European Journal of Immunology最新文献_第6页

Aging and Viral Evolution Impair Immunity Against Dominant Pan-Coronavirus-Reactive T Cell Epitope 衰老和病毒进化损害对显性泛冠状病毒反应性T细胞表位的免疫

IF 4.5 3区医学

European Journal of Immunology Pub Date : 2025-07-28 DOI: 10.1002/eji.202551888

Lucie Loyal, Karsten Jürchott, Ulf Reimer, Lil Meyer-Arndt, Larissa Henze, Norbert Mages, Jak Kostrzanowski, Bernhard Reus, Maike Mangold, Beate Kruse, Manuela Dingeldey, Birgit Sawitzki, Janine Michel, Marica Grossegesse, Karsten Schnatbaum, Holger Wenschuh, Andreas Nitsche, Nils Lachmann, Bernd Timmermann, Claudia Giesecke-Thiel, Julian Braun, Florian Kern, Andreas Thiel

{"title":"Aging and Viral Evolution Impair Immunity Against Dominant Pan-Coronavirus-Reactive T Cell Epitope","authors":"Lucie Loyal, Karsten Jürchott, Ulf Reimer, Lil Meyer-Arndt, Larissa Henze, Norbert Mages, Jak Kostrzanowski, Bernhard Reus, Maike Mangold, Beate Kruse, Manuela Dingeldey, Birgit Sawitzki, Janine Michel, Marica Grossegesse, Karsten Schnatbaum, Holger Wenschuh, Andreas Nitsche, Nils Lachmann, Bernd Timmermann, Claudia Giesecke-Thiel, Julian Braun, Florian Kern, Andreas Thiel","doi":"10.1002/eji.202551888","DOIUrl":"https://doi.org/10.1002/eji.202551888","url":null,"abstract":"Immune evasion by escape mutations subverts immunity against SARS-CoV-2. A role of pan-coronavirus immunity for more durable protection is being discussed, but has remained understudied. We here investigated the effects of age, mutations, and homo-/heterologous vaccination regimens on the dominant pan-coronavirus-specific cellular and humoral epitope iCope after SARS-CoV-2 infection and vaccination in detail. In older individuals, the quantitatively and qualitatively reduced iCope-reactive CD4+ T cell responses with narrow TCR repertoires could not be enhanced by vaccination and were further compromised by emerging spike mutations. In contrast, pan-coronavirus-reactive humoral immunity was affected only by mutations and not by age. Our results reveal a distinct deficiency of the dichotomous layer of pan-coronavirus immunity in the older, critical for long-term protection against SARS-CoV-2 variants.","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"55 7","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.202551888","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunogenicity-Guided Design of an Acinetobacter baumanii Vaccine 免疫原性导向的鲍曼不动杆菌疫苗设计

IF 4.5 3区医学

European Journal of Immunology Pub Date : 2025-07-28 DOI: 10.1002/eji.70019

Chenghua Zhu, Shuaiyuan Liang, Ning Yang, Shan Li, Jianpeng Xue, Runlu Zhou, Xiuwen Hong, Sixi Chen, Nan Gao, Qiang Du, Jianling Huang, Ganzhu Feng, Xingran Du

{"title":"Immunogenicity-Guided Design of an Acinetobacter baumanii Vaccine","authors":"Chenghua Zhu, Shuaiyuan Liang, Ning Yang, Shan Li, Jianpeng Xue, Runlu Zhou, Xiuwen Hong, Sixi Chen, Nan Gao, Qiang Du, Jianling Huang, Ganzhu Feng, Xingran Du","doi":"10.1002/eji.70019","DOIUrl":"https://doi.org/10.1002/eji.70019","url":null,"abstract":"<div>\u0000 \u0000 The development of vaccines represents a promising and safe strategy to combat multidrug-resistant (MDR) Acinetobacter baumannii (A. baumannii) infections. In this study, we designed and evaluated a dendritic cell (DC)-targeting multiepitope peptide-based biomimetic nanovaccine for its immunogenicity and protective efficacy in a murine model. Bioinformatics tools were employed to predict and screen B- and T-cell epitopes derived from the OmpW protein of A. baumannii, followed by immunological validation. The dominant epitopes were sequentially linked using 6-aminocaproic acid to synthesize a multiepitope peptide, rOmpW. Subsequently, rOmpW was encapsulated within polylactic-co-glycolic acid (PLGA) nanoparticles coated with neutrophil membranes (NM), and the surface was functionalized with a DC-targeting peptide (DCpep) to construct the biomimetic nanovaccine, DCpep-NM-PLGA-rOmpW. This biomimetic nanovaccine elicited robust Th1 and Th17 cellular immune responses, as well as humoral immunity, and demonstrated significant protective efficacy in a murine model of acute lethal pneumonia caused by A. baumannii. These findings underscore the translational potential of this biomimetic nanovaccine as a prophylactic strategy against A. baumannii infections.\u0000 </div>","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"55 7","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144716984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Signal Transducer and Activator of Transcription 3 (STAT3) Variant p.K709N Causes Hyper-IgE Syndrome Likely by Impaired STAT3-Dimer Formation 信号换能器和转录激活子3 （STAT3）变异体p.K709N可能因STAT3二聚体形成受损而导致高ige综合征

