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Journal of Pain & Palliative Care Pharmacotherapy最新文献

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Cannabis-Based Medicines for Nociplastic Pain: A Scoping Review of Efficacy, Safety, and Patient Outcomes. 以大麻为基础的药物治疗伤害性疼痛：疗效、安全性和患者预后的范围综述。
IF 1.3
Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2026-07-22 DOI: 10.1080/15360288.2026.2704788
Hugo Miguel-Seno, Paulo Reis-Pina
{"title":"Cannabis-Based Medicines for Nociplastic Pain: A Scoping Review of Efficacy, Safety, and Patient Outcomes.","authors":"Hugo Miguel-Seno, Paulo Reis-Pina","doi":"10.1080/15360288.2026.2704788","DOIUrl":"https://doi.org/10.1080/15360288.2026.2704788","url":null,"abstract":"<p><p>Cannabis-based medicines (CBM) are increasingly considered for nociplastic pain (NOCP) despite limited evidence. This scoping review mapped evidence on efficacy, safety, patient-reported outcomes, and pharmacokinetic/pharmacodynamic (PK/PD) considerations for CBM in NOCP. MEDLINE, Cochrane Library, Web of Science, and Scopus were searched through 2024. Eligibility included patients with NOCP or a nociplastic phenotype, any setting, any study design, and English language. Data were charted inductively, synthesized narratively, and risk of bias was assessed. Ten studies were included, predominantly secondary (reviews/opinions, consensus), with very limited primary data linking CBM to nociplastic mechanisms. Signals suggest modest benefits in fibromyalgia and chronic musculoskeletal pain, with improvements more evident for sleep, affective domains, and quality-of-life than for direct analgesia. Adverse effects were common (e.g., sedation, dizziness, psychiatric symptoms), particularly with tetrahydrocannabinol-dominant products. PK findings included low/variable oral bioavailability (∼6%), food and hepatic effects (notably for cannabidiol), and prolonged terminal half-life; PD effects included psychomotor and cognitive impairment. No study applied standardized nociplastic instruments. Co-administration cautions with opioids were noted, but no phenotype-specific opioid-sparing evidence was identified. Overall, evidence remains low-certainty and indirect, supporting adequately powered, longer-term trials with explicit NOCP phenotyping and standardized formulations. CBM show outcome-specific benefits balanced against dose- and formulation-dependent harms.</p>","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-27"},"PeriodicalIF":1.3,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148549486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrating Mixed Pain into Contemporary Approaches to Chronic Pain Management. 将混合性疼痛纳入当代慢性疼痛管理方法。
IF 1.3
Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2026-07-20 DOI: 10.1080/15360288.2026.2705425
Antonio Alcántara Montero, Rainer Freynhagen
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引用次数: 0
Morphine at 2 a.m.: Notes from a Room Where Pain Does Not Sleep. 吗啡在凌晨2点：从一个痛苦不眠的房间的笔记。
IF 1.3
Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2026-07-18 DOI: 10.1080/15360288.2026.2704782
Muhammad Rio Fariza
{"title":"Morphine at 2 a.m.: Notes from a Room Where Pain Does Not Sleep.","authors":"Muhammad Rio Fariza","doi":"10.1080/15360288.2026.2704782","DOIUrl":"https://doi.org/10.1080/15360288.2026.2704782","url":null,"abstract":"","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-3"},"PeriodicalIF":1.3,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148497464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
One Month Has Passed. 一个月过去了。
IF 1.3
Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2026-07-17 DOI: 10.1080/15360288.2026.2704797
Tarek Zieneldien
{"title":"One Month Has Passed.","authors":"Tarek Zieneldien","doi":"10.1080/15360288.2026.2704797","DOIUrl":"https://doi.org/10.1080/15360288.2026.2704797","url":null,"abstract":"","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-2"},"PeriodicalIF":1.3,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148471285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
When Medicine Waits Beside the Bed. 当药物在床边等待。
IF 1.3
Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2026-07-16 DOI: 10.1080/15360288.2026.2705431
Raditya Pratama Putra, Yulianti, Pramana
{"title":"When Medicine Waits Beside the Bed.","authors":"Raditya Pratama Putra, Yulianti, Pramana","doi":"10.1080/15360288.2026.2705431","DOIUrl":"https://doi.org/10.1080/15360288.2026.2705431","url":null,"abstract":"","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-2"},"PeriodicalIF":1.3,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148471412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comfort Measures. 舒适的措施。
IF 1.3
Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2026-07-16 DOI: 10.1080/15360288.2026.2704783
Rio Febriannur Rachman
{"title":"Comfort Measures.","authors":"Rio Febriannur Rachman","doi":"10.1080/15360288.2026.2704783","DOIUrl":"https://doi.org/10.1080/15360288.2026.2704783","url":null,"abstract":"","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-3"},"PeriodicalIF":1.3,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148456163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Suzetrigine and Craniofacial Pain: Between Physiological Plausibility and Emerging Evidence. 舒三嗪与颅面疼痛：生理合理性与新证据之间的关系。
IF 1.3
Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2026-07-16 DOI: 10.1080/15360288.2026.2704789
A Alcántara Montero
{"title":"Suzetrigine and Craniofacial Pain: Between Physiological Plausibility and Emerging Evidence.","authors":"A Alcántara Montero","doi":"10.1080/15360288.2026.2704789","DOIUrl":"https://doi.org/10.1080/15360288.2026.2704789","url":null,"abstract":"","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-3"},"PeriodicalIF":1.3,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148471391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond the blood. 除了血。
IF 1.3
Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2026-07-16 DOI: 10.1080/15360288.2026.2705432
Aprillia Rhamadhany, Mukhamad Zulianto
{"title":"Beyond the blood.","authors":"Aprillia Rhamadhany, Mukhamad Zulianto","doi":"10.1080/15360288.2026.2705432","DOIUrl":"https://doi.org/10.1080/15360288.2026.2705432","url":null,"abstract":"","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-2"},"PeriodicalIF":1.3,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148471289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Uninvited Guest. 不速之客。
IF 1.3
Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2026-07-16 DOI: 10.1080/15360288.2026.2705426
Mukhamad Zulianto
{"title":"The Uninvited Guest.","authors":"Mukhamad Zulianto","doi":"10.1080/15360288.2026.2705426","DOIUrl":"https://doi.org/10.1080/15360288.2026.2705426","url":null,"abstract":"","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-2"},"PeriodicalIF":1.3,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148456148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Where Invisible Pain Finds a Shape, a Voice, and a Witness. 在那里，看不见的痛苦找到了形状、声音和见证。
IF 1.3
Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2026-07-16 DOI: 10.1080/15360288.2026.2704803
Anam Miftakhul Huda, Pramana, Vinda Maya Setianingrum, Puspita Sari Sukardani
{"title":"Where Invisible Pain Finds a Shape, a Voice, and a Witness.","authors":"Anam Miftakhul Huda, Pramana, Vinda Maya Setianingrum, Puspita Sari Sukardani","doi":"10.1080/15360288.2026.2704803","DOIUrl":"https://doi.org/10.1080/15360288.2026.2704803","url":null,"abstract":"","PeriodicalId":16645,"journal":{"name":"Journal of Pain & Palliative Care Pharmacotherapy","volume":" ","pages":"1-2"},"PeriodicalIF":1.3,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148471348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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