{"title":"A nested case-control study of factors contributing to the development of medication-related osteonecrosis of the jaw in patients using bone resorption inhibitors in Mishima City.","authors":"Keisuke Seki, Atsushi Kamimoto, Maki Wada, Toshimitsu Iinuma","doi":"10.2334/josnusd.23-0096","DOIUrl":"https://doi.org/10.2334/josnusd.23-0096","url":null,"abstract":"<p><strong>Purpose: </strong>Medication-related osteonecrosis of the jaw (MRONJ) is characterized by necrosis of the jawbone with intraoral bacterial infection and has a significant negative impact on oral health-related quality of life. Risk factors for the onset are unknown, and definitive therapeutic approaches have not yet been defined. A case-control study at a single institution in Mishima City was conducted. The purpose of this study was to examine in detail the factors that contribute to the development of MRONJ.</p><p><strong>Methods: </strong>Medical records of MRONJ patients who visited Mishima Dental Center, Nihon University School of Dentistry, during the period 2015-2021 were extracted. Counter-matched sampling design was used to select participants matched for sex, age, and smoking for this nested case-control study. The incidence factors were statistically examined by logistic regression analysis.</p><p><strong>Results: </strong>Twelve MRONJ patients were used as cases and 32 controls were matched. After adjustment for potential confounders, injectable bisphosphonates (aOR = 24.5; 95% CI = 1.05, 575.0; P < 0.05) were significantly associated with the development of MRONJ.</p><p><strong>Conclusion: </strong>High-dose bisphosphonates may be a risk factor for the development of MRONJ. Patients who use these products require careful prophylactic dental treatment against inflammatory diseases, and dentists and physicians should maintain close communication.</p>","PeriodicalId":16646,"journal":{"name":"Journal of oral science","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9745479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical performance of two onlay designs for molars after root canal treatment.","authors":"Shujiang Chen, Meng Lu, Zhimin Zhu, Wenchuan Chen","doi":"10.2334/josnusd.22-0450","DOIUrl":"https://doi.org/10.2334/josnusd.22-0450","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the clinical performance of two proposed onlay designs.</p><p><strong>Methods: </strong>Molars with occlusal and/or mesial/distal defects after root canal treatment were classified by design into three groups. Onlays without shoulders were the control group (Group C, n = 50). The designed onlays were Group O (n = 50) and the designed mesio-occlusal/disto-occlusal onlays were Group MO/DO (n = 80). All onlays had an occlusal thickness of approximately 1.5-2.0 mm, and the designed onlays had a shoulder depth and width of approximately 1 mm. In Groups C and O, the box-shaped retention was 1.5 mm in depth. The proximal box was connected with a dovetail retention in Group MO/DO. Patients were examined every 6 months and followed for 36 months. Restorations were evaluated by using the modified United States Public Health Service Criteria. Statistical analysis was performed by using Kaplan-Meier analysis, the chi-square test, and Fisher's exact test.</p><p><strong>Results: </strong>No tooth fracture, debonding, secondary caries, or gingivitis was observed in any group. Groups O and MO/DO had satisfactory survival and success rates, and there was no significant difference in performance characteristics among the three groups (P > 0.05).</p><p><strong>Conclusion: </strong>The two proposed onlay designs were effective in protecting molars.</p>","PeriodicalId":16646,"journal":{"name":"Journal of oral science","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9745481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Combined effect of apigenin and reduced graphene oxide against Enterococcus faecalis biofilms.","authors":"Mi-Ah Kim, Kyung-San Min","doi":"10.2334/josnusd.22-0459","DOIUrl":"https://doi.org/10.2334/josnusd.22-0459","url":null,"abstract":"<p><strong>Purpose: </strong>Enterococcus faecalis (E. faecalis) is one of the major microorganisms that causes failure of endodontic treatment. This study aimed to investigate the antibacterial activity of apigenin and its synergistic effect with reduced graphene oxide (RGO) in treating E. faecalis biofilms.</p><p><strong>Methods: </strong>The antibacterial activities were characterized by viability analysis including colony forming units and confocal laser scanning microscopy (CLSM) analyses. The effect on biofilm biomass was measured using a crystal violet staining method. Live and dead bacteria bio-volumes were determined by CLSM analysis, and the morphology of E. faecalis biofilm after treatment with apigenin and apigenin + RGO was observed by scanning electron microscopy (SEM).