IF 4.5 3区医学

European Journal of Immunology Pub Date : 2025-07-28 DOI: 10.1002/eji.70015

Beate Hagl, Benedikt D. Spielberger, Betina Neumann, Simon J. Pelham, Dharmendra Pandey, Andreas Schlundt, Camille Barro, Anica Lechner, Christine Wolf, Elissa K. Deenick, Michael Sattler, Stuart G. Tangye, Simon Rothenfusser, Ellen D. Renner

{"title":"Signal Transducer and Activator of Transcription 3 (STAT3) Variant p.K709N Causes Hyper-IgE Syndrome Likely by Impaired STAT3-Dimer Formation","authors":"Beate Hagl, Benedikt D. Spielberger, Betina Neumann, Simon J. Pelham, Dharmendra Pandey, Andreas Schlundt, Camille Barro, Anica Lechner, Christine Wolf, Elissa K. Deenick, Michael Sattler, Stuart G. Tangye, Simon Rothenfusser, Ellen D. Renner","doi":"10.1002/eji.70015","DOIUrl":"https://doi.org/10.1002/eji.70015","url":null,"abstract":"STAT3-hyper-IgE syndrome (STAT3-HIES) is an inborn error of immunity caused by heterozygous dominant-negative mutations in the signal transducer and activator of transcription 3 (STAT3). In this study, we evaluate the functional relevance of a previously undescribed heterozygous STAT3 variant in a patient with clinical findings of STAT3-HIES. Flow cytometry, quantitative real-time PCR, pull-down assays, native PAGE, DNA-binding ELISA, and 3D-structural data analysis were performed. Genetic analysis identified the heterozygous STAT3 variant NM_139276.2:c.2127G>C (NP_644805.1:p.(K709N); short: p.K709N) in a patient with a clinical and laboratory phenotype characteristic of STAT3-HIES, including early onset severe eczema, chronic lung disease, eosinophilia, and elevated serum IgE levels. While STAT3 p.K709N did not significantly affect STAT3 phosphorylation, STAT3 target gene expression was impaired in patient cells. Expression of STAT3 p.K709N and wild-type STAT3 in STAT3-deficient cells indicated a dominant-negative effect by the mutation. Analysis of 3D-structural data and modeling suggested a central role of the affected amino acid K709 in stabilizing a C-terminal loop in STAT3 essential for dimer formation. Consequently, p.K709N resulted in diminished STAT3 dimerization and reduced DNA binding in patient cells. Functional analyses verified STAT3 p.K709N to cause STAT3-HIES and suggest that STAT3 p.K709N impairs STAT3 dimer formation.","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"55 7","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.70015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunological Impact of Oncolytic Adenoviruses On Cancer Therapy: Clinical Insights 溶瘤腺病毒对癌症治疗的免疫学影响：临床见解

