Journal of Orthodontic Science最新文献

{"title":"Unlocking ADAMTS-5: <i>In Silico</i> insights into TMJ proteomics and docking dynamics.","authors":"Anjusha Divakar, Nagachandran Kandasamy, Remmiya Mary Varghese, Sivakamavalli Jeyachandran, Lincy Rachel Thomas","doi":"10.4103/jos.jos_89_24","DOIUrl":"https://doi.org/10.4103/jos.jos_89_24","url":null,"abstract":"<p><strong>Background: </strong>Temporomandibular joint (TMJ) disorder refers to a condition involving dysfunction or pain in the jaw joint and the muscles that control jaw movement. It can affect one or both sides of the jaw and can cause various symptoms, including Jaw pain or tenderness; Difficulty or discomfort when chewing; Clicking, popping, or grating sounds in the jaw joint; Jaw locking or limited movement; Earache or pain around the ear; Headaches or migraines; Neck and shoulder pain; Swelling on the side of the face. TMJ disorder can have various causes, including injury to the jaw joint, teeth grinding or clenching (bruxism), arthritis, stress, misalignment of the jaw or teeth, and excessive gum chewing. Computer-aided drug design (CADD) comprises a range of theoretical and computational strategies employed in contemporary drug discovery. Molecular docking stands out as a key technique within CADD, aiding in the comprehension of drug-molecule interactions for rational drug design, mechanistic investigations, and the creation of stable complexes with heightened specificity and potential effectiveness. Through the docking process, valuable information regarding binding energy, free energy, and predictions of complex stability is obtained, offering significant insights into drug development endeavors.</p><p><strong>Aim: </strong>The objective of this research was to employ docking methodology to identify potential ADAMTS-5 protein for TMJ. Four ADAMTS-5 protein inhibitors previously reported in the literature were selected, and their compound structures were obtained from the Zinc15 database. The ADAMTS-5 protein was designated as the target and optimized utilizing the RCSB Protein Data Bank. Following pharmacophore modeling, 20 novel compounds were identified, and SwissDock was utilized to dock these compounds with the target protein. A comparison was made between the binding energies of the newly discovered compounds and those of previously published molecules with the target.</p><p><strong>Results: </strong>The results indicated that among the 20 ZINC1846088 and ZINC33606904 exhibited the highest binding energy and displayed superior properties compared to the other molecules.</p><p><strong>Conclusion: </strong>The study concluded that ZINC1846088 and ZINC33606904 exhibited greater binding affinity than the reported inhibitors of ADAMTS-5 protein. Therefore, these two molecules can be used as a potential and promising lead for the treatment of TMJ and could be employed in targeted drug therapy.</p><p><strong>Categories: </strong>Dentistry, TMJ.</p>","PeriodicalId":16604,"journal":{"name":"Journal of Orthodontic Science","volume":"14 ","pages":"11"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macroesthetics in orthodontics - A systematic review and meta-analysis.","authors":"Mohammad Khursheed Alam, Ahmed Hamoud L Alsharari, Maher A L Shayeb, Yahya Abdullah Alogaibi","doi":"10.4103/jos.jos_11_24","DOIUrl":"https://doi.org/10.4103/jos.jos_11_24","url":null,"abstract":"<p><p>Recent years have witnessed an increase in the popularity of macroesthetics (MES) in orthodontics, which focuses on gently and accurately increasing a patient's smile's esthetics. This systematic study's goal was to evaluate how well we currently understand how orthodontic MES affects a person's impression of their overall attractiveness. The terms \"orthodontic aesthetics,\" \"orthodontic macroesthetics,\" \"aesthetic orthodontics,\" and \"orthodontic smile design\" were thoroughly searched across different online databases. There were a total of four papers that were relevant included in the review. The importance of MES in orthodontics and the need for orthodontists to use a complete and specialized approach to treatment were emphasized in all the articles that were being evaluated. An odds ratio (OR) of 0.69 [0.60, 0.79] and a risk ratio (RR) of 0.77 [0.70, 0.85] further highlight the statistical significance of the different parameters that were assessed in terms of the impact of MES on esthetic perception. All the articles included in the investigation provide a comprehensive account of the state of the science regarding MES in orthodontics. The results add to our understanding of MES perception in orthodontics, but because of the limitations of the included research, they should be evaluated with caution. This review protocol was registered on the International Prospective Register of Systematic Reviews (PROSPERO; registration number: CRD42023397221).