Journal of Pain & Palliative Care Pharmacotherapy最新文献_第6页

Efficacy of Lavender Oil as an Adjunctive Treatment for Patients with Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Trial. 薰衣草油作为骨关节炎患者辅助治疗的疗效：一项随机、双盲、安慰剂对照试验

IF 0.9

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-06-01 Epub Date: 2025-04-07 DOI: 10.1080/15360288.2025.2485202

Mitra Abbasifard, Mehrnaz Aghaabasi, Zahra Kamiab, Mahmood Kahnooji, Gholamreza Bazmandegan, Neda Mohamadi

{"title":"Efficacy of Lavender Oil as an Adjunctive Treatment for Patients with Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Trial.","authors":"Mitra Abbasifard, Mehrnaz Aghaabasi, Zahra Kamiab, Mahmood Kahnooji, Gholamreza Bazmandegan, Neda Mohamadi","doi":"10.1080/15360288.2025.2485202","DOIUrl":"10.1080/15360288.2025.2485202","url":null,"abstract":"Patients with knee osteoarthritis (OA) experience decline in social and physical abilities. Lavender is a promising option. To determine the clinical efficacy of lavender oil in comparison with Piroxicam gel (PG) for the treatment of knee OA. A double-blind trial with 90 patients utilized random blocks to divide them into three groups including the lavender oil group, the PG group, and the control group for treatment comparison. The Visual Analogue Scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) were used to measure aspects of osteoarthritis, particularly physical function, pain, and stiffness. Control group had no change in VAS pain scores. Lavender oil and PG reduced scores after one month, but remained unchanged after two months. The VAS scores of the lavender oil group exhibited a significant reduction from 5.37 ± 0.68 to 3.00 ± 0.64, while PG decreased VAS score from 5.45 ± 0.98 to 3.62 ± 1.26 (p < 0.001). There was no significant difference between the two treatment groups. Altogether, Lavender oil has a similar effect as PG on pain severity and physical function in patients with knee OA. Lavender oil is recommended as an effective natural therapeutic agent and safe complementary treatment for knee OA.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"221-228"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Older Man with Clonus, Rigidity, Hyperreflexia, and Hand Tremors. 一位老年男性伴有阵挛、僵直、反射亢进和手部震颤。

IF 0.9

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-06-01 Epub Date: 2024-12-28 DOI: 10.1080/15360288.2024.2443013

Olga Abel, Yan Press

{"title":"An Older Man with Clonus, Rigidity, Hyperreflexia, and Hand Tremors.","authors":"Olga Abel, Yan Press","doi":"10.1080/15360288.2024.2443013","DOIUrl":"10.1080/15360288.2024.2443013","url":null,"abstract":"Serotonin toxicity (ST) is a preventable, life-threatening condition caused by serotonergic agents. It typically arises from combined drug use that affects serotonin's release and metabolism. While often presenting with mild symptoms that may be overlooked or misdiagnosed, severe toxicity is associated with significant mortality. The older population is particularly at risk due to altered drug pharmacokinetics, a tendency for multiple drug use, and symptom overlap with common neurodegenerative conditions. The case study discusses an older patient with prolonged ST developed with the use of several serotonergic drugs for postherpetic neuralgia. It emphasizes the challenges of polypharmacy in older patients, offering insights into the serotoninergic potential of multiple medicines commonly used in older adults, the pathophysiology, proper diagnosis and differential diagnoses, and management strategies of ST. Accurate diagnosis requires heightened vigilance from healthcare professionals regarding potential drug interactions and familiarity with the specific clinical criteria. Regular revision and adjustment of medications in older patients and preference for the non-pharmacological treatment of chronic pain are essential for preventing ST. This case report is a convenient way for many healthcare professionals to update their knowledge about ST, its diagnosis and management.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"237-243"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful Initiation of Buprenorphine for Chronic Non-Cancer Pain in an Opioid-Experienced Patient: A Case Report. 成功启动丁丙诺啡治疗阿片类药物经验患者的慢性非癌性疼痛：一例报告。

IF 0.9

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-06-01 Epub Date: 2025-02-12 DOI: 10.1080/15360288.2025.2459169

