European Journal of Immunology最新文献_第10页

Viral escape from NK-cell-mediated immunosurveillance: A lesson for cancer immunotherapy? NK-细胞介导的免疫监测中的病毒逃逸：癌症免疫疗法的教训？

IF 5.4 3区医学

European Journal of Immunology Pub Date : 2023-08-01 DOI: 10.1002/eji.202350465

Pouria Momayyezi, Eleni Bilev, Hans-Gustaf Ljunggren, Quirin Hammer

{"title":"Viral escape from NK-cell-mediated immunosurveillance: A lesson for cancer immunotherapy?","authors":"Pouria Momayyezi, Eleni Bilev, Hans-Gustaf Ljunggren, Quirin Hammer","doi":"10.1002/eji.202350465","DOIUrl":"10.1002/eji.202350465","url":null,"abstract":"Natural killer (NK) cells are innate lymphocytes that participate in immune responses against virus-infected cells and tumors. As a countermeasure, viruses and tumors employ strategies to evade NK-cell-mediated immunosurveillance. In this review, we examine immune evasion strategies employed by viruses, focusing on examples from human CMV and severe acute respiratory syndrome coronavirus 2. We explore selected viral evasion mechanisms categorized into three classes: (1) providing ligands for the inhibitory receptor NKG2A, (2) downregulating ligands for the activating receptor NKG2D, and (3) inducing the immunosuppressive cytokine transforming growth factor (TGF)-β. For each class, we draw parallels between immune evasion by viruses and tumors, reviewing potential opportunities for overcoming evasion in cancer therapy. We suggest that in-depth investigations of host–pathogen interactions between viruses and NK cells will not only deepen our understanding of viral immune evasion but also shed light on how NK cells counter such evasion attempts. Thus, due to the parallels of immune evasion by viruses and tumors, we propose that insights gained from antiviral NK-cell responses may serve as valuable lessons that can be leveraged for designing future cancer immunotherapies.","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"53 11","pages":""},"PeriodicalIF":5.4,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9977891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skin-derived TSLP stimulates skin migratory dendritic cells to promote the expansion of regulatory T cells 皮肤来源的TSLP刺激皮肤迁移的树突细胞以促进调节性T细胞的扩增。

IF 5.4 3区医学

European Journal of Immunology Pub Date : 2023-08-01 DOI: 10.1002/eji.202350390

Yukinori Tanaka, Yuichi Yokoyama, Taku Kambayashi

{"title":"Skin-derived TSLP stimulates skin migratory dendritic cells to promote the expansion of regulatory T cells","authors":"Yukinori Tanaka, Yuichi Yokoyama, Taku Kambayashi","doi":"10.1002/eji.202350390","DOIUrl":"10.1002/eji.202350390","url":null,"abstract":"Therapeutic strategies that enhance regulatory T (Treg) cell proliferation or suppressive function hold promise for the treatment of autoimmune and inflammatory diseases. We previously reported that the topical application of the vitamin D3 analog MC903 systemically expands Treg cells by stimulating the production of thymic stromal lymphopoietin (TSLP) from the skin. Using mice lacking TSLP receptor expression by dendritic cells (DCs), we hereby show that TSLP receptor signaling in DCs is required for this Treg expansion in vivo. Topical MC903 treatment of ear skin selectively increased the number of migratory DCs in skin-draining lymph nodes (LNs) and upregulated their expression of co-stimulatory molecules. Accordingly, DCs isolated from skin-draining LNs but not mesenteric LNs or spleen of MC903-treated mice showed an enhanced ability to promote Treg proliferation, which was driven by co-stimulatory signals through CD80/CD86 and OX40 ligand. Among the DC subsets in the skin-draining LNs of MC903-treated mice, migratory XCR1−CD11b+ type 2 and XCR1−CD11b− double negative conventional DCs promoted Treg expansion. Together, these data demonstrate that vitamin D3 stimulation of skin induces TSLP expression, which stimulates skin migratory DCs to expand Treg cells. Thus, topical MC903 treatment could represent a convenient strategy to treat inflammatory disorders by engaging this pathway.","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"53 10","pages":""},"PeriodicalIF":5.4,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.202350390","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10066131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proteomics reveals a global phenotypic shift of NK cells in HCV patients treated with direct-acting antivirals 蛋白质组学揭示了接受直接作用抗病毒药物治疗的丙型肝炎患者NK细胞的整体表型变化。

IF 5.4 3区医学

European Journal of Immunology Pub Date : 2023-07-29 DOI: 10.1002/eji.202250291

Wenjie Bi, Anke Kraft, Sophie Engelskircher, Jasmin Mischke, Moana Witte, Frank Klawonn, Marco van Ham, Markus Cornberg, Heiner Wedemeyer, Julia Hengst, Lothar Jänsch

