Journal of paediatrics and child health最新文献_第3页

Endoscopic Extraction of Gastric Bezoar Misdiagnosed as Menetrier's Disease. 内镜下胃牛黄提取术误诊为梅氏病。

IF 1.6 4区医学

Journal of paediatrics and child health Pub Date : 2025-07-01 DOI: 10.1111/jpc.70133

Ankit Agrawal, Moinak Sen Sarma

引用次数: 0

Saving Tiny Limbs: Successful Use of Nitroglycerin Ointment in a Preterm Infant. 挽救幼小的肢体：硝酸甘油软膏在早产儿中的成功应用。

IF 1.6 4区医学

Journal of paediatrics and child health Pub Date : 2025-07-01 DOI: 10.1111/jpc.70119

Irene Malni, Meta Starc, Francesca Marrazzo, Ursula Manzon, Davide Zanon, Laura Travan

引用次数: 0

Prevalence and Risk Factors of Autoimmune Thyroid and Coeliac Disease in Type 1 Diabetes Children and Adolescents; A Retrospective Cohort Analysis. 1型糖尿病儿童和青少年自身免疫性甲状腺和乳糜泻患病率及危险因素分析回顾性队列分析。

IF 1.6 4区医学

Journal of paediatrics and child health Pub Date : 2025-06-27 DOI: 10.1111/jpc.70121

William Lau, Shobhit Niraula, Anthony Liu, Gary M Leong

{"title":"Prevalence and Risk Factors of Autoimmune Thyroid and Coeliac Disease in Type 1 Diabetes Children and Adolescents; A Retrospective Cohort Analysis.","authors":"William Lau, Shobhit Niraula, Anthony Liu, Gary M Leong","doi":"10.1111/jpc.70121","DOIUrl":"https://doi.org/10.1111/jpc.70121","url":null,"abstract":"Aim: To determine the prevalence and risk factors for autoimmune thyroiditis (AITD) and coeliac disease (CD) in a T1D paediatric and adolescent population.Methods: This was a retrospective cohort analysis of 300 children and adolescents attending a diabetes outpatient clinic from 2017 to 2023. Screening for AITD and CD was done every 1 to 2 years after diagnosis of T1D. Chi-square analysis and logistic regression models were used to analyse clinical differences between T1D and AITD/CD.Results: The prevalence of AITD and CD in the cohort was 7.7% (n = 23) and 9.3% (n = 28) respectively. Higher rates of AITD were associated with female sex (p = 0.002) and having an additional autoimmune disease (p = 0.05). Subgroup analysis showed that Hashimoto's thyroiditis was associated with female sex (p = 0.02) while Graves' disease was associated with having an additional autoimmune disease (p = 0.047). Patients with AITD also had a lower mean height (p = 0.02) and higher BMI (p = 0.002) than patients without AITD. No significant differences were found in patients with CD. Female sex was associated with higher rates of having both AITD and CD (p = 0.01). Age of T1D onset, diabetic ketoacidosis, or autoimmune family history were not associated with either AITD or CD.Conclusions: Our study showed that the prevalence of autoimmune diseases in T1D remains high, with more cases of CD compared to AITD in our paediatric cohort. Our study suggests that regular screening for AITD and CD in T1D patients remains important and should continue to occur after the detection of one autoimmune disease.","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Demographics of Mothers Donating to a Nonprofit Human Milk Bank in Australia. 向澳大利亚非营利性母乳银行捐赠母乳的母亲的人口统计数据。

IF 1.6 4区医学

Journal of paediatrics and child health Pub Date : 2025-06-26 DOI: 10.1111/jpc.70117

Laura D Klein, Tong Wu, Laura Thomas, Richard Brown, Christine Sulfaro, Vanessa Clifford

