Journal of Nutrition最新文献

{"title":"Vitamin D Supplementation Enhances Hematologic Recovery in Vitamin D-Deficient Adults with Iron Deficiency Anemia.","authors":"Harlokesh Narayan Yadav, Satnam Singh Mehadwan, Nandini Dubey, Mukul Aggarwal, Arvind Kumar, Vishal Kumar Vishwakarma, Pranav Panchbhai, Gauri Chaturvedi, Maroof Ahmad Khan, Rajesh Sagar, Raj Kanwar Yadav, Arun Kumar","doi":"10.1016/j.tjnut.2026.101832","DOIUrl":"10.1016/j.tjnut.2026.101832","url":null,"abstract":"<p><strong>Background: </strong>Iron deficiency anemia (IDA) is the most common form of anemia worldwide. Emerging evidence suggests that vitamin D (VD) and micronutrient deficiencies may impair erythropoiesis and iron metabolism. However, clinical data on their combined effects in the Indian population are limited.</p><p><strong>Objectives: </strong>This study evaluated the impact of adjunctive VD supplementation alongside iron-containing micronutrient supplements and additional minerals (oral IDA therapy) in VD-sufficient (VD-S) and VD-deficient (VD-D) adults >18 y.</p><p><strong>Methods: </strong>Participants with IDA were categorized into group I (VD-S+Fe, n = 109), group II (VD-D+Fe, n = 138), and group III (VD-D+Fe+VD, n = 138). All groups received oral IDA therapy, including once-daily iron-containing micronutrient supplementation for 90 d (300 mg ferrous fumarate, folate, vitamin B₁₂), and additional minerals, whereas the VD-D+Fe+VD group additionally received VD supplementation [once weekly 60,000 international units (IU) cholecalciferol during the first 6 wk]. Hematologic, iron status, VD, and related biochemical parameters were assessed at baseline and after 90 d.</p><p><strong>Results: </strong>All groups showed significant within-group improvements in hematologic and iron parameters over 90 d (all P < 0.05). However, improvements were greatest in the VD-D+Fe+VD group, followed by the VD-S+Fe group, and least in the VD-D+Fe group. Adjusted analysis of covariance demonstrated significantly increased hemoglobin, hematocrit, red blood cell (RBC) count, mean corpuscular volume, red cell distribution width-coefficient of variation, ferritin, and other parameters in the VD-D+Fe+VD group compared with both other groups. Changes in VD levels were positively associated with improvements in hemoglobin, hematocrit, RBC indices, ferritin, and iron and inversely associated with red cell distribution width, transferrin, and total iron-binding capacity (all P < 0.05).</p><p><strong>Conclusions: </strong>VD deficiency was associated with a reduced hematologic response to iron-containing micronutrient supplementation for IDA. In participants with VD deficiency, adjunctive VD supplementation in combination with the iron-containing micronutrient supplement significantly enhanced hematologic recovery compared with the iron-containing micronutrient supplement alone. These findings suggest that optimizing VD status may improve treatment outcomes in IDA.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":"101832"},"PeriodicalIF":4.2,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148976986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: The Disease Model and Experimental Protocol Require Further Validation for Determining Health Benefits of Dietary Fiber.","authors":"A Allwyn Sundarraj, R Sinthiya, U S Rammiya","doi":"10.1016/j.tjnut.2026.101820","DOIUrl":"10.1016/j.tjnut.2026.101820","url":null,"abstract":"","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":"101820"},"PeriodicalIF":4.2,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148911755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Allwyn Sundarraj et al.","authors":"Peter J Mannon, Andrew K Benson, James Schnable, Wensheng Ding, Anthony F Juritsch, Devin J Rose","doi":"10.1016/j.tjnut.2026.101819","DOIUrl":"10.1016/j.tjnut.2026.101819","url":null,"abstract":"","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":"101819"},"PeriodicalIF":4.2,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148911937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bifidobacterium longum subsp. infantis M-63 Can Reach the Neonatal Gut Following WHO-Recommended Infant Formula Preparation at ≥70°C.","authors":"Akari Hiraku, Riko Mishima, Ayaka Hori, Shinto Kurosaki, Hiroki Kaneko, Ryuta Ejima, Eri Mitsuyama, Kana Kadowaki, Akira Sen, Saho Furukawa, Mai Morozumi, Muneya Tsuda, Hirohisa Izumi, Satoshi Arai, Noriyuki Iwabuchi, Miyuki Tanaka, Yukihiro Hishida, Daigo Ito, Toshitaka Odamaki","doi":"10.1016/j.tjnut.2026.101825","DOIUrl":"10.1016/j.tjnut.2026.101825","url":null,"abstract":"<p><strong>Background: </strong>The World Health Organization (WHO) recommends reconstituting powdered infant formula with water at ≥70°C to reduce risk of bacterial contamination. Although this practice is important for microbiological safety, it may also reduce the viability and/or functional activity of heat-sensitive bioactive components, such as probiotics. However, it remains unclear whether probiotics added to infant formula can reach the infant gut under WHO-recommended preparation conditions.