Journal of Obesity最新文献

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10-Year Weight Gain in 13,802 US Adults: The Role of Age, Sex, and Race. 13802名美国成年人10年体重增加:年龄、性别和种族的作用
IF 3.8
Journal of Obesity Pub Date : 2022-05-06 eCollection Date: 2022-01-01 DOI: 10.1155/2022/7652408
Larry A Tucker, Kayla Parker
{"title":"10-Year Weight Gain in 13,802 US Adults: The Role of Age, Sex, and Race.","authors":"Larry A Tucker, Kayla Parker","doi":"10.1155/2022/7652408","DOIUrl":"10.1155/2022/7652408","url":null,"abstract":"<p><strong>Purpose: </strong>The primary objective of the present investigation was to identify 10-year weight gain patterns in 13,802 US adults and also to determine the extent that differences in 10-year weight gains were associated with the key demographic variables: age, sex, and race.</p><p><strong>Methods: </strong>The study design was cross-sectional and included the years 2011-2018. Data for 2019-2020 were not available because of COVID. A multistage random sampling strategy was employed. Specifically, individual sample weights and randomly selected clusters and strata were used with each statistical model, allowing the results to be generalized to the US adult population.</p><p><strong>Results: </strong>Mean (±SE) 10-year weight gain was 4.2 ± 0.2 kg or 6.6 ± 0.2% of initial body weight. A total of 51% of the participants gained 5% or more body weight, 36% gained 10% or more, and 16% gained 20% or more across the 10-years. Age was linearly and inversely associated with 10-year weight gain, expressed in kg (<i>F</i> = 166.4, <i>P</i> < 0.0001) or percent weight gain (<i>F</i> = 246.9, <i>P</i> < 0.0001), after adjusting for sex and race. For each 1-year increase in age, 10-year weight gain decreased by 0.20 ± 0.02 kg and 0.28 ± 0.02 percent. After adjusting for age and race, 10-year weight gain (kg) was significantly greater (<i>F</i> = 73.6, <i>P</i> < 0.0001) in women (5.4 ± 0.3) than in men (2.6 ± 0.2). Weight gain also differed across races, kg (<i>F</i> = 27.7, <i>P</i> < 0.0001) and % (<i>F</i> = 28.5, <i>P</i> < 0.0001). Non-Hispanic Blacks gained more weight and NH Asians gained less weight than the other races.</p><p><strong>Conclusion: </strong>Without question, 10-year weight gain is a serious problem within the US adult population. Younger adults, women, and Non-Hispanic Blacks, particularly Black women, seem to experience the highest levels of 10-year weight gain. Consequently, obesity and weight gain prevention programs focusing on these at-risk individuals should be a public health priority.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9106499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41360479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic Effect of P-Cymene on Lipid Profile, Liver Enzyme, and Akt/Mtor Pathway in Streptozotocin-Induced Diabetes Mellitus in Wistar Rats 对-Cymene对链脲佐菌素诱导的Wistar大鼠糖尿病脂质、肝酶和Akt/Mtor通路的治疗作用
IF 3.3
Journal of Obesity Pub Date : 2022-04-26 DOI: 10.1155/2022/1015669
Maryam Arabloei Sani, P. Yaghmaei, Z. Hajebrahimi, N. Hayati Roodbari
{"title":"Therapeutic Effect of P-Cymene on Lipid Profile, Liver Enzyme, and Akt/Mtor Pathway in Streptozotocin-Induced Diabetes Mellitus in Wistar Rats","authors":"Maryam Arabloei Sani, P. Yaghmaei, Z. Hajebrahimi, N. Hayati Roodbari","doi":"10.1155/2022/1015669","DOIUrl":"https://doi.org/10.1155/2022/1015669","url":null,"abstract":"Diabetes is a serious public health problem in low- and middle-income countries. There is a strong link between hyperglycemia, oxidative stress, inflammation, and the development of diabetes mellitus. PI3K/Akt/mTOR is the main signaling pathway of insulin for controlling lipid and glucose metabolism. P-cymene is an aromatic monoterpene with a widespread range of therapeutic properties including antioxidant and anti-inflammatory activity. In the present study, the antidiabetic effects of p-cymene were investigated. Diabetes was induced using streptozotocin in male Wistar rats. The effects of p-cymene and metformin were studied on levels of glucose (Glu), lipid profile, liver