Journal of paediatrics and child health最新文献_第2页

Association Between Hammersmith Infant Neurological Examination and Bayley Scales of Infant Development in High-Risk Infants: A Retrospective Cohort Study. 高风险婴儿的哈默史密斯婴儿神经系统检查和贝利婴儿发育量表之间的关系：回顾性队列研究

IF 1.6 4区医学

Journal of paediatrics and child health Pub Date : 2025-03-06 DOI: 10.1111/jpc.70031

Meagan Roff, Brendan Tian, Emily Johnston, Vathana Sackett, Annie Bourke, Pramod Pharande, Lindsay Zhou, Abdul Razak, Atul Malhotra

引用次数: 0

Do the American Academy of Paediatrics Guidelines for Managing Febrile Infants Aged 22 to 28 Days Work for a Suburban Australian Emergency Department? A Retrospective Audit.

IF 1.6 4区医学

Journal of paediatrics and child health Pub Date : 2025-03-05 DOI: 10.1111/jpc.70025

Claudia O'Rourke, David Krieser, Areeba Athar, Vidanka Vasilevski, Linda Sweet, Doris Tham

{"title":"Do the American Academy of Paediatrics Guidelines for Managing Febrile Infants Aged 22 to 28 Days Work for a Suburban Australian Emergency Department? A Retrospective Audit.","authors":"Claudia O'Rourke, David Krieser, Areeba Athar, Vidanka Vasilevski, Linda Sweet, Doris Tham","doi":"10.1111/jpc.70025","DOIUrl":"https://doi.org/10.1111/jpc.70025","url":null,"abstract":"Aim: The American Academy of Paediatrics (AAP) 2021 guideline on the management of febrile infants provides a separate algorithm for the 22- to 28-day-old infant. Provided a specific combination of inflammatory markers is in the low-risk range, lumbar puncture (LP) and empiric antibiotics are optional. The Australian guidelines recommend LP and empiric antibiotics in all febrile neonates (< 29 days). We describe the management of this age group over 8 years and review how using the AAP guideline would alter management.Methods: A single-centre retrospective chart review was conducted at Sunshine Hospital, Melbourne. The medical records of 50 consecutive well-appearing febrile infants aged 22-28 days were reviewed. Data on investigations, antibiotics, and duration of hospital stay were compared to the AAP recommendations.Results: Of the 45 patients who met the inclusion criteria, 31% had no LP and 18% were observed without antibiotics. In the setting of normal inflammatory markers, these proportions increased to 48% and 27% respectively. All infants with abnormal inflammatory markers received these interventions. Using the AAP algorithm, 51% of patients would have been eligible for observation without LP or antibiotics. Two cases of bacteraemia were identified, both with abnormal inflammatory markers. Most infants were observed for 48 h (77%), with smaller proportions observed for 36 h (16%) and 24 h (7%).Conclusions: Clinicians frequently perform a more limited septic evaluation in 22- to 28-day-old infants when inflammatory markers are normal. A revised approach to fever in this age group could reduce unnecessary LP and antibiotic use by up to 50%.","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Renal Masses in Childhood: An Australian Perspective.

IF 1.6 4区医学

Journal of paediatrics and child health Pub Date : 2025-03-03 DOI: 10.1111/jpc.70021

S M Trinder, C Kiraly-Borri, H Dholaria, A Charles, D J Roebuck, A L Ryan

{"title":"Renal Masses in Childhood: An Australian Perspective.","authors":"S M Trinder, C Kiraly-Borri, H Dholaria, A Charles, D J Roebuck, A L Ryan","doi":"10.1111/jpc.70021","DOIUrl":"https://doi.org/10.1111/jpc.70021","url":null,"abstract":"Childhood renal masses comprise a heterogeneous group of conditions that have a wide range of presentations. This review outlines an approach to the diagnostic work-up of childhood renal masses and discusses the most common presentations and treatments. Renal tumours make up 5% of childhood cancer in Australia, with Wilms tumour being the most common under age 10 years. Significant advances have been made through global cooperative efforts to improve the understanding of biology, genetic basis, and classification of disease as well as standardise treatment protocols. As survival outcomes have improved, a focus on surveillance of the late effects of treatment is important. Around 10%-15% are related to cancer predisposition syndromes, and therefore consideration of this is critical at diagnosis and throughout care. Early involvement of a multi-disciplinary team is essential to ensure accurate diagnosis and management for these children and their families. Australia holds a unique perspective, as both European (SIOP) and North American (COG) treatment approaches are adopted across its paediatric oncology centres for malignant tumours. This results in flexibility in patient management but also necessitates careful decision-making regarding protocol selection.","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent Eczematous Rashes Surrounding Multiple Melanocytic Nevi in a Young Paediatric Patient.

