European Journal of Immunology最新文献_第7页

Granulysin Antimicrobial Activity Promotes Dormancy in Mycobacterium tuberculosis. 颗粒菌素抗菌活性促进结核分枝杆菌休眠。

IF 3.7 3区医学

European Journal of Immunology Pub Date : 2025-08-01 DOI: 10.1002/eji.70004

Sarah Schmidiger, Erin F McCaffrey, Jan M Schmidt, Owais Abdul Hameed, Max Mpina, Anneth Tumbo, Elirehema Mfinanga, Frederick Haraka, Hellen Hiza, Mohamed Sasamalo, Jerry Hella, Michael Walch, Jacques Fellay, Sébastien Gagneux, Klaus Reither, José M Carballido, Ainhoa Arbués, Damien Portevin

{"title":"Granulysin Antimicrobial Activity Promotes Dormancy in Mycobacterium tuberculosis.","authors":"Sarah Schmidiger, Erin F McCaffrey, Jan M Schmidt, Owais Abdul Hameed, Max Mpina, Anneth Tumbo, Elirehema Mfinanga, Frederick Haraka, Hellen Hiza, Mohamed Sasamalo, Jerry Hella, Michael Walch, Jacques Fellay, Sébastien Gagneux, Klaus Reither, José M Carballido, Ainhoa Arbués, Damien Portevin","doi":"10.1002/eji.70004","DOIUrl":"10.1002/eji.70004","url":null,"abstract":"Human tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) remains a global public health threat. Granulomas constitute a hallmark of TB pathogenesis that can clear, contain, or exacerbate an infection. Containment is exploited by Mtb as a hideout to persist in a dormant, antibiotic-tolerant state, only to resuscitate upon immunosuppression. The immune determinants of a granulomatous response driving Mtb persistence remain elusive. We here generated ex vivo granuloma-like structures from peripheral blood mononuclear cell specimens of TB patients and applied high-dimensional mass cytometry to elucidate immune factors prompting Mtb dormancy. Compared with healthy controls, patient-derived specimens rapidly forced Mtb to become dormant-like ex vivo. This observation correlated with an enrichment in activated, innate (-like) cytotoxic lymphocytes and required the presence of CD56+ lymphocytes or, more specifically, the content of their granules. Finally, we demonstrated that direct exposure to granulysin induces Mtb dormancy, thereby unravelling an immune escape mechanism to cytotoxic lymphocyte activity.","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"55 8","pages":"e70004"},"PeriodicalIF":3.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12332329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144797741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Suppressor of Cytokine Signaling Mimetics as a Therapeutic Approach in Autoimmune Encephalitis. 细胞因子信号模拟抑制因子作为自身免疫性脑炎的一种治疗方法。

IF 3.7 3区医学

European Journal of Immunology Pub Date : 2025-08-01 DOI: 10.1002/eji.70023

Rahul Pandey, Marina Bakay, Hakon Hakonarson

{"title":"Suppressor of Cytokine Signaling Mimetics as a Therapeutic Approach in Autoimmune Encephalitis.","authors":"Rahul Pandey, Marina Bakay, Hakon Hakonarson","doi":"10.1002/eji.70023","DOIUrl":"https://doi.org/10.1002/eji.70023","url":null,"abstract":"Autoimmune encephalitis (AE) is a debilitating neurological condition characterized by the immune system's attack on neuronal cells, often leading to significant cognitive and neurological impairments. Autoantibodies, particularly those targeting N-methyl-D-aspartate receptors (NMDAR), are linked to the disease. Additionally, cytokine dysregulation has been associated with heightened inflammatory responses in AE. Early intervention is critical for favorable outcomes. Recent findings have underscored the importance of suppressor of cytokine signaling (SOCS) proteins, particularly SOCS1, in regulating cytokine signaling pathways and maintaining immune balance. SOCS1 mimetics in particular, designed to enhance SOCS1 activity, represent a novel therapeutic approach aimed at mitigating inflammation and promoting neuroprotection. This review underscores the intricate interactions between cytokines, SOCS family proteins, and the pathophysiology of AE, emphasizing the potential of SOCS1 mimetics and potentially other SOCS mimetics as a targeted treatment. This review also emphasizes the need for further research to validate the efficacy and safety of SOCS1 mimetics in clinical settings and their role in improving outcomes for patients with AE.","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"55 8","pages":"e70023"},"PeriodicalIF":3.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HLA-DR-Expressing γδ T Cells Facilitate the Anti-Leukemia Activity of αβ T Cells. 表达hla - dr的γδ T细胞促进αβ T细胞抗白血病活性