enzymes, oxidative stress, and the expression of Akt, phospho-Akt, and mTOR (mammalian target of rapamycin) proteins, using biochemical, histological, and immunohistochemical analysis. Data have shown that p-cymene can improve serum levels of Glu, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), malondialdehyde (MDA), and the expression of mTOR, Akt, and phospho-Akt protein in diabetic animals. These results suggest that p-cymene has hypoglycemia, hypolipidemia, and antioxidant properties. It can regulate Akt/mTOR pathway and reduce hepatic and pancreas injury. It can be suggested for diabetes management alone or simultaneously with metformin.","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2022-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44879496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Connections between Children's Eating Habits, Mental Health, and Parental Stress. 儿童饮食习惯、心理健康与父母压力之间的关系
IF 3.8
Journal of Obesity Pub Date : 2022-04-12 eCollection Date: 2022-01-01 DOI: 10.1155/2022/6728502
Marco Tommasi, Francesca Toro, Alessandra Salvia, Aristide Saggino
{"title":"Connections between Children's Eating Habits, Mental Health, and Parental Stress.","authors":"Marco Tommasi, Francesca Toro, Alessandra Salvia, Aristide Saggino","doi":"10.1155/2022/6728502","DOIUrl":"10.1155/2022/6728502","url":null,"abstract":"<p><strong>Background: </strong>Obesity and eating disorders are increasing in occidental countries and can undermine physical and psychological health. Therefore, preventing the insurgency of unhealthy eating habits in childhood is fundamental. Parents can play an important role in assisting pediatricians, psychiatrists, and clinical psychologists in the diagnosis of eating disorders because they have an active role in observing and assessing the quality of their children's eating habits.</p><p><strong>Methods: </strong>In our study, we collected data from a sample of children (<i>n</i> = 125) and their parents (<i>n</i> = 161) without symptoms related to eating disorders. Parents assessed the eating habits, behavior problems, and mental health of their children and parental stress. In addition, we measured body mass index, anxiety, and lifestyle in children. Data were analyzed with bivariate correlation and MIMIC models.</p><p><strong>Results: </strong>Both mothers' and fathers' assessments of children's eating habits are reliable. Unhealthy eating habits are connected with children's behavioral problems and parental stress. We did not find significant differences in feeding styles and ways of assessing the quality of eating habits between mothers and fathers. Our study showed greater sensitivity of mothers toward the physical fitness of their children rather than fathers.</p><p><strong>Conclusions: </strong>Mothers and fathers both proved to be good observers of their children's eating behavior, and they could cooperate with medical and psychological operators in preventing the risk of obesity.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2022-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45594560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Anthropometric Indices with Menstrual Abnormality among Nursing Students of Nepal: A Cross-Sectional Study 尼泊尔护生人体测量指标与月经异常的关系:一项横断面研究
IF 3.3
Journal of Obesity Pub Date : 2022-03-18 DOI: 10.1155/2022/6755436
K. Amgain, Prativa Subedi, G. Yadav, Sujana Neupane, S. Khadka, S. Sapkota
{"title":"Association of Anthropometric Indices with Menstrual Abnormality among Nursing Students of Nepal: A Cross-Sectional Study","authors":"K. Amgain, Prativa Subedi, G. Yadav, Sujana Neupane, S. Khadka, S. Sapkota","doi":"10.1155/2022/6755436","DOIUrl":"https://doi.org/10.1155/2022/6755436","url":null,"abstract":"Introduction Obesity has been reported to be linked with menstrual abnormalities including abnormality in cycle length, duration, and period blood loss. However, which anthropometric parameter is a better marker of menstrual abnormality is yet unknown. This study aims to explore the association of BMI, waist-hip ratio (WHR), and waist-height