Journal of Nutrition最新文献

{"title":"p-Hydroxycinnamic Acids: Advancements in Synthetic Biology, Emerging Regulatory Targets in Gut Microbiota Interactions, and Implications for Animal Health.","authors":"Chunlai Ma, Ziqi Liang, Yuan Wang, Huiying Luo, Xiaojun Yang, Bin Yao, Tao Tu","doi":"10.1016/j.tjnut.2025.01.034","DOIUrl":"10.1016/j.tjnut.2025.01.034","url":null,"abstract":"<p><p>p-hydroxycinnamic acids (p-HCAs), a class of natural phenolic acid compounds extracted from plant resources and widely distributed, feature a C6-C3 phenylpropanoid structure. Their antioxidant, anti-inflammatory, and antibacterial activities have shown great potential for applications in food and animal feed. The interactions between p-HCAs and the gut microbiota, as well as their subsequent effects on animal health, have increasingly attracted the attention of researchers. In the context of a greener and safer future, the progress and innovation in biosynthetic technology have occupied a central position in ensuring the safety of food and feed. This review emphasizes the complex mechanisms underlying the interactions between p-HCAs and the gut microbiota, providing a solid explanation for the remarkable bioactivities of p-HCAs and their subsequent impact on animal health. Furthermore, it explores the advancements in the synthetic biology of p-HCAs. This review could aid in a basis for better understanding the underlying interactions between p-HCAs and gut microbiota and animal health.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143123051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Premeal Pistachio Supplementation on Cardiometabolic Risk Factors among Asian Indian Adults with Prediabetes: A Randomized Controlled Trial.","authors":"Karthikeyan Ashwini, Kuzhandhaivelu Abirami, Rajagopal Gayathri, Sekar Sasikala, Vasudevan Sudha, Shanmugam Shobana, Raman Ganesh Jeevan, Kamala Krishnaswamy, Vadivelu Deepika, Marimuthu Rajalakshmi, Mookambika Ramya Bai R, Karthikeyan Parkavi, Soundararajan Padmavathi, Ranjit Mohan Anjana, Ranjit Unnikrishnan, Frank B Hu, Walter C Willett, Jordi Salas-Salvadó, Shilpa N Bhupathiraju, Viswanathan Mohan","doi":"10.1016/j.tjnut.2024.12.005","DOIUrl":"10.1016/j.tjnut.2024.12.005","url":null,"abstract":"<p><strong>Background: </strong>Asian Indians are susceptible to developing type 2 diabetes at a lower age and often consume diets that are high in glycemic load and low in healthy fats.</p><p><strong>Objectives: </strong>This study aimed to evaluate the effect of 30 g prebreakfast and 30 g predinner supplementation of pistachios for 12 wk on glycated hemoglobin (HbA1c), other glycemic markers, anthropometry, and lipid profile of Asian Indians with prediabetes.</p><p><strong>Methods: </strong>In a 12-wk parallel arm, randomized controlled trial, we recruited 120 participants with prediabetes based on American Diabetes Association criteria. The intervention group (n = 60) consumed 60 g pistachios (30 g prebreakfast and predinner) whereas the control group (n = 60) followed a routine diet that excluded nuts. At baseline and 12 wk, we collected blood samples for biochemical analysis, anthropometrics, and 24-h recalls. Participants wore a continuous glucose monitoring (CGM) sensor during the trial's first and last 2 wk. Urinary N-methyl-trans-4-hydroxy-l-proline (MHP) was measured as a marker of pistachio consumption.</p><p><strong>Results: </strong>A total of 109 participants completed the study (follow-up rate = 90.8%). Compared with participants in the control group, those in the intervention group had significant reductions in HbA1c (mean between-group difference: -0.2; 95% confidence interval: -0.3, -0.1; P < 0.001] with no significant changes in fasting or 2-h post glucose load plasma glucose. Compared with the control group, the intervention group had significant reductions in serum triglyceride, waist circumference, lipid accumulation product, visceral adiposity index, and atherogenic index. Urinary MHP (mg/g creatinine) showed a 62% increase in the intervention compared with the control group (P < 0.05). CGM data revealed significant decreases in the incremental area under the curve, 2-h after breakfast (28%, p=0.01) and after dinner (17%, P = 0.002) in the intervention group compared to the control group.