Journal of Obesity最新文献

{"title":"Development and Cross-Validation of Anthropometric Predictive Equations to Estimate Total Body Fat Percentage in Adult Women in Sri Lanka.","authors":"Nirmala Rathnayake, Gayani Alwis, Janaka Lenora, Sarath Lekamwasam","doi":"10.1155/2020/2087346","DOIUrl":"10.1155/2020/2087346","url":null,"abstract":"<p><p>Attempts have been made to estimate body fat using anthropometry, and most of them are country-specific. This study was designed to develop and cross-validate anthropometric predictive equations to estimate the total body fat percentage (TBFP) of Sri Lankan adult women. A cross-sectional study was conducted in Galle, Sri Lanka, with two groups: Group A (group for equation development) and Group B (cross-validation group) (<i>n</i> = 175 each) of randomly selected healthy adult women aged 30-60 years. TBFP (%) was quantified with total body DXA (TBFP_DXA). Height (m), weight (kg), and skinfold thickness (SFT, mm) at six sites and circumferences (cm) at five sites were measured. In the first step, four anthropometric equations were developed based on the data obtained from multiple regression analyses (TBFP_DXA = dependent variable and anthropometric measurements and age = independent variables) with Group A. They were developed on the basis of circumferences (TBFP1), SFTs (TBFP2), circumferences and SFTs (TBFP3), and highly significant circumferences and SFTs (<i>r</i> ≥ 0.6) (TBFP4). In the second step, the newly developed equations were cross-validated using Group B. Three equations (TBFP1, TBFP2, and TBFP4) showed the agreement with cross-validation criteria. There were no differences between TBFP_DXA and TBFP estimated by these equations (<i>p</i> > 0.05). They showed higher measurement concordance with TBFP_DXA; correlation between measured TBFP with DXA and estimated with TBFP1, TBFP2, and TBFP4, respectively, was 0.80 (<i>R</i> ² = 0.65, SEE = 3.10), 0.83 (<i>R</i> ² = 0.69, SEE = 2.93), and 0.84 (<i>R</i> ² = 0.72, SEE = 2.78). Three anthropometric measurements based on predictive equations were developed and cross-validated to satisfactorily estimate the TBFP in adult women.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":"2020 ","pages":"2087346"},"PeriodicalIF":3.8,"publicationDate":"2020-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38212563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperglycaemia in Pregnancy and Anthropometric Parameters in the Offspring at 10 Years: A Community-Based Retrospective Cohort Study in Sri Lanka.","authors":"Himali P Herath,&nbsp;Rasika P Herath,&nbsp;Rajitha Wickremasinghe","doi":"10.1155/2020/2735148","DOIUrl":"https://doi.org/10.1155/2020/2735148","url":null,"abstract":"<p><strong>Background: </strong>Studies of developmental origins of health and disease have highlighted the possible role of intrauterine hyperglycaemia, increasing the future risk of obesity, diabetes, and cardiovascular diseases in the offspring. There is limited evidence from South Asian populations for risk estimates for childhood obesity that are attributable to maternal diabetes in utero.</p><p><strong>Objective: </strong>The aim of this study was to determine the association between hyperglycaemia in pregnancy (HIP) and anthropometric parameters in the offspring at 10-11 years of age.</p><p><strong>Methods: </strong>A community-based retrospective cohort study was conducted in Colombo district, Sri Lanka. In the first stage, children born in 2005 were identified, and the availability of antenatal records was assessed. In the second stage, the exposure status of participants was ascertained based on antenatal records and predefined criteria. In the third stage, height, weight, waist circumference, and triceps skinfold thickness (TSFT) of eligible participants were measured to ascertain the outcome status. Background characteristics were collected by interviewing mothers. A 24-hour dietary recall and a 3-day diet diary were recorded.</p><p><strong>Results: </strong>159 children of mothers with HIP (exposed) and 253 children of mothers with no HIP (nonexposed) participated. Mean ages (SD) of exposed and unexposed groups were 10.9 (0.3) and 10.8 (0.3) years, respectively. The median BMI (17.6 vs 16.1, <i>p</i> < 0.001), waist circumference (63 cm vs 59.3 cm, <i>p</i> < 0.001), and triceps skinfold thickness (13.7 mm vs 11.2 mm, <i>p</i> < 0.001) were significantly higher in the exposed group. Offspring of women with HIP were more likely to be overweight (aOR = 2.6, 95% CI 1.4-4.9) and have abdominal obesity (aOR = 2.7, 95% CI 1.1-6.5) and high TSFT (aOR = 2.2, 95% CI 1.06-4.7) at 10-11 years than children who were not exposed after adjusting for maternal BMI, maternal age at delivery, and birth order.</p><p><strong>Conclusions: </strong>Intrauterine exposure to HIP is a significant determinant of overweight, high TSFT, and abdominal obesity in the offspring.