帕金森病参与者主导的深部脑刺激频率影响研究。

IF 4 3区医学 Q2 NEUROSCIENCES

Journal of Parkinson's disease Pub Date : 2025-04-11 DOI:10.1177/1877718X251331904

Mark D McAuley, John M Dean, Ethan Heming, Alena A Ionova, Celestina A Onabajo, Madison Solie, Sara A Stephenson, Susan E Boehnke

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引用次数: 0

摘要

帕金森病的症状，包括步态障碍和语言障碍，严重影响生活质量。这项n-of-1研究检查了深部脑刺激（DBS）频率对一位54岁帕金森病患者的影响。参与者构思并领导研究，在项目设计和执行中嵌入患者的见解。使用步态无标记运动捕捉、语音分析录音和Kinarm机器人上肢协调和认知评估任务来评估三种DBS频率的影响。研究发现，DBS频率对步态、僵硬、言语和认知运动能力等多种症状具有临床显著影响。

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Parkinson's disease participant-led research on the impact of deep brain stimulation frequency.

Parkinson's disease symptoms, including gait disturbances and speech impairment, substantially impact quality of life. This n-of-1 study examined the effects of deep brain stimulation (DBS) frequency on a 54-year-old man with Parkinson's disease. The participant conceived and led the study, embedding patient insight within the project design and execution. The impacts of three DBS frequencies were assessed using markerless motion capture for gait, voice recording for speech analysis, and Kinarm robotic tasks of upper limb coordination and cognitive assessment. The study found that DBS frequency has a clinically significant impact on multiple symptoms, including gait, rigidity, speech and cognitive-motor ability.

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来源期刊

Journal of Parkinson's disease NEUROSCIENCES-

CiteScore

8.40

自引率

5.80%

发文量

338

审稿时长

>12 weeks

期刊介绍： The Journal of Parkinson''s Disease (JPD) publishes original research in basic science, translational research and clinical medicine in Parkinson’s disease in cooperation with the Journal of Alzheimer''s Disease. It features a first class Editorial Board and provides rigorous peer review and rapid online publication.