{"title":"Demographics of Mothers Donating to a Nonprofit Human Milk Bank in Australia.","authors":"Laura D Klein, Tong Wu, Laura Thomas, Richard Brown, Christine Sulfaro, Vanessa Clifford","doi":"10.1111/jpc.70117","DOIUrl":"https://doi.org/10.1111/jpc.70117","url":null,"abstract":"Background: Donated human milk is the preferred alternative source of nutrition when infants born preterm do not have access to enough maternal breast milk. Around the world, human milk banks have been established to ensure that vulnerable infants can access safe supplies of donor human milk. Milk donors are the foundation of milk banking, and understanding who donates milk in different settings is important for creating sustainable donor milk services. This study aimed to describe milk donors and donation characteristics to a nonprofit donor human milk service operated by Australia's national blood service (Lifeblood).Materials and methods: This retrospective cohort study used routinely collected data from Lifeblood's donor milk service over its first 6 years of operations, from 1 July 2018 to 30 June 2024. Records from all milk donors registered as of 30 June 2024 were included.Results: During the study period, 1794 women donated 23 714 L of human milk to Lifeblood. This includes 45 bereaved donors. The mean age for a milk donor was 32.4 ± 4.6 years (range 18.4-51.6 years). Donors with preterm births were over-represented compared to the general Australian population (29.4% vs. 8.6%). Among 1501 nonbereaved, completed donors, mean total donation volume was 13.4 L [range 0.5-229.1 L]. Donors provided the majority of their donations when their own infant was aged 1-3 months.Conclusions: This study provides the first description of characteristics of milk donors and their donations in Australia. These data will help inform donor recruitment strategies, particularly if need for pasteurised donor human milk increases in the future.","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Full-Spectrum Medicinal Cannabis Plant Extract 0.08% THC (NTI164) Improves Symptoms of Rett Syndrome: An Open-Label Study. 全谱药用大麻植物提取物0.08% THC （NTI164）改善Rett综合征的症状：一项开放标签研究。

IF 1.6 4区医学

Journal of paediatrics and child health Pub Date : 2025-06-26 DOI: 10.1111/jpc.70122

B A Keating, Y Ogru, T G Duthy, L Douglas, K Lichkus, E Isikgel, M C Fahey, C Ellaway

{"title":"Full-Spectrum Medicinal Cannabis Plant Extract 0.08% THC (NTI164) Improves Symptoms of Rett Syndrome: An Open-Label Study.","authors":"B A Keating, Y Ogru, T G Duthy, L Douglas, K Lichkus, E Isikgel, M C Fahey, C Ellaway","doi":"10.1111/jpc.70122","DOIUrl":"https://doi.org/10.1111/jpc.70122","url":null,"abstract":"Aim: The aim of this Phase I/II open-label study was to assess the safety and efficacy of NTI164, a novel full-spectrum medicinal cannabis plant extract 0.08% Δ-9-tetrahydrocannabinol (THC), in Rett syndrome (RTT).Methods: Eleven female participants (5-16 years) with a pathogenic variant in the MECP2 gene were recruited to this study, receiving NTI164 twice daily for 12 weeks. The primary outcome measure was the Clinical Global Impression-Improvement (CGI-I) Scale, with secondary outcomes measured using the CGI-Severity (CGI-S), RTT Behaviour Questionnaire (RSBQ), RTT-Symptom Index Score (RTT-SIS), RTT-Domain-Specific Concerns-Visual-Analog Scale (RTT-DSC-VAS), Impact of Childhood Neurological Disability/Quality of Life (ICND+QoL), and RTT-Caregiver Burden Inventory (RTT-CBI). Paired-samples t-test was used to assess significance between baseline and Week 12.Results: Improvements were seen in the total CGI-I score (p = 0.028), with improvements in communication skills (p = 0.003), mental alertness (p = 0.033), socialisation/eye contact (p = 0.0004), attentiveness (p = 0.001), and anxiety (p = 0.004). CGI-S also demonstrated better outcomes after NTI164 administration (p = 0.008). RSBQ showed improvements in total score (p = 0.0005), general mood (p = 0.0003), breathing problems (p = 0.041), repetitive face movements (p = 0.004), and fear/anxiety (p = 0.006). RTT-DSC-VAS showed positive developments in abilities to communicate choices (p = 0.041). ICND total score was improved (p = 0.003), as well as cognition (p = 0.027) and Quality of Life (p = 0.0002). Total score on the RTT-CBI was improved (p = 0.006).Conclusion: NTI164 demonstrated safety and improved some clinical and functional outcomes in RTT. These improvements justify ongoing research into NTI164, which may be a potential adjunct therapy in RTT.","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bracing Outcomes in Adolescent Idiopathic Scoliosis: The Role of Generalised Joint Hypermobility. 青少年特发性脊柱侧凸的支具治疗效果：广泛性关节活动过度的作用。

