Journal of Parkinson's disease最新文献

{"title":"Social interaction enhances the pleasurable urge to move to music in people with Parkinson's disease.","authors":"Jan Stupacher, Peter Vuust, Victor Pando-Naude","doi":"10.1177/1877718X261469682","DOIUrl":"10.1177/1877718X261469682","url":null,"abstract":"<p><p>BackgroundMusic- and dance-based interventions can improve motor symptoms in people with Parkinson's disease (PD), but two key questions remain: whether the rhythmic complexity of music influences intervention outcomes, and whether social interaction further enhances these effects.ObjectivesTo examine the effects of rhythmic complexity and interpersonal synchronization on subjective and objective movement responses to music in PD.MethodParticipants tapped to the beat of music with varying levels of rhythmic complexity across three cueing conditions: music alone, music with a visual beat cue, and socially with an assistant who also tapped to the beat. We measured pleasurable urge to move to music (PLUMM - or <i>groove</i>), felt synchrony with the music, beat-related movement energy, and synchronization variability in 40 individuals with mild-to-moderate PD and 36 age-matched controls.ResultsCompared to music alone, social interaction increased PLUMM, felt synchrony, beat-related movement, and synchronization stability, with the strongest effects for moderate to high rhythmic complexity. These effects were stronger in participants with PD than in controls. In contrast, visual cues had no effect. Moreover, PLUMM ratings were positively associated with social closeness toward the assistant, trait empathy, and the experience of social reward through music.ConclusionSocial interaction while moving to the beat of music enhanced both the urge to move and objective motor performance. Our findings show that improvements of motor symptoms through music- and dance-based interventions extend beyond enhanced temporal prediction through motor simulation; they also include socio-emotional mechanisms that promote pleasure and strengthen social bonding.Plain language summary titlePeople with Parkinson's move more to music when they move with others.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"1284-1295"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13442691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148604302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Greater burden of Alzheimer's Co-pathology in women with Parkinson's disease dementia.","authors":"Nathaniel Dunckley, Erika D Driver-Dunckley, Nan Zhang, Geidy E Serrano, Holly A Shill, Shyamal H Mehta, Christine Belden, Cecilia Tremblay, Alireza Atri, Charles H Adler, Thomas G Beach","doi":"10.1177/1877718X261470295","DOIUrl":"10.1177/1877718X261470295","url":null,"abstract":"<p><p>ObjectiveTo investigate sex differences in Alzheimer's disease (AD) related pathology among autopsy-confirmed Parkinson's disease (PD) cases.BackgroundAD and PD frequently co-occur in older adults, yet the influence of sex on AD pathology in the context of PD remains unexplored.MethodsAll subjects were enrolled in the Arizona Study of Aging and Neurodegenerative Disorders (AZSAND) and Brain and Body Donation Program (BBDP) and had annual standardized research clinical assessments by neuropsychologists, subspecialty behavioral and movement disorders neurologists, as well as comprehensive neuropathological examinations after death.ResultsAmong 230 autopsy-confirmed PD cases, females exhibited greater amyloid plaque pathology burden than males, regardless of a co-occurring AD diagnosis. Specifically, females with PD had significantly higher mean cortical total plaque scores (mean 6.5/15 vs. 4.9/15, <i>p</i> = 0.045) and greater CERAD neuritic plaque density (mean 1.7/3 vs. 1.3/3, <i>p</i> = 0.035). Females were also more likely to have a higher cortical plaque burden (plaque total ≥ 5: 56.8% vs. 39.7%, <i>p</i> = 0.015). In multivariable logistic regression models, female subjects showed greater than twice the odds of having an amyloid plaque burden ≥5 compared to males (OR = 2.18; 95% CI = 1.17-4.06; <i>p</i> = 0.014), when controlling for ApoE ε4 status, Lewy body density score, and age at death.ConclusionsFemale sex is associated with increased amyloid plaque pathology in PD, independent of ApoE ε4 status. These findings highlight a sex-specific vulnerability to AD pathology in PD patients and support the need for sex-informed approaches to reseach in mixed neurodegenerative disease.