</p><p><strong>Conclusions: </strong>A 12-wk, premeal load of 60 g pistachios lowers HbA1c and improves cardiometabolic profile among Asian Indians with prediabetes. This is among the first studies to investigate these effects in this ethnic group. This study was registered in the Clinical Trial Registry of India as CTRI/2020/11/029340.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surveillance and Evaluation of Vitamin D Nutrition and Its Health Impact in Chinese Older Adults.","authors":"Wenxuan Wu, Ji-Chang Zhou, Licheng Yang","doi":"10.1016/j.tjnut.2025.01.030","DOIUrl":"10.1016/j.tjnut.2025.01.030","url":null,"abstract":"<p><p>Vitamin D is an essential fat-soluble vitamin for humans and vitamin D deficiency (VDD) affects all age groups, with older adults being at high risk of VDD. A deficiency in vitamin D has been associated with a range of health concerns in older adults, including osteomalacia and osteoporosis. Additionally, there is limited evidence suggesting that VDD may be associated with increased risk of developing cognitive impairment, muscle-wasting disorders, cardiovascular disease, type 2 diabetes mellitus, and mortality. This review synthesizes the latest research advances in China and abroad to provide detailed information on the current status of vitamin D nutritional monitoring, causes of deficiency, health risks, and proposed intake for reducing risk of diet-related noncommunicable diseases in the Chinese older adults.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the Effectiveness of Protein Supplementation Combined with Resistance Training on Body Composition and Physical Function in Healthy Elderly Adults.","authors":"Haiping Tian, Wanwan Qiao, Xianxiu Wen","doi":"10.1016/j.tjnut.2025.01.017","DOIUrl":"10.1016/j.tjnut.2025.01.017","url":null,"abstract":"<p><strong>Background: </strong>The global population of individuals over 65 y is expected to reach 426 million by 2050. Aging is associated with a progressive loss of muscle mass, strength, and function, leading to sarcopenia and adverse outcomes such as physical disability and increased mortality. Interventions such as resistance training and protein supplementation have shown promise in mitigating these effects.</p><p><strong>Objectives: </strong>To determine the comparative effectiveness of protein supplementation, resistance training, and their combination on body composition and physical function in healthy older adults through a network meta-analysis.</p><p><strong>Methods: </strong>We conducted a systematic review and network meta-analysis following PRISMA guidelines and registered it in PROSPERO (CRD42021226561). We included randomized controlled trials comparing protein supplementation, resistance training, and their combination in participants aged ≥50 y. Data were extracted from PubMed, Web of Science, Embase, and Cochrane Library. The risk of bias was assessed using the Cochrane Collaboration Risk of Bias Tool.</p><p><strong>Results: </strong>A total of 38 randomized controlled trials involving 2610 participants were included. The combined intervention of protein supplementation and resistance training significantly improved lean body mass (standardized mean difference [SMD]: 0.44; 95% confidence interval [CI]: 0.05, 0.95) compared with protein supplementation alone. The combined intervention also showed significant improvements in muscle mass (SMD: 1.49; 95% CI: 0.11, 2.67). The combined intervention (SMD: 2.74; 95% CI: 0.76, 4.74) and resistance training alone (SMD: 2.53, 95% CI: 0.29, 4.84) significantly improved muscle strength compared with controls. The combined intervention (SMD: 4.98; 95% CI: 2.72, 7.17) and resistance training alone (SMD: 4.52; 95% CI: 2.30, 6.64) significantly improved physical function compared with protein supplementation alone.