{"title":"Proteomics reveals a global phenotypic shift of NK cells in HCV patients treated with direct-acting antivirals","authors":"Wenjie Bi, Anke Kraft, Sophie Engelskircher, Jasmin Mischke, Moana Witte, Frank Klawonn, Marco van Ham, Markus Cornberg, Heiner Wedemeyer, Julia Hengst, Lothar Jänsch","doi":"10.1002/eji.202250291","DOIUrl":"10.1002/eji.202250291","url":null,"abstract":"Chronic hepatitis C virus (HCV) infections compromise natural killer (NK)-cell immunity. Direct-acting antivirals (DAA) effectively eliminate HCV, but the long-term effects on NK cells in cured patients are debated. We conducted a proteomic study on CD56+ NK cells of chronic HCV-infected patients before and 1 year after DAA therapy. Donor-variation was observed in NK-cell proteomes of HCV-infected patients, with 46 dysregulated proteins restored after DAA therapy. However, 30% of the CD56+ NK-cell proteome remained altered 1 year post-therapy, indicating a phenotypic shift with low donor-variation. NK cells from virus-negative cured patients exhibited global regulation of RNA-processing and pathways related to “stimuli response”, “chemokine signaling”, and “cytotoxicity regulation”. Proteomics identified downregulation of vesicle transport components (CD107a, COPI/II complexes) and altered receptor expression profiles, indicating an inhibited NK-cell phenotype. Yet, activated NK cells from HCV patients before and after therapy effectively upregulated IFN-γ and recruited CD107a. Conversely, reduced surface expression levels of Tim-3 and 2B4 were observed before and after therapy. In conclusion, this study reveals long-term effects on the CD56+ NK-cell compartment in convalescent HCV patients 1 year after therapy, with limited abundance of vesicle transport complexes and surface receptors, associated with a responsive NK-cell phenotype.","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"53 11","pages":""},"PeriodicalIF":5.4,"publicationDate":"2023-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9947557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

T-cell signature cytokines distinguish pulmonary sarcoidosis from pulmonary tuberculosis T细胞标志性细胞因子区分肺结节病和肺结核。

IF 5.4 3区医学

European Journal of Immunology Pub Date : 2023-07-28 DOI: 10.1002/eji.202250255

Rashi Jain, Rinkee Kumari, Sushmita Chakraborty, Dipendra K. Mitra, Anant Mohan, Vijay Hadda, Karan Madan, Randeep Guleria

{"title":"T-cell signature cytokines distinguish pulmonary sarcoidosis from pulmonary tuberculosis","authors":"Rashi Jain, Rinkee Kumari, Sushmita Chakraborty, Dipendra K. Mitra, Anant Mohan, Vijay Hadda, Karan Madan, Randeep Guleria","doi":"10.1002/eji.202250255","DOIUrl":"10.1002/eji.202250255","url":null,"abstract":"Sarcoidosis is a systemic inflammatory disorder characterized by tissue infiltration due to mononuclear phagocytes and lymphocytes and associated noncaseating granuloma formation. Pulmonary sarcoidosis (PS) shares a number of clinical, radiological, and histopathological characteristics with that of pulmonary tuberculosis (PTB). Due to this, clinicians face issues in differentiating between PS and PTB in a substantial number of cases. There is a lack of any specific biomarker that can diagnose PS distinctively from PTB. We compared T-cell-based signature cytokines in patients with PS and PTB. In this study, we proposed a serum biomarker panel consisting of cytokines from cells: T helper (Th) 1 [interferon-gamma (IFN-γ); tumor necrosis factor-alpha (TNF-α)], Th9 [interleukin (IL)-9], Th17 [IL-17], and T regulatory (Treg) [IL-10; transforming growth factor-beta (TGF-β)]. We performed the principal component analysis that demonstrated that our serum cytokine panel has a significant predictive ability to differentiate PS from PTB. Our results could aid clinicians to improve the diagnostic workflow for patients with PS in TB endemic settings where the diagnosis between PS and PTB is often ambiguous.","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"53 10","pages":""},"PeriodicalIF":5.4,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10242573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How myeloid cells shape experimental autoimmune encephalomyelitis: At the crossroads of outside-in immunity 骨髓细胞如何塑造实验性自身免疫性脑脊髓炎：处于免疫外的十字路口。