</p>","PeriodicalId":16604,"journal":{"name":"Journal of Orthodontic Science","volume":"14 ","pages":"12"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036763/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Volumetric pulpal changes in permanent first molars following AdvanSyncTM and Twin Block functional appliance: A CBCT study.","authors":"Raj K Verma, Sanjeev Verma, Satinder P Singh, Vinay Kumar, Anjana Rajagopalan, Naveen K Subbaiah, Chaman Lal","doi":"10.4103/jos.jos_68_24","DOIUrl":"https://doi.org/10.4103/jos.jos_68_24","url":null,"abstract":"<p><strong>Introduction: </strong>Dental pulp may respond differently to adverse orthodontic forces. Major physiological effects of optimum orthodontic force application on dental pulp are vascular pulpal changes, pulpal calcification, and fibrosis. Functional appliances taking anchorage from the dentition tend to exert reciprocal higher orthodontic forces.</p><p><strong>Objective: </strong>To evaluate the 3D volumetric changes of the dental coronal pulp of maxillary and mandibular permanent first molars 6 months after AdvanSync^TM fixed functional and Twin Block removable functional appliance therapy and followed at 18 months of treatment (T2).</p><p><strong>Materials and methods: </strong>This retrospective study was performed on CBCT records obtained from a previous prospective study (Randomized Clinical Trial) comprising 32 patients [females: 17 (9.0-14.5 years), males: 15 (10.5-15.0 years)] who underwent functional mandibular advancement with Twin Block (group 1) and AdvanSync^TM (group 2). Pretreatment (T0), 6 months (T1), and 18 months (T2) follow-up CBCT were assessed for dental pulp volume by using ITK-SNAP software version 3.2.</p><p><strong>Results: </strong>Intragroup volumetric pulpal changes showed a significant decrease in #16, #26, and #36 at time intervals T0-T1, T0-T2, and T1-T2 in groups 1 and 2. Intergroup comparison of pulpal volume for #16 and #26 was statistically significant at T1. A statistically significant decrease in pulpal volume for #46 was observed at time intervals T0-T1, T0-T2, and T1-T2 in both groups.</p><p><strong>Conclusion: </strong>Functional appliance therapy with both Twin Block and AdvanSync^TM functional appliance tends to decrease the first molar pulpal volume.</p>","PeriodicalId":16604,"journal":{"name":"Journal of Orthodontic Science","volume":"14 ","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a self-ligating bracket system combined with corticision on the rate of orthodontic tooth movement: A controlled clinical trial.","authors":"Hazem Abd Elhafeez, Mahmoud M Fathy Aboelmahasen, Mohamed Helmi Saleh, Ahmed Ahmed Hussein Alfeqy, Ahmed Mohammed Abouelnour","doi":"10.4103/jos.jos_97_24","DOIUrl":"https://doi.org/10.4103/jos.jos_97_24","url":null,"abstract":"<p><strong>Background: </strong>The self-ligating bracket system and corticision are two methods for acceleration of orthodontic tooth movement (OTM).</p><p><strong>Objectives: </strong>The current study aimed to assess the effect of a self-ligating bracket system combined with corticision on the rate of OTM.</p><p><strong>Patients and methods: </strong>The present study was conducted on 16 female patients divided into two groups: an experimental group of eight patients treated by self-ligating bracket systems used as fixed orthodontic appliances combined with a corticision as a minimally invasive surgical technique for accelerating OTM, and a control group of eight patients treated only by self-ligating bracket systems used as fixed orthodontic appliances. The primary outcome was the percentage of change in Little's Index of Irregularity (LII). The secondary outcome was the time taken to finish the leveling and alignment stage.</p><p><strong>Results: </strong>In a comparison of the percentage of change in LII for the upper arch between the two groups, the experimental group recorded values that were significantly greater than those recorded in the control group at all time intervals T0-T7, except for T8-T10, which were similar. Both groups recorded (100 ± 0%), with no significant difference between groups (<i>P</i> = 1).