</p><p><strong>Conclusions: </strong>Combining exercise and protein supplementation is the most effective method for improving muscle mass, strength, and physical function in older adults. This approach should be considered to enhance physical health in this population. Future large-scale trials are necessary to confirm these findings.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Odd-Chain Fatty Acid-Enriched Fats Improve Growth and Intestinal Morphology and Function in Milk Replacer-Fed Piglets.","authors":"Geyan Duan, Mengmeng Li, Changbing Zheng, Mengliao Wan, Jiayi Yu, Bo Cao, Yulong Yin, Yehui Duan, Fang Cong","doi":"10.1016/j.tjnut.2025.01.021","DOIUrl":"10.1016/j.tjnut.2025.01.021","url":null,"abstract":"<p><strong>Background: </strong>The intestinal development and nutritional needs of piglets after birth are similar to those of human infants.</p><p><strong>Objectives: </strong>This study aimed to investigate the effect of different forms of odd-chain fatty acids (OCFAs) on the growth and intestinal morphology and function of milk replacer-fed piglets, as a model for human infants.</p><p><strong>Methods: </strong>Forty 7-d-old piglets from 8 sows were randomly assigned into 5 groups (n = 8, each from a different litter) and fed sow milk or milk replacers supplemented with different kinds of fats (control fats, docosahexaenoic acid algal oil-, OCFA algal oil-, and OCFA-enriched fats) for 21 d. One-way analysis of variance was performed to compare the milk replacer-fed piglet groups, and unpaired t test was used to compare sow milk- and milk replacer-fed piglets.</p><p><strong>Results: </strong>Milk replacers supplemented with OCFA-enriched fats increased the average daily gain (ADG), ratio of villus height to crypt depth, and protein expression of Ki67, phosphorylated (p)-mTOR, p-p70S6k, Occludin, Claudin, and ZO-1 in the selected intestines of piglets and decreased the protein expression of p-ULK1, Parkin, and PINK1 to levels similar to those of the sow milk-fed group (P < 0.05).</p><p><strong>Conclusion: </strong>Overall, milk replacers supplemented with OCFA-enriched fats improved the ADG and the intestinal morphology and function of piglets to levels comparable to those of the sow milk-fed piglets.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low Vitamin K Intake Impairs Cognition, Neurogenesis, and Elevates Neuroinflammation in C57BL/6 Mice.","authors":"Tong Zheng, Shannon Marschall, Jasper Weinberg, Xueyan Fu, Andrew Tarr, Barbara Shukitt-Hale, Sarah L Booth","doi":"10.1016/j.tjnut.2025.01.023","DOIUrl":"10.1016/j.tjnut.2025.01.023","url":null,"abstract":"<p><strong>Background: </strong>In addition to its important roles in blood coagulation and bone formation, vitamin K (VK) contributes to brain function. Low dietary VK intake, which is common among older adults, is associated with age-related cognitive impairment.</p><p><strong>Objectives: </strong>To elucidate the biological mechanisms underlying VK's effects on cognition, we investigated the effects of low VK (LVK) intake on cognition in C57BL/6 mice.</p><p><strong>Methods: </strong>Male and female 9-mo-old C57BL/6 mice (n = 60) were fed an LVK diet or a control diet for 6 mo. Behavioral tests were performed on a subset of mice (n = 26) at 15 mo, and brain tissues were collected for follow-up analyses.</p><p><strong>Results: </strong>Menaquinone-4, the predominant VK form in the brain, was significantly lower in LVK mice compared to controls (15.6 ± 13.3 compared with 189 ± 186 pmol/g, respectively, P < 0.01). LVK mice showed reduced recognition memory in the novel object test by spending a lower percentage of time exploring the novel object compared to controls (47.45% ± 4.17 compared with 58.08% ± 3.03, P = 0.04). They also spent a significantly longer time learning the task of locating the platform in the Morris water maze test. Within the hippocampal dentate gyrus, LVK mice had a significantly lower number of proliferating cells and fewer newly generated immature neurons compared to control mice. Additionally, more activated microglia cells were identified in the LVK mice.