IF 1.6 4区医学

Journal of paediatrics and child health Pub Date : 2025-02-27 DOI: 10.1111/jpc.70024

Chon-Wai Jeremy Chan, Matthew Verheyden, John Relic

引用次数: 0

Analysis of Risk Factors for Brain Injury in Infants With Small Gestational Age and Construction and Evaluation of Prediction Model.

IF 1.6 4区医学

Journal of paediatrics and child health Pub Date : 2025-02-27 DOI: 10.1111/jpc.70019

Qunfang Shi, Ye Yang, Ling Wang, Yu Wang

{"title":"Analysis of Risk Factors for Brain Injury in Infants With Small Gestational Age and Construction and Evaluation of Prediction Model.","authors":"Qunfang Shi, Ye Yang, Ling Wang, Yu Wang","doi":"10.1111/jpc.70019","DOIUrl":"https://doi.org/10.1111/jpc.70019","url":null,"abstract":"Aims: To evaluate brain injury risk factors in small for gestational age (SGA) infants, develop and validate a risk prediction model.Methods: Medical records from 326 SGA infants in the Neonatal Intensive Care Unit at Hebei University's Affiliated Hospital from September 2019 to September 2024 were reviewed. The infants were categorised into brain injury (n = 135) and no brain injury (n = 191) groups based on cranial MRI outcomes. Risk factors for brain injuries in SGA infants were identified through both univariate and multivariate logistic regression analyses, followed by constructing a nomogram to visualise these risk determinants. The predictive model's calibration, discrimination, clinical net benefit, and clinical usefulness were verified using calibration and ROC curves, along with decision curve analysis (DCA) and clinical impact curves (CIC).Results: Significant risk factors included advanced maternal age, gestational hypertension (GH), fetal distress, reduced gestational age, neonatal septicemia, abnormal platelet counts and elevated neutrophil-to-lymphocyte ratio (NLR). The calibration curve and Hosmer-Lemeshow test verified the model's high accuracy. The model demonstrated good discrimination with an ROC curve AUC of 87.4%. Both DCA and CIC evaluations indicated the model's high clinical utility.Conclusion: The developed multivariate logistic regression model effectively predicts the risk of craniocerebral injuries in SGA infants, serving as a valuable tool for early identification of at-risk neonates.","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fathers' Involvement in a Surgical Neonatal Intensive Care Unit: A Prospective Cohort Study.

IF 1.6 4区医学

Journal of paediatrics and child health Pub Date : 2025-02-26 DOI: 10.1111/jpc.70017

Karanbir Kaur, Priya Govindaswamy, Amit Trivedi, Sharon Laing

{"title":"Fathers' Involvement in a Surgical Neonatal Intensive Care Unit: A Prospective Cohort Study.","authors":"Karanbir Kaur, Priya Govindaswamy, Amit Trivedi, Sharon Laing","doi":"10.1111/jpc.70017","DOIUrl":"https://doi.org/10.1111/jpc.70017","url":null,"abstract":"Aim: To date, studies exploring patterns of fathers' involvement in their neonate's care in the neonatal intensive care unit (NICU) and barriers to involvement have utilised qualitative approaches, which can be time- and resource-consuming. This study aimed to explore the fathers' involvement in a surgical NICU using a novel tool along with identifying potential facilitators and barriers to fathers' involvement in their neonate's care.Methods: This single-centre prospective cohort study was conducted at a surgical NICU (SNICU). A novel questionnaire, Fathers' Involvement Questionnaire: Neonatal Intensive Care Unit (FIQ:NICU) comprising four sections, was developed based on current evidence and expert consensus. Study data were collected and managed using REDCap electronic data capture tools. Involvement scores are reported for individual items, subscales (Physical contact, Verbal Interaction, During Procedures, Cares/Feeding, Participation in rounds), and total score (possible range 0-92). Associations between subscales and total FIQ scores and confidence levels were explored using bivariate correlation (Pearson's r).Results: Thirty-two fathers participated. Total FIQ:NICU scores ranged from 20 to 74, mean score 55.1 (95% confidence interval 49.9-60.2), SD 14.24. Fathers reported the highest level of involvement in 'During Procedures' subscale (M = 2.88, SD = 1.00) and the lowest involvement in 'Cares/Feeding' (M = 1.67, SD = 0.83). All fathers reported support from their partner (100%) as a facilitator, followed by support from nurses (71.9%). The most frequently reported barrier was lines and tubes on their neonate (46.9%), followed by work/job commitments (34.4%).Conclusions: Support from healthcare professionals, psychologists and peers can increase father's involvement in their neonate's care in SNICU.","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

X-Linked Hypophosphataemia and Burosumab: A Systemic Disease With a New Treatment.