Milagros D Silva, Kyaw Zaw Linn

引用次数: 0

Opioid Allergy Cross-Reactivity: A Retrospective Study Across Three Opioid Classes. 阿片类药物过敏交叉反应：三类阿片类药物的回顾性研究。

IF 0.9

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-06-01 Epub Date: 2025-01-02 DOI: 10.1080/15360288.2024.2448531

Ali Khalaf, Matthew Lane, Jennifer Meyer Reid

{"title":"Opioid Allergy Cross-Reactivity: A Retrospective Study Across Three Opioid Classes.","authors":"Ali Khalaf, Matthew Lane, Jennifer Meyer Reid","doi":"10.1080/15360288.2024.2448531","DOIUrl":"10.1080/15360288.2024.2448531","url":null,"abstract":"IgE-mediated opioid hypersensitivities, or true allergies, are rare and most adverse reactions to opioids can be attributed to side effects or to pseudo-allergies. Given that immune-mediated allergies to opioids are uncommon, literature regarding cross-reactivity among opioid classes are limited. This retrospective study aimed to determine the rates of cross-reactivity and tolerance among patients with previously documented opioid allergy or adverse drug reaction (ADR) across three opioid drug classes (natural, semisynthetic, and synthetic opioids). Patients with documented allergy(s) and/or ADR(s) to opioids were assessed for outcomes of subsequent opioid exposure during any hospital admission at a Veterans Affairs hospital over a 10-year time-period. Veterans were sorted into three cohorts based on the opioid class of the previously documented allergy or ADR. Each cohort had three study arms, one for each class of subsequent opioid exposure. A total of 1507 patients were identified with previously documented allergy or ADR to at least one opioid and at least one subsequent opioid drug exposure. No cross-reactivity among any of the opioid drug classes were found resulting in 100% re-exposure tolerance rates with all study arms. These findings could increase confidence in utilizing opioids in patients with historically documented opioid allergies or ADRs.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"297-303"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Risk Prediction Models to Estimate Opioid-Induced Respiratory Depression, Oversedation, and Overdose in Patients with Cancer. 评估癌症患者阿片类药物引起的呼吸抑制、过度镇静和过量用药风险预测模型的比较

IF 0.9

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-06-01 Epub Date: 2025-03-20 DOI: 10.1080/15360288.2025.2481186

Norint P Tung, Parker K Kaleo, Eric J Roeland, Joseph D Ma

{"title":"Comparison of Risk Prediction Models to Estimate Opioid-Induced Respiratory Depression, Oversedation, and Overdose in Patients with Cancer.","authors":"Norint P Tung, Parker K Kaleo, Eric J Roeland, Joseph D Ma","doi":"10.1080/15360288.2025.2481186","DOIUrl":"10.1080/15360288.2025.2481186","url":null,"abstract":"Numerous opioid-induced respiratory depression (OIRD), oversedation, and overdose prediction models exist to quantify a probability or estimate risk severity for a future event. The primary aim was to determine OIRD, oversedation, and overdose risk severity (i.e., low, moderate, and high) and agreement of risk severity between three previously published prediction models. This single-center, retrospective analysis evaluated 134 patients with cancer. Sixty-five (49%) patients were Caucasian. Forty-three (32%) patients were diagnosed with gastrointestinal cancer. Predictive factors from prediction models were concurrent sedating medication (n = 119, 89%), female sex (n = 85, 63%), a mental health diagnosis (n = 68, 51%), and antidepressant use (n = 55, 41%). For most patients, risk severity varied between moderate to high risk. Risk class severity was significantly different between prediction models (p ≤ 0.05). Frequencies of risk severity agreement between all three prediction models, between two prediction models, and no agreement was 16% (n = 22), 69% (n = 93), and 14% (n = 19), respectively. Additional research is needed to evaluate model calibration to increase OIRD, oversedation, and overdose prediction model validity and generalizability for future clinical implementation.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"202-210"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peripheral Edema as an Adverse Drug Reaction to Mirtazapine in an Oral Cavity Cancer Patient Receiving Palliative Care at Tertiary Care Centre: A Case Report. 外周水肿是在三级医疗中心接受姑息治疗的口腔癌患者米氮平的不良反应：一个病例报告。

IF 0.9

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-06-01 Epub Date: 2025-01-02 DOI: 10.1080/15360288.2024.2447820