</p><p><strong>Conclusions: </strong>Our data indicate that LVK intake reduced menaquinone-4 concentrations in brain tissues and impaired learning- and memory-related cognitive function. This impairment may be related to the observed reduced hippocampal neurogenesis and elevated neural inflammation.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generative Artificial Intelligence in Nutrition: A Revolution in Accessibility and Personalization.","authors":"Nicola Pugliese, Federico Ravaioli","doi":"10.1016/j.tjnut.2025.01.025","DOIUrl":"10.1016/j.tjnut.2025.01.025","url":null,"abstract":"","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intimate Partner Violence and Women's Dietary Diversity: A Population-Based Investigation in 8 Low- and Middle-Income Countries.","authors":"Luissa Vahedi, Manuela Orjuela-Grimm, Pui Man Pamela Chan, Sarah R Meyer","doi":"10.1016/j.tjnut.2025.01.024","DOIUrl":"10.1016/j.tjnut.2025.01.024","url":null,"abstract":"<p><strong>Background: </strong>Intimate partner violence (IPV) poses a significant threat to the well-being of women and girls and is a highly prevalent form of gender-based violence. Evidence regarding the nutritional implications of IPV has focused primarily on intergenerational relationships with child nutrition and growth. There remains a knowledge gap regarding the association with women's own dietary intake.</p><p><strong>Objectives: </strong>We investigated relationships between past-year IPV (physical, emotional, and sexual) and women's dietary habits, using the Minimum Dietary Diversity for Women tool.</p><p><strong>Methods: </strong>The data sources analyzed were the cross-sectional Demographic and Health Surveys conducted in Cambodia (2021, N = 5618), Nepal (2022, N = 4155), Sierra Leone (2019, N = 3808), Nigeria (2018, N = 8313), Tajikistan (2017, N = 4792), Cote D'Ivoire (2022, N = 3654), Kenya (2022, N = 10,717), and the Philippines (2022, N = 12,240). Utilizing multivariable generalized linear models, we assessed the overall relationship between women's exposure to IPV and 1) the number of food groups consumed and 2) minimum dietary diversity.</p><p><strong>Results: </strong>Our results reveal heterogeneous relationship patterns between IPV and women's diet. Although none of the pooled estimates were significant and there were a large number of nonsignificant associations, IPV was associated with consuming a lower number of total food groups and reduced consumption of a diverse diet in Nigeria, Kenya, and the Philippines. There is evidence that in Tajikistan, physical violence relates to an increased number of food groups consumed.</p><p><strong>Conclusions: </strong>IPV is associated with altered dietary intake patterns within certain low- and middle-income countries. The directionality of associations may depend on local food environments and food access. Further research is needed to clarify the pathways underlying these findings. These pathways may involve impacts of IPV that influence diet and food access, for example, mental health symptoms and disorders and related coping mechanisms.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma Alkylresorcinols Is an Objective Biomarker for Gluten Intake in Young Children.","authors":"Elin M Hård Af Segerstad, Emelie Ericson-Hallström, Anna Bokström, Marina Armeni, Otto Savolainen, Carin Andrén Aronsson","doi":"10.1016/j.tjnut.2025.01.020","DOIUrl":"10.1016/j.tjnut.2025.01.020","url":null,"abstract":"<p><strong>Background: </strong>Alkylresorcinols are a well-established biomarker for whole-grain intake. There is evidence suggesting that total plasma alkylresorcinol concentration may also be used as a biomarker for gluten intake in adults.</p><p><strong>Objectives: </strong>The aim of this study was to evaluate if total alkylresorcinol concentration is a valid biomarker for gluten intake in young children.