of the survey and rehabilitation commencement using the Barthel Index and Functional Oral Intake Scale (FOIS). Changes in FOIS scores and caregiver guilt were assessed using the Wilcoxon signed rank test and McNemar test, respectively. The impact of oral intake changes on caregiving motivation was assessed using the Fisher exact test.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Between August 2019 and January 2021, 55 of 100 targeted caregivers responded (median age=64.5 years). A significant difference in FOIS scores was found (median rehabilitation duration=9.7 months). Despite 25 pneumonia cases, 65% of the caregivers continued to encourage oral intake. Guilt decreased from 48% during peak dysphagia to 22% at survey time (odds ratio=0.2, 95% CI=0.04–0.70; <i>P</i> &lt; 0.01). No association was found between caregiving motivation and improved oral intake.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Severe dysphagia impacted caregiver well-being, indicating preferences for patients' oral intake. To support caregivers, healthcare professionals should explore and integrate new multidisciplinary approaches into dysphagia rehabilitation strategies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"48 7","pages":"818-826"},"PeriodicalIF":3.2,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142017838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between new insertion of a long-term enteral feeding tube and mortality in adults admitted to the hospital with aspiration: A retrospective cohort study 新插入长期肠内喂食管与因吸入而入院的成人死亡率之间的关系:一项回顾性队列研究。
IF 3.2 3区 医学
Journal of Parenteral and Enteral Nutrition Pub Date : 2024-08-20 DOI: 10.1002/jpen.2680
Anthony D. Bai MD, MSc, Siddhartha Srivastava MD, MSc, Marie Leung MD, Heather Johnson MD, Amol A. Verma MD, MPhil, Fahad Razak MD, MSc
{"title":"Association between new insertion of a long-term enteral feeding tube and mortality in adults admitted to the hospital with aspiration: A retrospective cohort study","authors":"Anthony D. Bai MD, MSc,&nbsp;Siddhartha Srivastava MD, MSc,&nbsp;Marie Leung MD,&nbsp;Heather Johnson MD,&nbsp;Amol A. Verma MD, MPhil,&nbsp;Fahad Razak MD, MSc","doi":"10.1002/jpen.2680","DOIUrl":"10.1002/jpen.2680","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>We aimed to describe the association between insertion of a new long-term enteral feeding tube during admission for aspiration and in-hospital mortality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective cohort study across 28 Canadian hospitals from 2015 to 2022 included consecutive patients who were admitted for aspiration. Patients were categorized based on new long-term enteral feeding tube insertion during hospital stay or not. The primary outcome was the time to death in hospital. Secondary outcomes included time to discharge alive and hospital readmission for aspiration within 90 days. We used propensity score weighting to balance covariates, and a competing risk model to describe in-hospital death and discharge.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 12,850 patients admitted for aspiration, 852 (6.6%) patients received a long-term enteral feeding tube. In the hospital, 184 (21.6%) and 2489 (20.8%) patients in the enteral feeding tube group and no enteral feeding tube group died, respectively. Within 90 days of discharge, 127 (14.9%) and 1148 (9.6%) patients in the enteral feeding tube and no enteral feeding tube group were readmitted for aspiration, respectively. After balancing covariates, an enteral feeding tube was associated with a similar in-hospital mortality risk (subdistribution hazard ratio [sHR] = 1.05, 95% CI = 0.89–1.23; <i>P</i> = 0.5800), longer time to discharge alive (sHR = 0.58, 95% CI = 0.54–0.63; <i>P</i> &lt; 0.0001), and a higher risk of readmission (risk difference = 5.0%, 95% CI = 2.4%–7.6%; <i>P</i> = 0.0001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Initiation of long-term enteral tube feeding was not uncommon after admission for aspiration and was not associated with an improvement in the probability of being discharged alive from the hospital or readmitted for aspiration.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"48 7","pages":"841-849"},"PeriodicalIF":3.2,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jpen.2680","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of parenteral lipids on essential fatty acid deficiency in pediatric intestinal failure: A retrospective cohort study 肠外脂质对小儿肠功能衰竭患者必需脂肪酸缺乏症的影响:回顾性队列研究