Surendra Kumar Pingoliya, Yogendra Singhal

{"title":"Peripheral Edema as an Adverse Drug Reaction to Mirtazapine in an Oral Cavity Cancer Patient Receiving Palliative Care at Tertiary Care Centre: A Case Report.","authors":"Surendra Kumar Pingoliya, Yogendra Singhal","doi":"10.1080/15360288.2024.2447820","DOIUrl":"10.1080/15360288.2024.2447820","url":null,"abstract":"Mirtazapine is a selective serotonergic antidepressant that functions by blocking adrenergic alpha2-autoreceptors and heteroreceptors and inhibiting 5-HT2 and 5-HT3 receptors. It is a noradrenergic drug. Mirtazapine has anxiolytic or sleep-quality-improving effects, aggravates appetite-stimulation, and has stomach emptying functions. When treating poly-symptoms such as appetite loss, anxiety, depression, nausea, and sleeplessness off-label, mirtazapine is being used more and more. A not so common side effect of mirtazapine medication is peripheral edema. The ensuing case study will demonstrate how peripheral edema is an uncommon mirtazapine adverse effect. Peripheral edema was observed in a patient with advanced oral cavity cancer three days after starting a daily dose of 15 mg of mirtazapine for polysymptomatology. The peripheral edema completely resolved after stopping mirtazapine. To the best of our knowledge, this is the first instance of a patient with advanced oral cavity cancer experiencing peripheral edema as a result of receiving mirtazapine medication. Our study will assist medical professionals in identifying the potential use of mirtazapine in situations where peripheral edema develops quickly, facilitating its quick clearance.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"323-325"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Gravedigger. 掘墓人。

IF 0.9

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-06-01 Epub Date: 2025-02-24 DOI: 10.1080/15360288.2025.2470436

João Guilherme Bochnia Küster

引用次数: 0

Retrospective Observational Descriptive Study on Use and Rotations to Belbuca^®. 使用和旋转Belbuca®的回顾性观察性描述性研究。

IF 0.9

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-06-01 Epub Date: 2025-02-12 DOI: 10.1080/15360288.2025.2462602

Mia Barbieri, Neil K Shah, Julia Iskra, Nicholas Field, Stephen Gruver

{"title":"Retrospective Observational Descriptive Study on Use and Rotations to Belbuca®.","authors":"Mia Barbieri, Neil K Shah, Julia Iskra, Nicholas Field, Stephen Gruver","doi":"10.1080/15360288.2025.2462602","DOIUrl":"10.1080/15360288.2025.2462602","url":null,"abstract":"The purpose of this study was to better characterize morphine equivalent daily dose (MEDD) equivalencies with buccal buprenorphine, and identify real-world efficacy and safety outcomes associated with the use of buccal buprenorphine for chronic pain at a local VA Medical Center. This study was a retrospective chart review of Computerized Patient Record System (CPRS) patient records with outpatient prescriptions for buccal buprenorphine (Belbuca®). Overall, there was a high discontinuation rate of Belbuca®: being 60% or greater across all different patient groups. These high attrition rates may potentially be result of failure to titrate to an optimal dose of Belbuca® needed for adequate analgesia. Those fully rotated fared marginally better than those partially rotated in that those fully rotated discontinued at a lesser rate and less quickly than those who were partially rotated. From the results of this study, a local dosing scheme for Belbuca® based on baseline MEDD was created for facility level guidance. The exact MEDD conversion ratio, however, for individual buprenorphine products as well as MEDD contributed by these products on a patient's overall opioid related risk compared to other full agonist opioids still remains unclear and further studies are warranted.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"304-318"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Systematic Review and Meta-Analysis of The Efficacy of Endoscopic Ultrasound Guided Celiac Plexus Blocks for Chronic Pancreatitis Pain. 超声内镜引导下腹腔神经丛阻滞治疗慢性胰腺炎疼痛疗效的系统评价和meta分析。

IF 1

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-06-01 Epub Date: 2025-04-01 DOI: 10.1080/15360288.2025.2479481