IF 5.4 3区医学

European Journal of Immunology Pub Date : 2023-07-28 DOI: 10.1002/eji.202250234

Martin Diebold, Luca Fehrenbacher, Maximilian Frosch, Marco Prinz

{"title":"How myeloid cells shape experimental autoimmune encephalomyelitis: At the crossroads of outside-in immunity","authors":"Martin Diebold, Luca Fehrenbacher, Maximilian Frosch, Marco Prinz","doi":"10.1002/eji.202250234","DOIUrl":"10.1002/eji.202250234","url":null,"abstract":"Experimental autoimmune encephalomyelitis (EAE) is an animal model of central nervous system (CNS) autoimmunity. It is most commonly used to mimic aspects of multiple sclerosis (MS), a demyelinating disorder of the human brain and spinal cord. The innate immune response displays one of the core pathophysiological features linked to both the acute and chronic stages of MS. Hence, understanding and targeting the innate immune response is essential. Microglia and other CNS resident MUs, as well as infiltrating myeloid cells, diverge substantially in terms of both their biology and their roles in EAE. Recent advances in the field show that antigen presentation, as well as disease-propagating and regulatory interactions with lymphocytes, can be attributed to specific myeloid cell types and cell states in EAE lesions, following a distinct temporal pattern during disease initiation, propagation and recovery. Furthermore, single-cell techniques enable the assessment of characteristic proinflammatory as well as beneficial cell states, and identification of potential treatment targets. Here, we discuss the principles of EAE induction and protocols for varying experimental paradigms, the composition of the myeloid compartment of the CNS during health and disease, and systematically review effects on myeloid cells for therapeutic approaches in EAE.","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"53 10","pages":""},"PeriodicalIF":5.4,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.202250234","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10029979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A high-throughput 3D kinetic killing assay 高通量三维动态杀伤试验。

IF 5.4 3区医学

European Journal of Immunology Pub Date : 2023-07-27 DOI: 10.1002/eji.202350505

Renping Zhao, Archana K. Yanamandra, Bin Qu

引用次数: 0

Neutrophil subsets in noncancer liver diseases: Cellular crosstalk and therapeutic targets 非癌性肝病中的中性粒细胞亚群:细胞串扰和治疗靶点

IF 5.4 3区医学

European Journal of Immunology Pub Date : 2023-07-26 DOI: 10.1002/eji.202250324

Chen Huang, Xiaoli Fan, Yi Shen, Mengyi Shen, Li Yang

{"title":"Neutrophil subsets in noncancer liver diseases: Cellular crosstalk and therapeutic targets","authors":"Chen Huang, Xiaoli Fan, Yi Shen, Mengyi Shen, Li Yang","doi":"10.1002/eji.202250324","DOIUrl":"https://doi.org/10.1002/eji.202250324","url":null,"abstract":"Neutrophils are the most abundant circulating granulocytes, linking innate and adaptive immunity. Neutrophils can regulate inflammatory and immune responses through degranulation, reactive oxygen species generation, the production of cytokines and chemokines, and NETosis. Emerging evidence has indicated that neutrophils contribute to the pathogenesis of various noncancer liver diseases, including nonalcoholic fatty liver disease, alcohol-associated liver disease, hepatic ischemia‒reperfusion injury, and liver fibrosis. Cellular interactions among neutrophils, other immune cells, and nonimmune cells constitute a complex network that regulates the immune microenvironment of the liver. This review summarizes novel neutrophil subtypes, including CD177+ neutrophils and low-density neutrophils. Moreover, we provide an overview of the cellular cros stalk of neutrophils in noncancer liver diseases, aiming to shed new light on mechanistic studies of novel neutrophil subtypes. In addition, we discuss the potential of neutrophils as therapeutic targets in noncancer liver diseases, including inhibitors targeting NETosis, granule proteins, and chemokines.","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"53 9","pages":""},"PeriodicalIF":5.4,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.202250324","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"6435626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