IF 1.6 4区医学

Journal of paediatrics and child health Pub Date : 2025-06-26 DOI: 10.1111/jpc.70127

Senay Çerezci-Duygu, Gözde Yağcı, Kübra Nurdoğan, Halil Gökhan Demirkıran

{"title":"Bracing Outcomes in Adolescent Idiopathic Scoliosis: The Role of Generalised Joint Hypermobility.","authors":"Senay Çerezci-Duygu, Gözde Yağcı, Kübra Nurdoğan, Halil Gökhan Demirkıran","doi":"10.1111/jpc.70127","DOIUrl":"https://doi.org/10.1111/jpc.70127","url":null,"abstract":"Objective: To evaluate the effects of generalised joint hypermobility (JHM) on bracing outcomes in adolescent idiopathic scoliosis (AIS).Methods: Twenty-two female participants with a mean age of 12 ± 2 years who were diagnosed with AIS and planned to use a brace were included in the study. Assessments were performed at three different time points. Visit 1, 1-7 days before bracing; Visit 2, in-brace condition in the fourth week of bracing; Visit 3, out-brace condition in the sixth month of bracing. At Visit 1, the participants' Risser sign, curve type according Rigo classification and sagittal spinal range of motion defined in modified Schober's test were recorded. The nine-point Beighton scale and Hakim-Graham's five-part questionnaire were used to determine the presence of JHM. The following data were recorded from the antero-posterior radiographs at each of the three visits: coronal curvature, apical vertebral rotation, spine height, global coronal balance and apical translation.Results: In the in-brace evaluation, there was no difference in radiographic measurements between the groups defined as JHM present (n = 11) and JHM absent (n = 11). At the out-brace evaluation performed at the sixth month of brace use, the change in the Cobb angle representing the coronal curvature between the groups was found to be significant in favour of the JHM-present group (JHM-absent: 4 (1, 7) vs. JHM-present: 10 (6, 15)), and no difference was found in the other radiographic measurements.Conclusion: In AIS, scoliosis indicators such as coronal curvature, apical vertebral rotation, and coronal balance can be improved with bracing. Furthermore, the presence of JHM may have a possible impact when bracing is included in AIS management.Trial registration: National Library of Medicine platform (NCT06021314) (record verification on 25.08.2023).","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Complexities and Challenges of Managing Genetic Causes of Hyperphosphataemia, a Case Report. 管理高磷血症遗传原因的复杂性和挑战，一个病例报告。

IF 1.6 4区医学

Journal of paediatrics and child health Pub Date : 2025-06-26 DOI: 10.1111/jpc.70107

Farrah Rodrigues, Paul L Hofman, Catherine Quinlan, Margaret Zacharin

引用次数: 0

Parental Experiences of Having a Child Diagnosed With Septo-Optic Dysplasia. 孩子被诊断为视隔发育不良的父母经历。

IF 1.6 4区医学

Journal of paediatrics and child health Pub Date : 2025-06-24 DOI: 10.1111/jpc.70091

David J Cullingford, A Marie Blackmore, Mary B Abraham, Aris Siafarikas, Jenny Downs, Catherine S Y Choong

引用次数: 0

The Role of Vitamin D in Eosinophilic Esophagitis in Children. 维生素D在儿童嗜酸性食管炎中的作用。

IF 1.6 4区医学

Journal of paediatrics and child health Pub Date : 2025-06-24 DOI: 10.1111/jpc.70126