IF 1.6 4区医学

Journal of paediatrics and child health Pub Date : 2025-02-26 DOI: 10.1111/jpc.70015

Jessica L Sandy, Andrew Biggin, Aris Siafarikas, Peter J Simm, Christine P Rodda, Craig F Munns

{"title":"X-Linked Hypophosphataemia and Burosumab: A Systemic Disease With a New Treatment.","authors":"Jessica L Sandy, Andrew Biggin, Aris Siafarikas, Peter J Simm, Christine P Rodda, Craig F Munns","doi":"10.1111/jpc.70015","DOIUrl":"https://doi.org/10.1111/jpc.70015","url":null,"abstract":"X linked hypophosphataemia (XLH) is a systemic, chronic condition that significantly impairs quality of life. In XLH, a phosphate regulating endopeptidase homologue X-linked (PHEX) gene mutation leads to excess fibroblast growth factor 23 (FGF23), causing hypophosphataemia and subsequent rickets, lower limb deformity, pain and other sequelae, however there are likely other non-FGF23 mediated mechanisms contributing to disease. Burosumab is an FGF23 inhibiting monoclonal antibody that has been shown to be significantly more effective in treating X linked hypophosphataemia than previously available treatment (\"conventional therapy\" with oral phosphate and active vitamin D). Clinical trials and real-world studies have shown that burosumab can improve lower limb deformity, growth, pain, exercise capacity, biochemistry, rickets, and quality of life. However, the full effect of burosumab on the lives of individuals with X linked hypophosphataemia is yet to be determined. How burosumab may impact some of the lesser understood clinical features, including dental abscesses, craniosynostosis, enthesopathy, and osteoarthritis, is unclear. Whether burosumab mitigates the risk of complications associated with conventional therapy (nephrocalcinosis and hyperparathyroidism) has also not been established. There are conflicting recommendations on who should receive burosumab, when they should start it, and for how long they should continue taking it. This review summarises what is known, and more importantly what is unknown, about burosumab use in X linked hypophosphataemia. We highlight important areas for future research to better understand the impact of burosumab in XLH, improve management of XLH, assess cost benefit of, and advocate for fair and equitable access to burosumab.","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Osteoid Osteoma Presenting With Unilateral Leg Wasting.

IF 1.6 4区医学

Journal of paediatrics and child health Pub Date : 2025-02-26 DOI: 10.1111/jpc.70023

Amelia Yeoh, Sharon Ng, Adambarage Chandima De Alwis

引用次数: 0

Autologous Blood Patch and Lung Ultrasound for Persistent Air Leak in an Extremely Premature Neonate.

IF 1.6 4区医学

Journal of paediatrics and child health Pub Date : 2025-02-25 DOI: 10.1111/jpc.70022

Callum Gately

引用次数: 0

Missed Opportunities for Preventing or Diagnosing Acute Rheumatic Fever: A Retrospective Cohort Study of 20 Young Australians Diagnosed With Rheumatic Heart Disease on Screening Echocardiography.

IF 1.6 4区医学

Journal of paediatrics and child health Pub Date : 2025-02-23 DOI: 10.1111/jpc.16797

Oliver Rouhiainen, Jessica Gatti, Seide Ramadani, Jayden Stewart, Melanie Matthews, Helen Fairhurst, Bo Remenyi, Joshua R Francis, Jennifer Yan

{"title":"Missed Opportunities for Preventing or Diagnosing Acute Rheumatic Fever: A Retrospective Cohort Study of 20 Young Australians Diagnosed With Rheumatic Heart Disease on Screening Echocardiography.","authors":"Oliver Rouhiainen, Jessica Gatti, Seide Ramadani, Jayden Stewart, Melanie Matthews, Helen Fairhurst, Bo Remenyi, Joshua R Francis, Jennifer Yan","doi":"10.1111/jpc.16797","DOIUrl":"https://doi.org/10.1111/jpc.16797","url":null,"abstract":"Background and aim: A cross-sectional echocardiographic screening study in a remote Aboriginal community in Australia identified hyperendemic levels of rheumatic heart disease (RHD). 20/613 screened were newly diagnosed with RHD, and 18/20 had no known history of acute rheumatic fever (ARF). Our aim was to explore the medical histories of those newly diagnosed with RHD for potential (1) missed opportunities for primary prevention of ARF through management of Group A Streptococcal (Strep A) infection, and (2) missed opportunities for diagnosis of ARF.Methods: We assessed community clinic and tertiary hospital medical records of those children with new diagnoses of RHD (n = 20), and collected information regarding previous episodes of possible Strep A infection or its sequelae.Results: All 20 participants had previous documented possible or confirmed Strep A infections, predominantly in the form of impetigo or infected scabies (range 1-17 episodes per participant). At least 15/20 participants had potential Strep A infections where treatment that was documented may not have adequately covered Strep A. 11/20 participants had scabies diagnosed without documented scabies treatment. 2/20 participants had previously diagnosed ARF, however these were diagnosed within the month prior to the community-wide screening for RHD. 2/20 participants had undiagnosed, probable or possible ARF when classified retrospectively from review of their case documentation. 13/20 participants had non-specific presentations with joint complaints that may have represented an ARF episode but with inadequate workup to fulfil diagnostic criteria on retrospective assessment.","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0