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"1191-1200"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13443333/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148579068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital profiling of dysarthria in late- and early-onset Parkinson's disease.","authors":"Daniel Escobar-Grisales, Maira Rozenfeld Olchik, Tomás Arias-Vergara, Vanessa Brzoskowski Dos Santos, Amanda Lara Bressanelli, Ignacio Mata, Juan Rafael Orozco-Arroyave, Adolfo M García","doi":"10.1177/1877718X261467587","DOIUrl":"10.1177/1877718X261467587","url":null,"abstract":"<p><p>BackgroundDigital speech analysis affords robust markers of Parkinson's disease (PD). However, most studies target late-onset PD (LOPD), neglecting early-onset PD (EOPD) -an increasingly prevalent subtype. This proof-of-concept study tackles such gap.MethodsWe used machine learning to discriminate persons with EOPD (with symptom onset before age 50) and LOPD (with symptom onset after age 50) from healthy controls (HCs) through prosodic and articulatory features from natural speech.ResultsMaximal classification between patients and HCs was afforded by combined prosodic and articulation features in LOPD (AUC = 0.90) and by articulation alone in EOPD (AUC = 0.79), with chance-level discrimination between patient groups (AUC = 0.55). Motor severity (MDS-UPDRS-III) scores predicted by these features correlated with actual motor severity scores in both LOPD (<i>r</i> = 0.52, <i>p</i> < 0.001) and EOPD (<i>r</i> = 0.27, <i>p</i> < 0.001).ConclusionsDigital speech markers offer markers of PD irrespective of age of onset.Plain language summary titleVoice recordings capture motor symptoms in Parkinson's disease irrespective of age of onset.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"1125-1136"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13443339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148447676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abnormal motor control effort costs in Parkinson's disease patients with apathy.","authors":"Johannes Schönhals, Moaz Al Ajia, David Meder, Gabriel Gonzalez-Escamilla, Nils Schröter, Sergiu Groppa, Damian M Herz","doi":"10.1177/1877718X261457805","DOIUrl":"10.1177/1877718X261457805","url":null,"abstract":"<p><p>BackgroundIn Parkinson's disease, abnormalities in reward-effort trade-offs are thought to underlie both apathy and bradykinesia. However, it remains unclear whether effort cost computations contribute to these symptoms independently of reward, and which exact effort costs are involved.ObjectiveTo assess whether effort-based decision-making in the absence of any explicit rewards differs between Parkinson patients and healthy controls and to explore whether putative differences are related to apathy or bradykinesia.MethodsTo address this, we developed a novel decision-making task that isolated physical effort costs from reward processing. Twenty-one Parkinson patients tested on and off dopaminergic medication, and 20 healthy participants, had to choose between two options that differed only in their requirements of force effort, either requiring larger total amounts of force or greater changes in force. We quantified participants' preference for these different effort types and their sensitivity to changes in relative effort.ResultsPatients differed from healthy participants in both overall effort preference (<i>P</i> = 0.009) and sensitivity to changing efforts (<i>P</i> = 0.036), being more likely to choose options requiring overall lower force levels and more influenced by increasing requirements of changes in force. These effects were unaffected by dopaminergic medication. Importantly, sensitivity to increasing requirements for changes in force was associated with apathy (<i>P</i> = 0.004), but not bradykinesia.ConclusionOur findings suggest that, beyond well-known diminished responses to potential rewards, apathy in Parkinson's disease is related to aberrant effort cost computations, in particular those involving dynamic changes in movement, during decision-making.Plain Language Summary TitleHow effort influences decision-making in people with Parkinson's disease and apathy.