</p><p><strong>Objectives: </strong>To evaluate whether Bifidobacterium longum subsp. infantis M-63 (B. infantis M-63) added to infant formula can be detected in the neonatal gut when the formula is prepared with water at ≥70°C, following WHO recommendations.</p><p><strong>Methods: </strong>In this exploratory, randomized study with 2 supplementation levels, 34 term neonates received formula containing B. infantis M-63 reconstituted according to WHO-recommended conditions, from birth to 1 mo of age. Fecal recovery of the administered strain was assessed, together with analyses of gut microbiota composition and fecal metabolite profiles. Concurrent breastfeeding was permitted without restriction to reflect real-world feeding practices.</p><p><strong>Results: </strong>Although reconstitution at ≥70°C substantially reduced viable bacterial counts in the prepared formula, B. infantis M-63 was detected in fecal samples at high rates at 1 mo of age (low-dose 94.4%, high-dose 100%), with no significant differences in detection rates or fecal counts between dose groups. Gut microbiota composition shifted toward a Bifidobacterium-dominant profile over time regardless of dose. In addition, fecal recovery of the administered strain was positively associated with specific tryptophan-derived metabolites, including indole-3-lactic acid (ρ = 0.509, P = 0.002).</p><p><strong>Conclusions: </strong>Under WHO-recommended infant formula preparation conditions, B. infantis M-63 was detected in nearly all infants, together with a gut microbiota profile characteristic of early infancy. These findings provide in vivo evidence that B. infantis M-63 can reach the neonatal gut and suggest potential biological activity under microbiologically safe and practically relevant preparation conditions. This trial was registered at clinicaltrials.gov as UMIN000058303.</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":"101825"},"PeriodicalIF":4.2,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148911570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Athlete Food Skills Interventions Are Not Conceptually Aligned with Culinary Nutrition: A Scoping Review of the Missing Ingredient in Sports Nutrition.","authors":"Olivia Thomas, Sharon Croxford, Tansy Boggon, Louise M Burke, Adrienne Forsyth","doi":"10.1016/j.tjnut.2026.101804","DOIUrl":"10.1016/j.tjnut.2026.101804","url":null,"abstract":"<p><strong>Background: </strong>Nutrition underpins athletic health, performance, and recovery. However, many athletes do not achieve optimal dietary practices. Practical barriers, including limited time, financial constraints, and low confidence in food preparation, may limit the translation of nutrition knowledge into consistent dietary behaviors. Culinary nutrition (CN) integrates nutrition science with hands-on food skills and has emerged as a strategy to address translational gaps, yet its application in sports nutrition remains underexplored.</p><p><strong>Objectives: </strong>This scoping review aims to 1) characterize the design and hands-on activities of food skills interventions for athletes and 2) compare how these interventions align with the established definition of CN.</p><p><strong>Methods: </strong>Guided by the Joanna Briggs Institute Manual for Evidence Synthesis and Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guidelines, a systematic search of SportDiscus, Cumulative Index to Nursing and Allied Health Literature, PubMed, and Scopus was conducted in January 2026. Studies were included if they involved athletes and incorporated a hands-on food skill component. Two independent reviewers screened studies and extracted data using a standardized template. Researchers then synthesized the data to characterize intervention design and evaluate alignment with the constructs used to define CN.