IF 4.5 3区医学

European Journal of Immunology Pub Date : 2025-07-28 DOI: 10.1002/eji.70024

Reza Nadafi, Wenliang Dong, Victor W. van Beusechem

{"title":"Immunological Impact of Oncolytic Adenoviruses On Cancer Therapy: Clinical Insights","authors":"Reza Nadafi, Wenliang Dong, Victor W. van Beusechem","doi":"10.1002/eji.70024","DOIUrl":"https://doi.org/10.1002/eji.70024","url":null,"abstract":"Oncolytic immunotherapy, particularly using engineered adenoviruses, has emerged as a promising approach in cancer treatment due to its dual mechanism of action: selective tumor-cell destruction and inducing potent antitumor immune responses. This review focuses on the immunological effects observed in clinical trials involving conditionally replicating oncolytic adenoviruses (OAds), either with or without transgenes. These viruses primarily exert antitumor effects through mechanisms like direct oncolysis, apoptosis, necroptosis, and autophagy, while also activating innate and adaptive immune responses. Different genetic modification strategies have been employed to enhance the safety and therapeutic efficacy of OAds. However, these alterations may influence viral replication dynamics, oncolytic potency, and the duration of viral presence (i.e., persistence) within the tumor. Clinical data have shown that OAds can also profoundly alter the tumor microenvironment (TME), converting cold tumors to hot by increasing immune cell infiltration and activation. This conversion not only correlates with improved clinical outcomes but also creates conditions conducive to the efficacy of other immunotherapies, particularly immune checkpoint inhibitors (ICIs), which traditionally show limited activity in cold tumors. The synergistic potential of combining OAds with ICIs has shown promising results in improving clinical response rates. However, maximizing therapeutic benefit requires careful consideration of the OAd's immune-activating capabilities and optimal timing of combination strategies. This review provides critical insights into the current state of OAd-based immunotherapy, examining its role in modulating the TME, while addressing the complex interplay between oncolytic activity and sustained immune stimulation in clinical practice.","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"55 7","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.70024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine Learning Reassessment of Serum Immune Factors Shows No Unique Immune Profiles Linked to Disease Outcomes in SARS-CoV-2-infected Patients at Hospital Admittance 机器学习对血清免疫因子的重新评估显示入院时sars - cov -2感染患者的疾病结局没有独特的免疫特征

IF 4.5 3区医学

European Journal of Immunology Pub Date : 2025-07-25 DOI: 10.1002/eji.70001

Stefania Rossi, Imerio Capone, Enrico Cabri, Anna Giabelli, Ilaria Rossoni, Giulia Romagnoli, Stefano M. Santini, Cinzia Marcantonio, Roberto Giuseppetti, Umbertina Villano, Roberto Bruni, Anna R. Ciccaglione, Federica Frasca, Alessandra d'Auria, Ginevra Bugani, Gabriella d'Ettorre, Guido Antonelli, Carolina Scagnolari, Maddalena Fratelli, Lucia Gabriele

{"title":"Machine Learning Reassessment of Serum Immune Factors Shows No Unique Immune Profiles Linked to Disease Outcomes in SARS-CoV-2-infected Patients at Hospital Admittance","authors":"Stefania Rossi, Imerio Capone, Enrico Cabri, Anna Giabelli, Ilaria Rossoni, Giulia Romagnoli, Stefano M. Santini, Cinzia Marcantonio, Roberto Giuseppetti, Umbertina Villano, Roberto Bruni, Anna R. Ciccaglione, Federica Frasca, Alessandra d'Auria, Ginevra Bugani, Gabriella d'Ettorre, Guido Antonelli, Carolina Scagnolari, Maddalena Fratelli, Lucia Gabriele","doi":"10.1002/eji.70001","DOIUrl":"https://doi.org/10.1002/eji.70001","url":null,"abstract":"The complex pathophysiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) involves a hyperinflammatory state with excessive cytokine production, leading to an influenza-like syndrome that may need emergency care. The severity of SARS-CoV-2 varies widely, and collective serum immune factors, evaluated in emergency care patients, have not been shown to correlate with disease progression. We applied a machine learning approach to reassess and define serum immune profiles that could align with clinical laboratory parameters and predict disease outcomes in patients with respiratory virus infections, including those with SARS-CoV-2, seeking emergency care. Sixty-two plasma immune molecules, in a cohort of 67 symptomatic SARS-CoV-2, were analyzed for correlation with antibodies (Abs) to spike (S) and nucleocapsid (N) proteins, as well as with clinical laboratory parameters, to identify early indicators of disease prognosis at hospital admission. This approach allowed us to analyze and cluster unlabeled datasets, delineating three distinct serum immune signatures. Two showed significant and opposite modulations, correlating with poorer disease outcomes, while most patients with moderate disease displayed modest immune factor dysregulation. This highlights the complexity of immune responses in the severity of diseases caused by highly respiratory pathogenic virus like SARS-CoV-2, emphasizing the importance of evaluating overall immune imbalance rather than focusing on a few dysregulated factors.","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"55 7","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.70001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144695823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Platelet-Based Nanotechnology Improves Cancer Immunotherapy 基于血小板的纳米技术改善癌症免疫治疗