ratio (WHtR) with menstrual abnormalities. Methods This was a cross-sectional study conducted among 240 nursing students on two nursing campuses of Nepal. Demographic and menstrual characteristics related data were collected from the participants via the face-to-face interview technique followed by anthropometric measurements. Binary logistic regression was used to study the association of BMI, WHR, and WHtR with menstrual characteristics. Univariable and multivariable regression models were calculated at 95% confidence interval and a P value of 0.05 using a Statistical Package for Social Sciences, IBM SPSS® v21 (IBM, Armonk, New York). Results Out of 240 participants, 52 participants (21.67%) were underweight (<18.5 kg/m2), and 47 participants (19.58%) were either overweight (≥23 kg/m2) or obese (≥25 kg/m2). Overweight and obese BMI was associated with abnormality in menstrual cycle length (AOR = 4.24; 95% CI = 1.77–10.17), duration of the menstrual period (AOR = 2.52; 95% CI = 1.09–5.81), and periodic menstrual blood loss (AOR = 9.04; 95% CI = 3.55–23.01). Increase in WHtR (>0.5) was associated with abnormal cycle length (AOR = 3.09; 95% CI = 1.09–8.80) and abnormal period duration (AOR = 3.05; 95% CI = 1.10–8.44). An increase in WHR (>0.8) was associated with abnormal cyclical menstrual blood loss (AOR = 4.93; 95% CI = 1.55–15.71). Conclusions Obesity predisposes to menstrual irregularities. BMI is a better predictor of menstrual irregularity as the increase in BMI is associated with abnormality in menstrual cycle length, period duration, and blood loss. Increased WHR was associated with periodic blood loss only. Increased WHtR was associated with abnormal cycle length and period duration, but not menstrual blood loss.","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2022-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47308006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Prevalence of Obesity and Overweight among Adults in the Middle East Countries from 2000 to 2020: A Systematic Review and Meta-Analysis. 2000年至2020年中东国家成人肥胖和超重患病率:系统回顾和荟萃分析
IF 3.3
Journal of Obesity Pub Date : 2022-02-03 eCollection Date: 2022-01-01 DOI: 10.1155/2022/8074837
Hassan Okati-Aliabad, Alireza Ansari-Moghaddam, Shiva Kargar, Neda Jabbari
{"title":"Prevalence of Obesity and Overweight among Adults in the Middle East Countries from 2000 to 2020: A Systematic Review and Meta-Analysis.","authors":"Hassan Okati-Aliabad,&nbsp;Alireza Ansari-Moghaddam,&nbsp;Shiva Kargar,&nbsp;Neda Jabbari","doi":"10.1155/2022/8074837","DOIUrl":"https://doi.org/10.1155/2022/8074837","url":null,"abstract":"<p><strong>Background: </strong>Obesity has become a significant public health issue worldwide, and it is a major risk factor for many noncommunicable diseases. This systematic review aimed to identify the prevalence of obesity and overweight in the Middle East region and different countries in this region.</p><p><strong>Materials and methods: </strong>PubMed, Google Scholar, and MEDLINE databases were searched from 2000-2020 to identify relevant studies in the Middle East area. The survey was carried out using combinations of Medical Subject Headings (Mesh) keywords like \"body mass index\", \"obesity\", \"overweight\", \"prevalence\", \"Middle-East\", and \"Countries in the Middle East area\". Analysis of the data was done using STATA-14, and a random-effects model was used to estimate the pooled prevalence.</p><p><strong>Results: </strong>A total of 101 studies with 698905 participants have been identified that met inclusion criteria for this meta-analysis. The pooled estimates of the prevalence of obesity and overweight in the Middle East area were 21.17 (95% CI: 17.05-26.29) and 33.14 (95% CI: 26.87-40.87), respectively. The findings showed that obesity prevalence increased with age so that the highest prevalence of obesity and overweight was observed in people >40 years old. Obesity prevalence in the Middle East area remained steady between 2000-2006 and 2014-2020 (23%). During these time intervals, the prevalence of overweight decreased from 34.83 (95% CI: 32.40-37.45) to 32.85 (95% CI: 31.39-34.38).