Journal of Obstetrics and Gynaecology最新文献

{"title":"Hysteroscopic platelet-rich plasma and medically assisted reproduction outcomes: a systematic review and SWOT analysis.","authors":"Giosuè Giordano Incognito, Carla Ettore, Roberta Floresta, Maurizio Somma, Giorgia D'Amico, Orazio De Tommasi, Pierluigi Chieppa, Stefano Di Michele, Francesco Leonforte, Antonio Mistretta, Giuseppe Ettore","doi":"10.1080/01443615.2026.2725837","DOIUrl":"10.1080/01443615.2026.2725837","url":null,"abstract":"<p><strong>Background: </strong>Platelet-rich plasma (PRP) has been proposed as an adjuvant treatment in reproductive medicine. While most evidence refers to blind intrauterine instillation, subendometrial administration under hysteroscopic guidance allows targeted delivery under direct visualisation. This systematic review aimed to synthesise the available evidence on hysteroscopic PRP administration and its impact on clinical medically assisted reproduction (MAR) outcomes.</p><p><strong>Methods: </strong>A systematic search was conducted from inception to December 2025 across major databases. Studies were included if they evaluated hysteroscopic PRP administration in women undergoing MAR, comparing reproductive outcomes between treated and control groups.</p><p><strong>Results: </strong>Out of 142 records, 3 studies met the inclusion criteria. Study populations were heterogeneous and included women with refractory thin endometrium and/or a history of implantation failure. Hysteroscopic PRP administration protocols varied in timing, technique, and dosage. In a prospective case-control study, hysteroscopic intraendometrial PRP injection at a depth of 2-3 mm in the four uterine walls, using an ovum aspiration needle, on days 11-13 of the cycle prior to euploid frozen embryo transfer (ET), was associated with higher implantation (IR), clinical pregnancy (CPR), and live birth rates (LBR) compared with standard therapy. Conversely, no significant differences in CPR, miscarriage rate, or LBR were observed in an observational study evaluating a single intraendometrial PRP injection (35-40 mL, 2-3 mm depth), administered via endoscopic needle on days 6-8 of the menstrual cycle preceding frozen ET, alone or after electrical impulse therapy. A randomised controlled trial in women undergoing intrauterine insemination reported a significant improvement in CPR following hysteroscopic subendometrial PRP instillation in the four uterine walls (1.0 mL each).</p><p><strong>Conclusions: </strong>Current literature on hysteroscopic PRP administration in reproductive medicine is limited, and robust conclusions cannot yet be drawn. Well-designed randomised controlled trials with standardised protocols are needed to clarify its clinical role.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2725837"},"PeriodicalIF":2.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between miR-155 expression and Th17/Treg balance in URPL patients: a single-centre retrospective study.","authors":"Yingqiong Chen, Min Xu, Li Li, Min Dong, Haiyan Wang, Mingzhe Zhang","doi":"10.1080/01443615.2026.2661211","DOIUrl":"10.1080/01443615.2026.2661211","url":null,"abstract":"<p><strong>Background: </strong>Unexplained recurrent pregnancy loss (URPL) is frequently associated with T helper 17 cells/regulatory T cells (Th17/Treg) imbalance, but the association between microRNA (miR)-155 and Th17/Treg imbalance remains unclear. Therefore, this study preliminarily analysed this association in URPL patients.</p><p><strong>Methods: </strong>This retrospective study analysed 189 URPL patients (the live birth group: <i>n =</i> 112; the non-live birth group: <i>n =</i> 77) and 91 healthy pregnant women. miR-155, Th17 cells, Treg cells, and Th17/Treg-related cytokines were measured, and the association between miR-155 and Th17/Treg balance was evaluated. The discriminatory performance of miR-155 for adverse pregnancy outcomes (APOs) in URPL was explored with receiver operating characteristic (ROC) curves, and APOs-associated factors were analysed with logistic regression.</p><p><strong>Results: </strong>Serum miR-155 expression showed a graded decline: control group > live birth group > non-live birth group (all <i>P</i> < 0.001). The non-live birth group presented elevated Th17 cells, interleukin (IL)-17, IL-6, and Th17/Treg ratios but reduced Treg cells, IL-10, and transforming growth factor-beta 1 (TGF-β1) compared to other groups (all <i>P</i> < 0.001). miR-155 expression was correlated negatively with Th17 cells, Th17/Treg ratios, IL-17, and IL-6 and positively with Treg cells, IL-10, and TGF-β1 (all <i>P</i> < 0.001). For APOs in URPL patients, miR-155 expression had a strong discriminatory performance (area-under-the-curve = 0.801). Th17/Treg (<i>OR</i> = 1.048) and miR-155 (<i>OR</i> = 0.048) were independently associated with APOs in URPL (both <i>P</i> < 0.05).