肥胖患病率能否解释COVID-19指标(病例、死亡率和康复)?经合组织国家比较研究。

IF 3.8 Q2 ENDOCRINOLOGY & METABOLISM
Journal of Obesity Pub Date : 2022-06-20 eCollection Date: 2022-01-01 DOI:10.1155/2022/4320120
Yuval Arbel, Chaim Fialkoff, Amichai Kerner, Miryam Kerner
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引用次数: 4

摘要

SARS-CoV-2病毒病(COVID-19)被宣布为具有多重危险因素的全球大流行。根据最近的实证研究,肥胖被一些研究人员认为是SARS-CoV-2病毒并发症的严重危险因素之一。然而,其他学者认为存在肥胖生存悖论,并批评前一组研究,理由是他们缺乏对种族,社会经济地位或护理质量的控制。本次研究的目的是,以经合组织(OECD)的报告为基础,分析不同SARS-CoV-2病毒指标与全国肥胖之间的潜在关系。为了检验肥胖生存悖论的反直觉可能性,提出的经验模型通过应用二次设计并检验两种相互竞争的模型(即二次模型或线性模型)中哪一种更适合数据,从而放宽了单调变化的假设。研究结果表明,SARS-CoV-2病毒指数与肥胖率之间的关系比之前认为的更为复杂。因此,以色列卫生部于2020年4月发布的关于插管和重症监护治疗优先的伦理准则应该考虑到肥胖与SARS-CoV-2病毒之间的这些复杂关系。事实上,SARS-CoV-2病毒的死亡率呈线性上升,肥胖的患病率也在上升。然而,作为死亡原因的其他指标,如每10万人感染人数、严重SARS-CoV-2病毒病例率、SARS-CoV-2病毒患者康复率和SARS-CoV-2病毒,呈现出二次曲线,而不是线性曲线。这些非线性模式的原因可能由几种情况解释,如代谢储备增加、更积极的治疗、肥胖人群的其他非sars - cov -2病毒并发症,以及应在未来研究中检查的未知因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Can Obesity Prevalence Explain COVID-19 Indicators (Cases, Mortality, and Recovery)? A Comparative Study in OECD Countries.

SARS-CoV-2 virus disease (COVID-19) is declared a global pandemic with multiple risk factors. Obesity is considered by several researchers as one of the serious risk factors for SARS-CoV-2 virus complications based on recent empirical studies. Yet, other scholars argue in favor of the existence of an obesity survival paradox and criticize the former group of studies on the grounds that they lack controls for race, socioeconomic status, or quality of care. The objective of the current study is to analyze the potential relationships between different SARS-CoV-2 virus indicators and obesity on a country-wide level based on an OECD report. In an attempt to test the counterintuitive possibility of an obesity survival paradox, the proposed empirical model relaxes the assumption of monotonic change by applying the quadratic design and testing which one of the two competing models (i.e., quadratic or linear) better fits the data. Findings suggest more complex relationships between SARS-CoV-2 virus indices and obesity rates than previously thought. Consequently, ethical guidelines referring to priority in intubation and intensive care treatments-published by the Israeli Ministry of Health in April 2020-should account for these complex relationships between obesity and SARS-CoV-2 virus. Indeed, there is a linear increase in mortality rate from SARS-CoV-2 virus with an elevated prevalence of obesity. Yet, other indicators, such as the number of infected per 10,00,000 persons, rates of severe SARS-CoV-2 virus cases, rates of recovered SARS-CoV-2 virus patients, and SARS-CoV-2 virus, as the cause of death exhibit quadratic, rather than linear, patterns. The reasons for these nonlinear patterns might be explained by several conditions such as increased metabolic reserves, more aggressive treatment, other non-SARS-CoV-2 virus complications for obese persons, and unidentified factors that should be examined in future research.

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来源期刊
Journal of Obesity
Journal of Obesity ENDOCRINOLOGY & METABOLISM-
CiteScore
7.50
自引率
3.00%
发文量
19
审稿时长
21 weeks
期刊介绍: Journal of Obesity is a peer-reviewed, Open Access journal that provides a multidisciplinary forum for basic and clinical research as well as applied studies in the areas of adipocyte biology & physiology, lipid metabolism, metabolic syndrome, diabetes, paediatric obesity, genetics, behavioural epidemiology, nutrition & eating disorders, exercise & human physiology, weight control and health risks associated with obesity.
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