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"1241-1249"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13442672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148338826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agreement between relatives of Parkinson's patients and clinical observer in home diary assessments.","authors":"Carin Janz, Jonathan Timpka, Alexander Storch, Gesine Paul, Per Odin","doi":"10.1177/1877718X261461073","DOIUrl":"10.1177/1877718X261461073","url":null,"abstract":"<p><p>BackgroundThe Parkinson's Disease (PD) Home Diary (HD) is a common clinical outcome measure, but studies show only fair agreement between clinical observer and patient assessments, with no significant improvement after patient training.ObjectivesTo investigate the agreement between a clinical observer and relatives of PD patients when assessing the patient's motor status in the HD. Agreement was also assessed for relative-patient and patient-observer pairs.MethodsThis observational study included 28 PD patients with motor fluctuations and their relatives. It involved a screening visit with structured training on motor fluctuations and one day of motor ratings, where the observer, relative, and patient independently assessed the patient's motor state in the HD half-hourly.ResultsObserver, patient, and relative triads completed 445 HD assessment sets. Temporal agreement was fair for observer-relatives (Cohen's κ = 0.250) and relatives-patients (κ = 0.230), but slight for patients-observer (κ = 0.120). For observer-relatives, agreement was highest for \"On without dyskinesia\" (71%), and lowest for \"Off\" (26%). Daily time distributions differed significantly between relatives and the clinical observer for \"Off\" (<i>p</i> = 0.006) and \"On without dyskinesia\" (<i>p</i> = 0.012), but not for \"On with dyskinesia\" (<i>p</i> = 1.000).ConclusionsThis study reports fair temporal agreement of motor state assessments between relatives-observer and relatives-patients, with slight agreement between patients-observer. Relatives' assessments of daily time in different motor states showed significant differences from the clinical observer assessments. This further highlights the challenges in obtaining reliable motor status data and the need for further research into objective assessment methods.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"1263-1274"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13443092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep brain stimulation in alpha-synuclein models of Parkinson's disease: Bridging the translational gap.","authors":"Laura Kondrataviciute, Hanna Weber, Minesh Kapadia, David H Aguirre-Padilla, Mareike Fauser, Taufik A Valiante, William D Hutchison, Luka Milosevic, Alexander Storch, Lorraine V Kalia, Suneil K Kalia","doi":"10.1177/1877718X261459876","DOIUrl":"10.1177/1877718X261459876","url":null,"abstract":"<p><p>Deep brain stimulation (DBS) is an established therapy for advanced medication-resistant Parkinson's disease (PD), yet its ability to alter the course of the disease remains uncertain. Although preclinical research using toxin-induced PD models demonstrate neuroprotective effects, clinical studies in PD patients undergoing DBS have not substantiated these findings. This disconnect may be attributed to factors such as the initiation of DBS late in disease, stimulation protocols targeting symptoms rather than pathology, and the limited translational relevance of animal models lacking hallmark alpha-synuclein (α-Syn) aggregation. Incorporating α-Syn-based models may bridge this gap by facilitating the discovery of early electrophysiological biomarkers of pathological progression, refining stimulation parameters to enhance α-Syn clearance, and assessing if early DBS intervention can mitigate neurodegeneration. Yet, only a limited number of DBS studies have employed α-Syn models to date. This review examines the translational gap between preclinical neuroprotection claims and clinical outcomes, focusing on how α-Syn-based models could resolve current limitations in DBS research. Prioritizing these models could clarify whether DBS has the potential to extend beyond symptomatic relief and directly engage PD's underlying neurodegenerative mechanisms. Achieving this goal requires systematic investigation of DBS influences on α-Syn accumulation and its electrophysiological correlates in disease-relevant models.Plain language summary titleDeep Brain Stimulation in Alpha-Synuclein Models of Parkinson's Disease: Bridging the Translational Gap.