Journal of Obstetrics and Gynaecology最新文献

{"title":"High-density lipoprotein-related inflammatory indices and gynaecological cancer history: a cross-sectional analysis of NHANES.","authors":"Xiaoqin Yang, Sirong Cheng, Shanchen Wei, Xiaoxiao Liu, Wenxue Zhao, Ying Chu, Yali Huo","doi":"10.1080/01443615.2026.2721701","DOIUrl":"https://doi.org/10.1080/01443615.2026.2721701","url":null,"abstract":"<p><strong>Background: </strong>Cross-sectional associations of high-density lipoprotein-related inflammatory indices (HIRIs) - white-blood-cell-, lymphocyte-, monocyte-, neutrophil-, and platelet-to-high-density lipoprotein cholesterol (HDL-C) ratios (WHR, LHR, MHR, NHR, and PHR) - with self-reported gynaecological cancer (GC) history are unclear.</p><p><strong>Methods: </strong>We analysed 12,955 women from six National Health and Nutrition Examination Survey cycles (2007-2008 to 2017-March 2020 pre-pandemic), including 369 with GC history; cervical cancer (CC), 184; uterine cancer (UC), 127; and ovarian cancer (OC), 70. Primary analyses used survey-weighted logistic regression and restricted cubic spline (RCS) models with Benjamini-Hochberg false discovery rate (BH-FDR) correction; component-resolved and sensitivity analyses were supportive, and other secondary analyses were exploratory.</p><p><strong>Results: </strong>In fully adjusted models, overall GC history was nominally associated with PHR (odds ratio [OR] 1.26, 95% confidence interval [CI] 1.01-1.59; <i>p</i> = 0.045), the highest NHR tertile (OR 1.67, 95% CI 1.12-2.50; <i>p</i> = 0.013), and the highest WHR tertile (OR 1.56, 95% CI 1.04-2.34; <i>p</i> = 0.032). Subtype analyses showed selected nominal patterns, including an NHR tertile gradient for CC and WHR/LHR/PHR associations for UC; OC estimates were less stable. No primary logistic or RCS result survived BH-FDR correction. In supportive component-resolved analyses, the OC WHR white-blood-cell component met the BH-FDR threshold within the prespecified WHR-specific eight-test family (OR 2.40, 95% CI 1.35-4.25; <i>p</i> = 0.003; q = 0.025).</p><p><strong>Conclusions: </strong>HIRIs showed modest, heterogeneous cross-sectional associations with self-reported GC history, but the primary findings were not retained after multiplicity correction. These ratios appear to reflect both shared HDL-C and numerator-cell information and should be interpreted as descriptive, hypothesis-generating phenotypes rather than diagnostic, prognostic, or causal markers.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2721701"},"PeriodicalIF":2.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of aromatherapy on menopausal symptoms: a systematic review and meta-analysis.","authors":"Leila Bagheri, Ashraf Ghiasi, Fateme Biabani","doi":"10.1080/01443615.2026.2723303","DOIUrl":"10.1080/01443615.2026.2723303","url":null,"abstract":"<p><strong>Background: </strong>The postmenopausal period presents a significant challenge to women's health, characterised by vasomotor, psychological, and sleep disturbances. This systematic review and meta-analysis synthesised evidence on aromatherapy for menopausal symptoms.</p><p><strong>Methods: </strong>We searched Cochrane Library, Web of Science, ScienceDirect, PubMed, Scopus, SID, and Google Scholar until January 2, 2026. The protocol was registered (PROSPERO: CRD420261303084). Randomised controlled trials and quasi-experimental studies were included. The Cochrane Risk of Bias tool and GRADE approach were used for quality assessment and certainty of evidence. Meta-analyses were performed using RevMan 5.3.</p><p><strong>Results: </strong>Of 4435 records, 21 articles from 17 studies (<i>n</i> = 1347) were included. Aromatherapy significantly improved sexual function (MD: 7.05, 95% CI: 3.64-10.45), sleep quality (MD: -3.95, 95% CI: -5.94 to -1.97), overall menopausal symptoms (SMD: -1.00, 95% CI: -1.43 to -0.58), vasomotor symptoms (SMD: -0.79, 95% CI: -1.11 to -0.47), physical symptoms (SMD: -0.78, 95% CI: -1.10 to -0.46), somatic symptoms (MD: -1.34, 95% CI: -2.46 to -0.23), psychological symptoms (SMD: -0.59, 95% CI: -0.96 to -0.23), anxiety (SMD: -0.63, 95% CI: -1.10 to -0.16), and depression (SMD: -0.57, 95% CI: -0.85 to -0.28). No significant effect was found for urogenital symptoms. GRADE certainty was 'Very Low' for sexual function and sleep quality, and 'Low' for other outcomes.</p><p><strong>Conclusions: </strong>Preliminary evidence suggests that aromatherapy may be a beneficial complementary therapy for alleviating some menopausal symptoms. However, given the substantial heterogeneity, methodological limitations, and limited number of studies for subgroup analyses, firm clinical recommendations cannot be made at this time. More rigorous, large-scale, multi-centre randomised controlled trials with standardised interventions and consistent adverse event reporting are required before definitive clinical recommendations can be made.