Journal of Ovarian Research最新文献

{"title":"Correction: Follicular fluid-derived extracellular vesicles miR-34a-5p regulates granulosa cell glycolysis in polycystic ovary syndrome by targeting LDHA.","authors":"Xueying Cui, Xiaocan Lei, Tao Huang, Xueyan Mao, Zhiwei Shen, Xiuli Yang, Wanting Peng, Jingjing Yu, Shun Zhang, Peng Huo","doi":"10.1186/s13048-025-01666-7","DOIUrl":"https://doi.org/10.1186/s13048-025-01666-7","url":null,"abstract":"","PeriodicalId":16610,"journal":{"name":"Journal of Ovarian Research","volume":"18 1","pages":"82"},"PeriodicalIF":3.8,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010614/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: CRISPR/Cas9-mediated activation of NR5A1 steers female human embryonic stem cell-derived bipotential gonadal-like cells towards a steroidogenic cell fate.","authors":"Laura Danti, Karolina Lundin, Kirsi Sepponen, Dawit A Yohannes, Juha Kere, Timo Tuuri, Juha S Tapanainen","doi":"10.1186/s13048-025-01655-w","DOIUrl":"https://doi.org/10.1186/s13048-025-01655-w","url":null,"abstract":"","PeriodicalId":16610,"journal":{"name":"Journal of Ovarian Research","volume":"18 1","pages":"80"},"PeriodicalIF":3.8,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12004704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of pregnancy outcomes for high morphological scoring mosaic vs. low morphological scoring euploid embryos: a retrospective cohort study.","authors":"Tangyi Geng, Qiao Zhou, Ying Wang, Hui Ji, Kai Ding, Zichen Zheng, Ye Yang, Junqiang Zhang, Chun Zhao, Xiufeng Ling","doi":"10.1186/s13048-025-01665-8","DOIUrl":"https://doi.org/10.1186/s13048-025-01665-8","url":null,"abstract":"<p><strong>Background: </strong>Mosaic embryos have been proven to be capable of resulting in live births and have become an option for embryo transfer under certain circumstances. Recent guidelines suggested that embryo morphological scoring should be taken into consideration when selecting mosaic embryos for transfer. Therefore, we introduce a hypothesis that a high morphological scoring mosaic embryo is a better choice compared to a low morphological scoring euploid embryo.</p><p><strong>Materials and methods: </strong>This retrospective cohort study included 1641 embryo transfer cycles following next-generation sequencing (NGS)-based preimplantation genetic testing for aneuploidy (PGT-A). Participants were categorized into a mosaic group (87 cycles) and an euploid group (1554 cycles) based on the PGT-A results of the transferred embryos. Statistical methods including multivariate logistic regression analysis and propensity score matching (PSM) were employed to compare the pregnancy outcomes between mosaic and euploid embryo transfer cycles.</p><p><strong>Results: </strong>Multivariate logistic regression analysis showed that the transfer of mosaic embryos was a prognosis for the reducing live birth rate (P = 0.043). Furthermore, when comparing the pregnancy outcomes of the high morphological scoring mosaic embryo transfer group with the low morphological scoring euploid embryo transfer group, no significant differences were observed (P > 0.05). Additionally, no significant differences in pregnancy outcomes were found between both the high morphological score low proportion and segmental mosaic group and the low morphological score euploid group (P > 0.05).</p><p><strong>Conclusion: </strong>Our study indicated that morphological scoring has reference value when choosing between euploid and mosaic embryo transfers. Specifically, when the morphological score of euploid embryos is poor, mosaic embryos with high morphological scores could be a viable option after comprehensive prenatal consultation.