Possible Nonneurological Health Benefits of Ketogenic Diet: Review of Scientific Reports over the Past Decade

IF 3.8 Q2 ENDOCRINOLOGY & METABOLISM
Katarzyna Daria Gołąbek, B. Regulska-Ilow
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引用次数: 1

Abstract

The ketogenic diet (KD) has been used since the 1920s as a therapy for drug-resistant epilepsy. Due to the beneficial effects of this diet on the nervous system and the proposed multifaceted effects of ketones on health and disease, researchers have evaluated its use in other nonneurological conditions. The objective of this review was to analyze the most recent papers, which is why meta-analyses were used in which 75% of the studies were from 2012 to 2022. Authors also cited single studies from the last decade that lasted longer than 12 months to assess the long-term benefits of KD. Reports from the past decade have highlighted several significant areas regarding the impact of KD. One of these is the use of very low-calorie ketogenic diet (VLCKD) as an effective possibly safe and patient-motivating component of a long-term weight loss plan. Reports on the positive influence of KD on the health of obese individuals, and the possible resulting validity of its use, should be verified by patients' physical activity levels. A significant number of studies from the last decade evaluate the effect of KD on improving the health of individuals with type 2 diabetes as an effective tool in lowering glycated hemoglobin (Hb1Ac) and required doses of hypoglycemic drugs. The long-term studies indicate a possible beneficial effect of KD on cardiovascular function due to improvement lipid profile, changes in apolipoprotein (Apo) A1, adiponectin, and intercellular adhesion molecule-1 (ICAM-1).
生酮饮食可能的非神经系统健康益处:回顾过去十年的科学报告
生酮饮食(KD)自20世纪20年代以来一直用于治疗耐药性癫痫。由于这种饮食对神经系统的有益影响,以及酮类对健康和疾病的多方面影响,研究人员已经评估了它在其他非神经系统疾病中的应用。本综述的目的是分析最新的论文,这就是为什么75%的研究是在2012年至2022年期间进行的,因此使用了荟萃分析。作者还引用了过去十年中持续时间超过12个月的单一研究来评估KD的长期益处。过去十年的报告强调了KD影响的几个重要领域。其中之一是使用极低卡路里生酮饮食(VLCKD)作为长期减肥计划中有效且安全且激励患者的组成部分。关于KD对肥胖个体健康的积极影响的报告,以及可能产生的使用有效性,应该通过患者的身体活动水平来验证。在过去的十年中,大量的研究评估了KD作为降低糖化血红蛋白(Hb1Ac)和降糖药所需剂量的有效工具对改善2型糖尿病患者健康的影响。长期研究表明,KD可能通过改善血脂、改变载脂蛋白(Apo) A1、脂联素和细胞间粘附分子-1 (ICAM-1)对心血管功能产生有益影响。
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来源期刊
Journal of Obesity
Journal of Obesity ENDOCRINOLOGY & METABOLISM-
CiteScore
7.50
自引率
3.00%
发文量
19
审稿时长
21 weeks
期刊介绍: Journal of Obesity is a peer-reviewed, Open Access journal that provides a multidisciplinary forum for basic and clinical research as well as applied studies in the areas of adipocyte biology & physiology, lipid metabolism, metabolic syndrome, diabetes, paediatric obesity, genetics, behavioural epidemiology, nutrition & eating disorders, exercise & human physiology, weight control and health risks associated with obesity.
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