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":"2020 ","pages":"2735148"},"PeriodicalIF":3.3,"publicationDate":"2020-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/2735148","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38157512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing a Socioculturally Nuanced Systems Model of Childhood Obesity in Manhattan's Chinese American Community via Group Model Building.","authors":"Ewelina Swierad,&nbsp;Terry T-K Huang,&nbsp;Ellis Ballard,&nbsp;Karen Flórez,&nbsp;Sheng Li","doi":"10.1155/2020/4819143","DOIUrl":"https://doi.org/10.1155/2020/4819143","url":null,"abstract":"<p><p>The purpose of this study was to develop a qualitative and socioculturally tailored systems model of childhood obesity in the Chinese American community in Manhattan's Chinatown. We utilized group model building (GMB) methodology as a form of participatory systems modeling. The study was conducted in Manhattan's Chinatown community. We recruited 16 Chinese American adults from the community. GMB workshops engendered a causal loop diagram (CLD), the visualization of a complex systems model illustrating the structures, feedbacks, and interdependencies among socioculturally specific pathways underlying childhood obesity, in Manhattan's Chinatown community. The analysis of CLD revealed that participants considered the following factors to influence childhood obesity: (1) traditional social norms affecting body image, how children are raised, parental pressure to study, and trust in health of traditional foods; (2) grandparents' responsibility for children; (3) limited time availability of parents at home; and (4) a significant amount of children's time spent indoors. GMB represents a novel method to understand the complexity of childhood obesity in culturally specific populations and contexts. The study identified sociocultural subsystems that may underlie the development and perpetuation of childhood obesity among Chinese American children. Insights from the study can be useful in the design of future empirical studies and interventions.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":"2020 ","pages":"4819143"},"PeriodicalIF":3.3,"publicationDate":"2020-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/4819143","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25402850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Explaining the Inverse Association between Altitude and Obesity.","authors":"Ray M Merrill","doi":"10.1155/2020/1946723","DOIUrl":"https://doi.org/10.1155/2020/1946723","url":null,"abstract":"<p><strong>Purpose: </strong>To better understand the inverse association between altitude and adult obesity.</p><p><strong>Methods: </strong>An ecological study design was used, involving 3,108 counties in the contiguous United States. Data were from several national sources, and assessment involved various statistical techniques, including multiple regression analysis.</p><p><strong>Results: </strong>Living in counties at higher altitude is associated with lower adult obesity. Compared with counties <500 meters, the percent of adult obesity decreases by 5.18% at 500-999 meters, 9.69% at 1,000-1,499 meters, 16.77% at 1,500-1,999 meters, 24.14% at 2,000-2,499 meters, and 35.28% at ≥2,500 meters. After adjusting for physical inactivity, smoking, and other variables, corresponding decreases in adult obesity with higher altitude groupings are 3.87%, 5.64%, 8.03%, 11.41%, and 17.54%, respectively. Various mechanisms are presented as possible explanations for the association between higher altitude and lower obesity. In addition, altitude may indirectly influence adult obesity, primarily through its relationship with physical inactivity and smoking. In an adjusted regression model, adult obesity was most strongly associated with physical inactivity followed by adult smoking and then altitude. Together they explain 39.04% of the variation in adult obesity. After accounting for these variables, sunlight, precipitation, ambient air temperature, education, income, food insecurity, limited access to healthy foods, race, sex, and rural living explain an additional 4.68% of the variation in adult obesity.</p><p><strong>Conclusions: </strong>The inverse association between altitude and adult obesity remains significant after adjustment for several variables.