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"1115-1124"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13443142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Where does excessive beta in Parkinson's disease originate? Insights from a case of unilateral cortico-pallidal pathway dysfunction.","authors":"Leonardo Rigon, Valentina D'Onofrio, Laura Ludovica Grassi, Dario Ciprietti, Andrea Landi, Angelo Antonini, Andrea Guerra","doi":"10.1177/1877718X261471025","DOIUrl":"10.1177/1877718X261471025","url":null,"abstract":"<p><p>Plain language summary<b>Detecting the source of abnormal beta oscillations in Parkinson's Disease: evidence from a case of impaired connection between cerebral cortex and basal ganglia.</b>In Parkinson's Disease, a key feature is an exaggerated, oscillatory activity in the brain called the \"beta rhythm\", which occurs in the circuit, particularly relevant for motor functions, connecting the cortex (the outer brain layer) and the basal ganglia (the deeper structures). Scientists have long debated whether the exact source of this pathological activity was located in the cortex or in the basal ganglia. This report describes a critical clue from an unexpected event: a person with Parkinson's disease developed temporary swelling (edema) that affected both the sensorimotor cortex and the basal ganglia. Notably, this event was limited to one side of the brain and occurred in a subject who carried a medical device that enables recordings of the beta rhythm from inside the basal ganglia. In this peculiar case, the excessive beta rhythm on the affected side was completely suppressed and only returned once the swelling in the overlying sensorimotor cortex had resolved, even though the edema in the basal ganglia itself had recovered earlier. This unique observation suggests that the integrity of the cortex is essential for the pathological beta rhythm to occur in Parkinson's Disease, lending strong support to the theory that this disruptive electrical rhythm is generated in the cortex before spreading to deeper brain structures such as the basal ganglia.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"1342-1346"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13442690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148620358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Full recovery after severe bacterial encephalitis and brain abscess following deep brain stimulation surgery for Parkinson's disease.","authors":"Eline Amy Rouleau, Debby Eic Falck, Carel Fe Hoffmann, Victor J Geraedts, Rodi Zutt, Niels A van der Gaag, M Fiorella Contarino","doi":"10.1177/1877718X261470302","DOIUrl":"10.1177/1877718X261470302","url":null,"abstract":"<p><p>Encephalitis and cerebral abscesses are rare, serious complications of deep brain stimulation (DBS) surgery. We report on two patients with Parkinson's disease (PD) who developed a critical condition with focal neurological symptoms and decreased consciousness, after an initially uncomplicated subthalamic nucleus DBS implantation. Because of the clinical and radiological suspicion of encephalitis and brain abscess, DBS was explanted and the abscess drained. After prolonged antibiotic treatment they gradually fully recovered, with persistently improved PD symptoms in patient 1. Concluding, patients with DBS-related encephalitis or brain abscesses in a critical condition can have a favourable prognosis with proper and timely treatment.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"1347-1350"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13438653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148620339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and related factors of blood pressure regulation abnormalities in Parkinson's disease: Orthostatic hypotension and supine hypertension.","authors":"Jinyu Jia, Jianmin Zeng, Yifan Gong, Huan Zhou, Xiuli Zeng, Jing Zou","doi":"10.1177/1877718X261457798","DOIUrl":"10.1177/1877718X261457798","url":null,"abstract":"<p><p>BackgroundOrthostatic hypotension (OH) and supine hypertension (SH) are common in patients with Parkinson's disease (PD), contributing to disease-related morbidity and mortality. However, initial OH, a transient blood pressure that decreases immediately after standing, is often unrecognized, and the interactions among OH, SH, and anti-hypertensive therapy remain unclear.MethodsThis single-centre retrospective observational study included 183 patients with PD who underwent an active supine-to-stand test with beat-to-beat blood pressure