Journal of Parkinson's disease最新文献

{"title":"Intestinal biomarkers, microbiota composition, and genetic predisposition to inflammatory bowel disease as predictors of Parkinson's disease manifestation.","authors":"Zhi Chai, Yuxia Ouyang, Anketse Debebe, Mellissa Picker, Won-Jun Lee, Seth Fenton, Anouck Becker-Dorison, Kerstin Augustin-Emmerichs, Andreas Schwiertz, Susanne N Weber, Frank Lammert, Jianzhong Hu, Gang Fang, Marcus M Unger, Inga Peter","doi":"10.1177/1877718X251328567","DOIUrl":"10.1177/1877718X251328567","url":null,"abstract":"<p><p>BackgroundParkinson's disease (PD) is often accompanied by gastrointestinal symptoms. While elevated inflammatory biomarkers have been reported in PD patients compared to controls, the role of intestinal dysmotility and inflammation in disease manifestation is not fully understood.ObjectiveThis study sought to determine if fecal biomarkers and genetic predisposition to intestinal inflammation could help identify PD subtypes for future targeted therapies.MethodsThe association of disease activity, assessed through United Parkinson's disease Rating Scale (UPDRS) and Non-Motor Symptoms Questionnaire (NMSQ), with constipation severity, fecal calprotectin and six short-chain fatty acid (SCFA) levels, polygenic risk scores (PRS) for inflammatory bowel disease (IBD) and PD, and microbiota diversity were investigated in 95 participants with established PD using regression analyses. Unsupervised k-means clustering was applied to stratify PD patients based on inflammatory biomarkers.ResultsHaving constipation was linked to worse mentation (UPDRSI, adj.<i>p</i> = 0.03) and more limited daily living activities (UPDRSII, adj.<i>p</i> = 0.03), with symptom severity linearly associated with higher disease activity (UPDRSI, adj.<i>p</i> = 0.002; NMSQ-total, adj.<i>p</i> = 0.02). Fecal calprotectin was elevated in those with constipation (<i>p</i> = 0.02) and associated with longer disease duration irrespective of the age (adj.<i>p</i> = 0.02). Cluster analysis demonstrated that PD patients with a higher non-motor symptom UPDRSII score were more likely to have more severe constipation, lower fecal SCFA levels, lower bacterial diversity, and higher PRS-CD and PRS-IBD.ConclusionsGut dysmotility, along with pro-inflammatory intestinal profiles, and greater genetic predisposition to IBD were observed in PD patients with worse non-motor symptoms. Monitoring intestinal biomarkers may help identify PD patients for targeted interventions.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"766-779"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early thinking palliative care for people with Parkinson's disease: A thematic synthesis based on a systematic mixed-methods review.","authors":"Michela Garon, Christiane Weck, Valentina Leta, Bauke W Dijkstra, Catharina Muente, Giovanni Gentile, Dhaval Trivedi, Marieke M Groot, Stefan Lorenzl, Per Odin, Spyridon Konitsiotis, David J Pedrosa, Dimitrios I Fotiadis, Marjan J Meinders, Bastiaan R Bloem, Anette E Schrag, Laura Grover, Pille Taba, K Ray Chaudhuri, Angelo Antonini, Piret Paal","doi":"10.1177/1877718X251321110","DOIUrl":"10.1177/1877718X251321110","url":null,"abstract":"<p><p>BackgroundParkinson's disease is a progressive neurodegenerative disorder. Awareness and the evidence supporting the merits of palliative care (PC) approaches to people with Parkinson's disease (PwP) are increasing.ObjectiveThis review aimed to address four key questions related to PC for PwPs and their caregivers: i) What are the indicators for timely access to PC? ii) When should PC be introduced? iii) What are the current care models for providing PC? iv) What are the barriers and facilitators at the organizational level?MethodsA systematic literature search was conducted in PubMed, CINAHL, Cochrane, EMBASE, and MEDLINE (2006-2024). Six reviewers independently screened abstracts and full texts, and thematic synthesis was applied to develop analytical themes. Reporting followed PRISMA guidelines.ResultsOut of 894 studies, 70 were included. PwPs were infrequently referred to PC services, and while several referral criteria were identified, no consensus emerged. Barriers to accessing PC included insufficient information, inadequate education, difficulties determining referral timing, limited home-based care options, inconsistent provider support, and disparities linked to socioeconomic and cultural factors. Facilitators included improved care coordination and education for PwPs, caregivers, and healthcare providers. Effective PC models were identified, including home-based, hospital-based, and community-based approaches, which improved quality of life and reduced healthcare costs.ConclusionsEstablishing consensus on referral timing and criteria is essential for integrating PC into Parkinson's disease care. Overcoming barriers requires enhanced education, better care coordination, and targeted interventions to address disparities, ensuring comprehensive, patient-centred care for PwPs and their caregivers.