IF 3.7 3区医学

European Journal of Immunology Pub Date : 2025-08-01 DOI: 10.1002/eji.70025

Keli Yue, Shuang Liang, Ning Wu, Mingzhu Jia, Haitao Gao, Cong Cheng, Lijuan Hu, Jiangying Liu

{"title":"HLA-DR-Expressing γδ T Cells Facilitate the Anti-Leukemia Activity of αβ T Cells.","authors":"Keli Yue, Shuang Liang, Ning Wu, Mingzhu Jia, Haitao Gao, Cong Cheng, Lijuan Hu, Jiangying Liu","doi":"10.1002/eji.70025","DOIUrl":"https://doi.org/10.1002/eji.70025","url":null,"abstract":"In addition to exhibiting significant cytotoxic capabilities, γδ T cells play a crucial role as a bridge between innate and adaptive immunity. Although γδ T cells have been demonstrated to orchestrate interactions with other immune cells, their impact on αβ T cells in the setting of acute myeloid leukemia (AML) remains unexplored. In this study, we found that functional deficiencies of αβ T cells were significantly associated with the downregulation of HLA-DR+ γδ T cells in patients newly diagnosed with AML. Vδ2+ T cells, which constitute a predominant subset of γδ T cells in human peripheral blood, exhibited elevated levels of HLA-DR following ex vivo expansion. Notably, a lower dose of the expanded Vδ2+ T cells did not induce direct cytotoxicity against AML cells; instead, they significantly enhanced the cytotoxic capacity of primary αβ T cells toward AML cells. Furthermore, blockade of HLA-DR on Vδ2+ T cells markedly diminished this facilitating effect. Taken together, our findings demonstrate an important indirect role for Vδ2+ T cells beyond their direct killing ability in the context of anti-AML immunity and provide novel insights into the therapeutic potential of adoptive Vδ2+ T cell therapy.","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"55 8","pages":"e70025"},"PeriodicalIF":3.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144797742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial Organisation of Tumour cDC1 States Correlates with Effector and Stem-Like CD8+ T Cells Location 肿瘤cDC1状态的空间组织与效应细胞和干细胞样CD8+ T细胞定位相关

IF 3.7 3区医学

European Journal of Immunology Pub Date : 2025-07-31 DOI: 10.1002/eji.70011

Cécile Piot, Mariana Pereira da Costa, Adi Biram, Carlos M. Minutti, Kok Haw Jonathan Lim, Mary Green, Ania Mikolajczak, Robert P. Jenkins, Lucy Meader, Michael D. Buck, Ana Cardoso, Neil Rogers, Erik Sahai, Caetano Reis e Sousa