</p><p><strong>Conclusions: </strong>Serum miR-155 is reduced in URPL patients and is associated with Th17/Treg imbalance. miR-155 may serve as an exploratory marker to aid in distinguishing APOs in URPL patients, however, its value requires external validation through prospective, multicentre studies.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2661211"},"PeriodicalIF":2.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147973066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hotspots and research trends of exercise in polycystic ovary syndrome: a bibliometric analysis from 2005 to 2025.","authors":"Feng Sun, Mengyao Huan, Huimin Niu, Chuning Lin, Xinyi Zhang, Yuxin Liu, Feng Jiang, Chuyan Wu","doi":"10.1080/01443615.2026.2698103","DOIUrl":"10.1080/01443615.2026.2698103","url":null,"abstract":"<p><strong>Background: </strong>Polycystic Ovary Syndrome (PCOS) imposes substantial metabolic and reproductive burdens. Exercise has emerged as a crucial lifestyle intervention, and corresponding scientific interest has expanded. This study provides a comprehensive bibliometric analysis of global research on the intersecting PCOS and exercise.</p><p><strong>Methods: </strong>Relevant publications (2005-2025) were collected from the Web of Science Core Collection (WoSCC). CiteSpace, VOSviewer, and bibliometrix were applied to map publication trends, international collaboration patterns, and evolving research hotspots.</p><p><strong>Results: </strong>A total of 1,146 publications were identified, demonstrating sustained growth. The United States and Australia dominated productivity, collaborating primarily with India, the United Kingdom (UK), and Switzerland. Key research hotspots included metabolic syndrome, endothelial function, cardiovascular disease, and increasing emphasis on exercise-based interventions. Monash University and the University of Adelaide played central roles in institutional networks. Emerging themes, including oxidative stress and anxiety, have emerged in the broader PCOS literature and are closely linked to exercise-related biological pathways.</p><p><strong>Conclusions: </strong>Exercise is an increasingly prominent research focus in PCOS management. This analysis outlines the field's structural and thematic evolution and identifies opportunities for advancing scientific understanding. Strengthened international and multidisciplinary collaboration remains essential.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2698103"},"PeriodicalIF":2.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148421780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re-evaluating low-molecular-weight heparin use in recurrent missed miscarriage: current evidence and future directions.","authors":"Jaiden Townsend, Rami Attala","doi":"10.1080/01443615.2026.2700014","DOIUrl":"https://doi.org/10.1080/01443615.2026.2700014","url":null,"abstract":"<p><strong>Background: </strong>Recurrent missed miscarriage (RMM) is heterogenous and emotionally burdensome. Low-molecular-weight heparin (LMWH) plus low-dose aspirin improves live-birth rates in women with obstetric antiphospholipid syndrome (APS), but the value of the use of LMWH in APS-negative RMM with and without confirmed coagulation disorders remains controversial, and optimal dosing frequency is uncertain.</p><p><strong>Methods: </strong>We performed a narrative synthesis of randomised controlled trials (notably ALIFE and ALIFE2), Cochrane systematic reviews, pharmacokinetic studies, and national/international guidelines (RCOG, ESHRE). Emphasis was placed on live-birth outcomes, trial design limitations (including inclusion of chromosomally abnormal losses), pharmacokinetics relevant to once-daily (OD) versus twice-daily (BD) regimens, and safety/tolerability data.</p><p><strong>Results: </strong>Robust evidence supports LMWH plus low-dose aspirin in improving live-birth rates in women with APS. In APS-negative populations, randomised controlled trials and meta-analyses show no reproducible live-birth benefit; interpretation is limited by clinical heterogeneity, underpowering and failure to exclude chromosomally abnormal losses, which account for up to half of early miscarriages. Notably, these trials almost exclusively used once-daily LMWH. Pharmacokinetic data indicate that twice-daily dosing yields more stable anti-Xa levels than once-daily dosing; however, this is a pharmacokinetic rationale only, and no adequately powered trial has tested whether it improves clinical outcomes.