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"710-758"},"PeriodicalIF":5.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual hallucinations in Parkinson's disease are associated with deficits in social perception.","authors":"Louis Albert, Neza Vehar, Jevita Potheegadoo, Fosco Bernasconi, Olaf Blanke","doi":"10.1177/1877718X251336196","DOIUrl":"10.1177/1877718X251336196","url":null,"abstract":"<p><p>BackgroundMost structured visual hallucinations (VH) in Parkinson's disease (PD) involve animate-social objects, yet current theories fail to account for the prominent social component of VH in PD.ObjectiveTo study social perception in PD patients with VH in a behavioral task and its relationship with social traits such as perceived social isolation and anthropomorphism (tendency to ascribe human-like characteristics to non-human stimuli).MethodsIn this online web-based study, 28 PD with visual hallucinations (PD-VH), 55 PD patients without hallucinations (PD-nH), and 45 age-matched healthy controls (HC) performed a visual social task (human numerosity estimation), a control task, and filled an anthropomorphism and a loneliness questionnaire.ResultsOur data reveal a deficit in social visual perception characterized by a larger overestimation bias in human numerosity estimation in PD-VH versus control PD-nH and HC. Moreover, PD-VH had higher social traits of anthropomorphism and loneliness versus control PD-nH and HC and the overestimation bias was absent for non-human control stimuli.ConclusionsThese data describe a stronger social visual deficit and higher social traits in PD patients with VH, suggesting that neurodegenerative changes in PD-VH predominantly affect structures involved in social visual perception.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"892-903"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anxiety-related attentional characteristics and their relation to freezing of gait in people with Parkinson's: Cross-validation of the Adapted Gait Specific Attentional Profile (G-SAP).","authors":"Uri Rosenblum, Adam J Cocks, Meriel Norris, Elmar Kal, William R Young","doi":"10.1177/1877718X251326266","DOIUrl":"10.1177/1877718X251326266","url":null,"abstract":"<p><p>BackgroundAnxiety often exacerbates freezing of gait (FOG) in people with Parkinson's (PwP). Anxiety-related attentional processes and associated processing inefficiencies, like conscious movement processing (CMP) and ruminations, can substantially impact movement control. However, their impact on FOG remains largely unexplored.ObjectiveTo validate an adapted 10-item (1-5 Likert scale) Gait-Specific Attentional Profile (G-SAP) in PwP and assess if adapted G-SAP-subscales (Physiological Arousal, CMP, Rumination, and Processing Inefficiencies) are associated with self-reported FOG frequency.MethodsWe recruited 440 PwP (M_age = 65.5 ± 8.7; 5.8 ± 5.0 years since diagnosis) across the UK. Participants completed the adapted G-SAP and questionnaires on demographics, medical background, and FOG frequency. We assessed adapted G-SAP's internal consistency, structural validity, and subscale scores associations with FOG frequency.ResultsThe adapted G-SAP showed acceptable internal consistency (α≥0.66) and acceptable/good model fit (comparative fit index = 0.976). Physiological Arousal and CMP subscale scores presented weaker correlations for PwP with FOG (PwP + FOG, r = 0.52) compared to PwP without FOG (PwP-FOG, r = 0.77; p = 0.006). Higher Rumination (OR: 1.323, 95%CI: [1.214-1.440]) and Physiological Arousal (OR: 1.195, 95%CI:[1.037-1.377]) were significantly associated with higher FOG frequency, controlling for age, time since diagnosis and balance/gait problems.ConclusionsThe adapted G-SAP is reliable and convenient to measure and identify potentially maladaptive anxiety-related attentional processes that may impact FOG. Results suggest that PwP who experience more worrisome thoughts and greater physiological arousal in daily life are likelier to freeze. Compared to PwP-FOG, for PwP + FOG high physiological arousal was associated with reduced goal-directed focus of attention. Future research will determine if this is a causal risk factor.