</p><p><strong>Results: </strong>Ten studies met the inclusion criteria. Although food skills interventions varied by population, setting, duration, and delivery, all combined hands-on activities with didactic nutrition education. Studies represented a geographically diverse sample spanning 7 countries: Brazil, India, the United States, Australia, Canada, Ireland, and Germany. Participants included athletes competing across a range of levels, from secondary school and community sport to university and regional-level competition. Mean participant ages ranged from 11.9 to 22 y, and studies included male, female, and mixed-sex samples. Interventions targeted outcomes including nutrition knowledge, dietary behaviors, and psychosocial determinants (e.g., self-efficacy and readiness to change). Evaluation approaches were inconsistent. No studies directly measured food skills, and none fully aligned with core CN constructs.</p><p><strong>Conclusions: </strong>Greater conceptual clarity, stronger theoretical integration, establishment of standardization and best practices, and more interventional research exploring the impact of CN on individuals' health, well-being, and performance are needed to advance CN in sports contexts. This study was registered at Open Science Framework (https://osf.io/4cske/overview).</p>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":" ","pages":"101804"},"PeriodicalIF":4.2,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148945223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to ‘2020–2025 Dietary Guidelines for Americans in Pregnancy: Adherence Shortfalls and Associations with Gestational Weight Gain’ [J. Nutr. 2026; 156: 101198]","authors":"Leyre Notario-Barandiaran,&nbsp;Antonio J Signes-Pastor,&nbsp;Katherine P Himes,&nbsp;Margaret R Karagas","doi":"10.1016/j.tjnut.2026.101770","DOIUrl":"10.1016/j.tjnut.2026.101770","url":null,"abstract":"","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"156 9","pages":"Article 101770"},"PeriodicalIF":4.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148726602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EPA-Derived Oxylipin Incorporation into Tissues of High-Fat Diet–Fed Mice and Its Consequences for n-6 PUFA–Derived Oxylipins","authors":"Brooke E Bathon,&nbsp;Umar Chaudhry,&nbsp;Rosemary S Gray,&nbsp;Ximena M Bustamante-Marin,&nbsp;Rafia Virk,&nbsp;Kymberly M Gowdy,&nbsp;Saame Raza Shaikh","doi":"10.1016/j.tjnut.2026.101729","DOIUrl":"10.1016/j.tjnut.2026.101729","url":null,"abstract":"<div><h3>Background</h3><div>Eicosapentaenoic acid (EPA) potentially improves metabolic and inflammatory outcomes in obesity through oxylipin biosynthesis. To study the mechanisms of EPA, researchers administer EPA-derived oxylipins to obese mice. A limitation is that tissue polyunsaturated fatty acid (PUFA)–derived nonesterified oxylipin levels upon administration of EPA-derived oxylipins is poorly studied.</div></div><div><h3>Objectives</h3><div>This study aimed to quantify tissue levels of 5-hydroxyeicosapentaenoic acid (5-HEPE) and 18-hydroxyeicosapentaenoic acid (18-HEPE) upon administration of these molecules to high-fat diet (HFD)–fed mice. 5-HEPE and 18-HEPE were selected as they are elevated with dietary EPA.</div></div><div><h3>Methods</h3><div>C57BL/6J male mice (13 wk old) consuming an HFD were intraperitoneally administered 1 μg of 5-HEPE or 18-HEPE every 48 h over 2 wk, with the final administration 1 h before euthanasia. Four groups were analyzed: lean diet, HFD, HFD+5-HEPE, HFD+18-HEPE (5–8 mice/group). Fat/lean mass, insulin/glucose, and glucose tolerance were measured. Targeted mass spectrometry was used to quantify nonesterified oxylipins, which were analyzed via 1-way analysis of variance with a Benjamini–Hochberg correction.</div></div><div><h3>Results</h3><div>HFD-fed mice with or without HEPEs, relative to control, were glucose intolerant but not hyperglycemic or hyperinsulinemic. Several pulmonary HEPEs were decreased by 1.5- to 3-fold (<em>P</em> &lt; 0.1) with HFD compared with control. 5-HEPE and 18-HEPE administration did not elevate these oxylipins in lungs or spleen, although some pulmonary <em>n</em>–6 (ω-6) PUFA–derived oxylipins were decreased by ≤5-fold (<em>P</em> &lt; 0.1) with 5-HEPE. Splenic PUFA-derived nonesterified oxylipins were decreased by 4- to 73-fold (<em>P</em> &lt; 0.1) with 5-HEPE–treated mice. 5-HEPE and 18-HEPE administration increased plasma levels of these oxylipins by ≤3-fold (<em>P</em> &lt; 0.1).