IF 4.5 3区医学

European Journal of Immunology Pub Date : 2025-07-24 DOI: 10.1002/eji.70017

Yanlin Lv, Guanghui Ma

引用次数: 0

Ex Vivo Modeling and Pharmacological Modulation of Tissue Immune Responses in Inflammatory Bowel Disease Using Precision-Cut Intestinal Slices 利用精确切肠片对炎性肠病组织免疫反应进行离体建模和药理调节

IF 4.5 3区医学

European Journal of Immunology Pub Date : 2025-07-24 DOI: 10.1002/eji.70013

Klaudia Maria Grieger, Valerie Schröder, Susann Dehmel, Vanessa Neuhaus, Dirk Schaudien, Maximillian Fuchs, Helena Linge, Alexander Wagner, Ulf Kulik, Benjamin Gundert, Heiko Aselmann, Armin Braun, Christina Hesse, Katherina Sewald

{"title":"Ex Vivo Modeling and Pharmacological Modulation of Tissue Immune Responses in Inflammatory Bowel Disease Using Precision-Cut Intestinal Slices","authors":"Klaudia Maria Grieger, Valerie Schröder, Susann Dehmel, Vanessa Neuhaus, Dirk Schaudien, Maximillian Fuchs, Helena Linge, Alexander Wagner, Ulf Kulik, Benjamin Gundert, Heiko Aselmann, Armin Braun, Christina Hesse, Katherina Sewald","doi":"10.1002/eji.70013","DOIUrl":"https://doi.org/10.1002/eji.70013","url":null,"abstract":"Inflammatory bowel disease (IBD) affects approximately 5 million people worldwide, causing chronic inflammation and increased mortality. Despite advances in therapy, the underlying immune mechanisms remain poorly understood, highlighting the need for human-immunocompetent models to enhance translational research. This study aimed to investigate local immune responses using precision-cut intestinal slices (PCIS) from IBD patients and evaluate immunomodulatory treatment directly in patient tissue ex vivo. PCIS from ileal resections of IBD and non-IBD patients were stimulated with Concanavalin A (ConA) or lipopolysaccharide (LPS). Histological analysis of IBD-derived PCIS showed villus atrophy, infiltration of lymphocytes and macrophages, and RNA analysis revealed upregulation of IL-17 and interferon signaling pathways. LPS- and ConA-induced functional immune responses in the tissue, with IBD tissue exhibiting increased levels of specific cytokines compared with non-IBD tissue, including IL-17F and IL-21 after ConA-stimulation, and IL-22 as well as ENA-78 following LPS-stimulation. Pimecrolimus treatment led to a marked reduction in the release of IL-2, IL-17A, and IFN-γ, and inhibited the IBD supernatant-induced reduction in transepithelial electrical resistance. Our data provide the first in-depth characterization of local tissue immune responses in human PCIS, highlighting the potential of this model to study disease-specific immune activity and evaluate pharmacological interventions ex vivo.","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"55 7","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.70013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LAG3 Marks Activated but Hyporesponsive NK Cells LAG3标记活化但反应低下的NK细胞

IF 4.5 3区医学

European Journal of Immunology Pub Date : 2025-07-24 DOI: 10.1002/eji.70009

Valeria Vasilyeva, Olivia Makinson, Cynthia Chan, Maria Park, Colin O'Dwyer, Ayad Ali, Abrar Ul Haq Khan, Christiano Tanese de Souza, Mohamed S. Hasim, Sara Asif, Reem Kurdieh, John Abou-Hamad, Edward Yakubovich, Jonathan Hodgins, Paul Al Haddad, Giuseppe Pietropaolo, Julija Mazej, Hobin Seo, Qiutong Huang, Sarah Nersesian, Damien Chay, Nicolas Jacquelot, David Cook, Seung-Hwan Lee, Giuseppe Sciumè, Stephen Waggoner, Michele Ardolino, Marie Marotel