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":"2020 ","pages":"1946723"},"PeriodicalIF":3.3,"publicationDate":"2020-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/1946723","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38072547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology, Predisposing Factors, Biomarkers, and Prevention Mechanism of Obesity: A Systematic Review.","authors":"Melese Linger Endalifer, Gedefaw Diress","doi":"10.1155/2020/6134362","DOIUrl":"10.1155/2020/6134362","url":null,"abstract":"<p><p><i>Background</i>. Globally, obesity is becoming a public health problem in the general population. Various determinants were reported by different scholars even though there are inconsistencies. Different biomarkers of obesity were identified for the prediction of obesity. Even though researchers speculate the factors, biomarkers, consequences, and prevention mechanisms, there is a lack of aggregate and purified data in the area of obesity. <i>Summary</i>. In this review, the epidemiology, predisposing factors, biomarkers, consequences, and prevention approaches of obesity were reviewed. <i>Key Messages</i>. The epidemiology of obesity increased in low-, middle-, and high-income countries. Even if the factors vary across regions and socioeconomic levels, sociodemographic, behavioral, and genetic factors were prominent for the development of obesity. There are a lot of biomarkers for obesity, of which microRNA, adipocytes, oxidative stress, blood cell profile, nutrients, and microbiota were promising biomarkers for determination of occurrence of obesity. Since the consequences of obesity are vast and interrelated, multidimensional prevention strategy is mandatory in all nations.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":"2020 ","pages":"6134362"},"PeriodicalIF":3.3,"publicationDate":"2020-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38072548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Banded Sleeve Gastrectomy Improves Weight Loss Compared to Nonbanded Sleeve: Midterm Results from a Prospective Randomized Study.","authors":"Paolo Gentileschi,&nbsp;Emanuela Bianciardi,&nbsp;Leandro Siragusa,&nbsp;Valeria Tognoni,&nbsp;Domenico Benavoli,&nbsp;Stefano D'Ugo","doi":"10.1155/2020/9792518","DOIUrl":"https://doi.org/10.1155/2020/9792518","url":null,"abstract":"<p><strong>Background: </strong>Weight regain after laparoscopic sleeve gastrectomy (LSG) is nowadays a growing concern. Sleeve dilatation and loss of food restriction is considered the main mechanism. The placement of a silicon ring around the gastric tube seems to give benefits in the short term. We report the results of a randomized study comparing LSG and laparoscopic banded sleeve gastrectomy (LBSG) over a 4-year follow-up.</p><p><strong>Objectives: </strong>To evaluate the efficacy of banded sleeve gastrectomy compared to standard sleeve in the midterm.</p><p><strong>Methods: </strong>Between 01/2014 and 01/2015, we randomly assigned 50 patients to receive one of the two procedures. Patients' management was exactly the same, apart from the band placement. We analyzed differences in weight loss, operative time, complication rate, and mortality, with a median follow-up of 4 years.</p><p><strong>Results: </strong>Twenty five patients were assigned to receive LSG (Group A) and 25 LBSG (Group B). The mean preoperative BMI (body mass index) was 47.3 ± 6.58 kg/m² and 45.95 ± 5.85 kg/m², respectively. There was no significant difference in the operative time. No intraoperative or postoperative complications occurred. At 12-month follow-up, the mean BMI was 29.72 ± 4.40 kg/m² in Group A and 27.42 ± 4.47 kg/m² in Group B (<i>p</i>=0.186). After a median follow-up of 4 years, the mean BMI in Group B was significantly lower than Group A (24.10 ± 4.52 kg/m² vs 28.80 ± 4.62 kg/m²; <i>p</i>=0.00199).</p><p><strong>Conclusions: </strong>LBSG is a safe procedure, with no impact on postoperative complications. The banded sleeve showed a significant greater weight loss in the midterm follow-up. Considering the issue of weight regain observed after LSG, the placement of a perigastric ring during the first procedure may be a strategy to improve the results. This trial is registered with NCT04228185.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":"2020 ","pages":"9792518"},"PeriodicalIF":3.3,"publicationDate":"2020-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/9792518","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38073016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of One-Year Change in How Youth Perceive Their Weight.","authors":"Karen A Patte,&nbsp;Wei Qian,&nbsp;Scott T Leatherdale","doi":"10.1155/2020/7396948","DOIUrl":"https://doi.org/10.1155/2020/7396948","url":null,"abstract":"<p><p>Overall, perceptions of being at \"about the right weight\" appear advantageous for youth physical and mental health, regardless of BMI classification, whereas perceptions at either extreme (overweight or underweight) may negatively impact health behaviours and mental health. Instead of considering weight misperceptions as problematic, some researchers have proposed that underestimations of weight status may offer resiliency among individuals with overweight or obesity. Promoting \"about right\" WPs and preventing change to overweight or underweight perceptions may offer an effective public health strategy for supporting youth