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2723303"},"PeriodicalIF":2.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148911956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From measuring analytes to generating diagnoses: the AI-based tests for endometriosis.","authors":"Marwan Habiba","doi":"10.1080/01443615.2026.2738515","DOIUrl":"https://doi.org/10.1080/01443615.2026.2738515","url":null,"abstract":"","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2738515"},"PeriodicalIF":2.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ejiao (Asini Corii Colla) promotes thin endometrium repair via upregulation of the SDF-1/CXCR4 signalling axis in a mouse model.","authors":"Mingdan Tan, Hui Wei, Dongyun Wei, Tingli Lai, Jing Xiao","doi":"10.1080/01443615.2026.2723304","DOIUrl":"https://doi.org/10.1080/01443615.2026.2723304","url":null,"abstract":"<p><strong>Background: </strong>Thin endometrium (TE) severely impairs embryo implantation and pregnancy outcomes in reproductive medicine, while first-line oestrogen-based therapy has marked limitations including receptor insensitivity and systemic side effects. Ejiao (Asini Corii Colla), a classic Traditional Chinese Medicine tonic, is widely used for gynecological disorders, yet its mechanism in endometrial regeneration remains unclear. This study aimed to investigate the therapeutic effect of Ejiao on TE and its regulation of the SDF-1/CXCR4 signalling axis.</p><p><strong>Methods: </strong>A TE mouse model was established via intrauterine infusion of 95% ethanol in female C57BL/6J mice. Mice were randomly divided into 4 groups (n = 6 per group): sham operation control group, TE model group, oestradiol positive control group (0.04 mg/kg/d), and Ejiao intervention group (0.2 g/kg/d), with 4 weeks of daily gavage intervention. Oestrous cycle stability was verified by vaginal smears, endometrial morphology was evaluated by HE staining, and SDF-1/CXCR4 mRNA expression in uterine tissues was detected by qPCR.</p><p><strong>Results: </strong>All mice maintained stable oestrous cycling throughout the experiment. Ejiao treatment markedly restored endometrial thickness and glandular density in TE mice, with a superior reparative effect to oestradiol, and significantly upregulated the mRNA expression of SDF-1 and CXCR4 in uterine tissue (<i>P</i> < 0.05 vs. model and oestradiol groups).</p><p><strong>Conclusions: </strong>Ejiao effectively promotes endometrial regeneration in TE mice via upregulating the SDF-1/CXCR4 signalling axis, providing preclinical mechanistic evidence for its clinical application in TE treatment.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2723304"},"PeriodicalIF":2.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149169614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case for expanding access to minimally invasive and uterine-preserving surgery in complex fibroid disease.","authors":"Caitlin S Stukel, Mostafa A Borahay","doi":"10.1080/01443615.2026.2732306","DOIUrl":"https://doi.org/10.1080/01443615.2026.2732306","url":null,"abstract":"","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2732306"},"PeriodicalIF":2.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149017320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative early mobilisation protocol for endometrial cancer patients: a retrospective study.","authors":"Li Yu, Ying Jiang, Honglian Luo, Ying Wang","doi":"10.1080/01443615.2026.2628967","DOIUrl":"10.1080/01443615.2026.2628967","url":null,"abstract":"<p><strong>Background: </strong>Standardised early mobilisation within Enhanced Recovery After Surgery (ERAS) for endometrial cancer is lacking. This study developed and evaluated a protocol.</p><p><strong>Methods: </strong>This retrospective study analysed outcomes of a clinical quality improvement initiative conducted at a tertiary care centre (February 2021-May 2022). <i>Phase 1</i>: Protocol developed via evidence/expert consensus. <i>Phase 2</i>: Retrospective analysis of 90 patients who received care in two units during the study period. Patients admitted to unit A (<i>n</i> = 45) received a structured early mobilisation protocol implemented as part of routine clinical practice improvement, whilst patients admitted to unit B (<i>n</i> = 45) received standard care. Ward assignment was determined by bed availability at admission without researcher involvement in allocation. <i>Primary outcomes</i>: Pulmonary function, physical capacity (ambulation time/day 5 walking distance) and gastrointestinal recovery. <i>Secondary</i>: Complications, LOS, emotional status (Brief Profile of Mood States, BPOMS). Statistical analyses included effect sizes and 95% confidence intervals.