</p><p><strong>Conclusions: </strong>Despite the relative stabilization of the overweight and obesity trend in the Middle East, current interventions to combat the overweight epidemic need to be maintained and strengthened because the prevalence of overweight and obesity in this region is still very high. The prevalence of obesity increases with age so that people over 40 have the highest percentage of obesity and overweight. Therefore, implementing intervention programs to prevent and control obesity and overweight in the Middle East is essential.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2022-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8831052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39915405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 46
Age-Related Trends in Body Composition among Women Aged 20-80 Years: A Cross-Sectional Study. 20-80岁女性身体成分的年龄相关趋势:一项横断面研究
IF 3.3
Journal of Obesity Pub Date : 2022-02-02 eCollection Date: 2022-01-01 DOI: 10.1155/2022/4767793
Nirmala Rathnayake, Hasanga Rathnayake, Sarath Lekamwasam
{"title":"Age-Related Trends in Body Composition among Women Aged 20-80 Years: A Cross-Sectional Study.","authors":"Nirmala Rathnayake,&nbsp;Hasanga Rathnayake,&nbsp;Sarath Lekamwasam","doi":"10.1155/2022/4767793","DOIUrl":"https://doi.org/10.1155/2022/4767793","url":null,"abstract":"<p><p>The determinants of body composition are likely to vary geographically due to the diversity of genetic and environmental factors between populations. Age-related trends in body composition in a population help understanding the health issues that are linked with different body compartments. In general, such studies are scarce in the South Asian region and this cross-sectional study examined the age-related trends in body composition in a selected group of healthy women aged 20-80 years in Sri Lanka. The study included randomly selected 784 healthy women aged 20-80 years from the Southern province, Sri Lanka. Women were divided into five age groups: 20-29 years (<i>n</i> = 79), 30-39 years (<i>n</i> = 144), 40-49 years (<i>n</i> = 185), 50-59 years (<i>n</i> = 281), and ≥60 years (<i>n</i> = 85). Total body bone mineral density (TBBMD, g/cm<sup>2</sup>), total body bone mineral content (TBBMC, g), total body fat mass (TBFM, kg), and total body lean mass (TBLM, kg) were measured with central-type dual-energy X-ray absorptiometry (DXA). Multivariate analysis of variance with Bonferroni post hoc test was performed. The age-related trends of TBBMD and TBBMC were similar with a peak in 40-49-year age group. Between 50 and 59 and ≥60 age categories, TBBMD and TBBMC showed a rapid decline: 16% and 23%, respectively. The rate of TBBMD decline was 0.008 g/cm<sup>2</sup> per year after 50 years. TBFM increased by 14% between age categories 20-29 and 40-49 years and remained unchanged after 49 years. TBLM increased by 15% between age groups 20-29 and 40-49 years and then decreased by 13% between age categories 50-59 and ≥60 years. Of the 13% decrease in TBLM after 50 years, 9% loss occurred after 59 years. The trends observed help to understand the occurrence of diseases linked with body composition.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2022-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8828324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39791268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Laparoscopic Banded One Anastomosis Gastric Bypass: A Single-Center Series. 腹腔镜带状胃旁路吻合术:单中心系列。
IF 3.3
Journal of Obesity Pub Date : 2022-01-29 eCollection Date: 2022-01-01 DOI: 10.1155/2022/4942052
Michela Campanelli, Emanuela Bianciardi, Domenico Benavoli, Giulia Bagaglini, Giorgio Lisi, Paolo Gentileschi