</p><p><strong>Conclusions: </strong>Routine LMWH for APS-negative RMM is not supported outside clinical trials. Key knowledge gaps include the effect of pre-randomisation genetic stratification (euploid-only cohorts), directly comparing OD vs BD LMWH regimens, and incorporation of patient-centred and health-economic outcomes. Well-designed, adequately powered trials with genetic and phenotypic enrichment and embedded pharmacokinetic sub-studies are required to resolve clinical equipoise.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2700014"},"PeriodicalIF":2.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of laparoscopic myomectomy for large and high-order fibroids: a single-centre service evaluation.","authors":"Rebecca McMurray, Maxine Reindorf, Brooke Vandermolen, Mehrnoosh Aref-Adib, Funlayo Odejinmi","doi":"10.1080/01443615.2026.2630227","DOIUrl":"10.1080/01443615.2026.2630227","url":null,"abstract":"<p><strong>Background: </strong>Ethnic minority patients experience a higher uterine fibroid disease burden and reduced access to minimally invasive myomectomy. Restrictive selection criteria may disproportionately exclude these patients from laparoscopic surgery.</p><p><strong>Methods: </strong>This was a prospective service-evaluation database analysed retrospectively, including all conventional (non-robotic) laparoscopic myomectomies performed between January 2004 and December 2024 at a single UK university hospital. Primary outcomes were estimated blood loss (EBL), length of hospital stay (LOS) and operating time. Secondary outcomes were blood transfusion rate, conversion to laparotomy and analysis of fibroid burden by ethnicity. Outcomes were compared between patients with large fibroids (>10 cm), high-order fibroids (>10 fibroids removed), both and neither. We performed inferential descriptive statistics using SPSS v27 (SPSS Inc., Chicago, IL).</p><p><strong>Results: </strong>Among 550 patients, 164 had large fibroids, 30 high-order fibroids, 18 both and 338 neither. Ethnic minority patients represented 77%, 93%, 89% and 72% of these groups, respectively. Mean EBL was higher in large fibroid (345 mL) and combined groups (483 mL) compared with neither (211 mL), without associated increases in transfusion, conversion to laparotomy, or LOS. Black African and Black Caribbean patients had greater fibroid burden and higher blood loss than Caucasian patients, reflecting disease severity rather than ethnicity as an independent determinant of outcome.</p><p><strong>Conclusions: </strong>In a specialist setting, laparoscopic myomectomy is feasible and safe for patients with large and/or multiple fibroids, including those from ethnic minority backgrounds with higher disease burden. Expansion of access within appropriately resourced centres may help reduce inequities in fibroid care.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2630227"},"PeriodicalIF":2.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147486391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and diagnostic performance of a modified O-RADS model incorporating septa number and blood flow for adnexal lesions.","authors":"Ning Zhao, Dehong Che, Xiaokang Hu","doi":"10.1080/01443615.2026.2703279","DOIUrl":"https://doi.org/10.1080/01443615.2026.2703279","url":null,"abstract":"<p><strong>Background: </strong>Ovarian tumours are common among women, with ultrasound serving as the primary diagnostic tool. The O-RADS system classifies tumours into categories 1-5 based on malignancy risk. Category 4 tumours are the most challenging to diagnose, as they may be either benign or malignant, often leading to unnecessary surgery.</p><p><strong>Methods: </strong>This prospective study enrolled 723 patients with pathologically confirmed adnexal masses from July 2023 to May 2026. A total of 805 masses were included. All underwent standardised ultrasound with dynamic cine loop storage. Category 4 masses were subclassified into 4a (low-risk) and 4b (high-risk) based on locule count (>10 as high-risk) and colour score. Pathological results served as the gold standard.</p><p><strong>Results: </strong>Among 225 O-RADS Category 4 masses, the malignancy rate was 19.1% (43/225). The 4b subclass (86 masses) had a malignancy rate of 45.3% (39/86), significantly higher than the 4a subclass (139 masses, 2.9% (4/139)). Masses with >10 locules showed a 53.3% malignancy rate, while those with colour score 3-4 had a 38.6% malignancy rate. The combined model achieved an area under the curve of 0.956, significantly outperforming single predictors. Decision curve analysis indicated that this model could reduce unnecessary surgeries by approximately 18%.