</p>","PeriodicalId":16610,"journal":{"name":"Journal of Ovarian Research","volume":"18 1","pages":"79"},"PeriodicalIF":3.8,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12004691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curcumin and its formulations for the treatment of polycystic ovary syndrome: current insights and future prospects.","authors":"Pooja Mallya, Shaila A Lewis","doi":"10.1186/s13048-025-01660-z","DOIUrl":"https://doi.org/10.1186/s13048-025-01660-z","url":null,"abstract":"<p><p>Polycystic ovary syndrome (PCOS) is a common gynaecological complication with alarmingly high incidence of 6-20% in women of reproductive age and leads to multifaceted symptoms such as menstrual irregularities, hyperandrogenism, polycystic ovaries, and insulin resistance. Several therapeutic methods have been recommended for PCOS including lifestyle modification, insulin sensitizer (metformin), ovulation inducers (letrozole, clomiphene citrate), hormonal pills, and surgical intervention (ovarian drilling and oophorectomy); however, these treatment modalities often cause adverse effects. Currently, phytochemicals and plant extracts have been recommended for PCOS. Among these, few phytochemicals and their formulations, curcumin (CUR) (a bioactive polyphenol from Curcuma longa), has emerged as a promising complementary PCOS therapy due to its antioxidant, anti-inflammatory, insulin-sensitizing, and ovulation inducing properties. However, CUR's clinical application is hindered by poor solubility and bioavailability. In this review, we summarize and discuss various formulations of CUR and combination therapies that have demonstrated potential in treating PCOS in animal models.</p>","PeriodicalId":16610,"journal":{"name":"Journal of Ovarian Research","volume":"18 1","pages":"78"},"PeriodicalIF":3.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defining the LH surge in natural cycle frozen-thawed embryo transfer: the role of LH, estradiol, and progesterone.","authors":"Raoul Orvieto, Nira Morag, Elena Rubin, Ravit Nahum","doi":"10.1186/s13048-025-01658-7","DOIUrl":"https://doi.org/10.1186/s13048-025-01658-7","url":null,"abstract":"<p><strong>Objective: </strong>Several replacement protocols for frozen-thawed ET (FET) exist, with no advantage of one protocol over the others. In the present retrospective and observational study we aim to evaluate the hormonal changes round the LH surge, for better determination of the LH surge and improving the NC FET outcome. We reviewed the computerized files of all consecutive women admitted to our IVF Institute, between January 1, 2023 and June 30, 2024, who underwent NC FET cycles in our IVF Institute. The elimination of bias in this selection, for the purposes of this study, was achieved by including only patients who had two consecutive hormonal blood tests and transvaginal ultrasound evaluations prior to ovulation, on two days (D- 2) before and one day before ovulation (D- 1). Data on patient demographics and infertility-treatment-related variables were collected from the files. We studied and compared several variable between patients who conceived and those who did not, including the % changes in LH (D- 1 minus D- 2/D- 2), in estradiol (D- 2 minus D- 1/D- 2) and % change in progesterone (D- 1 minus D- 2/D- 2) levels.</p><p><strong>Results: </strong>Six hundreds and sixty-eight NC FET cycles were performed during the study periods. Pregnancy was achieved in 348 patients (pregnancy rate, 52% per cycle). Figure that is not-significantly higher than our previous reported outcome, when the LH surge was defined only by the rise in LH level (46% per cycle). Patients who conceived were significantly younger, with no in-between group differences in LH, E2 and progesterone levels. Moreover, while no differences were observed in the % changes in E2, nor LH levels, the % change in progesterone levels was significantly higher in those who conceived (1.9 + 1.5 vs 1.6 + 1.4, p < 0.013), as compared to those who did not.</p><p><strong>Conclusions: </strong>Patients undergoing NC FET should be monitored by LH, estradiol and progesterone levels. We suggest that the LH surge should be determined by an increase in LH, concomitant to a drop in estradiol and a threefold increase in progesterone levels between D- 2 to D- 1. Further large prospective studies are needed to elucidate the aforementioned recommendation prior to its routine implementation.