</p><p><strong>Results: </strong>The intervention group was associated with significantly better first ambulation (6.8 ± 2.1 h vs. 18.5 ± 4.3 h, mean difference: 11.7 h, 95% CI: 10.3-13.1, <i>p</i> < 0.001), day 5 walking distance (385 ± 68 m vs. 142 ± 45 m, mean difference: 243 m, 95% CI: 220-266, <i>p</i> < 0.001), time to first flatus (28.5 ± 6.2 h vs. 48.3 ± 8.5 h, mean difference: 19.8 h, 95% CI: 16.9-22.7, <i>p</i> < 0.001), fewer pulmonary complications (8.9% vs. 24.4%, OR: 0.30, 95% CI: 0.09-0.96, <i>p</i> = 0.047), shorter LOS (4.2 ± 1.1 d vs. 6.8 ± 1.5 d, mean difference: 2.6 d, 95% CI: 2.0-3.2, <i>p</i> < 0.001) and improved BPOMS anxiety/depression scores.</p><p><strong>Conclusions: </strong>This retrospective analysis suggests that the structured early mobilisation protocol, implemented as a clinical quality improvement initiative, was associated with improved recovery, reduced complications/LOS and better emotional wellbeing in endometrial cancer patients within ERAS.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2628967"},"PeriodicalIF":2.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146213516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global burden and trends of pelvic organ prolapse: an observational trend study from 1990 to 2021.","authors":"Shiguang Li, Baofang Zhang, Ping Li, Dongdong Hua, Tiantian Fu, Guohui Yan, Zhaoxia Liang, Danqing Chen","doi":"10.1080/01443615.2026.2617556","DOIUrl":"10.1080/01443615.2026.2617556","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to estimate the global trend of age-standardised incidence rates (ASIR) and age-standardised disability-adjusted life years (AS-DALYs) of pelvic organ prolapse from 1990 to 2021, and analyse the separate effects of age, period and birth cohort.</p><p><strong>Methods: </strong>Data of pelvic organ prolapse's ASIR and AS-DALYs were obtained from the Global Burden of Disease (GBD) 2021. The regions were classified by the socio-demographic index (SDI). An age-period-cohort (APC) model was employed to analyse the effect of every age, period and birth cohort on pelvic organ prolapse's ASIR.</p><p><strong>Results: </strong>In 2021, the global ASIR and AS-DALY were 317.51 (95% UI, 267.67-378.25) and 8.68 (95% UI, 4.26-16.38) per 100,000 population, respectively. The rates decreased globally and in five SDI regions from 1990 to 2021. APC analysis demonstrated that ASIR significantly increased with advancing age, exhibiting a bi-peak curve, with one peak appearing around 50 years and the other around 70 years.</p><p><strong>Conclusion: </strong>Over the past 32 years, the global ASIR and AS-DALY of pelvic organ prolapse have continued to decrease significantly, while in low SDI regions, the rates remain high. These findings highlight the need for targeted pelvic organ prolapse prevention programs and proper investment in pelvic floor care in low SDI regions.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2617556"},"PeriodicalIF":2.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146125295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive performance of multiple anthropometric obesity indicators for female infertility risk: a cross-sectional study.","authors":"Yaru Yang, Qing Xie, Yaying Lin, Shuaichao Li, Chunlin Dong, Jingjing Peng, Jinjin Yu, Yuan Wang, Yibo Wu","doi":"10.1080/01443615.2026.2680122","DOIUrl":"10.1080/01443615.2026.2680122","url":null,"abstract":"<p><strong>Background: </strong>Various obesity metrics are used to assess female infertility risk, but their relative prognostic value remains unclear. This cross-sectional study systematically evaluated 16 anthropometric indices to identify the most effective predictors.</p><p><strong>Methods: </strong>Using National Health and Nutrition Examination Survey (NHANES) 2017-2020 data (<i>n</i> = 1154 reproductive-aged women), we applied a three-phase framework: (1) weighted restricted cubic spline (RCS) models were applied to examine potential non-linear associations between 16 anthropometric obesity indicators and female infertility risk, with univariate analyses used to assess their statistical associations, (2) two model states ('real-world settings' and 'ideal-world settings') were constructed based on the union and intersection of indicator datasets, and weighted logistic regression models were developed for each state and (3) predictive performance and clinical utility were assessed using receiver operating characteristic (ROC) curves, calibration curves and decision curve analysis (DCA), with key diagnostic metrics compared to identify optimal predictors.