IF 3.2 3区 医学
Journal of Parenteral and Enteral Nutrition Pub Date : 2024-08-08 DOI: 10.1002/jpen.2678
Parker Johnson PharmD, Victoria L. Phillips PharmD, Nathan Lamb PharmD, Kexin Guo MS, Lihui Zhao PhD, Katherine M. Brennan MSN, Joshua D. Prozialeck MD, Valeria C. Cohran MD
{"title":"Effect of parenteral lipids on essential fatty acid deficiency in pediatric intestinal failure: A retrospective cohort study","authors":"Parker Johnson PharmD,&nbsp;Victoria L. Phillips PharmD,&nbsp;Nathan Lamb PharmD,&nbsp;Kexin Guo MS,&nbsp;Lihui Zhao PhD,&nbsp;Katherine M. Brennan MSN,&nbsp;Joshua D. Prozialeck MD,&nbsp;Valeria C. Cohran MD","doi":"10.1002/jpen.2678","DOIUrl":"10.1002/jpen.2678","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Pediatric patients with intestinal failure require long-term parenteral nutrition owing to impaired enteral nutrition absorption. A potential complication is essential fatty acid deficiency (EFAD), resulting from decreased linoleic and α-linolenic acid concentrations and defined by an increased triene:tetraene ratio (TTR; Mead acid:arachidonic acid). Historically, soybean oil lipid emulsion (SOLE) was the only commercially available parenteral lipid in the United States. Recently, a composite lipid emulsion (CLE) and fish oil lipid emulsion (FOLE) received US Food and Drug Administration approval. This study investigated whether lipid emulsion regimen impacts EFAD incidence in pediatric patients with intestinal failure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study was a 10-year retrospective cohort study of pediatric patients with intestinal failure who received parenteral SOLE, CLE, or FOLE. The primary outcome was EFAD incidence, defined as a TTR ≥ 0.2. Secondary outcomes included TTR ≥ 0.05, cholestasis incidence, lipid dose effect on EFAD incidence, and fatty acid parameter differences.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 144 fatty acid profiles from 47 patients were reviewed. EFAD did not occur in any lipid emulsion group. There were no differences in the incidence of TTR ≥ 0.05 or cholestasis. The effect of dose could not be evaluated because of no EFAD incidence. Lastly, although each group had varied fatty acid parameters, none saw decreased essential fatty acid levels.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study found that, with close monitoring, the lipid emulsion regimen did not impact EFAD incidence. This suggests that FOLE and CLE do not increase EFAD risk compared with SOLE in pediatric patients with intestinal failure.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"48 7","pages":"793-801"},"PeriodicalIF":3.2,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141902094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are minor burned patients really hypermetabolic? 轻度烧伤患者真的代谢过高吗?
IF 3.2 3区 医学
Journal of Parenteral and Enteral Nutrition Pub Date : 2024-08-05 DOI: 10.1002/jpen.2676
Gilberto Fabian Hurtado-Torres MD, PhD
{"title":"Are minor burned patients really hypermetabolic?","authors":"Gilberto Fabian Hurtado-Torres MD, PhD","doi":"10.1002/jpen.2676","DOIUrl":"10.1002/jpen.2676","url":null,"abstract":"","PeriodicalId":16668,"journal":{"name":"Journal of Parenteral and Enteral Nutrition","volume":"48 7","pages":"776"},"PeriodicalIF":3.2,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141889549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutritional approach of patients with minor burns: A neglected aspect of burn care? 轻度烧伤患者的营养方法:烧伤护理中被忽视的一个方面?
IF 3.2 3区 医学
Journal of Parenteral and Enteral Nutrition Pub Date : 2024-08-05 DOI: 10.1002/jpen.2677
Anne-Françoise Rousseau MD, PhD, Marjorie Fadeur RD, Benoit Misset MD
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