{"title":"Spatial Organisation of Tumour cDC1 States Correlates with Effector and Stem-Like CD8+ T Cells Location","authors":"Cécile Piot, Mariana Pereira da Costa, Adi Biram, Carlos M. Minutti, Kok Haw Jonathan Lim, Mary Green, Ania Mikolajczak, Robert P. Jenkins, Lucy Meader, Michael D. Buck, Ana Cardoso, Neil Rogers, Erik Sahai, Caetano Reis e Sousa","doi":"10.1002/eji.70011","DOIUrl":"https://doi.org/10.1002/eji.70011","url":null,"abstract":"CD8+ T cells are central to targeting and eliminating cancer cells. Their function is critically supported by type 1 conventional dendritic cells (cDC1s), which both prime antigen-specific CD8+ T cells in tumour-draining lymph nodes (tdLNs) and sustain primed CD8+ T cells within tumours. Despite their importance, the spatiotemporal organisation of cDC1s within tumours and their diverse functional roles remain poorly understood. Here, we use scRNAseq and unbiased spatial analysis to construct a detailed map of cDC1 states and distribution within immunogenic mouse tumours during CD8+ T-cell-mediated rejection. We reveal two distinct cDC1 activation states characterised by differential expression of genes linked to anti-tumour immunity, including Cxcl9 and Il12b. Strikingly, Il12b-expressing cDC1s are CCR7+ and enriched at tumour borders, where they closely associate with stem-like TCF1+ CD8+ T cells. In contrast, CCR7– Cxcl9-expressing cDC1s are preferentially found within the tumour parenchyma alongside effector CD8+ T cells. Analysis of a published dataset of human tumours similarly reveals a spatial association between CCR7+ cDC1 and stem-like TCF1+ CD8+ T cells. These findings uncover a highly spatially coordinated interaction between cDC1s and CD8+ T cells within tumours, shedding light on the intricate cellular dynamics that underpin effective anti-tumour immunity.","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"55 8","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.70011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144751720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cover Story: Eur. J. Immunol. 8'25 封面故事：欧元。[j] .免疫学杂志。8'25 .

IF 3.7 3区医学

European Journal of Immunology Pub Date : 2025-07-31 DOI: 10.1002/eji.70031

引用次数: 0

Issue Information: Eur. J. Immunol. 8'25 发行信息：欧元。[j] .免疫学杂志。8'25 .

IF 3.7 3区医学

European Journal of Immunology Pub Date : 2025-07-31 DOI: 10.1002/eji.70032

引用次数: 0

Aging and Viral Evolution Impair Immunity Against Dominant Pan-Coronavirus-Reactive T Cell Epitope 衰老和病毒进化损害对显性泛冠状病毒反应性T细胞表位的免疫

IF 4.5 3区医学

European Journal of Immunology Pub Date : 2025-07-28 DOI: 10.1002/eji.202551888

Lucie Loyal, Karsten Jürchott, Ulf Reimer, Lil Meyer-Arndt, Larissa Henze, Norbert Mages, Jak Kostrzanowski, Bernhard Reus, Maike Mangold, Beate Kruse, Manuela Dingeldey, Birgit Sawitzki, Janine Michel, Marica Grossegesse, Karsten Schnatbaum, Holger Wenschuh, Andreas Nitsche, Nils Lachmann, Bernd Timmermann, Claudia Giesecke-Thiel, Julian Braun, Florian Kern, Andreas Thiel

{"title":"Aging and Viral Evolution Impair Immunity Against Dominant Pan-Coronavirus-Reactive T Cell Epitope","authors":"Lucie Loyal, Karsten Jürchott, Ulf Reimer, Lil Meyer-Arndt, Larissa Henze, Norbert Mages, Jak Kostrzanowski, Bernhard Reus, Maike Mangold, Beate Kruse, Manuela Dingeldey, Birgit Sawitzki, Janine Michel, Marica Grossegesse, Karsten Schnatbaum, Holger Wenschuh, Andreas Nitsche, Nils Lachmann, Bernd Timmermann, Claudia Giesecke-Thiel, Julian Braun, Florian Kern, Andreas Thiel","doi":"10.1002/eji.202551888","DOIUrl":"https://doi.org/10.1002/eji.202551888","url":null,"abstract":"Immune evasion by escape mutations subverts immunity against SARS-CoV-2. A role of pan-coronavirus immunity for more durable protection is being discussed, but has remained understudied. We here investigated the effects of age, mutations, and homo-/heterologous vaccination regimens on the dominant pan-coronavirus-specific cellular and humoral epitope iCope after SARS-CoV-2 infection and vaccination in detail. In older individuals, the quantitatively and qualitatively reduced iCope-reactive CD4+ T cell responses with narrow TCR repertoires could not be enhanced by vaccination and were further compromised by emerging spike mutations. In contrast, pan-coronavirus-reactive humoral immunity was affected only by mutations and not by age. Our results reveal a distinct deficiency of the dichotomous layer of pan-coronavirus immunity in the older, critical for long-term protection against SARS-CoV-2 variants.","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"55 7","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.202551888","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunogenicity-Guided Design of an Acinetobacter baumanii Vaccine 免疫原性导向的鲍曼不动杆菌疫苗设计

