Journal of Nutrition最新文献

{"title":"Suggested PACE Phenotype Ignored Parent-Child Feeding Dynamics","authors":"Ellyn Satter, Barbara Lohse","doi":"10.1016/j.tjnut.2024.10.002","DOIUrl":"10.1016/j.tjnut.2024.10.002","url":null,"abstract":"","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"154 12","pages":"Pages 3852-3853"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns and Determinants of Micronutrient Dietary Biomarkers and Their Associations with Dietary Intakes in Young Children","authors":"Joanna L Clasen ,&nbsp;Jimin Yang ,&nbsp;Leena Hakola ,&nbsp;Petra Arohonka ,&nbsp;Kristian Lynch ,&nbsp;Hemang M Parikh ,&nbsp;Carin Andrén Aronsson ,&nbsp;Ulla Uusitalo ,&nbsp;Jill M Norris ,&nbsp;Suvi M Virtanen ,&nbsp;Iris Erlund","doi":"10.1016/j.tjnut.2024.10.001","DOIUrl":"10.1016/j.tjnut.2024.10.001","url":null,"abstract":"<div><h3>Background</h3><div>Circulating dietary biomarkers are not direct proxies for intake, as the biomarkers reflect not only food and supplement consumption but also nutrient absorption, metabolism, and tissue distribution. Therefore, along with nutrient intake, several other upstream factors can impact dietary biomarker concentrations, including demographic, medical history, and genetic factors.</div></div><div><h3>Objectives</h3><div>The aim of this study was to explore the dietary and nondietary determinants of circulating levels of vitamins A, C, D, and E among children aged 6 mo–4 y.</div></div><div><h3>Methods</h3><div>Plasma retinol, β-carotene, ascorbic acid, 25(OH)D, α-tocopherol, and γ-tocopherol were measured in 2887 samples from 1490 children enrolled in The Environmental Determinants of Diabetes in the Young study. Dietary intake was assessed with 3-d food records. Associations of genetic and environmental factors with biomarker concentrations were examined using multivariable linear regression models with random intercepts.</div></div><div><h3>Results</h3><div>All biomarkers except retinol were positively associated with intake of the same nutrient. Inverse associations were identified between recent gastrointestinal infection and β-carotene, ascorbic acid, and α-tocopherol, whereas recent respiratory infection was associated inversely with plasma retinol. Several genetic determinants of biomarker status were identified, validating previously reported findings. For some genetic and environmental exposures, we found evidence of statistical interaction with same-nutrient intake, indicating that the association between intake and biomarker concentration is dependent on the level or status of these other exposures. For example, the association between β-carotene intake and concentration is weaker among children with a recent respiratory infection.</div></div><div><h3>Conclusions</h3><div>Our findings suggest that nondietary exposures including childhood infections can alter micronutrient metabolism. This summary of micronutrient determinants will facilitate improved design of future analyses exploring the role of diet in childhood chronic disease etiology through a better understanding of relevant potential confounders and mediators of the diet–outcome relationships.</div></div>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"154 12","pages":"Pages 3749-3760"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Soluble Fiber α-Cyclodextrin and the Fecal Losses of Dietary Fat in Adults – A Double Blind, Randomized, Placebo-Controlled, Crossover Study","authors":"Kai-Lin Catherine Jen,&nbsp;Joseph D Artiss","doi":"10.1016/j.tjnut.2024.09.029","DOIUrl":"10.1016/j.tjnut.2024.09.029","url":null,"abstract":"","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"154 12","pages":"Pages 3847-3849"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142348628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D in Multiple Sclerosis: A Comprehensive Umbrella Review","authors":"Hamid Abbasi ,&nbsp;Sara Khoshdooz ,&nbsp;Emad Alem ,&nbsp;Farnush Bakhshimoghaddam ,&nbsp;Saeid Doaei ,&nbsp;Mark O Goodarzi","doi":"10.1016/j.tjnut.2024.10.004","DOIUrl":"10.1016/j.tjnut.2024.10.004","url":null,"abstract":"<div><h3>Background</h3><div>Multiple sclerosis (MS) is an inflammatory neuroimmune disease with a multifaceted etiology and long-lasting adverse effects. Several studies have explored the role of 25-hydroxyvitamin D (25(OH)D) serum levels, vitamin D receptor (VDR) gene polymorphisms, and vitamin D supplementation (VDS) in individuals with MS.</div></div><div><h3>Objectives</h3><div>The aim of this study was to evaluate the relationship of MS with 25(OH)D serum levels, VDR gene polymorphisms, and VDS.