</p><p><strong>Conclusion: </strong>The modified O-RADS model effectively stratifies malignancy risk in adnexal masses, improving diagnostic accuracy and potentially reducing unnecessary surgical interventions.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2703279"},"PeriodicalIF":2.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148648325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Including support people in gestational diabetes mellitus education: Understanding providers' perspectives.","authors":"Erica A Mitchell, Patricia N E Roberson, Oluwafemifola Oyedeji, Ellen Oakes, Jordan Tasman, Rebecca Purvis, Lynlee Wolfe, Jill M Maples","doi":"10.1080/01443615.2026.2688959","DOIUrl":"https://doi.org/10.1080/01443615.2026.2688959","url":null,"abstract":"<p><p>Gestational Diabetes Mellitus (GDM) is a common pregnancy complication associated with adverse health outcomes. Health risks are reduced when GDM is well-controlled. Education and social support are key to optimal management; yet support people are rarely included in education. Semi-structured interviews were conducted with 10 healthcare providers (i.e., physicians, dieticians) to understand their perspectives on a) the role of support people in self-management, and b) including support people in education. Thematic analysis was used to identify common themes across interviews. Three themes emerged: (1) knowledge, (2) engagement, and (3) impact. Understanding what causes GDM is essential, and educating support people can improve engagement in implementing lifestyle changes and supporting patients in management. Social support can also reduce patient burden and stress. While relationship strain is possible, patients and support people who approach management together may find that it strengthens their relationship. Implications for designing education for patients and support people are discussed.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2688959"},"PeriodicalIF":2.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148338948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sociodemographic factors shaping knowledge-attitude-behaviour pathways in postpartum fall prevention.","authors":"Lan Yang, Li Xu","doi":"10.1080/01443615.2026.2678173","DOIUrl":"https://doi.org/10.1080/01443615.2026.2678173","url":null,"abstract":"<p><strong>Background: </strong>Postpartum falls threaten maternal and infant safety, yet evidence on postpartum women's fall-prevention knowledge, attitude, and behaviour (KAB) and their sociodemographic correlates remains limited. This study examined postpartum fall-prevention KAB and associations among KAB dimensions and in-hospital fall occurrence.</p><p><strong>Methods: </strong>In this cross-sectional study, 1,220 postpartum women from a tertiary hospital in Chengdu, China, completed a general questionnaire and a self-developed Postpartum Fall Prevention KAB Scale (Cronbach's α = 0.926). Multivariable linear regression examined associations of maternal education, companion education, and residence with KAB scores. Structural equation modelling examined associations among knowledge, attitude, behaviour, and in-hospital fall occurrence.</p><p><strong>Results: </strong>Higher maternal education was associated with higher knowledge (B = 0.22, 95% CI 0.06 to 0.38; <i>p</i> = 0.009), attitude (B = 0.23, 95% CI 0.02 to 0.43; <i>p</i> = 0.030), and behaviour scores (B = 0.57, 95% CI 0.02 to 1.11; <i>p</i> = 0.044). Residence was associated with attitude score (B = 0.77, 95% CI 0.13 to 1.41; <i>p</i> = 0.020), but not with knowledge or behaviour. Companion education was associated with behaviour score (B = -0.67, 95% CI -1.15 to -0.20; <i>p</i> = 0.005), but not with knowledge or attitude. In the structural model, knowledge was associated with attitude (estimate = 0.289, 95% CI 0.206 to 0.379; p < 0.001) and behaviour (estimate = 0.663, 95% CI 0.455 to 0.908; <i>p</i> < 0.001), and attitude was associated with behaviour (estimate = 0.471, 95% CI 0.304 to 0.634; <i>p</i> < 0.001). behaviour was not associated with in-hospital fall occurrence (estimate = 0.001, 95% CI -0.001 to 0.002; <i>p</i> = 0.506).</p><p><strong>Conclusions: </strong>Maternal education, residence, and companion education were associated with postpartum fall-prevention KAB scores. The findings support associations broadly consistent with the KAB framework, but causality cannot be inferred. Tailored fall-prevention education should be evaluated in longitudinal, multi-centre studies.