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"829-842"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of theta burst stimulation on the Parkinsonian gait disorder and cortical gait-network activity.","authors":"Janina Dutke, Jonas Gehlenborg, Miriam Heise, Wolfgang Hamel, Christian Gerloff, Götz Thomalla, Tim Magnus, Andreas K Engel, Christian Ke Moll, Alessandro Gulberti, Monika Pötter-Nerger","doi":"10.1177/1877718X251320941","DOIUrl":"10.1177/1877718X251320941","url":null,"abstract":"<p><p>BackgroundThe Parkinsonian gait disorder and freezing of gait (FoG) are challenging symptoms of Parkinson's disease (PD).ObjectiveTo assess the effect of subthalamic theta burst deep brain stimulation (TBS-DBS) on the Parkinsonian gait performance in real-world conditions and cortical activity indexed by mobile EEG.MethodsIn this monocentric, randomised, double-blind, short-term study, 12 age-matched controls (11 male, age 59 ± 8 years) and 15 PD participants (14 male, age 62 ± 9 years, disease duration 15 ± 6 years) with subthalamic stimulation (76 ± 39 months) were assessed with clinical scores (FoG-Course, MDS-UPDRS) and a standardized gait course simulating everyday life situations. Three DBS algorithms were applied in a randomized order with intertrial waiting periods of 30 min: (1) OFF-DBS; (2) cDBS; (3) TBS-DBS (interburst frequency 5 Hz, intraburst frequency 200 Hz) with regular medication. During the standardized gait course a mobile, 24-channel EEG system and 6 wearable axial kinematic sensors were used.ResultsThe primary outcome, the relative change of FoG-Course by DBS, was not superior with TBS-DBS compared to cDBS in the entire sample. Seven of fifteen PD participants rated subjectively TBS-DBS equal or better than cDBS (\"TBS-preference group\"). EEG recordings revealed movement-induced alpha and beta suppression in premotor and motor cortex in both cDBS and TBS-DBS conditions in PD with slightly different patterns between the DBS modes.ConclusionsIn this pilot trial, TBS-DBS showed benefits in the subjective perception of gait in a subgroup of PD patients accompanied by specific cortical network changes. TBS-DBS merits further investigation in future larger cohort studies with longer observation periods.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"843-857"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing the diagnostic potential of electroretinography in Parkinson's disease: A review of protocol and cohort criteria.","authors":"Victoria Soto Linan, Marc Hébert, Martin Lévesque","doi":"10.1177/1877718X251331863","DOIUrl":"https://doi.org/10.1177/1877718X251331863","url":null,"abstract":"<p><p>Electroretinography has emerged as a promising tool for identifying retinal functional anomalies in major psychiatric and neurodevelopmental disorders, such as schizophrenia, major depressive disorder, bipolar disorder, and autism spectrum disorder, positioning it as a potential biomarker of monoaminergic dysfunction. However, despite its potential, electroretinography studies in Parkinson's disease (PD) over the past decades have been inconsistent, largely due to variations in research methodologies. These limitations diminish its potential and hinder the association between retinal electrophysiological responses and PD neuropathology. To address this challenge, this review examines the most relevant sources of data variability and reduced reproducibility in electroretinography studies aimed at detecting a retinal functional signature characteristic of PD. We propose the consolidation of four key protocol factors and five cohort criteria to enhance the diagnostic accuracy of electroretinography in PD biomarker research. As electroretinography protocols are adapted from their clinical origins for research purposes, we argue that careful attention must be given to electrode type and placement, as well as to factors like age, sex, disease duration and severity, medication intake, psychiatric conditions, and comorbidities in cohort selection to ensure reproducible results. Suggesting that past inconsistencies in these areas may explain the variability in reported results and contribute to the lack of consensus on which electroretinography parameters comprise a disease signature in PD, we ultimately offer recommendations to improve the utility of electroretinography techniques as early biomarkers for PD.