Nina M Frerichs , Tim GJ de Meij , Hendrik J Niemarkt
{"title":"Fiber for Thought: How Fiber-Based Microbiota-Modulation Can Impact Pediatric Brain Health","authors":"Nina M Frerichs , Tim GJ de Meij , Hendrik J Niemarkt","doi":"10.1016/j.tjnut.2025.05.011","DOIUrl":"10.1016/j.tjnut.2025.05.011","url":null,"abstract":"","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"155 7","pages":"Pages 2086-2088"},"PeriodicalIF":3.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giovanna D’Abbronzo , Giuseppe Scidà , Cinzia Quaglia, Angela A Rivellese, Lutgarda Bozzetto, Giovanni Annuzzi, Marilena Vitale
{"title":"Application-Based Bioelectrical Impedance Analysis Provides Accurate Body Composition Parameters in a More Cost-Efficient and Time-Efficient Way","authors":"Giovanna D’Abbronzo , Giuseppe Scidà , Cinzia Quaglia, Angela A Rivellese, Lutgarda Bozzetto, Giovanni Annuzzi, Marilena Vitale","doi":"10.1016/j.tjnut.2025.05.013","DOIUrl":"10.1016/j.tjnut.2025.05.013","url":null,"abstract":"<div><h3>Background</h3><div>In clinical practice, there is an increasing demand for methods that provide accurate, precise, and real-time body composition measurements while reducing costs and data collection time.</div></div><div><h3>Objectives</h3><div>This study aimed to evaluate the validity of an application-based bioelectric impedance analysis (BIA) system for determining body composition compared with a standard BIA method.</div></div><div><h3>Methods</h3><div>A total of 109 individuals with type 1 diabetes (56 men and 53 women), aged 18–70 y, with a body mass index of 25.0–35.0 kg/m<sup>2</sup> and glycated hemoglobin concentrations of 7.0%–9.0%, were recruited. Participants were randomly assigned to start with either the application-based BIA system or the standard method (A-wave BIA quantum-V) and then switched to the other method. Anthropometric parameters, blood pressure, and metabolic profiles were also assessed.</div></div><div><h3>Results</h3><div>The comparison between the 2 methods showed a negligible difference in resistance but a significant difference in reactance (–4.9%). The degree of consistency was excellent for both resistance [intraclass correlation coefficient (ICC) = 0.990, <em>P</em> < 0.001] and reactance (ICC = 0.903, <em>P</em> < 0.001), with individual differences falling within acceptable ranges. Furthermore, body composition parameters, including fat-free mass, fat mass, skeletal muscle mass, total body water, and extracellular water, showed only minor and nonsignificant differences between the 2 methods.</div></div><div><h3>Conclusions</h3><div>These findings suggest that the application-based BIA system is a valid and reliable tool for assessing body composition, offering healthcare professionals, including dietitians and nutritionists, a cost-effective and time-efficient alternative to standard BIA methods.</div></div>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"155 7","pages":"Pages 2443-2448"},"PeriodicalIF":3.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anna M Amini , Ruihan Zhou , Katharina Austermann , Dominika Králová , Gessica Serra , Ibrahim S Ibrahim , Giulia Corona , Triana Bergillos-Meca , Hassan Aboufarrag , Paul A Kroon , Jeremy PE Spencer , Parveen Yaqoob
{"title":"Acute Effects of an Anthocyanin-Rich Blackcurrant Beverage on Markers of Cardiovascular Disease Risk in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial","authors":"Anna M Amini , Ruihan Zhou , Katharina Austermann , Dominika Králová , Gessica Serra , Ibrahim S Ibrahim , Giulia Corona , Triana Bergillos-Meca , Hassan Aboufarrag , Paul A Kroon , Jeremy PE Spencer , Parveen Yaqoob","doi":"10.1016/j.tjnut.2025.05.017","DOIUrl":"10.1016/j.tjnut.2025.05.017","url":null,"abstract":"<div><h3>Background</h3><div>Epidemiologic evidence suggests an inverse association between anthocyanin consumption and cardiovascular disease (CVD) risk. Modulation of vascular function and hemostasis may contribute to this, but there is limited clinical evidence.</div></div><div><h3>Objectives</h3><div>The present study investigated the acute effects of an anthocyanin-rich blackcurrant beverage, compared with a matched placebo, on selected markers of CVD risk in healthy middle-aged subjects in response to a high-fat meal.