</p><p><strong>Results: </strong>Thirteen obesity indicators showed predictive value for infertility; Anthropometric Body Shape Index (ABSI) exhibited a U-shaped association, whereas the others demonstrated positive linear relationships. Body mass index (BMI), Weight-Adjusted Waist Index (WWI) and Conicity Index (CI) demonstrated relatively better predictive performance (AUC > 0.65), with WWI showing slightly stronger association with infertility than the other indicators in both model states (adjusted OR = 1.40, 95% CI: 1.10-1.77; AUC = 0.656; results were consistent across the two model states).</p><p><strong>Conclusions: </strong>Thirteen obesity indicators predicted infertility; ABSI was U-shaped, others were linear. WWI was slightly superior, though differences were modest.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2680122"},"PeriodicalIF":1.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148150000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Statement: Vaginal length and sexual function after vertical versus horizontal closure of the vaginal cuff after abdominal hysterectomy: a randomised clinical trial.","authors":"","doi":"10.1080/01443615.2026.2687340","DOIUrl":"https://doi.org/10.1080/01443615.2026.2687340","url":null,"abstract":"","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2687340"},"PeriodicalIF":1.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148239689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of oral calcium carbonate on uterine contractility: a pilot randomised controlled trial.","authors":"Tina M Bui, Michelle Nelson, Rabia Rehman, Robert J Stowe Ii, Kristina A Roloff, Guillermo J Valenzuela","doi":"10.1080/01443615.2026.2697258","DOIUrl":"10.1080/01443615.2026.2697258","url":null,"abstract":"<p><strong>Background: </strong>Ineffective uterine contractions contribute to labour dystocia and are a leading indication for primary caesarean delivery. Although oxytocin is the standard therapy for augmentation, prolonged exposure may result in receptor desensitisation and reduced effectiveness. Calcium is essential for myometrial contraction; however, systemic calcium homeostasis is tightly regulated, and it is unclear whether oral calcium supplementation can meaningfully influence uterine activity. This study aimed to evaluate the effect of oral calcium carbonate on uterine contractility.</p><p><strong>Methods: </strong>We conducted a single-centre randomised controlled pilot trial at a tertiary care teaching hospital (ClinicalTrials.gov: NCT07056062). Term patients with singleton foetus in cephalic presentation and an intrauterine pressure catheter in place were randomised 1:1 to receive a single 2,000 mg oral dose of calcium carbonate or no intervention. Uterine activity was measured using Montevideo units (MVUs) at baseline and at 30-minute intervals for two hours. Secondary outcomes included contraction frequency, peak contraction pressure, labour duration, mode of delivery, oxytocin dose, and postpartum haemorrhage. Oxytocin infusion rates were held constant during the observation period.</p><p><strong>Results: </strong>Eighty-nine patients were analysed (45 control; 44 intervention) with similar baseline characteristics. No statistically significant difference in baseline MVUs was observed between groups (<i>p</i> = 0.1825). Although absolute MVUs were higher in the intervention group at 30 minutes (<i>p</i> = 0.0500), this difference was not sustained at subsequent time points and was absent in change-from-baseline analyses, suggesting no clinically meaningful treatment effect. No statistically significant differences were identified in secondary outcomes.</p><p><strong>Conclusions: </strong>Oral calcium carbonate did not result in a statistically significant improvement in uterine contractility or clinical outcomes. These findings likely reflect the limited physiologic effect of oral calcium on serum calcium levels. Oral calcium carbonate appears unlikely to be an effective intervention for labour augmentation; future research should focus on strategies with more controllable mechanisms.</p>","PeriodicalId":16627,"journal":{"name":"Journal of Obstetrics and Gynaecology","volume":"46 1","pages":"2697258"},"PeriodicalIF":2.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148549496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}