</p>","PeriodicalId":16610,"journal":{"name":"Journal of Ovarian Research","volume":"18 1","pages":"77"},"PeriodicalIF":3.8,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11995576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Granulosa cell-specific FOXJ2 overexpression induces premature ovarian insufficiency by triggering apoptosis via mitochondrial calcium overload.","authors":"Yunxia Zhang, Qiqian Wu, Furong Bai, Yanqin Hu, Bufang Xu, Yujie Tang, Jingwen Wu","doi":"10.1186/s13048-025-01651-0","DOIUrl":"https://doi.org/10.1186/s13048-025-01651-0","url":null,"abstract":"<p><strong>Background: </strong>Follicle development is a complicated biological process that produces mature oocytes, and requires nutrients, growth factors, and steroids produced by ovarian granulosa cells (GCs). High fork head box J2 (FOXJ2) expression might negatively regulate ovarian function; however, the mechanism is unclear. This study aimed to investigate the effect and mechanism of FOXJ2 overexpression in GCs on regulating follicle development and fertility.</p><p><strong>Methods: </strong>A GC-specific conditional Foxj2 knock-in mouse model (Amh-cre; Foxj2^tg/tg mouse) was generated. Reproductive phenotypes were compared between Amh-cre; Foxj2^tg/tg and control mice using fertility evaluation, oocyte collection, estrus cycle analysis, hormone evaluation, and ovarian follicle assessment. Then, RNA sequencing and bioinformatic analyses were used to detect the altered transcriptome of GCs collected from the Amh-cre; Foxj2^tg/tg and wild-type mice. Western blotting, transmission electron microscopy, immunofluorescence staining, and flow cytometry were used to explore apoptosis and mitochondrial calcium homeostasis. Furthermore, Chromatin immunoprecipitation-PCR and dual-luciferase reporter assays were used to detect the target gene of FOXJ2. Moreover, short hairpin RNA interference was performed on primary GCs and human ovarian granulosa-like tumor (KGN) cells to explore the relationship between FOXJ2 and its target gene in apoptosis and mitochondrial calcium overload.</p><p><strong>Results: </strong>FOXJ2 overexpression in GCs led to reduced fertility, hormonal abnormalities, and follicle atresia, starting at the initiation of sexual maturity, resulting in a premature ovarian insufficiency (POI)-like phenotype. Increased apoptosis and mitochondrial calcium overload were detected in the GCs of Amh-cre; Foxj2^tg/tg mice. Mcu (encoding a mitochondrial calcium uniporter) was observed to be upregulated in the GCs of the Amh-cre; Foxj2^tg/tg mice and was a direct target of FOXJ2. Moreover, Mcu knockdown restored mitochondrial calcium homeostasis and reduced the apoptosis in the GCs of the Amh-cre; Foxj2^tg/tg mice and in KGN cells transfected with FOXJ2-overexpression lentivirus.</p>","PeriodicalId":16610,"journal":{"name":"Journal of Ovarian Research","volume":"18 1","pages":"75"},"PeriodicalIF":3.8,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11984056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-cell RNA sequencing reveals the intra-tumoral heterogeneity and immune microenvironment of small cell carcinoma of the ovary, hypercalcemic type.","authors":"Yi Gao, Kewei Zheng, Haowen Tan, Mingyi Kang, Bingjian Lu, Ling Chen, Jing Xu, Chong Lu, Ranran Chai, Congjian Xu, Yu Kang","doi":"10.1186/s13048-025-01649-8","DOIUrl":"https://doi.org/10.1186/s13048-025-01649-8","url":null,"abstract":"<p><strong>Purpose: </strong>Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare and lethal cancer lacking effective treatment. Its genomic mutations and tumor microenvironment need further exploration.</p><p><strong>Methods: </strong>We performed whole-exome sequencing or gene panel test to explore the SMARCA4 mutation spectrum in SCCOHT (15 samples). Single-cell RNA sequencing was conducted on one primary lesion with matched normal ovarian tissue and one recurrent lesion to investigate the intra-tumoral heterogeneity and immune microenvironment. Multiplex immunofluorescence staining validated T cell infiltration and PD-1 expression.</p><p><strong>Results: </strong>13/15 (86.7%) patients harbored SMARCA4 mutations. The loss of heterozygosity (LOH) occurred in 10/15 (66.7%) patients. Cancer cells and immune cells were observed in SCCOHT tumors. Cancer cells were further divided into seven subtypes and one from recurrent lesion exhibited the highest stemness accompanied by high expression of genes related to cell mitosis (AURKB, CHEK2, CCNB1, WEE1), DNA repair (BRCA1, RAD51) and epigenetic (EZH2, DNMT1). Immune cells mainly included macrophages and T cells. Lipid-associated tumor-associated macrophages (TAMs) was mainly in primary lesion while inflammatory cytokine-enriched TAMs in recurrent lesion. CD4⁺/ CD8⁺ T cell infiltration was observed in SCCOHT tumor and a certain proportion of T cells expressed PD-1.