IF 4.5 3区医学

European Journal of Immunology Pub Date : 2025-07-28 DOI: 10.1002/eji.70019

Chenghua Zhu, Shuaiyuan Liang, Ning Yang, Shan Li, Jianpeng Xue, Runlu Zhou, Xiuwen Hong, Sixi Chen, Nan Gao, Qiang Du, Jianling Huang, Ganzhu Feng, Xingran Du

{"title":"Immunogenicity-Guided Design of an Acinetobacter baumanii Vaccine","authors":"Chenghua Zhu, Shuaiyuan Liang, Ning Yang, Shan Li, Jianpeng Xue, Runlu Zhou, Xiuwen Hong, Sixi Chen, Nan Gao, Qiang Du, Jianling Huang, Ganzhu Feng, Xingran Du","doi":"10.1002/eji.70019","DOIUrl":"https://doi.org/10.1002/eji.70019","url":null,"abstract":"<div>\u0000 \u0000 The development of vaccines represents a promising and safe strategy to combat multidrug-resistant (MDR) Acinetobacter baumannii (A. baumannii) infections. In this study, we designed and evaluated a dendritic cell (DC)-targeting multiepitope peptide-based biomimetic nanovaccine for its immunogenicity and protective efficacy in a murine model. Bioinformatics tools were employed to predict and screen B- and T-cell epitopes derived from the OmpW protein of A. baumannii, followed by immunological validation. The dominant epitopes were sequentially linked using 6-aminocaproic acid to synthesize a multiepitope peptide, rOmpW. Subsequently, rOmpW was encapsulated within polylactic-co-glycolic acid (PLGA) nanoparticles coated with neutrophil membranes (NM), and the surface was functionalized with a DC-targeting peptide (DCpep) to construct the biomimetic nanovaccine, DCpep-NM-PLGA-rOmpW. This biomimetic nanovaccine elicited robust Th1 and Th17 cellular immune responses, as well as humoral immunity, and demonstrated significant protective efficacy in a murine model of acute lethal pneumonia caused by A. baumannii. These findings underscore the translational potential of this biomimetic nanovaccine as a prophylactic strategy against A. baumannii infections.\u0000 </div>","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"55 7","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144716984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Signal Transducer and Activator of Transcription 3 (STAT3) Variant p.K709N Causes Hyper-IgE Syndrome Likely by Impaired STAT3-Dimer Formation 信号换能器和转录激活子3 （STAT3）变异体p.K709N可能因STAT3二聚体形成受损而导致高ige综合征

IF 4.5 3区医学

European Journal of Immunology Pub Date : 2025-07-28 DOI: 10.1002/eji.70015

Beate Hagl, Benedikt D. Spielberger, Betina Neumann, Simon J. Pelham, Dharmendra Pandey, Andreas Schlundt, Camille Barro, Anica Lechner, Christine Wolf, Elissa K. Deenick, Michael Sattler, Stuart G. Tangye, Simon Rothenfusser, Ellen D. Renner