</p><p><strong>Conclusion: </strong>The combination of two methods for acceleration of OTM, a self-ligating bracket system combined with corticision, accelerates the rate of OTM more than in the case of using a self-ligating bracket system only.</p>","PeriodicalId":16604,"journal":{"name":"Journal of Orthodontic Science","volume":"14 ","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036755/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of expired orthodontic bonding material on primary human gingival fibroblasts: <i>In vitro</i> study.","authors":"Maysaa Z Khojah, Abdel-Rahman Youssef, Elham N Alsahafi","doi":"10.4103/jos.jos_67_24","DOIUrl":"https://doi.org/10.4103/jos.jos_67_24","url":null,"abstract":"<p><strong>Aim: </strong>Composite resins and bonding agents are indispensable in orthodontic practice, necessitating a thorough understanding of their cytotoxic effects, particularly when expired. This study aimed to evaluate the influence of expired composite and bonding materials on human gingival fibroblasts (hGFs).</p><p><strong>Materials and methods: </strong>Both expired and nonexpired composite resins and bonding agents were tested on hGFs using direct exposure methods. Viability assays, morphological evaluations, and wound healing assays were conducted at 24 and 72 hours post exposure.</p><p><strong>Results: </strong>Exposure to both expired and nonexpired materials led to significant reductions in hGF viability and alterations in morphology. Wound healing assays demonstrated impaired migratory abilities of hGFs following exposure to these materials.</p><p><strong>Conclusion: </strong>The study highlights the importance of prudent material selection, handling, and monitoring in orthodontic practice to mitigate adverse effects on gingival tissues. Proper management of expired materials is crucial for cost-effectiveness, waste reduction, and patient safety. Further research into the long-term impacts of expired materials on gingival and periodontal health is imperative to ensure clinical treatment safety and efficacy. This investigation provides valuable insights into the biocompatibility of orthodontic bonding materials and emphasizes the necessity for continued vigilance in their usage to uphold patient welfare and treatment quality.</p>","PeriodicalId":16604,"journal":{"name":"Journal of Orthodontic Science","volume":"14 ","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Difference in force decay latex and non-latex elastic band based on duration of elastic use and salivary pH concentration: <i>In vitro</i> study.","authors":"Rasdiana Bakri, Baharuddin M Ranggang, Nasyrah Hidayati","doi":"10.4103/jos.jos_58_24","DOIUrl":"https://doi.org/10.4103/jos.jos_58_24","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to determine the difference in force decay between latex and non-latex elastic bands based on duration of use and salivary pH concentration.</p><p><strong>Material and method: </strong>The calculation of the sample size in this study used Federer. Total sample size is 80 and divided into four groups. First group consists of 20 elastic bands made from latex immersed in artificial saliva pH 5.2, second group consists of 20 elastic bands made from latex immersed in artificial saliva pH 6.7, third group consists of 20 elastic bands made from non-latex immersed in artificial saliva pH 5.2, and fourth group consists of 20 non-latex elastic bands immersed in artificial saliva pH 6.7. All samples were incubated at 37°C, and force magnitude was measured with a digital force gauge.</p><p><strong>Results: </strong>The most force decay occurred in the first 24 hours when immersed in artificial saliva and was constant for up to 72 hours<i>.</i> The elastic band immersed in salivary pH concentration showed greater force decay compared with pH 6.7 both latex and non-latex.</p><p><strong>Conclusion: </strong>There was a significant difference in force decay of elastic bands made from latex and non-latex based on duration of elastic use. Force decay of elastic bands made from non-latex was greater than latex material. There was a difference in force decay elastic bands made from latex and non-latex based on the pH concentration of saliva. Force decay elastic band made from non-latex is greater than latex material and greater at pH 5.2 compared to 6.7.