</div></div><div><h3>Methods</h3><div>Twenty-three volunteers aged 39.9 ± 8.1 y [body mass index (BMI) (in kg/m<sup>2</sup>) 22.9 ± 2.3] completed a double-blind, randomized, placebo-controlled, crossover trial. Volunteers consumed either a 200 mL blackcurrant beverage (744 mg polyphenols comprising 711 mg anthocyanins and 32 mg procyanidins) or a placebo, together with a high-fat breakfast (52.3 g fat) followed by a lunch (30 g fat) at 3 h, and the postprandial vascular response was compared. The primary endpoints were the assessment of vascular function by flow-mediated dilation (FMD) and the inhibition of collagen- and adenosine diphosphate-induced platelet aggregation. Secondary outcomes included blood pressure (BP), digital volume pulse waveforms, circulating numbers of endothelium- and platelet-derived extracellular vesicles, plasma concentrations of interleukin (IL)-8, and plasma and urinary concentrations of polyphenols and their metabolites were also evaluated.</div></div><div><h3>Results</h3><div>There was a significant cumulative improvement in FMD following consumption of an anthocyanin-rich blackcurrant beverage compared with a matched placebo in conjunction with a high-fat meal over a 6 h postprandial period. There was a trend for an inhibitory effect of the blackcurrant beverage on agonist-induced platelet aggregation and significant effects on the secondary outcomes, systolic BP and IL-8, although these were exploratory and not adjusted for multiple testing. Plasma concentrations of hippuric acid and isovanillic acid were strong independent predictors of FMD, and 4-hydroxybenzaldehyde and isoferulic acid glucuronide were predictors of systolic BP and diastolic BP.</div></div><div><h3>Conclusions</h3><div>An anthocyanin-rich blackcurrant beverage mitigates the effects of a high-fat meal on vascular function and markers of CVD risk, and this is associated with the appearance of specific plasma anthocyanin phenolic metabolites.</div><div>This trial was registered at <span><span>classic.clinicaltrials.gov</span><svg><path></path></svg></span> as NCT02459756.</div></div>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"155 7","pages":"Pages 2275-2289"},"PeriodicalIF":3.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhiyuan Ren , Wenxing Guo , Junjing Li , Yuangui Cheng , Wen Jiang , Wei Wang , Min Gao , Wen Wu , Ziyun Pan , Ying Yang , Elizabeth N Pearce , Shuyao Dong , Chongdan Wang , Wanqi Zhang
{"title":"High Water Iodine Concentrations Are Associated With the Prevalence of Subclinical Hypothyroidism, Thyroid Nodules, and Goiter Among Pregnant Women in Shandong, China","authors":"Zhiyuan Ren , Wenxing Guo , Junjing Li , Yuangui Cheng , Wen Jiang , Wei Wang , Min Gao , Wen Wu , Ziyun Pan , Ying Yang , Elizabeth N Pearce , Shuyao Dong , Chongdan Wang , Wanqi Zhang","doi":"10.1016/j.tjnut.2024.12.024","DOIUrl":"10.1016/j.tjnut.2024.12.024","url":null,"abstract":"<div><h3>Background</h3><div>Both iodine deficiency and iodine excess can harm the thyroid glands during pregnancy. In areas without iodine fortification, the relationship between the water iodine concentration (WIC) and thyroid disease in pregnant women requires further investigation.</div></div><div><h3>Objectives</h3><div>The aim of this study was to evaluate the relationship between WICs and the prevalence of thyroid disease in pregnant women residing in areas with high WICs without access to iodized salt.</div></div><div><h3>Methods</h3><div>A cross-sectional survey was conducted in Shandong Province. Water and urine samples were collected, and the iodine content was assessed. Venous blood samples were taken to measure thyroid hormones and antibodies. Ultrasound was used to assess thyroid size and detect nodules.</div></div><div><h3>Results</h3><div>A total of 1073 pregnant women were included in this study. As the WIC increased, the urinary iodine concentration also increased, according to linear regression analysis (β: 0.5; <em>P</em> < 0.001). The lowest prevalence of subclinical hypothyroidism (SH) and thyroid dysfunction (TD) was observed at a WIC of 10–40 μg/L, whereas the lowest prevalence of thyroid nodules (TNs) and goiter was seen at a WIC of 40–100 μg/L. Logistic regression analysis showed that WIC was significantly associated with thyroid diseases. WIC of <10 μg/L was associated with TD prevalence (OR: 1.8; 95% CI: 1.1, 3.1), and WIC of >100 μg/L was associated with SH, TN, and goiter prevalence (SH—OR: 10.8; 95% CI: 1.4, 84.0; TN—OR: 2.5; 95% CI: 1.1, 5.6; goiter—OR: 2.4; 95% CI: 1.1, 5.6).