European Journal of Immunology最新文献_第9页

Issue Information: Eur. J. Immunol. 1'26 发行信息：欧元。[j] .免疫学杂志，2006

IF 3.7 3区医学

European Journal of Immunology Pub Date : 2026-01-05 DOI: 10.1002/eji.70128

引用次数: 0

Cover Story: Eur. J. Immunol. 1'26 封面故事：欧元。[j] .免疫学杂志，2006

IF 3.7 3区医学

European Journal of Immunology Pub Date : 2026-01-05 DOI: 10.1002/eji.70129

引用次数: 0

Thrombospondin-1 Is a Contact Sensor Triggering Adhesion in T Cells and Platelets While Differentially Regulating 2D and 3D Motility in T Cells 血小板反应蛋白-1是一种接触式传感器，可触发T细胞和血小板的粘附，同时对T细胞的2D和3D运动进行差异调节。

IF 3.7 3区医学

European Journal of Immunology Pub Date : 2025-12-28 DOI: 10.1002/eji.70122

Karl-Gösta Sundqvist

{"title":"Thrombospondin-1 Is a Contact Sensor Triggering Adhesion in T Cells and Platelets While Differentially Regulating 2D and 3D Motility in T Cells","authors":"Karl-Gösta Sundqvist","doi":"10.1002/eji.70122","DOIUrl":"10.1002/eji.70122","url":null,"abstract":"<div>\u0000 \u0000 The regulation of cell adhesion and motility is poorly understood. The present study uncovers a mechanism by which cells sense the microenvironment and regulate adhesion and motility. The C-terminal of TSP-1 was found to sense cell contact, which triggered N-terminal cleavage, adhesion, and cytoplasmic spreading in T cells and platelets on ICAM-1-coated surfaces. uPA was associated with TSP-1, an inhibitor of uPA antagonized cleavage, and zymography showed that uPA cleaves TSP-1, indicating that uPA caused the contact-triggered cleavage. In adhering T cells 2D, TSP-1 induced polar cell shape independent of LRP1, while interaction with LRP1 induced migration by internalizing TSP-1. In contrast, the development of polar cell shape, as well as migration 3D, was caused by direct interaction of TSP-1 with LRP1. Unlike its enhancing effect on polarity and migration 2D, contact sensing, and hence TSP-1 cleavage, inhibited 3D migration. Polar cell shape and migration, 2D and 3D, were driven by full-length TSP-1. CXCL12, which inhibits cleavage, stimulated migration. TSP-1 was limiting for ability of T cells to develop polar cell shape and migrate. These results indicate that TSP-1 is a contact sensor triggering adhesion in platelets and T cells, while driving and regulating motility in T cells.\u0000 </div>","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"55 12","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145848587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatially Resolved Profiling of Compartmentalized Muscle and Brain Inflammation 区隔性肌肉和脑炎症的空间解析分析。

IF 3.7 3区医学

European Journal of Immunology Pub Date : 2025-12-22 DOI: 10.1002/eji.70119

Thorge Dobbertin, Lucas Schirmer

{"title":"Spatially Resolved Profiling of Compartmentalized Muscle and Brain Inflammation","authors":"Thorge Dobbertin, Lucas Schirmer","doi":"10.1002/eji.70119","DOIUrl":"10.1002/eji.70119","url":null,"abstract":"Spatial omics technologies enable high-resolution mapping of transcriptomic, proteomic, and metabolic profiles within intact tissues, revealing how immune, stromal, and parenchymal cells interact in situ during inflammation. Chronic inflammation in skeletal muscle and the central nervous system is spatially organized within defined niches that shape disease progression and therapeutic response. In skeletal muscle, spatial analyses have uncovered fiber-type-specific vulnerability, regenerative trajectories, and immune–stromal crosstalk in disorders such as Duchenne muscular dystrophy and inclusion body myositis. In the central nervous system, these approaches have revealed compartmentalized neuroinflammation in multiple sclerosis, innate immune activation in amyotrophic lateral sclerosis, and immune evasion in glioma. Integration with single-cell gene expression enables inference of cell–cell communication networks and identification of spatial gradients of immune activation and tissue remodeling. Despite major advances, clinical translation remains limited by small cohorts, methodological variability, and insufficient functional validation. As spatial profiling becomes more accessible, standardized, and scalable, it promises to stratify inflammatory disease states, identify tissue-resident immune programs, and guide mechanism-based therapies. Hence, spatial omics provide an unprecedented opportunity to resolve the cellular architecture of inflammation, revealing not only where immune activity occurs, but how it is orchestrated within complex tissue microenvironments.","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"55 12","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12723349/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145809027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ccl21a, Rather Than Ccl21b, is Essential for Thymocyte Migration in Mouse 在小鼠胸腺细胞迁移中，Ccl21a比Ccl21b更重要。