</p>","PeriodicalId":16604,"journal":{"name":"Journal of Orthodontic Science","volume":"14 ","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of miniscrew-assisted maxillary expansion in the treatment of unilateral maxillary constriction: A finite element study.","authors":"Shravan Shetty, Phad Sharad Trimbakrao, Utkarsh Mangal, Suraj Patil, Shah Mohammed Abdul Khader, M V Ashith, Satish Shenoy","doi":"10.4103/jos.jos_71_24","DOIUrl":"https://doi.org/10.4103/jos.jos_71_24","url":null,"abstract":"<p><strong>Objective: </strong>The present study focused on evaluating and comparing the stresses and displacements generated by various designs of miniscrew-assisted maxillary expansion appliances. The primary focus of this study is on a modified design for treating unilateral maxillary constriction, analyzed using the finite element method (FEM).</p><p><strong>Materials and methods: </strong>Using computed tomography (CT) scans and the modeling software Mimics, a three-dimensional (3D) mesh model of the skull and related maxillary structures was created. First, the necessary material characteristics were determined using FEM. Three models of miniscrew-assisted maxillary expansion appliances were then tested with ANSYS simulation software: (a) a bone-anchored rapid palatal expander (BARPE), (b) a conventional miniscrew-assisted rapid palatal expansion (C-MARPE), and (c) an asymmetric design of a MARPE focusing on unilateral expansion (U-MARPE). The asymmetric U-MARPE design features an attachment connecting the expander to the teeth on only one half of the maxilla. The stress, displacement, and distribution predictions for all three types of expanders were subsequently evaluated via FEM.</p><p><strong>Results: </strong>Tooth displacement in the U-MARPE (on the expander-to-tooth attachment side) and C-MARPE groups was greater than that in the BARPE group. The stresses on the teeth were lowest in the BARPE and U-MARPE groups (on the expander-to-no-tooth attachment side). C-MARPE exhibited a symmetrical stress distribution around the miniscrew areas. Overall, U-MARPE generated the greatest amount of asymmetric von Mises stress and displacement on the dental landmarks.</p><p><strong>Conclusion: </strong>This research indicates that, compared to other models, U-MARPE achieves more favorable unilateral expansion effects. The current U-MARPE design can be effectively used to correct unilateral transverse anomalies.</p>","PeriodicalId":16604,"journal":{"name":"Journal of Orthodontic Science","volume":"14 ","pages":"10"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"McNamara analysis comparison between Indigenous and Chinese ethnic with skeletal class I malocclusion in Medan.","authors":"Ervina Sofyanti, Angeline Christy, Felix Edwin, Maria Sitanggang, Erliera Sufarnap, Zamri Radzi","doi":"10.4103/jos.jos_92_24","DOIUrl":"https://doi.org/10.4103/jos.jos_92_24","url":null,"abstract":"<p><strong>Objectives: </strong>To compare lateral cephalometric variables based on McNamara analysis between Indigenous and Chinese-Indonesian ethnic patients with skeletal class I malocclusion from Medan city.</p><p><strong>Materials and methods: </strong>Simple random sampling of retrospective data from pre-treatment lateral cephalograms of orthodontic adult patients of three successive generations of the Mongoloid race in Medan from 2015 to 2023. Thus, the <i>unpaired t</i>-test and <i>Mann-Whitney</i> test were conducted after the normality test to compare the cephalometric analysis between Indigenous and Chinese-Indonesian ethnicities.</p><p><strong>Results: </strong>This cross-sectional study analyzed 32 Indigenous and 34 Chinese ethnic lateral cephalograms. There were significant differences (<i>P</i> < 0.05) between Indigenous and Chinese ethnic in the lower pharynx, nasolabial angle, A to N perpendicular, maxillomandibular differential, and Pog to N Perpendicular variables for skeletal parameters. There were also significant differences (<i>P</i> < 0.05) in nasolabial angle for the soft tissue parameter and lower pharynx for the airway parameter. Conversely, there were no significant differences (<i>P</i> > 0.05) between these groups in the Co-A, Co-gnathion, lower anterior facial height (LAFH), facial axis angle, and mandibular plane angle for skeletal parameters. There were also no significant differences (<i>P</i> > 0.05) in upper incisor to A and lower incisor to A-Pog for dental parameters. Furthermore, there were also no significant differences (<i>P</i> > 0.05) in cant of the upper lip for soft tissue parameters and upper pharynx for airway.