</div></div><div><h3>Conclusions</h3><div>WIC is associated with thyroid function among pregnant women. WIC of <10 μg/L is a risk factor for TD, whereas WIC of >100 μg/L is a risk factor for SH, TN, and goiter. These findings suggest that intermediate WICs are most conducive to thyroid health in pregnant women and that assessing local WICs could help improve maternal health.</div></div>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"155 7","pages":"Pages 2069-2075"},"PeriodicalIF":3.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Juan Carlos Figueroa, Elizabeth Fs Roberts, Faith Cole, Zoe Boudart, Talia Gordon, Alejandra Rodríguez Atristain, Martha M Téllez-Rojo, José Luis Figueroa Oropeza, Brisa N Sánchez
{"title":"Intermittent Water Supply and Beverage Consumption Patterns among Adolescents and Adults in Mexico: A Nationally Representative, Cross-Sectional Analysis.","authors":"Juan Carlos Figueroa, Elizabeth Fs Roberts, Faith Cole, Zoe Boudart, Talia Gordon, Alejandra Rodríguez Atristain, Martha M Téllez-Rojo, José Luis Figueroa Oropeza, Brisa N Sánchez","doi":"10.1016/j.tjnut.2025.06.020","DOIUrl":"10.1016/j.tjnut.2025.06.020","url":null,"abstract":"<p><strong>Background: </strong>Given increasing water scarcity, water is managed by providing an intermittent water supply (IWS) to residents. Ethnographic findings have shown that residents with IWS have limited access to drinking water and may increase the consumption of highly processed, industrialized beverages.</p><p><strong>Objectives: </strong>We examined whether the frequency of water supply is associated with beverage consumption patterns.</p><p><strong>Methods: </strong>We used beverage items from the food frequency and household questionnaires from Mexico's 2022 Encuesta Nacional de Salud y Nutrición. Latent class analysis (LCA) was used to identify beverage consumption patterns. Survey-weighted bivariate analysis and multinomial regression (adjusted for demographic variables) quantified the relationship between the frequency of water supply and beverage consumption patterns.</p><p><strong>Results: </strong>LCA classified individuals into 1 of 3 beverage consumption patterns: those who, relative to other beverages, have higher consumption of plain water (48.4%); industrialized beverages (26.0%); or beverages prepared at home (25.5%). The frequency of water supply and beverage consumption patterns was significantly associated (crude P = 0.033). People with daily intermittency followed beverage consumption patterns that featured more industrialized beverages than plain water, compared with those who had a daily 24/7 water supply. Among those with daily intermittency, 40.6% followed the plain water beverage pattern, 37.3% the industrialized beverage pattern, and 22.1% the prepared at home beverage pattern. In contrast, among those with a daily 24/7 water supply, 49.9% followed the plain water beverage pattern, 21.7% the industrialized beverage pattern, and 28.4% the prepared at home beverage pattern. In adjusted analysis, people with daily intermittency were more likely to exhibit the industrialized compared with the plain water beverage pattern (odds ratio = 2.23, 95% confidence interval: 1.14, 4.35), compared with those who receive water 24/7. Receiving water less than daily was not significantly associated with beverage consumption patterns.</p><p><strong>Conclusions: </strong>Our findings suggest an association between IWS and consumption of industrialized beverages, and thus its potential contribution to chronic disease risk.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gloria Wong, Miriam E Clegg, Damian Ross, Julie A Lovegrove, Kim G Jackson