monitoring. Logistic regression was used to identify factors associated with OH and SH, and linear regression was performed to examine the determinants of postural blood pressure decline and changes in cerebral haemodynamics.ResultsOH occurred in 72.1% of patients, including 27.9% with symptomatic OH; SH was present in 21.9%. Female sex (<i>P</i> = 0.013) and anti-hypertensive therapy (<i>P</i> = 0.026) were associated with lower odds of OH. Older age (<i>P</i> = 0.017), arterial hypertension (<i>P</i> = 0.002), and a high Hoehn and Yahr stage (<i>P</i> = 0.006) were associated with higher odds of SH (AUC 0.80). Increased supine systolic and diastolic blood pressure were associated with increased postural decline (β = 0.40, <i>P</i> < 0.001; β = 0.31, <i>P</i> = 0.001), whereas anti-hypertensive therapy was associated with decreased postural decline. Among patients with complete middle cerebral artery monitoring data, changes in the pulsatility index were correlated with reductions in cerebral blood flow velocity (β = -11.24; <i>P</i> = 0.002).ConclusionsThis study comprehensively characterized the prevalence and determinants of OH and SH in patients with PD. SH was associated with greater decreases in postural blood pressure, whereas anti-hypertensive therapy was associated with smaller decreases. Pulsatility index variation may serve as a physiological marker of cerebral haemodynamic adaptation during an orthostatic challenge.Plain language summary titleUnderstanding Blood Pressure Changes in People with Parkinson's Disease.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"1250-1262"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13442677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148156998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Helicobacter pylori</i> infection, peptic ulcer, gastritis and risk of Parkinson's disease: A nationwide matched cohort study.","authors":"Sara Licaj, Alexander Ploner, Agnieszka Szwajda, Sara Hägg, Fang Fang, Jonas F Ludvigsson, Karin Wirdefeldt","doi":"10.1177/1877718X261466875","DOIUrl":"10.1177/1877718X261466875","url":null,"abstract":"<p><p>BackgroundGastrointestinal symptoms are frequent in Parkinson's disease (PD) and may precede diagnosis by decades, suggesting a possible role in its pathogenesis. Patients with PD have higher rates of <i>Helicobacter pylori</i> (<i>H. pylori</i>) infection than the general population, although its potential contribution to PD development remains unclear. Similarly, evidence linking gastritis and peptic ulcer to PD risk is limited.MethodsUsing the nationwide ESPRESSO cohort, we investigated associations between <i>H. pylori</i> infection, peptic ulcer, gastritis, and future risk of PD. Individuals diagnosed with these conditions between 1987 or 1990 and 2017 were matched to ≤5 referents from the general population by age, sex, calendar year, and county of residence. Stratified Cox models estimated hazard ratios (HRs), adjusting for country of birth, education, chronic obstructive pulmonary disease, and number of healthcare visits. Incident PD was identified from the National Patient Register.ResultsThe <i>H. pylori</i> cohort included 48,258 exposed individuals and 231,805 referents; the peptic ulcer cohort included 52,761 exposed individuals and 274,313 referents, while the gastritis cohort included 242,325 exposed individuals and 1,053,688 referents. <i>H. pylori</i> infection (HR: 1.14, 95% CI: 1.02-1.28) and gastritis (HR: 1.14, 95% CI: 1.09-1.19) were associated with a marginally increased PD risk, but we found no significant association in peptic ulcer (HR: 1.08, 95% CI: 0.98-1.19). We observed increased PD risk up to ten years after gastritis diagnosis and no time-varying association for <i>H. pylori</i> and peptic ulcer.Conclusions<i>H. pylori</i> and gastritis may have some relevance for PD development but are unlikely to be major contributors to its pathogenesis.Plain language summary titleUsing gastrointestinal biopsies to explore the link between <i>Helicobacter pylori</i> infection, peptic ulcer, gastritis and Parkinson's disease: findings from a nationwide Swedish cohort study.</p>","PeriodicalId":16660,"journal":{"name":"Journal of Parkinson's disease","volume":" ","pages":"1164-1173"},"PeriodicalIF":5.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13443069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148447693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}