Zu Zu Kyaw Lwin, Steven T Leach, Usha Krishnan

{"title":"The Role of Vitamin D in Eosinophilic Esophagitis in Children.","authors":"Zu Zu Kyaw Lwin, Steven T Leach, Usha Krishnan","doi":"10.1111/jpc.70126","DOIUrl":"https://doi.org/10.1111/jpc.70126","url":null,"abstract":"Aim: To determine the prevalence of Vitamin D (VD) deficiency in children with Eosinophilic Oesophagitis (EoE) compared to controls and to analyse the relationship between VD status and EoE treatment outcomes.Methods: This was a retrospective case-control study. Children with EoE who had available VD data at the time of EoE diagnosis were included in the study group. Age- and sex-matched controls were sourced from endoscopic records of children without EoE. The prevalence of VD deficiency in the two groups was calculated and compared using three cut-off values for deficiency (< 50, < 75 and < 100 nmol/L). The study also examined the correlation between VD levels at diagnosis and EoE treatment response, and the relationship between EoE treatment and follow-up VD levels.Results: Our study showed no significant difference in the mean VD levels between the EoE (n = 106) and control (n = 212) groups. Among VD-deficient patients with EoE (< 50 nmol/L), higher VD levels were significantly correlated with a lower number of eosinophils per high power field (R = 0.58, p = 0.028) post-treatment of EoE. Moreover, post-treatment patients with EoE (not on VD supplementation) had improved VD levels compared to levels at diagnosis (p = 0.049).Conclusions: In this study, higher VD levels were associated with a greater reduction in eosinophil count with treatment in VD-deficient patients with EoE. This finding raises the possibility of a beneficial role for VD supplementation in improving treatment outcomes in VD-deficient patients with EoE. Further prospective studies are warranted to confirm these observations.","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-World Outcomes of the 2022 American Academy of Pediatrics Hyperbilirubinemia Guideline. 2022年美国儿科学会高胆红素血症指南的实际结果。

IF 1.6 4区医学

Journal of paediatrics and child health Pub Date : 2025-06-23 DOI: 10.1111/jpc.70124

Sagee Nissimov, Amitai Kohn, Rimona Keidar, Ayelet Livne, Yaakov Berkovitz, Iris Morag

{"title":"Real-World Outcomes of the 2022 American Academy of Pediatrics Hyperbilirubinemia Guideline.","authors":"Sagee Nissimov, Amitai Kohn, Rimona Keidar, Ayelet Livne, Yaakov Berkovitz, Iris Morag","doi":"10.1111/jpc.70124","DOIUrl":"https://doi.org/10.1111/jpc.70124","url":null,"abstract":"Objectives: To evaluate the clinical impact and adherence to the 2022 American Academy of Pediatrics guideline for neonatal hyperbilirubinemia in comparison with the 2004 guideline.Methods: We conducted a retrospective study of all infants born at ≥ 35 weeks post-menstrual age during June-July from 2021 to 2023. Infants were categorised into two epochs: Epoch 1 (E1), treated according to the 2004 guidelines (2021-2022), and Epoch 2 (E2), treated according to the 2022 guidelines (2023). We assessed phototherapy rates, hyperbilirubinemia-related outcomes and non-adherence, defined as phototherapy treatment despite bilirubin levels > 2.0 mg/dL below the threshold.Results: Among 4071 infants, 255 required phototherapy (183 in E1 and 72 in E2). The phototherapy rate decreased from 6.6% in E1 to 5.5% in E2 (p = 0.227). However, a significant increase in lack of adherence was observed in E2, with 47.2% receiving phototherapy below the threshold compared to 26.2% in E1 (p = 0.002). Infants in E2 underwent more skin-breaking procedures (p = 0.016) and had a higher rate of positive direct antiglobulin tests (p = 0.04). No differences were observed in the duration of phototherapy exposure, length of hospital stay or rate of readmissions.Conclusion: While adherence to guidelines was suboptimal, and rates of phototherapy did not significantly decline, a greater proportion of treated infants had hemolytic risk factors, suggesting more targeted use of phototherapy. Improved efforts are needed to enhance compliance with the guideline, which may in turn help minimise unnecessary interventions.","PeriodicalId":16648,"journal":{"name":"Journal of paediatrics and child health","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0