</p><p><strong>Conclusions: </strong>It is advisable to consider certain landmarks and reference lines based on McNamara cephalometry parameters that showed a significant difference between Indigenous and Chinese ethnic groups with skeletal class I malocclusion when determining diagnosis and formulating individualized orthodontic treatment plans for multiethnic subpopulation patients in Medan.</p>","PeriodicalId":16604,"journal":{"name":"Journal of Orthodontic Science","volume":"14 ","pages":"6"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of overbite improvement in deep bite correction using clear aligner therapy.","authors":"Thu-Trang Pham, Hong Thuy Pham Thi, Cao Binh Tran, Ngoc Quang Dong, Viet Hoang","doi":"10.4103/jos.jos_87_24","DOIUrl":"https://doi.org/10.4103/jos.jos_87_24","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to determine the accuracy of overbite correction in patients with deep bite using the clear aligner therapy (CAT).</p><p><strong>Materials and methods: </strong>This retrospective study included 31 patients prescribed orthodontic treatment using CAT from January 2020 to January 2024. Clinical information was collected via X-ray results at pre-treatment and post-treatment stages. Treatment outcomes were measured at three stages: pre-treatment, post-treatment (clinical results), and predict treatment (predict results) as programmed in ClinCheck®.</p><p><strong>Results: </strong>Significant changes were observed in X-ray in both overbite (3.85 ± 1.38 mm to 2.93 ± 1.13 mm) and overjet (5.19 ± 1.79 mm to 3.43 ± 1.14 mm) following CAT. For clinical crown lengthening (CCL) of tooth 31, significant differences were noted between pre-treatment and post-treatment (-0.31 ± 0.66 mm) and between predicted and clinical results (-0.21 ± 0.58 mm). For CCL of tooth 41, significant differences were found between pre-treatment and post-treatment (-0.36 ± 0.66 mm) and between prediction and post-treatment (-0.32 ± 0.65 mm). The percentage of deep bites differed significantly between pre-treatment vs predicted treatment (38.10 ± 14.90%), pre-treatment vs post-treatment (11.80 ± 14.30%), and predicted treatment vs post-treatment (-26.40 ± 12.60%). Similar trends were observed in mean overbite (2.77 ± 1.07 mm, 0.69 ± 0.93 mm, and - 2.08 ± 0.83 mm, respectively).</p><p><strong>Conclusions: </strong>Our findings support the use of CAT as a reliable and aesthetic option for treating deep bite malocclusions.</p>","PeriodicalId":16604,"journal":{"name":"Journal of Orthodontic Science","volume":"14 ","pages":"8"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental maturity in children with cleft lip and palate compared with children without cleft lip and palate living in the Western Region of Saudi Arabia.","authors":"Wafa A Alswajy, Fahad F Alsulaimani","doi":"10.4103/jos.jos_142_24","DOIUrl":"https://doi.org/10.4103/jos.jos_142_24","url":null,"abstract":"<p><strong>Background: </strong>Dental maturity assessment is crucial for orthodontic treatment planning, especially in children with cleft lip and palate (CLP), as they often exhibit delayed dental development. The correlation between dental, skeletal, and chronological age remains uncertain, particularly in complex cases like CLP.</p><p><strong>Objective: </strong>The aim of this study was to compare the development of permanent teeth in children with cleft lip and palate (CLP) to that of normal children without CLP of the same age and gender.</p><p><strong>Materials and methods: </strong>The study evaluated panoramic radiographs from 240 children with CLP (112 males, 128 females, ages 5-15, mean age 9.28 years) and 350 healthy controls (187 males, 163 females). Dental age was assessed using the Demirjian method, which evaluates the mineralization stages of seven mandibular teeth on the left side. Radiographs were coded to minimize bias, and dental maturity scores were converted to dental age using gender-specific conversion tables.</p><p><strong>Results: </strong>No significant difference in dental age was observed between children with and without CLP across most age groups. However, at age 9, male CLP patients exhibited significantly delayed dental maturity compared to females. High correlations were noted between dental and chronological ages in both groups.</p><p><strong>Conclusion: </strong>Dental maturity in Saudi children with CLP is generally comparable to their non-CLP counterparts, except for delayed dental development in males at age 9.</p>","PeriodicalId":16604,"journal":{"name":"Journal of Orthodontic Science","volume":"14 ","pages":"9"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}