</p><p><strong>Methods: </strong>Nonfasting plasma alkylresorcinol concentrations were analyzed by normal-phase ultrahigh-pressure liquid chromatography-tandem mass spectrometry in 65 children aged 18 mo included in a randomized controlled trial. The intervention group was following a gluten-free diet (n = 21, 31.3%), whereas the diet was unrestricted in the control group (n = 44, 65.7%). Alkylresorcinol concentrations in the 65 children were validated against simultaneously collected 3-d food records estimating total gluten intake.</p><p><strong>Results: </strong>Gluten intake in controls was median 5.8 grams/d (IQR: 2.8-9.4, max 17.1) compared with 0.0 g/d (IQR: 0.0-0.0, max 0.7, P < 0.001) in the intervention group. In the control group, wheat accounted for mean 85% (SD: 0.1) of the gluten intake. The intervention group had lower alkylresorcinol levels (median: 7.2 nmol/L; IQR: 4.0-10.5) compared with controls (median: 269; IQR: 116-505 nmol/L, P < 0.001). The correlation between alkylresorcinol concentrations and gluten intake was ρ = 0.68 (P < 0.001). Alkylresorcinol concentrations increased by 35.7% [95% confidence interval (CI): 25.9, 46.2, P < 0.001] for every g/d increase of gluten intake. The Cohen's weighted kappa between quartiles of alkylresorcinol and gluten intake was 0.73 (95% CI: 0.59, 0.86).</p><p><strong>Conclusions: </strong>Alkylresorcinol concentrations increased with gluten intake in young nonfasting children. The findings suggest that alkylresorcinol concentrations may be a useful biomarker for gluten intake in young children. This trial was registered at clinicaltrials.gov as NCT03562221.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Carbohydrate Quality Is Associated with Epigenetic Age Acceleration: a Cross-Sectional Study of the CARDIA Cohort.","authors":"So-Yun Yi, Lyn M Steffen, David R Jacobs, Brian Joyce, Weihua Guan, Daniel Duprez, Kamakshi Lakshminarayan, Yinan Zheng, Lifang Hou","doi":"10.1016/j.tjnut.2025.01.022","DOIUrl":"10.1016/j.tjnut.2025.01.022","url":null,"abstract":"<p><strong>Background: </strong>Dietary intake is one lifestyle factor that is expected to impact gene expression by altering DNA methylation (DNAm), thus affecting epigenetic aging. Studies on the association between quality of carbohydrates and epigenetic age acceleration (EAA) are scarce despite the evidence that quality may be more important than amount of carbohydrates consumed.</p><p><strong>Objectives: </strong>We aimed to identify the cross-sectional associations of carbohydrate quality and fiber-rich food score with EAA in the Coronary Artery Risk Development in Young Adults (CARDIA) study.</p><p><strong>Methods: </strong>Trained interviewers administered the CARDIA Diet History to obtain dietary intake at examination year 20. EAA measures, PhenoAge acceleration (PhenoAA) and GrimAge acceleration (GrimAA), were generated based on epigenetic age estimates calculated using DNAm profiling data from fasting blood samples at examination years 20, 25, and 30. Linear mixed-effects regression models were used to evaluate the association of carbohydrate quality, defined using carbohydrate:fiber ratio, and fiber-rich food score with EAA measures.</p><p><strong>Results: </strong>After adjusting for demographic and lifestyle factors, quartiles of carbohydrate quality (defined using carbohydrate:fiber ratio) were inversely associated with PhenoAA and GrimAA; the highest carbohydrate quality quartile showing a difference (standard error [SE]) of -1.19 (0.2) y for PhenoAA (P-trend < 0.001) and -1.20 (0.1) y for GrimAA (P-trend < 0.001) compared with the lowest carbohydrate quality quartile. Similarly, quartiles of fiber-rich food score (created based on daily intakes of whole grains, fruit, vegetables, nuts, and legumes) were inversely associated with PhenoAA and GrimAA; the highest quartile showing a difference (SE) of -1.06 (0.2) y for PhenoAA (P-trend = 0.002) and -1.31 (0.2) y for GrimAA (P-trend < 0.001) compared with the lowest quartile.</p><p><strong>Conclusions: </strong>Our findings suggest that consuming a high carbohydrate quality diet and a dietary pattern composed of fiber-rich foods is cross-sectionally associated with slower biological aging.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}