{"title":"Laparoscopic Banded One Anastomosis Gastric Bypass: A Single-Center Series.","authors":"Michela Campanelli,&nbsp;Emanuela Bianciardi,&nbsp;Domenico Benavoli,&nbsp;Giulia Bagaglini,&nbsp;Giorgio Lisi,&nbsp;Paolo Gentileschi","doi":"10.1155/2022/4942052","DOIUrl":"https://doi.org/10.1155/2022/4942052","url":null,"abstract":"<p><strong>Introduction: </strong>Laparoscopic one anastomosis gastric bypass (LOAGB) is a relatively new procedure for the treatment of morbid obesity and related comorbidities. On average, this procedure results in good postoperative weight loss with a low complication rate. Recent publications suggest that dumping syndrome and weight regain might be reduced by placing a silicone ring over the gastric pouch during the procedure, so called laparoscopic banded one anastomosis gastric bypass (LBOAGB).</p><p><strong>Methods: </strong>86 patients undergoing LBOAGB between 2018 and 2020 were enrolled in this retrospective study. Hospital records were used to assess weight loss, comorbidity resolution, and any complications either in the short or medium term.</p><p><strong>Results: </strong>54 Female and 32 male patients were included with a mean age of 43 years (25-64), preoperative body mass index of 42 kg/m<sup>2</sup> (35-49), and preoperative weight of 114 kg (86-162). Thirty-four patients presented with type 2 diabetes (39.5%), 42 patients (49%) diagnosed with hypertension, 24 presented with OSAS (28%), and 21 (24%) hypercholesterolaemia patients were included. In total, 36 patients were diagnosed with multiple comorbidities. The operative data showed an average operative time of 48 minutes with 3.4% of patients suffering from early (minor) complications and 2.3% with a late (minor) complication. One patient required reoperation due to intra-abdominal bleeding. The median length of hospital stay was 2.5 days. Median follow-up was 18 months (5-36). In that period, no patient required ring removal or conversion to Roux-en-Y gastric bypass surgery. Food intolerance/vomiting was present in 1 patient (1.1%), bile reflux was present in 1 patient (1.1%), and no stomal ulcers were observed. Mean % excess weight loss at 12 and 24 months was 72% and 80%, respectively. Fifty-two out of 86 patients (60%) had a complete resolution of comorbidities. A CONUT score >2 (mild malnutrition) was found in 40% of patients, while a CONUT score 0-1 was found in 60% of patients.</p><p><strong>Conclusion: </strong>LBOAGB shows promising results in terms of safety and efficacy in the short term. Further prospective studies will be required to evaluate the consistency of the results in the long term.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2022-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8817855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39898221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Obesity, Adipose Tissue, and Inflammation Answered in Questions. 肥胖、脂肪组织和炎症问题解答。
IF 3.8
Journal of Obesity Pub Date : 2022-01-22 eCollection Date: 2022-01-01 DOI: 10.1155/2022/2252516
Vanessa A Guerreiro, Davide Carvalho, Paula Freitas
{"title":"Obesity, Adipose Tissue, and Inflammation Answered in Questions.","authors":"Vanessa A Guerreiro, Davide Carvalho, Paula Freitas","doi":"10.1155/2022/2252516","DOIUrl":"10.1155/2022/2252516","url":null,"abstract":"<p><p><i>Background</i>. Obesity is a global health problem of epidemic proportions, which is characterized by increased adipose tissue (AT) mass and significant repercussions in different body apparati and systems. AT is a special connective tissue, which contains several types of cells, in addition to adipocytes, and is a highly active endocrine and immune organ, which directly modulates many processes, including energy balance, metabolism, and inflammation. <i>Summary</i>. In this paper, the authors list and attempt to answer in a brief and simple way several questions regarding the complex relationships between obesity, adipose tissue, and inflammation, with the objective to provide an easy way to understand the main changes that occur in this pathological state. The questions are the following: Is adipose tissue only made up of adipocytes? Are adipocytes just a reservoir of free fatty acids? Do different types of fatty tissue exist? If so, which types? Can we further subcategorize the types of adipose tissue? Is it possible to form new adipocytes during