health over time. However, limited prospective evidence exists on factors that shape perceptions of weight status over time. The current study examined modifiable predictors of one-year change in weight perception among youths. We used 2-year linked data of 18,112 grade 9-12 students from Year 3 (Y₃:2014-2015) and Year 4 (Y₄:2015-2016) of the COMPASS study. Generalized Estimating Equation models tested screen use, physical activity, and bullying victimization as predictors of change from perceptions of \"about the right weight\" to \"overweight\" or \"underweight\" perceptions, adjusting for Y₃ covariates (body mass index, ethnicity, and grade) and school cluster. Results support the value of team sports among females and resistance exercise among males as protective against changes to overweight or underweight perceptions over one year. Also, various forms of bullying victimization predicted overweight perceptions in males and females. Watching TV/movies or messaging/texting for over 2 hours/day was associated with overweight and underweight perceptions, respectively, in females only. Playing video/computer games for over 2 hours/day was associated with overweight perceptions in males and underweight perceptions in females. Findings support the potential of bullying prevention, limiting certain screen use, and supporting engagement in team sports for females and resistance exercise for males as strategies to maintain perceptions of being at \"about the right weight.\"</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":"2020 ","pages":"7396948"},"PeriodicalIF":3.3,"publicationDate":"2020-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/7396948","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38072549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weight Change and Its Association with Cardiometabolic Risk Markers in Overweight and Obese Women.","authors":"Liyana Ahmad Zamri,&nbsp;Geeta Appannah,&nbsp;Siti Yazmin Zahari Sham,&nbsp;Fazliana Mansor,&nbsp;Rashidah Ambak,&nbsp;Noor Safiza Mohd Nor,&nbsp;Tahir Aris","doi":"10.1155/2020/3198326","DOIUrl":"https://doi.org/10.1155/2020/3198326","url":null,"abstract":"<p><strong>Objectives: </strong>To examine the association of weight loss magnitude with changes in cardiometabolic risk markers in overweight and obese women from low socioeconomic areas engaged in a lifestyle intervention.</p><p><strong>Methods: </strong>Analyses were performed on 243 women (mean body mass index 31.27 ± 4.14 kg/m²) who completed a 12-month lifestyle intervention in low socioeconomic communities in Klang Valley, Malaysia. Analysis of covariance (ANCOVA) was used to compare changes of cardiometabolic risk factors across weight change categories (2% gain, ±2% maintain, >2 to <5% loss, and 5 to 20% loss) within intervention and control group.</p><p><strong>Results: </strong>A graded association for changes in waist circumference, fasting insulin, and total cholesterol (<i>p</i>=0.002, for all variables) across the weight change categories were observed within the intervention group at six months postintervention. Participants who lost 5 to 20% of weight had the greatest improvements in those risk markers (-5.67 cm CI: -7.98 to -3.36, -4.27 <i>μ</i>U/mL CI: -7.35, -1.19, and -0.59 mmol/L CI: -.99, -0.19, respectively) compared to those who did not. Those who lost >2% to <5% weight reduced more waist circumference (-4.24 cm CI: -5.44 to -3.04) and fasting insulin (-0.36 <i>μ</i>U/mL CI: -1.95 to 1.24) than those who maintained or gained weight. No significant association was detected in changes of risk markers across the weight change categories within the control group except for waist circumference and adiponectin.</p><p><strong>Conclusion: </strong>Weight loss of >2 to <5% obtained through lifestyle intervention may represent a reasonable initial weight loss target for women in the low socioeconomic community as it led to improvements in selected risk markers, particularly of diabetes risk.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":"2020 ","pages":"3198326"},"PeriodicalIF":3.3,"publicationDate":"2020-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/3198326","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37927656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomic Links between Sugar-Sweetened Beverage Intake and Obesity.","authors":"Bingjie Zhou,&nbsp;Reiko Ichikawa,&nbsp;Laurence D Parnell,&nbsp;Sabrina E Noel,&nbsp;Xiyuan Zhang,&nbsp;Shilpa N Bhupathiraju,&nbsp;Caren E Smith,&nbsp;Katherine L Tucker,&nbsp;Jose M Ordovas,&nbsp;Chao-Qiang Lai","doi":"10.1155/2020/7154738","DOIUrl":"https://doi.org/10.1155/2020/7154738","url":null,"abstract":"<p><strong>Background: </strong>Sugar-sweetened beverage (SSB) consumption is highly associated with obesity, but the metabolic mechanism underlying this correlation is not understood.