</p><p><strong>Conclusions: </strong>SCCOHT exhibits universal SMARCA4 LOH and significant intra-tumoral heterogeneity, suggesting potential therapeutic targets, including CHEK2, CCNB1, and WEE1. Exhausted T cells and distinct TAM subsets infiltrate tumors. Targeting macrophage polarization or cytokine signaling may also be promising. These findings provide insights for developing novel therapies to improve outcomes in SCCOHT.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":16610,"journal":{"name":"Journal of Ovarian Research","volume":"18 1","pages":"76"},"PeriodicalIF":3.8,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11983804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphometric analysis of neoplastic cell clusters in high-grade serous ovarian cancer ascites identifies a promising prognostic factor: a retrospective study.","authors":"Benoît Thibault, Romina D'Angelo, Samy Rigal, Mélanie White-Koning, Guillaume Bataillon, Julie Guillermet-Guibert, Céline Basset","doi":"10.1186/s13048-025-01653-y","DOIUrl":"10.1186/s13048-025-01653-y","url":null,"abstract":"<p><p>High-grade serous carcinoma of the ovary is the most frequent intraperitoneal malignancy in women. It is associated with a poor prognostic outcome owing to the late appearance of clinical signs leading to a delayed diagnosis, and with resistance to platinum-based chemotherapy. One of the clinical signs is the development of ascites. The detection of neoplastic cells in ascites fluid is important as it indicates tumor progression and is associated with shorter survival. Microscopic cytospin analysis of this fluid reveals the cytological and architectural features of the neoplastic cells, allowing the pathologist to identify rapidly the malignancy and the histologic type. In association with immunocytochemistry, this process ensures a definite diagnosis and provides a specific etiology. Our objective was to provide proof-of-principle that the automatized analysis of general cytomorphological criteria, such as carcinomatous cell clustering, in malignant ascites fluid is of prognostic value in high-grade serous carcinoma. We performed a retrospective analysis of the ascites fluid of 24 advanced-stage high-grade serous ovarian cancer patients naïve of treatment. We found that the low number of neoplastic cell clusters in fluid was significantly associated with shorter overall and progression-free survival after adjusting for WHO performance status, Sugarbaker score, age and BMI. These results were independent of the peritoneal implantation of neoplastic cells. We believe this is a promising strategy to improve high-grade serous carcinoma diagnostics using a more informative but simple analysis of ascites tumor cell morphology.</p>","PeriodicalId":16610,"journal":{"name":"Journal of Ovarian Research","volume":"18 1","pages":"74"},"PeriodicalIF":3.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11980077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upregulation of TRPS1 promotes proliferation, migration, and invasion in ovarian clear cell carcinoma and correlates with poor patient prognosis.","authors":"Jingfang Liu, Beier Wu, Shihan Wan, Yanlu Jin, Li Yang, Meijuan Wu, Jie Xing, Jiejie Zhang, Xin Chen, Aijun Yu","doi":"10.1186/s13048-025-01603-8","DOIUrl":"10.1186/s13048-025-01603-8","url":null,"abstract":"<p><strong>Objective: </strong>Tricho-rhino-phalangeal syndrome-1 (TRPS1), an atypical GATA transcription factor, plays a critical role in diverse physiological and pathological processes and holds potential as a biomarker for diseases and targeted tumor therapies. This study explores TRPS1 expression in ovarian clear cell carcinoma (OCCC), its correlation with patient prognosis, and its involvement in OCCC pathogenesis.