{"title":"LAG3 Marks Activated but Hyporesponsive NK Cells","authors":"Valeria Vasilyeva, Olivia Makinson, Cynthia Chan, Maria Park, Colin O'Dwyer, Ayad Ali, Abrar Ul Haq Khan, Christiano Tanese de Souza, Mohamed S. Hasim, Sara Asif, Reem Kurdieh, John Abou-Hamad, Edward Yakubovich, Jonathan Hodgins, Paul Al Haddad, Giuseppe Pietropaolo, Julija Mazej, Hobin Seo, Qiutong Huang, Sarah Nersesian, Damien Chay, Nicolas Jacquelot, David Cook, Seung-Hwan Lee, Giuseppe Sciumè, Stephen Waggoner, Michele Ardolino, Marie Marotel","doi":"10.1002/eji.70009","DOIUrl":"https://doi.org/10.1002/eji.70009","url":null,"abstract":"NK cells are critical for immunosurveillance, yet become dysfunctional when chronically stimulated by virally infected or cancerous cells. This phenomenon is similar to T cell exhaustion but less characterized, limiting therapeutic interventions. As shown for T cells, NK cells often display an increased expression of immune checkpoint proteins (ICP) following chronic stimulation, and ICP blockade therapies are currently being explored for several cancer types, with remarkable patient benefits. Nevertheless, the nature of ICP expression in NK cells is still poorly documented. In this study, we aimed to identify the conditions that lead to and the phenotype of immune checkpoint LAG3-expressing NK cells. Using various experimental models, we found that LAG3 is expressed by murine NK cells upon activation in different contexts, including in response to cancer and acute viral infections. LAG3 marks a subset of immature, proliferating, and activated cells, which, despite activation, have a reduced capacity to respond to a broad range of stimuli. Further characterization also revealed that LAG3+ NK cells exhibit a transcriptional signature similar to that of exhausted CD8+ T cells. Taken together, our results support the use of LAG3 as a marker of dysfunctional NK cells across diverse chronic and acute inflammatory conditions.","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"55 7","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.70009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-Antigens Select B Cells: A New Perspective on B Cell Selection and Function 自体抗原选择B细胞：B细胞选择和功能的新视角

IF 4.5 3区医学

European Journal of Immunology Pub Date : 2025-07-22 DOI: 10.1002/eji.202451720

Mike Aoun, Rikard Holmdahl

{"title":"Self-Antigens Select B Cells: A New Perspective on B Cell Selection and Function","authors":"Mike Aoun, Rikard Holmdahl","doi":"10.1002/eji.202451720","DOIUrl":"https://doi.org/10.1002/eji.202451720","url":null,"abstract":"The adaptive immune system is shaped by self-recognition, creating a paradox where autoreactivity is essential for immune regulation, yet implicated in autoimmune diseases. Traditionally, B cell selection in the bone marrow (BM) has been viewed through the lens of negative selection, eliminating potentially harmful clones. Emerging evidence challenges this perspective, revealing a subset of B suppressor cells (Bsup) that actively regulate immune homeostasis. Unlike conventional negative selection, C1-specific Bsup cells, which recognize collagen type II (Col2), engage Col2-specific regulatory T cells (Tregs) to suppress inflammation in healthy individuals. This suggests that Bsup play a role in both peripheral and central tolerance, akin to Tregs. However, the molecular mechanisms governing Bsup selection, differentiation, and function remain unknown. Understanding how Bsup distinguish homeostatic from pathogenic autoreactivity could transform autoimmune disease treatment, shifting the focus from eliminating autoreactive B cells to harnessing their regulatory potential for precision immunotherapy.","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"55 7","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.202451720","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Homozygosity for the Common IL23R R381Q Variant Associates with Increased Susceptibility to Chronic Mucocutaneous Candidiasis 常见IL23R R381Q变异的纯合性与慢性皮肤粘膜念珠菌病的易感性增加相关

IF 4.5 3区医学

European Journal of Immunology Pub Date : 2025-07-20 DOI: 10.1002/eji.70002

Margaux Gerbaux, Frederik Staels, Mathijs Willemsen, Julika Neumann, Leoni Bücken, Lize Van Meerbeeck, Willem Roosens, Adrian Liston, Stéphanie Humblet-Baron, Rik Schrijvers

引用次数: 0