Non-motor symptoms in prodromal Parkinson's disease are linked to reduced quality of life.

IF 4 3区 医学 Q2 NEUROSCIENCES
Sinah Röttgen, Marie-Sophie Lindner, Aline Seger, Johanna Kickartz, Kim-Lara Weiß, Christopher Ej Doppler, Gereon R Fink, Anja Ophey, Michael Sommerauer
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引用次数: 0

Abstract

Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) highlights an early α-synucleinopathy. This study compared health-related quality of life (hrQoL) in 62 individuals with iRBD with 19 healthy controls (HC) and 29 individuals with Parkinson's disease (PD) and identified factors linked to poorer hrQoL. HrQoL was significantly lower in individuals with iRBD (83.33 ± 16.96) compared to HC (92.29 ± 5.49, p = 0.027). Poorer hrQoL in individuals with iRBD was linked to severity of multiple non-motor symptoms, most prominently fatigue and depressive symptoms being significant predictors (p < 0.001, adjusted R2 = 0.81). This study highlights the importance of non-motor symptoms for hrQoL in prodromal PD.

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来源期刊
CiteScore
8.40
自引率
5.80%
发文量
338
审稿时长
>12 weeks
期刊介绍: The Journal of Parkinson''s Disease (JPD) publishes original research in basic science, translational research and clinical medicine in Parkinson’s disease in cooperation with the Journal of Alzheimer''s Disease. It features a first class Editorial Board and provides rigorous peer review and rapid online publication.
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