Non-motor symptoms in prodromal Parkinson's disease are linked to reduced quality of life.

IF 4 3区医学 Q2 NEUROSCIENCES

Journal of Parkinson's disease Pub Date : 2025-03-01 Epub Date: 2025-01-31 DOI:10.1177/1877718X241310726

Sinah Röttgen, Marie-Sophie Lindner, Aline Seger, Johanna Kickartz, Kim-Lara Weiß, Christopher Ej Doppler, Gereon R Fink, Anja Ophey, Michael Sommerauer

引用次数: 0

Abstract

Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) highlights an early α-synucleinopathy. This study compared health-related quality of life (hrQoL) in 62 individuals with iRBD with 19 healthy controls (HC) and 29 individuals with Parkinson's disease (PD) and identified factors linked to poorer hrQoL. HrQoL was significantly lower in individuals with iRBD (83.33 ± 16.96) compared to HC (92.29 ± 5.49, p = 0.027). Poorer hrQoL in individuals with iRBD was linked to severity of multiple non-motor symptoms, most prominently fatigue and depressive symptoms being significant predictors (p < 0.001, adjusted R² = 0.81). This study highlights the importance of non-motor symptoms for hrQoL in prodromal PD.

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前驱帕金森病的非运动症状与生活质量下降有关。

孤立的快速眼动（REM）睡眠行为障碍（iRBD）强调早期α-突触核蛋白病。这项研究比较了62名iRBD患者与19名健康对照者（HC）和29名帕金森病患者（PD）的健康相关生活质量（hrQoL），并确定了与hrQoL较差相关的因素。iRBD组HrQoL（83.33±16.96）明显低于HC组（92.29±5.49,p = 0.027）。iRBD患者较差的hrQoL与多种非运动症状的严重程度相关，最显著的是疲劳和抑郁症状是显著的预测因子（p R2 = 0.81）。本研究强调了非运动症状对PD前驱期患者hrQoL的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Parkinson's disease NEUROSCIENCES-

CiteScore

8.40

自引率

5.80%

发文量

338

审稿时长

>12 weeks

期刊介绍： The Journal of Parkinson''s Disease (JPD) publishes original research in basic science, translational research and clinical medicine in Parkinson’s disease in cooperation with the Journal of Alzheimer''s Disease. It features a first class Editorial Board and provides rigorous peer review and rapid online publication.