</p><p><strong>Objective: </strong>Our objective was to examine metabolomic links between SSB intake and obesity to understand metabolic mechanisms.</p><p><strong>Design: </strong>We examined the association of plasma metabolomic profiles with SSB intake and obesity risk in 781 participants, aged 45-75 y, in the Boston Puerto Rican Health Study (BPRHS) using generalized linear models, controlling for potential confounding factors. Based on identified metabolites, we conducted pathway enrichment analysis to identify potential metabolic pathways that link SSB intake and obesity risk. Variants in genes encoding enzymes known to function in identified metabolic pathways were examined for their interactions with SSB intake on obesity.</p><p><strong>Results: </strong>SSB intake was correlated with BMI (<i>β</i> = 0.607, <i>P</i>=0.045). Among 526 measured metabolites, 86 showed a significant correlation with SSB intake and 148 with BMI (<i>P</i> ≤ 0.05); 28 were correlated with both SSB intake and BMI (<i>P</i> ≤ 0.05). Pathway enrichment analysis identified the phosphatidylcholine and lysophospholipid pathways as linking SSB intake to obesity, after correction for multiple testing. Furthermore, 8 of 10 genes functioning in these two pathways showed strong interaction with SSB intake on BMI. Our results further identified participants who may exhibit an increased risk of obesity when consuming SSB.</p><p><strong>Conclusions: </strong>We identified two key metabolic pathways that link SSB intake to obesity, revealing the potential of phosphatidylcholine and lysophospholipid to modulate how SSB intake can increase obesity risk. The interaction between genetic variants related to these pathways and SSB intake on obesity further supports the mechanism.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":"2020 ","pages":"7154738"},"PeriodicalIF":3.3,"publicationDate":"2020-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/7154738","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37927657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors Associated with Cardiac Autonomic Modulation in Obese Individuals.","authors":"Camila Oliveira, Erika Aparecida Silveira, Lorena Rosa, Annelisa Santos, Ana Paula Rodrigues, Carolina Mendonça, Lucas Silva, Paulo Gentil, Ana Cristina Rebelo","doi":"10.1155/2020/7185249","DOIUrl":"10.1155/2020/7185249","url":null,"abstract":"<p><p>Obesity leads to an imbalance in the autonomic nervous system, especially in increased sympathetic modulation and decreased vagal tone, and some anthropometric, metabolic, and lifestyle variables may increase the risk of developing cardiovascular disease. <i>Objective</i>. To analyze the association between cardiovascular autonomic modulation and biochemical and anthropometric markers, food intake, and physical activity level in severely obese individuals. <i>Methodology</i>. The present study is a cutout of a randomized clinical trial \"Effect of nutritional intervention and olive oil in severe obesity\" (DieTBra Trial), where the baseline data were analyzed. Anthropometric data, biochemical exams, heart rate variability (HRV), accelerometry, and 24 h recall (R24H) of obese patients (body mass index BMI ≥35 kg/m²) were collected. <i>Results</i>. 64 obese patients were analyzed, with a mean age of 39.10 ± 7.74 years (27 to 58 years). By HRV analysis, in the frequency domain, the obese had a higher predominance of sympathetic autonomic modulation (low frequency (LF) 56.44 ± 20.31 nu) and lower parasympathetic modulation (high frequency (HF) 42.52 ± 19.18 nu). A negative association was observed between the variables Homeostasis Evaluation Model (HOMA-IR) and HF (<i>p</i> = 0.049). In the physical activity analysis, there was a negative association between moderate to vigorous physical activity and the sympathetic component (<i>p</i> = 0.043), and for sedentary time (ST), there was a negative association with HF (<i>p</i> = 0.049) and LF/HF (<i>p</i> = 0.036) and a positive association with LF (<i>p</i> = 0.014). For multiple linear regression, waist circumference (WC) and HOMA-IR values were negatively associated with HF (<i>β</i> = -0.685, <i>p</i> = 0.010; <i>β</i> = -14.989, <i>p</i> = 0.010; respectively). HOMA-IR (<i>β</i> = 0.141, <i>p</i> = 0.003) and the percentage of lipids ingested (<i>β</i> = -0.030, <i>p</i> = 0.043) were negatively associated with LF/HF. <i>Conclusion</i>. Among the cardiovascular risk variables studied, insulin resistance and central adiposity showed the greatest influence on cardiac autonomic modulation of obese, increasing the risk for cardiovascular disease.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":"2020 ","pages":"7185249"},"PeriodicalIF":3.3,"publicationDate":"2020-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/7185249","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37857275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}