Lipid Accumulation Product Is More Related to Insulin Resistance than the Visceral Adiposity Index in the Maracaibo City Population, Venezuela.

IF 3.8 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Obesity Pub Date : 2021-06-07 eCollection Date: 2021-01-01 DOI:10.1155/2021/5514901

Valmore Bermúdez, Juan Salazar, Jorge Fuenmayor, Manuel Nava, Ángel Ortega, Pablo Duran, Milagros Rojas, Roberto Añez, Alejandra Rivas-Montenegro, Lissé Angarita, Maricarmen Chacín, Clímaco Cano, Manuel Velasco, Joselyn Rojas

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Abstract

Background: Visceral adiposity is related to insulin resistance (IR), a metabolic state considered as a risk factor for other cardiometabolic diseases. In that matter, mathematical indexes such as the visceral adiposity index (VAI) and the lipid accumulation product (LAP) could indirectly assess IR based on visceral adiposity.

Objective: To evaluate the association and diagnostic accuracy of VAI and LAP to diagnose IR in the adult population of Maracaibo city.

Methods: This is a cross-sectional descriptive study with multistage sampling. Receiver operating characteristic (ROC) curves were built to determine VAI and LAP cutoff points to predict IR. A set of logistic regression models was constructed according to sociodemographic, psychobiologic, and metabolic variables.

Results: 1818 subjects were evaluated (51.4% women). The area under the curve (AUC) values for LAP and VAI were 0.689 (0.665-0.714) and 0.645 (0.619-0.670), respectively. Both indexes showed a higher IR risk in the upper tertile in bivariate analysis. However, in the logistic regression analysis for the IR risk, only the 2nd (OR: 1.91; 95% CI: 1.37-2.65; p < 0.01) and 3rd (OR: 5.40; 95% CI: 3.48-8.39; p < 0.01) LAP tertiles showed a significant increase. This behaviour was also observed after adjusting for hs-C-reactive protein (hs-CPR).

Conclusion: Although both indexes show a low predictive capacity in individuals with IR in the Maracaibo city population, the LAP index was more strongly associated with IR.

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在委内瑞拉马拉开波市的人群中，脂质累积产物与胰岛素抵抗的关系比内脏脂肪指数更密切。

背景：内脏脂肪与胰岛素抵抗（IR）有关，胰岛素抵抗是一种代谢状态，被认为是其他心脏代谢疾病的风险因素。因此，内脏脂肪指数（VAI）和脂质累积乘积（LAP）等数学指标可根据内脏脂肪间接评估胰岛素抵抗：评估马拉开波市成人内脏脂肪指数（VAI）和脂质累积乘积（LAP）与内脏脂肪指数（VAI）和脂质累积乘积（LAP）之间的关联以及诊断内脏脂肪指数（IR）的准确性：这是一项采用多阶段抽样的横断面描述性研究。建立了接收者操作特征曲线（ROC），以确定预测 IR 的 VAI 和 LAP 临界点。根据社会人口学、心理生物学和代谢变量建立了一组逻辑回归模型：共评估了 1818 名受试者（51.4% 为女性）。LAP和VAI的曲线下面积（AUC）值分别为0.689（0.665-0.714）和0.645（0.619-0.670）。在双变量分析中，这两个指数都显示出上三分层的 IR 风险较高。然而，在 IR 风险的逻辑回归分析中，只有 LAP 第 2（OR：1.91；95% CI：1.37-2.65；p <0.01）和第 3（OR：5.40；95% CI：3.48-8.39；p <0.01）个三分位数显示出显著增加。在对 hs-C 反应蛋白（hs-CPR）进行调整后，也观察到了这种行为：结论：在马拉开波市的人群中，虽然这两个指数对红外患者的预测能力都较低，但 LAP 指数与红外的相关性更强。

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来源期刊

Journal of Obesity ENDOCRINOLOGY & METABOLISM-

CiteScore

7.50

自引率

3.00%

发文量

审稿时长

21 weeks

期刊介绍： Journal of Obesity is a peer-reviewed, Open Access journal that provides a multidisciplinary forum for basic and clinical research as well as applied studies in the areas of adipocyte biology & physiology, lipid metabolism, metabolic syndrome, diabetes, paediatric obesity, genetics, behavioural epidemiology, nutrition & eating disorders, exercise & human physiology, weight control and health risks associated with obesity.