{"title":"Sequential Meals Containing Animal and Plant-Based Saturated Fats Have Differential Effects on Postprandial Gut Hormones but No Impact on Satiety Compared with Unsaturated Fats in Generally Healthy Males: Findings from the Randomized Controlled Crossover CocoHeart Study.","authors":"Gloria Wong, Miriam E Clegg, Damian Ross, Julie A Lovegrove, Kim G Jackson","doi":"10.1016/j.tjnut.2025.06.027","DOIUrl":"10.1016/j.tjnut.2025.06.027","url":null,"abstract":"<p><strong>Background: </strong>Saturated fat (SFA)-rich meals are often linked to elevated postprandial triacylglycerol responses compared with unsaturated fats. Despite the growing popularity of coconut oil in the United Kingdom diet, effects of this SFA-rich oil on postprandial lipemia and physiological appetite responses are unclear.</p><p><strong>Objectives: </strong>This study compared sequential high-fat test meals rich in butter and coconut oil with a vegetable oil blend (safflower and olive oil) on postprandial triacylglycerol (primary outcome), lipids, glucose, and gut hormones responses, and physiological measures of appetite in healthy males.</p><p><strong>Methods: </strong>In a single-blind, randomized acute 3-armed crossover study, 13 males (53 ± 3 years, body mass index 24.4 ± 3.0 kg/m<sup>2</sup>) consumed sequential test meals containing SFA-rich oils/fats or a vegetable oil blend (breakfast 53.6 g and lunch 33.6 g fat) on 3 occasions, each separated by a 4-wk period. Blood samples and satiety ratings were collected prior to and at regular intervals over 480 min posttest breakfast. Blood pressure and arterial stiffness were measured at 0, 150, 300, and 480 min. Postprandial data were analyzed using linear mixed models and satiety ratings using analysis of covariance.</p><p><strong>Results: </strong>Postprandial triacylglycerol, glucose, insulin, ghrelin, blood pressure, and arterial stiffness or perceived satiety responses were similar between the test fat/oils. The incremental area under the curve (iAUC) for the postprandial glucose-dependent insulinotropic polypeptide response was higher with vegetable oil compared with the SFA-rich meals whereas the glucagon-like peptide-1 response was lower after the butter than coconut and vegetable oil-rich meals (P ≤ 0.012). The iAUC for the peptide YY response was lower after butter than coconut oil-rich meals (P ≤ 0.048), but not different compared with vegetable oil.</p><p><strong>Conclusions: </strong>Despite varying fatty acid compositions, postprandial triacylglycerol responses were similar between fats/oils. Our findings suggest that butter and coconut oil have differential effects on gut hormone responses compared with unsaturated fats without an impact on satiety in generally healthy males.</p><p><strong>Trial registration number: </strong>NCT05264233.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lilia Bliznashka, Monica George Michail, Dalia Elsabbagh, Aulo Gelli
{"title":"Effect of Adding Milk to a Micronutrient-Fortified High-Energy Biscuit School Feeding Programme in Yemen: A Cluster-Randomized Controlled Trial.","authors":"Lilia Bliznashka, Monica George Michail, Dalia Elsabbagh, Aulo Gelli","doi":"10.1016/j.tjnut.2025.06.021","DOIUrl":"10.1016/j.tjnut.2025.06.021","url":null,"abstract":"<p><strong>Background: </strong>Two billion children globally are estimated to live in conflict-affected areas. School feeding programs (SFPs) are a widely implemented safety net that supports children during and after conflict.</p><p><strong>Objectives: </strong>We evaluated the effectiveness of providing milk alongside a high-energy biscuit (HEB) SFP in Yemen on children's and caregivers' outcomes.</p><p><strong>Methods: </strong>We implemented a 2-arm longitudinal cluster-randomized controlled trial from December 2023 to May 2024. Forty-two schools in Al Mukha district were randomly assigned (1:1) to control, where children received HEBs (2 packets [100 g] daily), or milk, where children received HEBs plus a 120 mL carton of ultra-high temperature milk. Children aged 6-18 y were randomly selected for enrolment. The primary outcomes were children's dietary diversity and milk consumption. Secondary outcomes were children's cognition, learning, attendance, nutritional status, and health. Tertiary outcomes were child and caregiver mental health and household food security. We conducted intent-to-treat analysis using linear mixed-effects models accounting for clustering.