{"title":"Signal Transducer and Activator of Transcription 3 (STAT3) Variant p.K709N Causes Hyper-IgE Syndrome Likely by Impaired STAT3-Dimer Formation","authors":"Beate Hagl, Benedikt D. Spielberger, Betina Neumann, Simon J. Pelham, Dharmendra Pandey, Andreas Schlundt, Camille Barro, Anica Lechner, Christine Wolf, Elissa K. Deenick, Michael Sattler, Stuart G. Tangye, Simon Rothenfusser, Ellen D. Renner","doi":"10.1002/eji.70015","DOIUrl":"https://doi.org/10.1002/eji.70015","url":null,"abstract":"STAT3-hyper-IgE syndrome (STAT3-HIES) is an inborn error of immunity caused by heterozygous dominant-negative mutations in the signal transducer and activator of transcription 3 (STAT3). In this study, we evaluate the functional relevance of a previously undescribed heterozygous STAT3 variant in a patient with clinical findings of STAT3-HIES. Flow cytometry, quantitative real-time PCR, pull-down assays, native PAGE, DNA-binding ELISA, and 3D-structural data analysis were performed. Genetic analysis identified the heterozygous STAT3 variant NM_139276.2:c.2127G>C (NP_644805.1:p.(K709N); short: p.K709N) in a patient with a clinical and laboratory phenotype characteristic of STAT3-HIES, including early onset severe eczema, chronic lung disease, eosinophilia, and elevated serum IgE levels. While STAT3 p.K709N did not significantly affect STAT3 phosphorylation, STAT3 target gene expression was impaired in patient cells. Expression of STAT3 p.K709N and wild-type STAT3 in STAT3-deficient cells indicated a dominant-negative effect by the mutation. Analysis of 3D-structural data and modeling suggested a central role of the affected amino acid K709 in stabilizing a C-terminal loop in STAT3 essential for dimer formation. Consequently, p.K709N resulted in diminished STAT3 dimerization and reduced DNA binding in patient cells. Functional analyses verified STAT3 p.K709N to cause STAT3-HIES and suggest that STAT3 p.K709N impairs STAT3 dimer formation.","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"55 7","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.70015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunological Impact of Oncolytic Adenoviruses On Cancer Therapy: Clinical Insights 溶瘤腺病毒对癌症治疗的免疫学影响：临床见解

IF 4.5 3区医学

European Journal of Immunology Pub Date : 2025-07-28 DOI: 10.1002/eji.70024

Reza Nadafi, Wenliang Dong, Victor W. van Beusechem

{"title":"Immunological Impact of Oncolytic Adenoviruses On Cancer Therapy: Clinical Insights","authors":"Reza Nadafi, Wenliang Dong, Victor W. van Beusechem","doi":"10.1002/eji.70024","DOIUrl":"https://doi.org/10.1002/eji.70024","url":null,"abstract":"Oncolytic immunotherapy, particularly using engineered adenoviruses, has emerged as a promising approach in cancer treatment due to its dual mechanism of action: selective tumor-cell destruction and inducing potent antitumor immune responses. This review focuses on the immunological effects observed in clinical trials involving conditionally replicating oncolytic adenoviruses (OAds), either with or without transgenes. These viruses primarily exert antitumor effects through mechanisms like direct oncolysis, apoptosis, necroptosis, and autophagy, while also activating innate and adaptive immune responses. Different genetic modification strategies have been employed to enhance the safety and therapeutic efficacy of OAds. However, these alterations may influence viral replication dynamics, oncolytic potency, and the duration of viral presence (i.e., persistence) within the tumor. Clinical data have shown that OAds can also profoundly alter the tumor microenvironment (TME), converting cold tumors to hot by increasing immune cell infiltration and activation. This conversion not only correlates with improved clinical outcomes but also creates conditions conducive to the efficacy of other immunotherapies, particularly immune checkpoint inhibitors (ICIs), which traditionally show limited activity in cold tumors. The synergistic potential of combining OAds with ICIs has shown promising results in improving clinical response rates. However, maximizing therapeutic benefit requires careful consideration of the OAd's immune-activating capabilities and optimal timing of combination strategies. This review provides critical insights into the current state of OAd-based immunotherapy, examining its role in modulating the TME, while addressing the complex interplay between oncolytic activity and sustained immune stimulation in clinical practice.","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"55 7","pages":""},"PeriodicalIF":4.5,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.70024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0