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":"15 4","pages":"694-709"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mild cognitive impairment is not predictive of dementia up to 15 years after subthalamic deep brain stimulation in Parkinson's disease.","authors":"Sine Fjeldhøj, Birgitte Liang Chen Thomsen, Palle Møller Pedersen, Steen Rusborg Jensen, Anders Clausen, Merete Karlsborg, Bo Jespersen, Ove Ketil Bergdal, Annemette Løkkegaard","doi":"10.1177/1877718X251334049","DOIUrl":"10.1177/1877718X251334049","url":null,"abstract":"<p><p>BackgroundCognitive impairment and dementia are common findings in patients with Parkinson's disease (PD). However, the long-term effects of subthalamic deep brain stimulation (STN-DBS) on cognition remain unclear.ObjectiveWe report short- and long-term effects of STN-DBS on cognition in PD.MethodsWe analyzed neuropsychological data before STN-DBS surgery, 3-month post-surgery, 1-year post-surgery and in a long-term follow-up (8-15 years post-surgery) to examine the effects of STN-DBS on cognition.Results81 patients with a mean disease duration of 13.0 years were examined before surgery. 50.6% were identified with mild cognitive impairment (MCI), having a mean disease duration of 14.2 years. Pre-surgical PD-MCI was not associated with clinically diagnosed dementia (PD-D) before death or before long-term follow-up (OR 0.8, 95% CI 0.3-2.2, p = 0.714), but disease duration at the time of surgery was associated with development of PD-D (OR 1.2, 95% CI 1.1-1.3, p = 0.005). Verbal fluency declined significantly 3 months after surgery, while other domains remained unaffected. In neuropsychological testing at long-term follow-up (N = 29), global cognitive impairment or dementia was found in 19 patients. The presence of depressive symptoms before surgery was associated to PD-D at long-term follow-up. Death before long-term follow-up was more common in patients with pre-surgical MCI than in patients with normal cognition.ConclusionsInfluence on cognition was described in a short- and long-term follow-up study up to 15 years after STN-DBS surgery in PD. Disease duration, but not pre-surgical MCI was associated with development of dementia. Impaired verbal fluency was observed both in a short- and long-term follow-up.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"879-891"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific progression of Parkinson's disease: A longitudinal mixed-models analysis.","authors":"Anne-Marie Hanff, Christopher McCrum, Armin Rauschenberger, Gloria A Aguayo, Claire Pauly, Sonja R Jónsdóttir, Olena Tsurkalenko, Maurice P Zeegers, Anja K Leist, Rejko Krüger","doi":"10.1177/1877718X251339201","DOIUrl":"10.1177/1877718X251339201","url":null,"abstract":"<p><p>BackgroundDespite its relevance, the clinical progression of motor- and non-motor symptoms associated with Parkinson's disease (PD) is poorly described and understood, particularly in relation to sex-specific differences in clinical progression.ObjectiveIdentification of differential aspects in disease progression in men and women with PD.MethodsLinear mixed-model analyses of 802 people with typical PD from the Luxembourg Parkinson's study's prospective cohort (median time of follow-up = three years). We estimated the effect of time and its moderation by sex (alpha ≤ 0.05), including confidence intervals, for the following outcomes: MDS-UPDRS I-IV, Starkstein Apathy Scale, Beck Depression Inventory, Montreal Cognitive Assessment (MoCA), Sniffin' sticks, bodily discomfort, rapid eye movement sleep behavior disorder questionnaire, PD Sleep Scale (PDSS), Munich Dysphagia Test-PD, Functional Mobility Composite Score, and the MDS-based tremor and postural instability and gait disturbances scale. In addition, the marginal means illustrated the symptoms' trajectories in men and women. Men and women had similar age.ResultsOverall, we observed a slower progression (interaction effect) in women compared to men, especially for MoCA (-0.159, 95%CI [-0.272, -0.046], p = 0.006), PDSS (-0.716, 95%CI [-1.229, -0.203], p = 0.006), PIGD (0.133, 95%CI [0.025 0.241], p = 0.016), and MDS-UPDRS II (0.346, 95%CI [0.120, 0.572], p = 0.003). The finding for MDS-UPDRS II was significant (FWER of 5%) after adjustment for multiple comparisons (Bonferroni-Holm).ConclusionsNext to the further exploration of sex-specific progression, interventions, proactive monitoring and communication strategies tailored to the symptoms progression and needs of men and women need to be developed.