</div></div><div><h3>Methods</h3><div>We assessed relevant articles published in PubMed, Scopus, and Web of Science from the inception up to 24 February, 2024. Meta-analyses that investigated the link of 25(OH)D serum levels, VDR gene polymorphisms including Apal (rs7975232), BsmI (rs1544410), Taql (rs731236), and Fokl (rs10735810), and VDS with the risk and clinical manifestations of MS were included. The methodological quality of selected articles was assessed by the Assessment of Multiple Systematic Reviews version 2. The statistical analysis of this umbrella review was carried out using RStudio version 2023.03.1 and R version 4.3.2, simultaneously.</div></div><div><h3>Results</h3><div>A total of 23 of 304 records were entered into this umbrella review with a pooled sample size of 37,567 participants. Eleven articles were rated as high quality, 1 was moderate quality, 1 was low quality, and 10 were critically low quality. The homozygote model of FokI (FF+ff compared with Ff) was significantly associated with an 8% reduction of MS risk (odds ratio: 0.92, 95% confidence interval: 0.86, 0.98; <em>I</em>² = 0%, <em>P</em> &gt; 0.99).</div></div><div><h3>Conclusion</h3><div>According to existing clinical evidence, the risk of MS may be associated with VDR gene polymorphism. Further studies are needed to explore the association of MS and vitamin D.</div></div><div><h3>Trial registration number</h3><div>This trial was registered at International Prospective Register of Systematic Reviews (PROSPERO) as registration number CRD42024521541.</div></div>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"154 12","pages":"Pages 3505-3520"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the Effects of Inappropriate Meal Timing-Induced and Genetic Models of Circadian Clock Disruption on Uterine mRNA Expression Profiles","authors":"Yuchen Chen ,&nbsp;Takashi Hosono ,&nbsp;Masanori Ono ,&nbsp;Takiko Daikoku ,&nbsp;Natsumi Toyoda ,&nbsp;Satoshi Nomura ,&nbsp;Kyosuke Kagami ,&nbsp;Shunsuke Orisaka ,&nbsp;Shin-ichi Horike ,&nbsp;Yifan Shi ,&nbsp;Pingping Xu ,&nbsp;Jun-ichi Morishige ,&nbsp;Tomoko Fujiwara ,&nbsp;Hiroshi Fujiwara ,&nbsp;Hitoshi Ando","doi":"10.1016/j.tjnut.2024.10.011","DOIUrl":"10.1016/j.tjnut.2024.10.011","url":null,"abstract":"<div><h3>Background</h3><div>Accumulating evidence reveals that inappropriate meal timing contributes to the development of lifestyle-related diseases. An underlying mechanism is thought to be the disruption of the intracellular circadian clock in various tissues based on observations in both systemic and tissue-specific clock gene-deficient mice. However, whether the effects of conditional clock gene knockout are comparable to those of inappropriate meal timing remains unclear.</div></div><div><h3>Objectives</h3><div>This study aimed to compare the effects of a recently developed 28-h feeding cycle model with those of a core clock gene <em>Bmal1</em> uterine conditional knockout (<em>Bmal1</em> cKO) model on uterine mRNA expression profiles.</div></div><div><h3>Methods</h3><div>The models were generated by subjecting C57BL/6J mice to an 8-h/20-h feeding/fasting cycle for 2 wk and crossing <em>Bmal1</em>-floxed mice with <em>PR</em>-<em>Cre</em> mice. Microarray analyses were conducted using uterine samples obtained at the beginning of the dark and light periods.</div></div><div><h3>Results</h3><div>The analyses identified 516 and 346, significantly 4-fold and 2-fold, up- or downregulated genes in the 28-h feeding cycle and <em>Bmal1</em> cKO groups, respectively, compared with each control group. Among these genes, only 7 (1.4%) and 63 (18.2%) were significantly up- or downregulated in the other model. Moreover, most (<em>n</em> = 44, 62.9%) of these genes were oppositely regulated. These findings were confirmed by gene set enrichment analyses.</div></div><div><h3>Conclusions</h3><div>This study reveals that a 28-h feeding cycle and <em>Bmal1</em> cKO differently affect gene expression profiles and highlights the need for considering this difference to assess the pathophysiology of diseases associated with inappropriate meal timing.</div></div>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"154 12","pages":"Pages 3718-3725"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meals Containing Equivalent Total Protein from Foods Providing Complete, Complementary, or Incomplete Essential Amino Acid Profiles do not Differentially Affect 24-h Skeletal Muscle Protein Synthesis in Healthy, Middle-Aged Women","authors":"Emily J Arentson-Lantz ,&nbsp;Zachary Von Ruff ,&nbsp;Gavin Connolly ,&nbsp;Frank Albano ,&nbsp;Sean P Kilroe ,&nbsp;Adam Wacher ,&nbsp;Wayne W Campbell ,&nbsp;Douglas Paddon-Jones","doi":"10.1016/j.tjnut.2024.10.010","DOIUrl":"10.1016/j.tjnut.2024.10.010","url":null,"abstract":"<div><h3>Background</h3><div>Dietary protein quality can be assessed by skeletal muscle protein synthesis (MPS) stimulation. Limited knowledge exists on how consuming isonitrogenous meals with varied protein qualities affects postprandial and 24-h MPS.