adulthood? What is the role of inflammation? What is the role of macrophages? Are macrophages central mediators of obesity-induced adipose tissue inflammation and insulin resistance? What causes macrophage infiltration into adipose tissue? What is the role of hypoxia in AT alterations? Is there cross talk between adipocytes and immune cells? What other changes occur in AT in obesity? Does metabolically healthy obesity really exist? Is this a benign condition? <i>Key messages</i>. Obesity is a complex disease with numerous metabolic consequences, which are mainly the result of dysfunction that occurs in the adipose tissue of patients with this pathology. Understanding the pathophysiology of AT and the changes that occur in obesity would contribute to a better approach to patients with obesity, with the inherent medical implications that could result from this.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":null,"pages":null},"PeriodicalIF":3.8,"publicationDate":"2022-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8938152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40317492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case-Control Study of the Association of Leptin Gene Polymorphisms with Plasma Leptin Levels and Obesity in the Kerala Population. 喀拉拉邦人群瘦素基因多态性与血浆瘦素水平和肥胖关系的病例对照研究
IF 3.3
Journal of Obesity Pub Date : 2022-01-01 DOI: 10.1155/2022/1040650
Sudharmadevi K Manju, Thottathil R Anilkumar, G Vysakh, Balakumaran K Leena, Vijayalekshmi Lekshminarayan, Pradeep G Kumar, Trivikrama K Shenoy
{"title":"A Case-Control Study of the Association of Leptin Gene Polymorphisms with Plasma Leptin Levels and Obesity in the Kerala Population.","authors":"Sudharmadevi K Manju,&nbsp;Thottathil R Anilkumar,&nbsp;G Vysakh,&nbsp;Balakumaran K Leena,&nbsp;Vijayalekshmi Lekshminarayan,&nbsp;Pradeep G Kumar,&nbsp;Trivikrama K Shenoy","doi":"10.1155/2022/1040650","DOIUrl":"https://doi.org/10.1155/2022/1040650","url":null,"abstract":"<p><strong>Background: </strong>Over the last few years, the importance of leptin in energy metabolism has been extensively studied in both animal models and in humans. Very few results are available on the association between human leptin gene (<i>LEP</i>) variants and obesity traits in India. We designed this study to analyse the polymorphisms in human leptin gene and the association of sequence variants with obesity among the population in Kerala, South India.</p><p><strong>Methods: </strong>In this case-control design of 148 study participants, data were collected on socioeconomic aspects and anthropometric measurements. Plasma glucose, insulin, leptin, and lipid profile were measured. Genotyping was done by automated DNA sequencing.</p><p><strong>Results: </strong>The common Single Nucleotide Polymorphism (SNP) of 5'-UTR of <i>LEP</i> - 2548G/A was found to be present in the study population with \"A\" variant as dominant allele. A novel synonymous mutation Thr5Thr of exon 2 of <i>LEP</i> was identified in heterozygous form in one subject with morbid obesity with hyperleptinemia. A novel missense mutation Phe17Leu was observed in two subjects with obesity in heterozygous condition. A novel missense mutation Lys36Arg in exon 2 of <i>LEP</i> was observed in one subject with abdominal obesity and decreased serum leptin level.</p><p><strong>Conclusion: </strong><i>LEP</i> - 2548G/A at 5'-untranslated region was found to be common with the mutant \"A\" variant in the study population. SNPs of exons in <i>LEP</i> were found to be rare but associated with morbid obesity and altered levels of serum leptin in the study population in Kerala, India.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9812639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10538859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Retracted: Measures of Adiposity and Risk of Testing Positive for SARS-CoV-2 in the UK Biobank Study. 撤回:英国生物库研究中的肥胖测量和SARS-CoV-2检测阳性的风险。
IF 3.3
Journal of Obesity Pub Date : 2022-01-01 DOI: 10.1155/2022/9848453
Journal Of Obesity
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