Retrospective Observational Descriptive Study on Use and Rotations to Belbuca®.

IF 1 Q3 ANESTHESIOLOGY
Mia Barbieri, Neil K Shah, Julia Iskra, Nicholas Field, Stephen Gruver
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引用次数: 0

Abstract

The purpose of this study was to better characterize morphine equivalent daily dose (MEDD) equivalencies with buccal buprenorphine, and identify real-world efficacy and safety outcomes associated with the use of buccal buprenorphine for chronic pain at a local VA Medical Center. This study was a retrospective chart review of Computerized Patient Record System (CPRS) patient records with outpatient prescriptions for buccal buprenorphine (Belbuca®). Overall, there was a high discontinuation rate of Belbuca®: being 60% or greater across all different patient groups. These high attrition rates may potentially be result of failure to titrate to an optimal dose of Belbuca® needed for adequate analgesia. Those fully rotated fared marginally better than those partially rotated in that those fully rotated discontinued at a lesser rate and less quickly than those who were partially rotated. From the results of this study, a local dosing scheme for Belbuca® based on baseline MEDD was created for facility level guidance. The exact MEDD conversion ratio, however, for individual buprenorphine products as well as MEDD contributed by these products on a patient's overall opioid related risk compared to other full agonist opioids still remains unclear and further studies are warranted.

使用和旋转Belbuca®的回顾性观察性描述性研究。
本研究的目的是更好地表征吗啡当量日剂量(MEDD)与口腔丁丙诺啡的等效性,并确定在当地VA医疗中心使用口腔丁丙诺啡治疗慢性疼痛的实际疗效和安全性结果。本研究是对计算机患者记录系统(CPRS)门诊处方颊用丁丙诺啡(Belbuca®)的患者记录进行回顾性图表回顾。总的来说,Belbuca®的停药率很高:在所有不同的患者组中为60%或更高。这些高损耗率可能是由于未能滴定到充分镇痛所需的最佳剂量Belbuca®。完全旋转的患者比部分旋转的患者表现稍好,因为完全旋转的患者比部分旋转的患者停药的速度和速度要慢。根据本研究的结果,建立了基于基线MEDD的Belbuca®局部给药方案,用于设施级指导。然而,与其他完全激动剂阿片类药物相比,丁丙诺啡单个产品的确切MEDD转化率以及这些产品对患者整体阿片类药物相关风险的MEDD贡献仍不清楚,需要进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.60
自引率
9.10%
发文量
40
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