</p><p><strong>Results: </strong>One thousand two hundred ninety-nine children were enrolled. After 5 mo, the intervention increased milk consumption but had no effect on dietary diversity. Children's cognition [mean difference (MD): 1.00 (95% CI: 0.40, 1.61)], literacy [MD: 1.14 (95% CI: 0.36, 1.92)], and numeracy [MD: 1.06 (95% CI: 0.46, 1.67)] scores improved. Cough symptoms declined: MD: -0.12 (95% CI: -0.2, -0.03). There were no changes in school attendance or nutritional status. The intervention reduced conduct problems in children [MD: -0.52 (95% CI: -0.97, -0.08)], severe anxiety in caregivers [MD: -0.03 (95% CI: -0.06, -0.001)], and household severe food insecurity [MD: -0.09 (95% CI: - 0.17, -0.001)].</p><p><strong>Conclusions: </strong>Adding a daily milk drink to an HEB SFP in Yemen resulted in numerous benefits for children and their families. Hybrid models to incrementally improve meal quality are feasible, acceptable, and lead to meaningful impacts. More research is needed on medium- and long-term benefits.</p><p><strong>Registration: </strong>The trial was registered with ISRCTN (ISRCTN12225603).</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ranadip Chowdhury , Ankita Maddheshiya , Sunita Taneja , Nita Bhandari , Partha P Majumder , Tor A Strand , Ravindra Mohan Pandey , Anura V Kurpad , Souvik Mukherjee
{"title":"Impact of an Integrated Intervention Package During Preconception, Pregnancy, and Early Childhood on the Gut Microbiome at Six Months of Age: Findings from the Women and Infants Integrated Growth Study (WINGS) Randomized Controlled Trial","authors":"Ranadip Chowdhury , Ankita Maddheshiya , Sunita Taneja , Nita Bhandari , Partha P Majumder , Tor A Strand , Ravindra Mohan Pandey , Anura V Kurpad , Souvik Mukherjee","doi":"10.1016/j.tjnut.2025.04.016","DOIUrl":"10.1016/j.tjnut.2025.04.016","url":null,"abstract":"<div><h3>Background</h3><div>The infant gut microbiome is essential for healthy growth and development. However, limited research has explored how interventions targeting maternal and infant health, nutrition, and psychosocial conditions during preconception, pregnancy, and early childhood impact microbiome development. To address this research gap and better understand the potential impact of such interventions, this study was designed to evaluate their effects on the infant gut microbiome.</div></div><div><h3>Objective</h3><div>The aim was to evaluate the effects of an integrated intervention package on infant gut microbiome at 6 mo of age compared with routine care.</div></div><div><h3>Methods</h3><div>The study was embedded in a randomized factorial trial involving women aged 18–30 y. Participants were randomly assigned to receive either a preconception intervention package or routine care until pregnancy. Pregnant women were then randomly assigned to receive a pregnancy and early childhood intervention package or routine care. The intervention included health care for growth-related conditions, nutrition, water, sanitation, and hygiene (WASH), and psychosocial care. Stool samples from 392 infants (185 from the preconception, pregnancy, and early childhood intervention group and 207 from the routine care group) were collected at 6 mo, followed by microbiome DNA isolation and high-throughput sequencing of the V3-V4 region of 16S rRNA gene. Generalized linear models were used to estimate the mean relative abundance of core gut microbiome phyla, genera, and species between the intervention and routine care groups.</div></div><div><h3>Results</h3><div>Infants in the group who received preconception, pregnancy, and early childhood intervention had a significantly lower mean relative abundance of <em>Klebsiella</em> genus under the Pseudomonadota phylum (45% lower; 95% confidence interval [CI]: 18, 63) and <em>Klebsiella pneumoniae</em> species (38% lower; 95% CI: 8, 59) compared with routine care group. In contrast, the relative abundance of <em>Megasphaera</em> (72% higher; 95% CI: 7, 175), <em>Prevotella</em> (72% higher; 95% CI: 3, 187), and <em>Bifidobacterium breve</em> (34% higher; 95% CI: 2, 79) was significantly higher in the group received preconception, pregnancy and early childhood intervention compared with routine care.