T-cell subsets in allergy and tolerance induction 过敏和耐受诱导中的T细胞亚群。

IF 5.4 3区医学

European Journal of Immunology Pub Date : 2023-07-25 DOI: 10.1002/eji.202249983

Ina Suhrkamp, Alexander Scheffold, Guido Heine

{"title":"T-cell subsets in allergy and tolerance induction","authors":"Ina Suhrkamp, Alexander Scheffold, Guido Heine","doi":"10.1002/eji.202249983","DOIUrl":"10.1002/eji.202249983","url":null,"abstract":"Antigen-specific T lymphocytes are the central regulators of tolerance versus immune pathology against otherwise innocuous antigens and key targets of antigen-specific immune therapy. Recent advances in the understanding of T cells in tolerance and allergy resulted from improved technologies to directly characterize allergen-specific T cells by multiparameter flow cytometry or single-cell sequencing. This unravelled phenotypically and functionally distinct populations, such as Type 2a T helper cells (Th2a), follicular Th cells (Tfh), regulatory T cells (Treg), Type 1 regulatory T cells (Tr1), and follicular T regulatory cells. Here we will discuss the role of the different Th-cell subsets in the healthy state, during sensitization and development of allergy, and in tolerance induction by allergen immunotherapy (AIT). To date, the mechanisms of AIT as the only causal treatment of allergy are not completely understood. The analyses of allergen-specific T cells directly ex vivo during AIT support the concept of specific-Th2(a) cell deletion rather than an expansion of allergen-specific Tr1 or Treg cells as underlying mechanism.","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"53 10","pages":""},"PeriodicalIF":5.4,"publicationDate":"2023-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.202249983","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9921482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional cytokine production marks influenza A virus-specific CD4 T cells with high expression of survival molecules 多功能细胞因子的产生标志着甲型流感病毒特异性CD4 T细胞具有高表达的生存分子。

IF 5.4 3区医学

European Journal of Immunology Pub Date : 2023-07-25 DOI: 10.1002/eji.202350559

Lotus M. Westerhof, Jonathan Noonan, Kerrie E. Hargrave, Elizabeth T. Chimbayo, Zhiling Cheng, Thomas Purnell, Mark R. Jackson, Nicholas Borcherding, Megan K. L. MacLeod

{"title":"Multifunctional cytokine production marks influenza A virus-specific CD4 T cells with high expression of survival molecules","authors":"Lotus M. Westerhof, Jonathan Noonan, Kerrie E. Hargrave, Elizabeth T. Chimbayo, Zhiling Cheng, Thomas Purnell, Mark R. Jackson, Nicholas Borcherding, Megan K. L. MacLeod","doi":"10.1002/eji.202350559","DOIUrl":"10.1002/eji.202350559","url":null,"abstract":"Cytokine production by memory T cells is a key mechanism of T cell mediated protection. However, we have limited understanding of the persistence of cytokine producing T cells during memory cell maintenance and secondary responses. We interrogated antigen-specific CD4 T cells using a mouse influenza A virus infection model. Although CD4 T cells detected using MHCII tetramers declined in lymphoid and non-lymphoid organs, we found similar numbers of cytokine+ CD4 T cells at days 9 and 30 in the lymphoid organs. CD4 T cells with the capacity to produce cytokines expressed higher levels of pro-survival molecules, CD127 and Bcl2, than non-cytokine+ cells. Transcriptomic analysis revealed a heterogeneous population of memory CD4 T cells with three clusters of cytokine+ cells. These clusters match flow cytometry data and reveal an enhanced survival signature in cells capable of producing multiple cytokines. Following re-infection, multifunctional T cells expressed low levels of the proliferation marker, Ki67, whereas cells that only produce the anti-viral cytokine, interferon-γ, were more likely to be Ki67+. Despite this, multifunctional memory T cells formed a substantial fraction of the secondary memory pool. Together these data indicate that survival rather than proliferation may dictate which populations persist within the memory pool.","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"53 11","pages":""},"PeriodicalIF":5.4,"publicationDate":"2023-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9890410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The vitamin B5/coenzyme A axis: A target for immunomodulation? 维生素B5/辅酶A轴：免疫调节的靶点？

IF 5.4 3区医学

European Journal of Immunology Pub Date : 2023-07-22 DOI: 10.1002/eji.202350435

Richard Miallot, Virginie Millet, Franck Galland, Philippe Naquet

{"title":"The vitamin B5/coenzyme A axis: A target for immunomodulation?","authors":"Richard Miallot, Virginie Millet, Franck Galland, Philippe Naquet","doi":"10.1002/eji.202350435","DOIUrl":"10.1002/eji.202350435","url":null,"abstract":"Coenzyme A (CoA) serves as a vital cofactor in numerous enzymatic reactions involved in energy production, lipid metabolism, and synthesis of essential molecules. Dysregulation of CoA-dependent metabolic pathways can contribute to chronic diseases, such as inflammatory diseases, obesity, diabetes, cancer, and cardiovascular disorders. Additionally, CoA influences immune cell activation by modulating the metabolism of these cells, thereby affecting their proliferation, differentiation, and effector functions. Targeting CoA metabolism presents a promising avenue for therapeutic intervention, as it can potentially restore metabolic balance, mitigate chronic inflammation, and enhance immune cell function. This might ultimately improve the management and outcomes for these diseases. This review will more specifically focus on the contribution of pathways regulating the availability of the CoA precursor Vitamin B5/pantothenate in vivo and modulating the development of Th17-mediated inflammation, CD8-dependent anti-tumor immunity but also tissue repair processes in chronic inflammatory or degenerative diseases.","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"53 10","pages":""},"PeriodicalIF":5.4,"publicationDate":"2023-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.202350435","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9961142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0