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"805-818"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between neuropsychological profile and regional brain FDG uptake in progressive supranuclear palsy.","authors":"Johanna Doll-Lee, Martin Klietz, Stephan Greten, Bruno Kopp, Georg Berding, Matthias Brendel, Ida Wilkens, Sabrina Katzdobler, Johannes Levin, Adrian Danek, Sophia Rogozinski, Günter Höglinger, Monika Pötter-Nerger, Carsten Buhmann, Ralph Buchert, Florian Wegner","doi":"10.1177/1877718X251343080","DOIUrl":"10.1177/1877718X251343080","url":null,"abstract":"<p><p>BackgroundProgressive supranuclear palsy (PSP) is a rare neurodegenerative movement disorder clinically characterized by falls, axial rigidity, vertical supranuclear gaze palsy, bradykinesia, and cognitive decline. There is a relative lack of studies on the functional neuroimaging correlates of cognitive impairment in PSP.ObjectiveThis study investigated the relationship between regional cerebral glucose metabolism as assessed by static ¹⁸F-fluorodeoxyglucose positron emission tomography (FDG-PET) with global scaling and the profile of cognitive performance according to the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) test battery in a sample of PSP patients representative of clinical practice.Methods22 PSP patients from three tertiary movement disorder centers with CERAD testing and FDG-PET in close proximity were included retrospectively. Neuropsychological test performance was assessed for correlation with FDG uptake on a voxel-by-voxel basis with cluster-level correction for multiple testing, separately for each subtest.ResultsIn comparison to matched healthy controls, PSP patients showed reduced FDG uptake in the left inferior frontal gyrus and right angular gyrus. Reduced overall cognitive performance according to Montreal Cognitive Assessment was associated with reduced FDG uptake in the right frontal eye field. Word list learning correlated with FDG uptake in the left frontal eye field, while language fluency was linked to FDG uptake in the bilateral premotor and supplementary motor areas.ConclusionsReduction of FDG uptake in PSP primarily affects frontal brain regions and is linked to the performance in specific cognitive domains. These findings may have implications for the interpretation of FDG-PET to support the etiological diagnosis of PSP.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"904-912"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances of transcranial electrical stimulation in healthy aging and Parkinson's disease: Effects on dual tasking.","authors":"Martina Putzolu, Alessandro Botta, Carola Cosentino, Susanna Mezzarobba, Gaia Bonassi, Elisa Ravizzotti, Sara Terranova, Giovanna Lagravinese, Elisa Pelosin, Laura Avanzino","doi":"10.1177/1877718X251327758","DOIUrl":"10.1177/1877718X251327758","url":null,"abstract":"<p><p>Dual tasking involves the simultaneous execution of two actions. In the context of healthy aging and neurodegenerative disorders, such as Parkinson's disease (PD) engagement in dual tasking frequently results in impaired gait or upper limb performance, thereby affecting functional independence. Transcranial electrical stimulation is a non-invasive technique able to modulate brain activity, which might represent a potential tool for reducing dual task interference. The goal of this review is to provide a comprehensive summary of the most recent findings about the use of transcranial electrical stimulation in improving dual tasking in the elderly and people with PD, including considerations about the optimal stimulation parameters. Differences in terms of stimulation protocols emerged across the included studies. Among transcranial electrical stimulation techniques, transcranial direct current stimulation (tDCS) was the most frequently employed. Currently, using tDCS to target dorsolateral prefrontal cortex either alone or in a multi-site fashion, along with a concurrent complex task, appears to be the most promising method for reducing dual task interference. Nevertheless, the lack of control over interindividual variability, the heterogeneity in outcome measures assessing dual tasking, and the variations in protocol elements like the frequency and the number of sessions prevented us from drawing definitive conclusions about the best paradigm.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"677-693"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}