IF 3.7 3区医学

European Journal of Immunology Pub Date : 2025-12-20 DOI: 10.1002/eji.70114

Izumi Ohigashi, Hitomi Kyuma, Eri Otsu, Shinichi Hayashi, Tatsuya Takemoto, Yousuke Takahama

{"title":"Ccl21a, Rather Than Ccl21b, is Essential for Thymocyte Migration in Mouse","authors":"Izumi Ohigashi, Hitomi Kyuma, Eri Otsu, Shinichi Hayashi, Tatsuya Takemoto, Yousuke Takahama","doi":"10.1002/eji.70114","DOIUrl":"10.1002/eji.70114","url":null,"abstract":"Self-tolerance in T cells is a vital self-defense strategy for mammals to specifically respond to invading pathogens. During T cell development in the thymus, thymocytes migrate from the cortex to the medulla to sequentially acquire non-self-reactivity and self-tolerance. This cortex-to-medulla migration is regulated by CCR7-mediated chemokine signaling. Previous studies have identified CCL21 but not CCL19 as a functional ligand for this CCR7-dependent migration. CCL21 in the mouse is encoded by multiple genes, including CCL21Ser-encoding Ccl21a and several CCL21Leu-encoding genes, including Ccl21b. The importance of Ccl21a in thymocyte migration has been demonstrated, whereas the role of CCL21Leu-encoding genes remains unclear. By producing mice specifically deficient in Ccl21b, we show that Ccl21b plays little to no role in the cortex-to-medulla migration of developing thymocytes. CCL21Leu-encoding gene transcripts remain detectable even in the absence of Ccl21b, suggesting that Ccl21b is not a major source of CCL21Leu. We further show that the copy number of CCL21Leu-encoding genes is smaller than the currently estimated copy number in a public database. These findings underscore the predominant role of Ccl21a over Ccl21b in the mouse thymus.","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"55 12","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12717634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145792843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CD Molecules Nomenclature 2025: Antibody Validation and Expression Profiling of Immune System G Protein-Coupled Receptors CD分子命名2025：免疫系统G蛋白偶联受体的抗体验证和表达谱。

IF 3.7 3区医学

European Journal of Immunology Pub Date : 2025-12-20 DOI: 10.1002/eji.70099

Javier Fernández-Calles, Daniela Kužílková, Fanny Hedin, Violeta Bakardjieva-Mihaylova, Karolina Škvárová Kramarzová, Menno C. van Zelm, Antonio Cosma, Tomas Kalina, Pablo Engel, the Human Cell Differentiation Molecules (HCDM) organization

{"title":"CD Molecules Nomenclature 2025: Antibody Validation and Expression Profiling of Immune System G Protein-Coupled Receptors","authors":"Javier Fernández-Calles, Daniela Kužílková, Fanny Hedin, Violeta Bakardjieva-Mihaylova, Karolina Škvárová Kramarzová, Menno C. van Zelm, Antonio Cosma, Tomas Kalina, Pablo Engel, the Human Cell Differentiation Molecules (HCDM) organization","doi":"10.1002/eji.70099","DOIUrl":"10.1002/eji.70099","url":null,"abstract":"Monoclonal antibodies (mAbs) targeting cell-surface molecules are pivotal in biomedical research, diagnostic applications, and biotechnology. Over the past four decades, the CD nomenclature system, established by the Human Leukocyte Differentiation Antigens Workshops and endorsed by the International Union of Immunological Societies (IUIS), has provided a standardized naming convention for both mAbs and the cell surface molecules they target. G protein-coupled receptors (GPCRs) represent the largest family of cell-surface receptors, playing essential roles in both innate and adaptive immune responses. Despite their significance, GPCRs are underrepresented in terms of well-validated mAbs available for flow cytometry and therapeutic applications. At the Eleventh HLDA Workshop (HLDA11), new CD nomenclature has been assigned to thirteen GPCR cell-surface molecules expressed on immune cells: CD198 (CCR8), CD199 (CCR9), CD372 (CCR10), CD373 (CX3CR1), CD374 (XCR1), CD375 (GPR15), CDw376 (GPR26), CD377 (SSTR3), CD378 (C3AR1), CDw379 (FPR2), CD380 (LTB4R), CDw381 (GPR183), and CDw382 (F2RL1). In this article, we introduce the newly established CD nomenclature for mAbs targeting the GPCR family. We detail the quantitative expression profiles of these molecules on various subsets of leukocytes and provide validation data for these mAbs. The implications of these expression profiles are discussed for the potential therapeutic targeting of immune-mediated diseases and cancer.","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"55 12","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12717635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145792824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Staphylococcal Enterotoxin A Shapes Monocyte Transcription and Macrophage Polarization: Implications for Immune Responses in Infection and Inflammation 葡萄球菌肠毒素A塑造单核细胞转录和巨噬细胞极化：感染和炎症免疫反应的意义。