</p><p><strong>Research objectives and methods: </strong>To investigate TRPS1 expression, we analyzed ovarian tissues from 50 OCCC patients and 25 normal tissues (from patients with uterine leiomyoma) via immunohistochemistry. Statistical methods, including Chi-square tests, Kaplan-Meier survival analysis, and Cox regression, were employed to evaluate the correlation between TRPS1 expression and clinicopathological parameters. In OCCC cell lines (TOV21G and ES-2), TRPS1 expression was quantified using qRT-PCR and Western blot. Functional studies were conducted by silencing TRPS1 in TOV21G cells with small interfering RNA and inducing overexpression in ES-2 cells using a plasmid. Cellular proliferation and migration were assessed through CCK-8, colony formation, and Transwell assays. Finally, Western blot analysis was performed to investigate the link between TRPS1 and EMT-related molecular pathways.</p><p><strong>Results: </strong>TRPS1 protein expression was significantly higher in OCCC tissues compared to normal tissues and was positively associated with lymph node metastasis and advanced clinical stage. High TRPS1 expression was linked to shorter overall and recurrence-free survival in OCCC patients. In vitro, TRPS1 knockdown suppressed cell proliferation, migration, and invasion, accompanied by reduced levels of invasion-promoting proteins (N-cadherin, MMP2, MMP9) and increased expression of the invasion-inhibiting protein E-cadherin. Conversely, TRPS1 overexpression promoted the expression of invasion-promoting proteins.</p><p><strong>Conclusions: </strong>TRPS1 is overexpressed in OCCC and is associated with poor prognosis, serving as an independent predictor of patient outcomes. Its elevated expression enhances OCCC cell proliferation, migration, and invasion by regulating proteins involved in the epithelial-to-mesenchymal transition (EMT) pathway. These findings highlight TRPS1 as a critical player in OCCC pathogenesis and a potential biomarker and therapeutic target for disease management.</p>","PeriodicalId":16610,"journal":{"name":"Journal of Ovarian Research","volume":"18 1","pages":"73"},"PeriodicalIF":3.8,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ovarian cancer and the heart: pathophysiology, chemotherapy-induced cardiotoxicity, and new therapeutic strategies.","authors":"Megha Nair, Arun Samidurai, Anindita Das, Sham S Kakar, Rakesh C Kukreja","doi":"10.1186/s13048-025-01636-z","DOIUrl":"10.1186/s13048-025-01636-z","url":null,"abstract":"<p><p>Ovarian Cancer (OC) is recognized as the most lethal gynecologic malignancy, characterized by numerous genetic mutations that trigger uncontrolled cellular growth and replication. Emerging evidence suggests that non-coding RNAs including miRNAs and lncRNAs significantly influence OC through their multiple roles including tumor initiation, progression, metastasis, immune evasion, and chemoresistance, making them promising diagnostic markers and therapeutic targets. The primary approach to treating OC typically involves cytoreductive surgery followed by chemotherapy. However, the chemotherapeutic agents, particularly the anthracyclines such as doxorubicin (DOX), are known for their cardiotoxic effects, which can range from acute to chronic, potentially leading to heart failure and death. To enhance the overall treatment response and to minimize cardiotoxicity, alternative strategies have been explored. These include the use of liposomal doxorubicin (DOXIL) as a substitute for DOX, various radiotherapies, immunotherapies, and the co-administration of angiotensin-converting enzyme inhibitors and/or beta-blockers. Phosphodiesterase-5 inhibitors (PDE5i) have also demonstrated efficacy in reducing cardiotoxicity linked to cancer treatments and in promoting apoptosis in cancer cells across multiple cancer types. Although there is no current clinical trial directly examining the impact of PDE5i on reducing cardiotoxicity in OC, however emerging therapies such as Withaferin A, PARP inhibitors, and nanoparticle combination therapy show promise. Additional research is essential to develop treatments that are both effective against OC and less harmful to the heart.</p>","PeriodicalId":16610,"journal":{"name":"Journal of Ovarian Research","volume":"18 1","pages":"72"},"PeriodicalIF":3.8,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11971845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}