</p><p><strong>Results: </strong>The viability of E. faecalis in biofilms decreased by apigenin treatment in a dose-dependent manner. While apigenin alone did not significantly affect the biofilm biomass, apigenin + RGO reduced the biomass in an apigenin concentration-dependent manner. Likewise, the bio-volume of live bacteria decreased and the bio-volume of dead bacteria increased in apigenin-treated biofilms. According to SEM images, apigenin + RGO-treated samples showed less E. faecalis in biofilms than apigenin-only treated samples.</p><p><strong>Conclusion: </strong>The results suggested that the combined use of apigenin and RGO could be a potential strategy for effective endodontic disinfection.</p>","PeriodicalId":16646,"journal":{"name":"Journal of oral science","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10119139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Validity of analysis of masticatory movement using a two-dimensional mandibular movement recording device.","authors":"Masaoki Yokoyama, Hiroshi Shiga, Marie Komino, Hanako Uesugi, Mako Sano, Tohru Naitoh","doi":"10.2334/josnusd.23-0060","DOIUrl":"https://doi.org/10.2334/josnusd.23-0060","url":null,"abstract":"<p><p>To clarify the validity of analysis of masticatory movement using a two-dimensional (2D) mandibular movement recording device, masticatory movements (pattern of movement path, opening distance, masticatory width, and cycle time) were compared between simultaneous recordings made by 2D and three-dimensional (3D) devices in healthy adults. The 2D device can perform the same level of mandibular movement analysis as the 3D device if the distance between LED and camera is fixed (15 cm), and the findings indicated the suitability of the 2D device for clinical application.</p>","PeriodicalId":16646,"journal":{"name":"Journal of oral science","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9743094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ji-Yoon Shin, Mi-Ah Kim, Hee-Jin Kim, Prasanna Neelakantan, Mi-Kyung Yu, Kyung-San Min
{"title":"Evaluation of machine-assisted irrigation on removal of intracanal biofilm and extrusion of sodium hypochlorite using a three-dimensionally printed root canal model.","authors":"Ji-Yoon Shin, Mi-Ah Kim, Hee-Jin Kim, Prasanna Neelakantan, Mi-Kyung Yu, Kyung-San Min","doi":"10.2334/josnusd.23-0025","DOIUrl":"https://doi.org/10.2334/josnusd.23-0025","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to compare the biofilm removal and apical extrusion of sodium hypochlorite (NaOCl) following machine-assisted irrigation using a three-dimensionally (3D) printed dentin-insert model.</p><p><strong>Methods: </strong>Multispecies biofilms were formed in a 3D-printed curved root canal model with dentin insert. The model was then placed in a container that was filled with 0.2% agarose gel containing 0.1% m-Cresol purple. Root canals were irrigated with 1% NaOCl using syringe irrigation, sonically agitated (EndoActivator or EDDY) or ultrasonically activated (Endosonic Blue) irrigation. Samples were photographed and the color-changed area was measured. Biofilm removal was assessed using colony-forming unit counting, confocal laser scanning microscopic analysis and scanning electron microscopic observations. The data were analyzed using one-way ANOVA, followed by Tukey test (P < 0.05).</p><p><strong>Results: </strong>EDDY and Endosonic Blue demonstrated significantly greater reduction of biofilms compared to other groups. No significant differences were observed in the remaining biofilm volume in syringe irrigation and EndoActivator groups. Furthermore, EDDY and Endosonic Blue presented with numerous exposed dentinal tubules. EDDY showed significantly greater NaOCl extrusion compared to other groups.</p><p><strong>Conclusion: </strong>Ultrasonic activation with a small-sized nickel-titanium file irrigation system may be beneficial in intracanal biofilm removal avoiding extrusion of NaOCl beyond the root apex.</p>","PeriodicalId":16646,"journal":{"name":"Journal of oral science","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9745462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Insulin facilitates synaptic transmission via gap junctions between fast-spiking interneurons in the rat insular cortex.","authors":"Satoshi Kosukegawa, Yuka Nakaya, Satomi Kobayashi, Kohei Kitano, Sachie Matsumura, Shohei Ogisawa, Manabu Zama, Mitsuru Motoyoshi, Masayuki Kobayashi","doi":"10.2334/josnusd.22-0438","DOIUrl":"https://doi.org/10.2334/josnusd.22-0438","url":null,"abstract":"<p><strong>Purpose: </strong>Inhibitory synaptic currents from fast-spiking neurons (FSNs), a typical gamma-aminobutyric acid (GABA)ergic interneuron in the cerebral cortex, to pyramidal neurons are facilitated by insulin. FSNs frequently show electrical synapses to FSNs, however, the effect of insulin on these electrical synapses is unknown. The aim of this study was to evaluate effects of insulin on electrical synaptic potentials between FSNs.