IF 3.7 3区医学

European Journal of Immunology Pub Date : 2025-12-19 DOI: 10.1002/eji.70104

Claudia Arasa, Khaleda Rahman Qazi, David Brodin, Manuel Mata Forsberg, Eva Sverremark-Ekström

{"title":"Staphylococcal Enterotoxin A Shapes Monocyte Transcription and Macrophage Polarization: Implications for Immune Responses in Infection and Inflammation","authors":"Claudia Arasa, Khaleda Rahman Qazi, David Brodin, Manuel Mata Forsberg, Eva Sverremark-Ekström","doi":"10.1002/eji.70104","DOIUrl":"10.1002/eji.70104","url":null,"abstract":"Staphylococcal enterotoxins (SE) crosslink the MHC-II on antigen-presenting cells (APC) with the T-cell receptor, inducing a polyclonal T-cell response. Although APCs are the initial targets of SE and are critical in shaping subsequent T-cell activation, the effects of SE on APC function remain poorly understood. This study investigates the immunomodulatory effects of staphylococcal enterotoxin A (SEA) on monocytes and their differentiation into monocyte-derived dendritic cells (moDC) or macrophages (MDM). Transcriptomic analyses of human monocytes via RNA sequencing revealed SEA-induced enrichment of gene pathways associated with inflammation, infection, and dermatitis, effects that were amplified in the presence of T cells. Phenotypic and functional characterization showed that SEA-primed monocytes differentiated into MDM with an altered polarization, deviating from classical M1/M2 pathways. SEA-primed MDM exhibited downregulation of key markers, including HLA-DR, CD80, CD86, and PD-L1. Functional assays demonstrated that SEA-primed MDM pushed hyperinflammatory T-cell responses, with significantly enhanced proliferation and IFN-γ secretion. In contrast, following SEA-priming, moDC retained robust antigen-presenting capabilities and displayed enhanced expression of molecules involved in T-cell interactions. These findings provide mechanistic insights into SEA-mediated immune modulation, illustrating how SEA reprograms MDM functions and amplifies proinflammatory T-cell responses. This advances our understanding of superantigen-driven immune interactions, offering a foundation for developing therapeutic strategies to mitigate superantigen-mediated immune conditions.","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"55 12","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12716226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145792863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights Into Complex Murine Models of Allergy and Anaphylaxis: The Central Role of IgE and Mast Cells in Advancing Human Therapies 对复杂的小鼠过敏和过敏反应模型的见解：IgE和肥大细胞在推进人类治疗中的核心作用。

IF 3.7 3区医学

European Journal of Immunology Pub Date : 2025-12-19 DOI: 10.1002/eji.70117

Yuka Nagata, Ryo Suzuki

{"title":"Insights Into Complex Murine Models of Allergy and Anaphylaxis: The Central Role of IgE and Mast Cells in Advancing Human Therapies","authors":"Yuka Nagata, Ryo Suzuki","doi":"10.1002/eji.70117","DOIUrl":"10.1002/eji.70117","url":null,"abstract":"Immunoglobulin E (IgE)–mediated immediate hypersensitivity reactions underlie most allergic responses and are characterized by rapid mast cell (MC) activation and the subsequent release of mediators. These processes have been studied in rodent models via IgE or allergen sensitization, which replicate essential aspects of human allergic responses. Because allergic diseases exhibit diverse clinical manifestations, varying in phenotype, allergen specificity, immune response, and pathophysiological mechanisms, it is essential to employ a variety of models to comprehensively address distinct aspects of allergic responses and mechanisms. Allergic responses in mouse models can vary depending on factors such as experimental condition and murine strain, and these variations influence the ability of the model to reflect manifestations of human disease. This review aimed to summarize the characteristics of various murine allergy models, primarily focusing on wild-type strains, highlighting the impact of sensitization strategy, administration route, and murine strain on allergic disease outcomes. Given the pivotal role of MCs in allergic disease, achieving a deeper understanding of their characteristics across models is expected to enhance the applicability of these models and facilitate the development of MC-targeted therapies.","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"55 12","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12716187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145792890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Augmented MHC Class I on Professional Antigen-Presenting Cells and Enhanced Cytokine Production by CD8+ T Cells in Type 2 Diabetes Mellitus 2型糖尿病专业抗原呈递细胞增强MHC I类及CD8+ T细胞增强细胞因子产生