</div></div><div><h3>Objectives</h3><div>We assessed the effects of protein quality and complementary proteins on MPS. We hypothesized that meals containing a moderate amount of high-quality, complete protein would stimulate postprandial and 24-h MPS. Meals containing two complementary, plant-based incomplete proteins would stimulate MPS less, and meals containing plant-based incomplete proteins at each meal, but complementary over 24 h would not stimulate MPS.</div></div><div><h3>Methods</h3><div>This quasi-experimental study included a randomized, crossover design to assess protein quality and a nonrandomized low-protein control. We measured postprandial and 24-h MPS responses of healthy middle-aged women (<em>n</em> = 9, age 56 ± 4 y), to 3 dietary conditions: isonitrogenous meals containing 23 g protein/meal from <em>1</em>) complete protein (lean beef), <em>2</em>) 2 incomplete, but complementary protein sources (navy/black beans and whole wheat bread), and <em>3</em>) single incomplete protein sources (black beans or whole wheat bread at 1 meal), but providing a complete amino acid profile over 24 h. In the low-protein group women (<em>n</em> = 8, 54 ± 5 y) consumed a single breakfast meal containing 5 g of protein. Venous blood and vastus lateralis samples were obtained during primed, constant infusions of L-[ring-¹³C₆]phenylalanine to measure mixed muscle fractional synthetic rates (FSR).</div></div><div><h3>Results</h3><div>Meals containing complete, complementary, or incomplete proteins did not differentially influence FSR responses after breakfast (<em>P</em> = 0.90) or 24 h (<em>P</em> = 0.38). At breakfast, the complete (<em>P</em> = 0.030) and complementary (<em>P</em> = 0.031) protein meals, but not the incomplete protein meal (<em>P</em> = 0.38), had greater FSR responses compared with the low-protein control meal.</div></div><div><h3>Conclusions</h3><div>Isonitrogenous meals containing a moderate serving of total protein from foods providing complete, complementary, or incomplete essential amino acid profiles do not differentially stimulate muscle protein synthesis after a meal and daily.</div></div><div><h3>Trial registration number</h3><div>This clinical trial was registered at <span><span>clinicaltrials.gov</span><svg><path></path></svg></span> as NCT03816579.</div></div><div><h3>URL</h3><div><span><span>https://www.clinicaltrials.gov/ct2/show/NCT03816579?term=NCT03816579&amp;draw=2&amp;rank=1</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"154 12","pages":"Pages 3626-3638"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pigs Can Detect Multiple Amino Acid Deficiencies in a Choice Feeding Setting","authors":"Ilaria Minussi ,&nbsp;J Elizabeth Bolhuis ,&nbsp;Alfons JM Jansman ,&nbsp;Walter JJ Gerrits","doi":"10.1016/j.tjnut.2024.10.024","DOIUrl":"10.1016/j.tjnut.2024.10.024","url":null,"abstract":"<div><h3>Background</h3><div>It is unknown whether pigs can detect deficiencies in multiple amino acids (AA) and consequently change their feed choice.</div></div><div><h3>Objectives</h3><div>We investigated whether pigs compensate for a diet deficient in three AA (Thr, Trp, and Val) by selecting multiple diets and whether this compensation is affected by the supplemented AA concentration.</div></div><div><h3>Methods</h3><div>Pair-housed 5-wk-old pigs (<em>n</em> = 96) were exposed to one of four treatments: <em>1</em>) AA-adequate: offered a low-protein (LP) diet adequate in AA for growth (LP⁺); <em>2</em>) AA-deficient: offered LP diet deficient in Thr, Trp, and Val by 20% (LP^–); <em>3</em>) Two-choice between LP⁺ and LP^–; and <em>4</em>) Four-choice between LP^– and three diets supplemented with Thr, Trp, Val at +40% (<em>n</em> = 12 pens/treatment) from d0 to d21 (phase 1). From d21 to d28, AA concentration of supplemented diets increased to +60% (phase 2). Average daily feed intake (ADFI) and gain (ADG) were recorded.</div></div><div><h3>Results</h3><div>Dietary treatment did not affect ADFI and ADG in phase 1 (<em>P</em> &gt; 0.05). In phase 2, ADFI and ADG were higher in AA-adequate and two-choice treatments than in AA-deficient treatment with four-choice in between (<em>P</em> &lt; 0.05). In both phases, Thr, Trp, and Val intake was lower in AA-deficient treatment than in other treatments. For the two-choice treatment, consumption of LP^– was higher than LP⁺ in both phases (<em>P</em> &lt; 0.05 and <em>P</em> &lt; 0.001). Four-choice treatment consumed more LP^– and Trp-supplemented than Thr- and Val-supplemented diets in phase 1 (<em>P</em> &lt; 0.001); in phase 2, consumption of the Trp-supplemented diet was the highest (<em>P</em> &lt; 0.01).