</p><p><strong>Methods: </strong>Electrical synaptic potentials via gap junctions between FSNs were recorded to examine how insulin modulates these potentials in the rat insular cortex (IC).</p><p><strong>Results: </strong>Bath application of insulin (10 nM), which increases the spike firing rate of pyramidal neurons and unitary inhibitory postsynaptic currents recorded from FSN to pyramidal neuron connections, slightly but significantly increased electrical synaptic currents. The mean ratio of electrical synapses, the coupling coefficient that is obtained by postsynaptic voltage responses divided by presynaptic voltage amplitude, was 8.3 ± 1.1% in control and 9.2 ± 1.1% (n = 14) during 10 nM insulin application. Input resistance and voltage responses to large hyperpolarizing currents (-140 pA) were not changed by insulin.</p><p><strong>Conclusion: </strong>These results suggest that insulin facilitates spike synchronization by increasing electrical synaptic currents via gap junctions of GABAergic FSNs in the IC.</p>","PeriodicalId":16646,"journal":{"name":"Journal of oral science","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9209760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of the plaque-removal efficacy of ultra-soft single-headed, triple-headed, and T-shaped toothbrushes and the subjective perceptions of users.","authors":"Ju-Hui Wu, Jhen-Yi Li, Je-Kang Du, Chen-Yi Lee","doi":"10.2334/josnusd.22-0307","DOIUrl":"https://doi.org/10.2334/josnusd.22-0307","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the plaque-removal efficacy of ultra-soft single-headed, triple-headed, and T-shaped toothbrushes and the subjective perceptions of users.</p><p><strong>Methods: </strong>In this randomized, single-blind, crossover study, 30 healthy adult participants were randomly divided into three groups of 10, who tested the three types of toothbrushes in differing order, with a 1-week washout period between the tests. Dental plaque scores were recorded before and after toothbrushing, and questionnaires on subjective perceptions after toothbrushing were collected.</p><p><strong>Results: </strong>The participants included 16 female participants and 14 male participants (average age: 29.4 ± 6.7 years). All three toothbrush types were effective in reducing dental plaque by 36-46%; however, the cleaning effect of the ultra-soft single-headed toothbrush was inferior to that of the triple-headed and T-shaped toothbrushes, the difference being statistically significant. The users' subjective perceptions suggested that the ultra-soft single-headed toothbrush was significantly superior to the other two toothbrush types. Plaque scores for the lower posterior tooth surfaces were higher than those for the upper posterior tooth surfaces, particularly on the left side, for both the ultra-soft single-headed and T-shaped toothbrushes.</p><p><strong>Conclusion: </strong>Healthcare practitioners should identify the type of toothbrush bristles used by individuals and provide appropriate oral health information.</p>","PeriodicalId":16646,"journal":{"name":"Journal of oral science","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9209780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jovana Milutinovic, Ema Aleksic, Stevan Avramov, Katarina Kalevski, Milica Gajic, Djordje Pejanovic, Jasmina Milic
{"title":"Esthetic preferences of orthodontists, dentists, and plastic surgeons for balanced facial profiles.","authors":"Jovana Milutinovic, Ema Aleksic, Stevan Avramov, Katarina Kalevski, Milica Gajic, Djordje Pejanovic, Jasmina Milic","doi":"10.2334/josnusd.22-0396","DOIUrl":"https://doi.org/10.2334/josnusd.22-0396","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this investigation was to determine whether the facial esthetics of subjects rated as \"attractive\" can be related to specific cephalometric soft tissue parameters.</p><p><strong>Methods: </strong>The profile silhouettes of 100 subjects (45 males and 55 females) were rated by 60 esthetics specialists (20 orthodontists, 20 dentists, and 20 plastic surgeons) using a Likert scale, and 30 of the subjects were selected as being \"attractive\". The cephalometric measurements of the attractive group were then compared with norms for the general Caucasian population.</p><p><strong>Results: </strong>The effects of specific measured parameters on profile beauty grades were assessed using the median test, and the following variables were found to show significant correlations between the Caucasian norms and the attractive profile group: the ratio of the upper to lower face height (P = 0.011), the ratio of the subnasale - labrale inferius (Sn-Li) and labrale inferius - menton (Li-Me`) lines (P = 0.011), the distance between the chin and the subnasale perpendicular (P = 0.002), upper lip thickness (P = 0.021), soft tissue chin thickness (P = 0.021), vertical height ratio (P = 0.021), and nasolabial angle (P = 0.021).