IF 3.7 3区医学

European Journal of Immunology Pub Date : 2025-12-19 DOI: 10.1002/eji.70109

Shan Liu, Tharushika Jayasinghe, Daria Kamińska, Xiaoqiang Xu, Xu Ren, Yang Jiao, Ying Kong, Xiaozhen Li, Ke Li, Antony N. Antoniou, Wang Li, Katarzyna Błażewska, Edyta Gendaszewska-Darmach, Jing Xu, Malgorzata A. Garstka

{"title":"Augmented MHC Class I on Professional Antigen-Presenting Cells and Enhanced Cytokine Production by CD8+ T Cells in Type 2 Diabetes Mellitus","authors":"Shan Liu, Tharushika Jayasinghe, Daria Kamińska, Xiaoqiang Xu, Xu Ren, Yang Jiao, Ying Kong, Xiaozhen Li, Ke Li, Antony N. Antoniou, Wang Li, Katarzyna Błażewska, Edyta Gendaszewska-Darmach, Jing Xu, Malgorzata A. Garstka","doi":"10.1002/eji.70109","DOIUrl":"10.1002/eji.70109","url":null,"abstract":"Effective antigen presentation by major histocompatibility complex (MHC) molecules to T cells is crucial for adaptive immunity. In type 2 diabetes mellitus (T2DM), metabolic dysregulation and chronic inflammation may impair these processes. We conducted a cross-sectional study to compare immune phenotypes between people with T2DM and healthy controls, and to correlate these findings with clinical parameters. People with T2DM exhibited augmented MHC I levels on B cells and CD14+ monocytes, and a shift in T cell polarization toward proinflammatory phenotypes. This was characterized by increased frequencies of type 1 cytotoxic T (Tc1) cells, and higher production of interferon-gamma (IFN-γ) and interleukin (IL)-10 by CD8+ T cells. Additionally, people with T2DM had higher frequencies of CD28+ and IFN-γ+ CD4+ T cells, and elevated expression of CD28, IFN-γ, IL-10, and IL-17A by CD4+ T cells. The shift toward a Tc1 phenotype correlated positively with blood glucose and negatively with insulin levels. Likewise, Th1 cell frequencies and IL-17 production by CD4+ T cells correlated positively with blood glucose, while IL-10+CD4+ T cell percentages correlated positively with insulin levels. Our findings suggest that T2DM is associated with a proinflammatory T-cell profile, polarization of which is linked to metabolic parameters.","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"55 12","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12716204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145792848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of the SARS-CoV-2-Specific T Cell Responses in Rheumatoid Arthritis Subjects Vaccinated for COVID-19 Protection 类风湿关节炎患者接种COVID-19疫苗后sars - cov -2特异性T细胞反应的表征

IF 3.7 3区医学

European Journal of Immunology Pub Date : 2025-12-19 DOI: 10.1002/eji.70105

Jaeyoon Song, Ricardo da Silva Antunes, Mehrnaz Agili Seyede, Monica Guma, Alessandro Sette, Alessandra Franco

{"title":"Characterization of the SARS-CoV-2-Specific T Cell Responses in Rheumatoid Arthritis Subjects Vaccinated for COVID-19 Protection","authors":"Jaeyoon Song, Ricardo da Silva Antunes, Mehrnaz Agili Seyede, Monica Guma, Alessandro Sette, Alessandra Franco","doi":"10.1002/eji.70105","DOIUrl":"10.1002/eji.70105","url":null,"abstract":"The efficacy of mRNA-based vaccines to prevent COVID-19 in autoimmune patients is controversial due to immunosuppressive therapies. Here, we characterized the T cell responses to SARS-CoV-2 in rheumatoid arthritis (RA) subjects, who received as few as one or up to seven vaccine injections. The study population had different disease severities and an association with other autoimmune comorbidities. All the subjects studied showed SARS-CoV-2 spike-specific CD4+ T helper (Th) cells in circulation, and in most of the subjects, CD8+ cytotoxic T cells. CD4+ and CD8+ T cells were CCR6+, suggesting trafficking to tissues. T cell memory did not correlate with the number of vaccine boosts received. Nonspike-specific T cells were enumerated in subjects who had symptomatic or asymptomatic COVID-19. Spike- and nonspike-specific regulatory T cells (Treg) were detectable in most subjects. CD4− CD8− double-negative (DN) T cells expanded in response to SARS-CoV-2 peptides. DN T cells co-cultured with autologous myeloid dendritic cells (DC) differentiated into CD8+ T cells, depending upon the strength of the stimuli. RA subjects responded to mRNA-based vaccination for COVID-19 protection, with no correlation with the number of injections. DN T cells differentiated into CD8+ T cells after stimulation, potentially exacerbating inflammation in RA vaccine recipients.","PeriodicalId":165,"journal":{"name":"European Journal of Immunology","volume":"55 12","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12716210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145792865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0