</div></div><div><h3>Conclusions</h3><div>The findings indicate that improving maternal and infant health, nutrition, and psychosocial conditions enhances the relative abundance of beneficial gut bacteria at 6 mo of age, supporting healthy growth and development.</div><div>This trial was registered at Clinical Trials Registry–India as CTRI/2020/10/028770; <span><span>https://ctri.nic.in/Clinicaltrials/advsearch2.php</span><svg><path></path></svg></span></div></div>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"155 7","pages":"Pages 2355-2366"},"PeriodicalIF":3.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144523858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Global Perspectives on China’s Iodine Dietary Reference Intakes: Revisions, Public Health Implications, and Future Strategies","authors":"Wenxing Guo , Wen Chen , Wanqi Zhang","doi":"10.1016/j.tjnut.2025.03.019","DOIUrl":"10.1016/j.tjnut.2025.03.019","url":null,"abstract":"<div><div>Iodine is an essential trace element for the human body and a fundamental precursor for the synthesis of thyroid hormones, playing a critical role in maintaining thyroid function. Since iodine cannot be synthesized by the body, it must be obtained from external sources. The development of dietary reference intakes for iodine has evolved over time, with various countries establishing guidelines based on local dietary surveys, iodine status assessments, and health outcomes. The dietary reference intakes of iodine vary widely across different regions due to differences in dietary habits, food fortification policies, and iodine supplementation practices. This review primarily synthesizes and analyzes the latest research data on iodine intake reference values set by China and compares these values with those established by other countries and organizations. Additionally, this review examines primary dietary sources of iodine, such as iodized salt, dairy products, and seafood, and discusses challenges posed by public health initiatives like salt-reduction campaigns that may impact overall iodine intake. Furthermore, it highlights current global trends in iodine nutrition while emphasizing countries where iodine intake is classified as sufficient, deficient, or excessive. By comparing iodine intake recommendations worldwide, this review aims to provide a comprehensive understanding of iodine nutrition and its impact on public health. It also identifies gaps in current research and offers insights into future directions for ensuring optimal iodine intake through updated guidelines and public health interventions.</div></div>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"155 7","pages":"Pages 2076-2085"},"PeriodicalIF":3.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ting Meng , Jingjing Wang , Derek Headey , Shenggen Fan
{"title":"Reshaping Chinese Agrifood Systems to Enhance Human Nutrition: A Scoping Review of Research","authors":"Ting Meng , Jingjing Wang , Derek Headey , Shenggen Fan","doi":"10.1016/j.tjnut.2025.05.009","DOIUrl":"10.1016/j.tjnut.2025.05.009","url":null,"abstract":"<div><div>Food security in China has broadened to include achieving balanced nutrition and health while addressing resource and environmental burdens, mitigating climate change, improving livelihoods, and promoting social equity and welfare. This review aimed to explore how China has established the link among agriculture, nutrition, and multiple goals through a system approach over the past decade. A scoping review method was used to analyze the recent research trajectory in China, with a specific focus on research on agrifood systems and improved human nutrition in China from 2014 to 2023. The results show a shift in research focus from predominantly agricultural production to an emphasis on food consumption and diets, thereby providing an evidence base for transforming agrifood systems. Future research should explore how to promote this transformation through technological innovation, agrifood policy optimization, and in-depth stakeholder engagement to further improve human nutrition, although not compromising environmental goals of the agrifood system.</div></div>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"155 7","pages":"Pages 2045-2056"},"PeriodicalIF":3.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}