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2678173"},"PeriodicalIF":2.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148308696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy biomarkers as early indicators of cardiovascular risk: a discussion article.","authors":"Giulia Renda, Daniele Falco, Sabina Gallina, Anna Vittoria Mattioli","doi":"10.1080/01443615.2026.2709737","DOIUrl":"https://doi.org/10.1080/01443615.2026.2709737","url":null,"abstract":"<p><p>Pregnancy provides a unique opportunity for early cardiovascular prevention by revealing maternal vascular and cardiometabolic vulnerability. Placental growth factor (PlGF), uterine artery Doppler and emerging inflammatory biomarkers may improve the identification of placental dysfunction and adverse pregnancy outcomes. However, their ability to predict long-term maternal cardiovascular risk remains uncertain. PlGF performance varies according to gestational age, clinical setting, population and assay platform, while inflammatory biomarkers such as S100A8/A9 remain investigational. Importantly, detecting placental dysfunction, recognising an adverse pregnancy outcome as a cardiovascular risk marker and demonstrating incremental long-term prognostic value are distinct concepts. Current evidence does not support biomarker-guided postpartum cardiovascular management. Obstetric history should therefore remain the principal trigger for cardiovascular counselling and follow-up. Prospective studies should determine whether standardised angiogenic and inflammatory biomarkers improve prediction beyond clinical and obstetric characteristics and whether their use translates into better cardiovascular outcomes.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2709737"},"PeriodicalIF":2.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148701607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional constipation in pregnancy and its association with dietary intake and physical activity: a cross-sectional study.","authors":"Roghayyeh Valizadeh, Khadije Hajizadeh, Zahra Ayyari-Maralani, Mojgan Mirghafourvand","doi":"10.1080/01443615.2026.2727541","DOIUrl":"https://doi.org/10.1080/01443615.2026.2727541","url":null,"abstract":"<p><strong>Background: </strong>Functional constipation (FC) is a common complaint during pregnancy and has been reported to be associated with physical activity and dietary intake. However, previous studies have reported inconsistent findings. Therefore, this study aimed to determine the prevalence of FC and examine its association with physical activity and dietary intake among pregnant women.</p><p><strong>Method: </strong>In this cross-sectional study, 381 healthy pregnant women attending urban health centres in Tabriz, Iran, between January 2024 and February 2025, were selected using a multistage cluster sampling method. FC was diagnosed according to the Rome IV criteria. Data were collected through face-to-face interviews using the International Physical Activity Questionnaire (IPAQ) and the Food Frequency Questionnaire (FFQ). Multivariable Generalised Estimating Equations (GEE) analysis was performed to identify factors associated with FC.</p><p><strong>Results: </strong>The overall prevalence of FC throughout pregnancy was 37%. In the first trimester, 41 out of 73 women (56%) had FC, while in the second trimester 53 out of 146 women (36%), and in the third trimester 47 out of 162 women (29%) were affected. Multivariate GEE indicated that both higher dietary fibre intake (aOR= 0.88, 95%CI 0.86-0.91, <i>p</i> < 0.001) and higher fluid intake (aOR= 0.59, 95%CI 0.52-0.67, <i>p</i> < 0.001) were associated with a reduced risk of FC. A normal BMI was associated with a lower risk of FC (aOR= 0.35, 95% CI 0.16-0.77, <i>p</i> = 0.009), whereas, secondary education was associated with a higher risk (aOR= 2.81, 95%CI 1.33-5.95, <i>p</i> = 0.007). Physical activity (aOR= 1.00; 95%CI 1.00 to 1.01; <i>p</i> = 0.168), and other demographic characteristics (<i>p</i> > 0.05) were not independently associated with FC after adjustment.</p><p><strong>Conclusion: </strong>FC is highly prevalent during pregnancy and may adversely affect women's quality of life. Higher dietary fibre and fluid intake were associated with lower odds of FC, highlighting the importance of healthy lifestyle behaviours during pregnancy. Prospective longitudinal studies are warranted to confirm these findings.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2727541"},"PeriodicalIF":2.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}