Luke Kar Man Chan, Tanish Rao, Paolo Masangcay, Samuel Chia Lin Kuo, Tai-Tak Wan

{"title":"A Systematic Review and Meta-Analysis of The Efficacy of Endoscopic Ultrasound Guided Celiac Plexus Blocks for Chronic Pancreatitis Pain.","authors":"Luke Kar Man Chan, Tanish Rao, Paolo Masangcay, Samuel Chia Lin Kuo, Tai-Tak Wan","doi":"10.1080/15360288.2025.2479481","DOIUrl":"10.1080/15360288.2025.2479481","url":null,"abstract":"Chronic pancreatitis is a globally prevalent progressive disease, with pain affecting up to 90% of patients, significantly impairing quality of life and leading to high rates of disability, hospitalizations, and opioid dependence. Pain management is crucial in treating chronic pancreatitis, with endoscopic ultrasound-guided celiac plexus block (EUS-CPB) recognized as an interventional option. This systematic review and meta-analysis, following PRISMA guidelines, synthesized data from 12 studies (5 randomized control trials and 7 observational) on the efficacy of EUS-CPB in managing chronic pancreatitis pain. The overall analysis revealed a significant pain relief proportion of 0.64 (n=612) with moderate heterogeneity. Subgroup analyses revealed a proportion of 0.72 in RCTs and 0.59 in observational studies. Common complications included diarrhea and exacerbation of abdominal pain, with no reported mortality. Despite variations in efficacy due to study heterogeneity and patient differences, the findings suggest EUS-CPB as a safe and effective option, with effects lasting weeks to months. Recent studies have demonstrated the applicability of EUS-CPB across ethnically diverse and pediatric populations. However, limitations including small sample sizes and study variability highlight the need for personalized treatment approaches. Future larger randomized sham-controlled trials are recommended to better assess the duration of pain relief and impact on opioid use.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"254-265"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Prophylactic Dual Histamine Blockade on Filgrastim-Induced Bone Pain in Female Cancer Patients: Single Institutional Analysis. 预防性双组胺阻断对非格昔汀引起的女性癌症患者骨痛的影响：单一机构分析。

IF 0.9

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2025-06-01 Epub Date: 2025-03-27 DOI: 10.1080/15360288.2025.2482884

Noor Ul Ain Azam, Fauzia Abdus Samad, Abdus Samad Syed, Asif Riaz Khan, Aalia Mushtaq, Faraz Saif

{"title":"Effect of Prophylactic Dual Histamine Blockade on Filgrastim-Induced Bone Pain in Female Cancer Patients: Single Institutional Analysis.","authors":"Noor Ul Ain Azam, Fauzia Abdus Samad, Abdus Samad Syed, Asif Riaz Khan, Aalia Mushtaq, Faraz Saif","doi":"10.1080/15360288.2025.2482884","DOIUrl":"10.1080/15360288.2025.2482884","url":null,"abstract":"Bone pain is the commonest side-effect faced by cancer patients receiving granulocyte colony stimulating factor (G-CSF) therapy for the primary or secondary prevention of febrile neutropenia. We conducted a prospective quasi-experimental study at our setup to see the efficacy of dual histamine blockade (combined H1 and H2 receptor blockers) for preventing G-CSF-induced bone pain. Adult female patients with solid tumors who had received filgrastim for the primary prophylaxis of febrile neutropenia and met our inclusion criteria, were enrolled (n = 119). This population was analyzed for the development of significant bone pain 24 h after the administration of Filgrastim. Significant bone pain in our study was defined as emergence of new onset pain measuring ≥4 on 11-point Numerical rating scale (NRS) or at least ≥ 2-point increase in score when compared to the baseline pain (if any). Those patients who experienced significant bone pain (n = 47) were given Loratadine 10 mg and Famotidine 20 mg orally half an hour before the next filgrastim administration. Pain assessment was done 24 h after Filgrastim administration, using NRS and data was analyzed. The mean NRS score in our patients after administration of filgrastim was 6.87 ± 1.055. Most of these patients (n = 34 i.e 72%) experienced relief in bone pain after dual histamine blockade use. The mean NRS score following the use of dual antihistamines was 4.36 ± 1.870. The NRS score improved by a mean of 2.51 after using dual histamine blockade, which was statistically significant (p-value= 0.0005). We propose that dualhistamine blockade may prove to be an effective option for prophylaxis of G-CSF-induced-bone-pain. Randomized control trials on larger and more diverse patient populations are required to reinforce the findings.","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"211-220"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143720056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0