</div></div><div><h3>Conclusions</h3><div>Pigs can detect multiple AA deficiencies and compensate by consuming AA-supplemented diets. In a two-choice setting, pigs proportionally decrease consumption of a supplemented diet with increased dietary AA concentration. However, when given the choice between individual AA-supplemented diets, pigs proportionally decrease consumption of a highly concentrated Val diet and increase preference for a highly concentrated Trp diet.</div></div>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"154 12","pages":"Pages 3652-3663"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food Records Show Daily Variation in Diet during Pregnancy: Results from the Temporal Research in Eating, Nutrition, and Diet during Pregnancy Study","authors":"Samantha Kleinberg ,&nbsp;James D Pleuss ,&nbsp;Andrea L Deierlein","doi":"10.1016/j.tjnut.2024.10.038","DOIUrl":"10.1016/j.tjnut.2024.10.038","url":null,"abstract":"<div><h3>Background</h3><div>Diet is critical for pregnant individuals and their offspring, but insight into diet during pregnancy mainly comes from questionnaires and recalls.</div></div><div><h3>Objectives</h3><div>To obtain detailed real-time dietary data during pregnancy to evaluate intra- and interindividual variation in intakes.</div></div><div><h3>Methods</h3><div>Pregnant individuals were recruited from a New York City health system December 2020–June 2023. Participants collected dietary intakes for 14 d (mean gestational weeks = 17.6) and again roughly 4 wk later (mean gestational weeks = 24.5). Participants logged each eating occasion using a smartphone and study-developed app, and wore a smartwatch capturing physiologic data.</div></div><div><h3>Results</h3><div>In total, 150 individuals completed ≥1 data collection round, with 134 completing both rounds. Mean daily eating window was 10.82 h, with weekends having a significantly shorter window than weekdays (<em>P</em> &lt; 0.001). Eating window was correlated with energy intake (<em>r</em> = 0.401, <em>P</em> &lt; 0.001), driven by later last eating occasions. There was high intraindividual variation in macro- and micronutrient intakes [intraclass correlation coefficient (ICC), range 0.11–0.40] and food type (ICC range: 0.08–0.34), and differences between weekdays and weekends (less protein and micronutrients on weekends). Few participants’ mean intakes met daily recommended dietary allowances for key micronutrients (under 15% for iron, magnesium, vitamin D, and vitamin E; under 30% for calcium, folate, zinc, and vitamin A).</div></div><div><h3>Conclusions</h3><div>Dietary intakes varied substantially within and between individuals, and mean nutrient intake estimates did not capture nutrient adequacy for individuals or populations. Future work that examines individual daily dietary intakes throughout pregnancy among diverse populations is needed.</div></div>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"154 12","pages":"Pages 3780-3789"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to K Jenn and J Artiss","authors":"Michael D Jensen,&nbsp;Kelli A Lytle","doi":"10.1016/j.tjnut.2024.09.030","DOIUrl":"10.1016/j.tjnut.2024.09.030","url":null,"abstract":"","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"154 12","pages":"Pages 3850-3851"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142348624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poultry Nutrition: Achievement, Challenge, and Strategy","authors":"Ke-Xin Cao ,&nbsp;Zhang-Chao Deng ,&nbsp;Shi-Jun Li ,&nbsp;Dan Yi ,&nbsp;Xi He ,&nbsp;Xiao-Jun Yang ,&nbsp;Yu-Ming Guo ,&nbsp;Lv-Hui Sun","doi":"10.1016/j.tjnut.2024.10.030","DOIUrl":"10.1016/j.tjnut.2024.10.030","url":null,"abstract":"<div><div>Poultry, a vital economic animal, provide a high-quality protein source for human nutrition. Over the past decade, the poultry industry has witnessed substantial achievements in breeding, precision feeding, and welfare farming. However, there are still many challenges restricting the sustainable development of the poultry industry. First, overly focused breeding strategies on production performance have been shown to induce metabolic diseases in poultry. Second, a lack of robust methods for assessing the nutritional requirements poses a challenge to the practical implementation of precision feeding. Third, antibiotic alternatives and feed safety management remain pressing concerns within the poultry industry. Lastly, environmental pollution and inadequate welfare management in farming have a negative effect on poultry health. Despite numerous proposed strategies and innovative approaches, each faces its own set of strengths and limitations. In this review, we aim to provide a comprehensive understanding of the poultry industry over the past decade, by examining its achievements, challenges, and strategies, to guide its future direction.</div></div>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"154 12","pages":"Pages 3554-3565"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}