</p><p><strong>Conclusion: </strong>A straight profile with a fuller and more protruded upper lip, a higher nasal tip, and a smaller lower facial third are considered to be the most attractive facial features, and may be useful for improvement of facial esthetics.</p>","PeriodicalId":16646,"journal":{"name":"Journal of oral science","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9209762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luciana C Boggian, Ana V Silva, Geovana R Santos, Geovanna F Oliveira, Winston L Silva, Ismar Nery Neto, Orlando A Guedes, Carlos Estrela
{"title":"Effect of intra-radicular cleaning protocols after post-space preparation on marginal adaptation of a luting agent to root dentin.","authors":"Luciana C Boggian, Ana V Silva, Geovana R Santos, Geovanna F Oliveira, Winston L Silva, Ismar Nery Neto, Orlando A Guedes, Carlos Estrela","doi":"10.2334/josnusd.22-0344","DOIUrl":"https://doi.org/10.2334/josnusd.22-0344","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effect of intra-radicular cleaning protocols after post-space preparation (PSP) on marginal adaptation of a luting agent to root dentin.</p><p><strong>Methods: </strong>Eighty bovine incisors were sectioned transversely to obtain 18-mm-long root sections. The roots were prepared with ProTaper instruments and filled using Tagger's hybrid technique. PSP was performed at a length of 14 mm using #3-5 Largo drills. The roots were distributed into eight groups according to the chelating solution used (17% EDTA or 0.2% Chitosan) and the chelating activation/delivery method employed (conventional needle irrigation [CNI], EndoActivator [EA], XP-Endo Finisher [XPF] or passive ultrasonic irrigation [PUI]). The fiber posts were cemented using self-adhesive resin cement, and the roots were sectioned to obtain three discs from each root third. The dentin discs were observed under an optical microscope at ×40 magnification to assess marginal adaptation. The different protocols were compared considering the frequency of the marginal adaptation scores using the Kruskal-Wallis test, followed by the Dwass-Steel-Critchlow-Fligner test (α = 5%).</p><p><strong>Results: </strong>The use of 17% EDTA resulted in better marginal adaptation (P < 0.001). PUI yielded results that were similar to those for EA (P = 0.949) and superior to those for XPF (P = 0.020). The combination of 17% EDTA + PUI provided a greater number of interfaces without marginal gaps (P < 0.001).</p><p><strong>Conclusion: </strong>The cleaning protocol influenced the marginal adaptation of resin cement to root dentin.</p>","PeriodicalId":16646,"journal":{"name":"Journal of oral science","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9209782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sigve Slettvoll, Rasmus C Thaning, Torbjørn Ø Pedersen
{"title":"Tooth extraction prior to radiotherapy for oropharyngeal cancer increases the risk of osteoradionecrosis.","authors":"Sigve Slettvoll, Rasmus C Thaning, Torbjørn Ø Pedersen","doi":"10.2334/josnusd.22-0392","DOIUrl":"https://doi.org/10.2334/josnusd.22-0392","url":null,"abstract":"<p><strong>Purpose: </strong>Osteoradionecrosis of the jaw is a therapy-resistant condition that may occur after treatment for head and neck cancer. The aim of this study was to investigate the incidence of osteoradionecrosis in patients with oropharyngeal cancer in relation to tooth extraction prior to radiation therapy.</p><p><strong>Methods: </strong>Patients who had undergone radiation therapy for oropharyngeal cancer 5-10 years earlier were included and evaluated for the development of osteoradionecrosis (n = 75).</p><p><strong>Results: </strong>Among the 75 patients, 62 had molar teeth present in the >50 Gy radiation field and 36 of those patients had teeth extracted prior to radiation therapy. Extraction of molars before radiotherapy significantly increased the risk of developing osteoradionecrosis (P < 0.05). There were no identifiable statistically significant correlations between the time from tooth extraction and the start of radiation therapy, the number of teeth in the radiation field, smoking habits, human papillomavirus-status, gender, age or tumor location and the development of osteoradionecrosis.</p><p><strong>Conclusion: </strong>Tooth extraction prior to radiation therapy increases the risk of developing osteoradionecrosis. For patients with good oral hygiene and absence of dental disease, avoidance of tooth extraction in the radiation field could therefore reduce the risk of complications.</p>","PeriodicalId":16646,"journal":{"name":"Journal of oral science","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9239468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}