</div></div><div><h3>Conclusions</h3><div>HFD lowered several pulmonary HEPEs, and 5-HEPE had a strong impact on unesterified oxylipin levels. 5-HEPE and 18-HEPE levels were elevated in circulation upon administration but not in lungs or spleen, suggesting rapid metabolism in these tissues or limited uptake due to the dose and timing of administration.</div></div>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"156 9","pages":"Article 101729"},"PeriodicalIF":4.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148456205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Nova Classification: What Would Plato and Paracelsus Say?","authors":"Julie A Miller Jones","doi":"10.1016/j.tjnut.2026.101749","DOIUrl":"10.1016/j.tjnut.2026.101749","url":null,"abstract":"","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"156 9","pages":"Article 101749"},"PeriodicalIF":4.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148584590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Proven Interventions: Why Strengthening Local Systems Is Essential to Improve Child Nutrition at Scale","authors":"Ranadip Chowdhury,&nbsp;Sunita Taneja,&nbsp;Nita Bhandari","doi":"10.1016/j.tjnut.2026.101741","DOIUrl":"10.1016/j.tjnut.2026.101741","url":null,"abstract":"","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"156 9","pages":"Article 101741"},"PeriodicalIF":4.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Consumption of Fortified Complementary Food and Promotion of Responsive Feeding on the Hemoglobin and Micronutrient Status of Young Children in a Controlled, Cluster Randomized Trial in the District of Amparafaravola in Madagascar","authors":"Yannick Razafindratsima,&nbsp;Andry Razakandrainy,&nbsp;Sonia Fortin,&nbsp;Rindra Randremanana,&nbsp;Charlotte Ralison,&nbsp;Christèle Icard-Vernière,&nbsp;Nelly Fioroni,&nbsp;Frank T Wieringa,&nbsp;Claire Mouquet-Rivier","doi":"10.1016/j.tjnut.2025.101346","DOIUrl":"10.1016/j.tjnut.2025.101346","url":null,"abstract":"<div><h3>Background</h3><div>Micronutrient deficiencies are a serious public health problem in early childhood in Madagascar.</div></div><div><h3>Objectives</h3><div>We aimed to evaluate the effects of responsive feeding (RF) and the consumption of fortified complementary foods (FCFs), either alone or combined, on hemoglobin (Hb) concentrations and micronutrient status of young children.</div></div><div><h3>Methods</h3><div>A 2 × 2 factorial randomized controlled intervention trial in infants (<em>n</em> = 706), recruited at 6–7 mo of age, was conducted. The control group received counseling on water, sanitation, and hygiene (WASH) practices, whereas the 3 intervention groups received, in addition to WASH, promotion of RF, provision of daily FCF or both (FCF + RF). Hb concentrations and micronutrient status (iron, zinc, vitamin A, and thiamine) were evaluated at baseline and at the end of the intervention after 9 mo, whereas anthropometry was assessed 3 times monthly. The impact of interventions was evaluated through generalized mixed models.</div></div><div><h3>Results</h3><div>Prevalence of micronutrient deficiency was high, with 85% of children affected by 1 or more deficiencies. Consumption of FCF increased concentrations of Hb (+5.43 g/L, 95% confidence interval [95% CI]: +2.52, +8.3) and retinol-binding protein (RBP: +0.09 μmol/L; 95% CI: +0.04, +0.14). Promotion of RF had only a positive effect on RBP (RBP: +0.06 μmol/L; 95% CI: +0.01, +0.11), but surprisingly, a negative impact on iron, zinc, and thiamine status was observed. There were significant interactions between RF and FCF for most indicators of micronutrient status.</div></div><div><h3>Conclusions</h3><div>The study confirms the potential of FCF on improving micronutrient status of young children, but surprisingly, RF tended to have a negative impact, warranting more research into appropriate RF training modules.</div></div><div><h3>Registry number</h3><div>The study protocol was registered under the Pan African clinical trials registry (<span><span>http://www.edctp.org/pan-african-clinical-trials-registry/</span><svg><path></path></svg></span>) under the number PACTR201906819960554.</div></div>","PeriodicalId":16620,"journal":{"name":"Journal of Nutrition","volume":"156 9","pages":"Article 101346"},"PeriodicalIF":4.2,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145948881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}