Journal of Neurogastroenterology and Motility最新文献

{"title":"Preoperative Esophageal Physiologic Testing in Bariatric Surgery: How Far Should We Go?","authors":"Tae Hee Lee","doi":"10.5056/jnm25236","DOIUrl":"10.5056/jnm25236","url":null,"abstract":"","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":"32 3","pages":"467"},"PeriodicalIF":3.7,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13425009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148592052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Utility of the Functional Sphincter Area: A Novel Functional Lumen Imaging Probe Parameter for the Assessment of Anal Sphincter Structure and Function in Fecal Incontinence.","authors":"Alexander O'Connor, Donghua Liao, Matthew Davenport, Abhiram Sharma, Dipesh H Vasant, Asbjørn M Drewes, Edward Kiff, John McLaughlin, Karen Telford","doi":"10.5056/jnm25014","DOIUrl":"10.5056/jnm25014","url":null,"abstract":"<p><strong>Background/aims: </strong>: The functional lumen imaging probe (FLIP) is a unique tool to measure the anal sphincter during distension. Using detailed geometric data generated by FLIP, we present the functional sphincter area (FSA), a novel measurement of sphincter morphology with potential clinical utility in the investigation of fecal incontinence (FI).</p><p><strong>Methods: </strong>: Parous female patients with FI presenting to a tertiary pelvic floor unit were prospectively recruited. FLIP measurements were obtained alongside endoanal ultrasound and high-resolution anorectal manometry.</p><p><strong>Results: </strong>: Thirty-one parous female patients with FI (median age: 62) were recruited. On endoanal ultrasound, 14 (45.2%) were found to have a sphincter defect in either the external sphincter (n = 10), or in both the external and internal sphincter (n = 4). The FSA demonstrated a consistent pattern of change during distension of the FLIP bag in all patients. At rest, the FSA was greater in those without anal sphincter defects at 30 mL (72.6 vs 53.2 mm²; <i>P</i> = 0.029) and 40 mL (71.5 vs 45.5 mm²; <i>P</i> = 0.048) bag volumes. The same pattern was observed during voluntary squeeze at 30 mL (67.8 vs 42.8 mm²; <i>P</i> = 0.044) and 40 mL (61.2 vs 38.6 mm²; <i>P</i> = 0.040) bag volumes. By contrast, there were no differences in symptom severity or manometry measurements between the 2 groups.</p><p><strong>Conclusions: </strong>: The FSA may offer a clinically useful parameter and, in combination with other FLIP measurements, could become a useful tool to assess the structure and function of the anal canal in FI.</p>","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":"32 3","pages":"362-371"},"PeriodicalIF":3.7,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13430075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148592138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Dyspepsia and Gastric Emptying Scintigraphy: Why 4-Hour Imaging and a 255-kcal Meal Matter.","authors":"Tae Hee Lee","doi":"10.5056/jnm25199","DOIUrl":"10.5056/jnm25199","url":null,"abstract":"","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":"32 3","pages":"466"},"PeriodicalIF":3.7,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13424847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148591801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Physical Activity on Functional Dyspepsia: A Mendelian Randomization and Randomized Controlled Study.","authors":"Zhongcao Wei, Zhiwei Tao, Yujie Hao, Na Liu, Jinhai Wang, Xin Xing","doi":"10.5056/jnm25159","DOIUrl":"10.5056/jnm25159","url":null,"abstract":"<p><strong>Background/aims: </strong>: The relationship between physical activity (PA) and functional dyspepsia (FD) remains unclear due to a lack of robust evidence. We conducted a Mendelian randomization (MR) analysis to assess potential genetic associations, followed by a randomized controlled trial (RCT) assessing the therapeutic effects of moderate-intensity exercise in FD patients.</p><p><strong>Methods: </strong>: In the MR analysis, genetic variants associated with PA traits from genome-wide association studies were analyzed. For the RCT, 260 FD patients were randomized to moderate-intensity exercise intervention or a control group. The primary endpoint was the adequate relief rate of dyspeptic symptoms.</p><p><strong>Results: </strong>: Using MR, a potential inverse association of strenuous sports activity against the development of FD was estimated (inverse variance weighte OR = 0.92, 95% CI = 0.88-0.98, <i>P</i> = 0.0047). Additionally, a suggestive inverse association was observed between other exercises (eg, swimming, cycling, keep fit, and fishing) (inverse variance weighte OR = 0.964; 95% CI, 0.937-0.993; <i>P</i> = 0.013) and FD risk. In the previous high-quality study, other exercises (eg, swimming, cycling, keep fit, and fishing) were considered moderate intensity exercise. Therefore, the MR study suggest that moderate intensity exercise may reduce the occurrence of FD. In the subsequent RCT, 114 participants in the exercise intervention group and 113 in the control group completed the study. The exercise group demonstrated a significantly higher adequate relief rate (46.9% vs 30.8%, <i>P</i> = 0.008) and greater reductions in symptom scores (all <i>P</i> < 0.05) versus controls.</p><p><strong>Conclusions: </strong>: PA, particularly moderate-intensity exercise, may reduce the risk of FD.</p>","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":"32 3","pages":"405-416"},"PeriodicalIF":3.7,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13424849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148592161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological, Molecular and Motility Changes in Human Small Intestine After Loop Ileostomy.","authors":"Eon Chul Han, Tae Sik Sung, Seung-Bum Ryoo, Kil-Yong Lee, Yoon-Hye Kwon, Kyu Joo Park","doi":"10.5056/jnm25226","DOIUrl":"10.5056/jnm25226","url":null,"abstract":"<p><strong>Background/aims: </strong>: Morphological and functional changes occur after loop ileostomy surgery such as villous atrophy and decreased contractility. This study aims to examine the changes in motility of the proximal and distal limbs of the ileostomy. Morphological, molecular and functional approaches of smooth muscle are attempted to elucidate the cause of the changes in motility.</p><p><strong>Methods: </strong>: Full thickness strips of circular muscle were prepared from 25 patients (median age 64 years). Western blot was performed to quantify the expression of contractile proteins. Expression of genes was quantified using quantitative real-time polymerase chain reaction.</p><p><strong>Results: </strong>: The distal limb showed morphological atrophy and a significant reduction in the contractile response to acetylcholine and potassium chloride, as well as a reduced relaxation response to sodium nitroprusside. However, no changes in the number of platelet derived growth factor receptor-α-positive (PDGFRα⁺) cells and interstitial cell of Cajal (ICC) were observed between the proximal and distal limbs. Western blot analysis confirmed that the expression levels of proteins associated with contraction such as myosin phosphatase targeting subunit 1, protein kinase C-potentiated phosphatase inhibitor protein-17 kDa, and Rho-associated, coiled-coil containing protein kinase 1, were significantly down-regulated in the distal limb. Despite the decrease in the expression of these proteins, neuronal cells and smooth muscle cells were preserved in the distal limb that has been diverted after ileostomy.</p><p><strong>Conclusions: </strong>: Although morphological, molecular and motility changes including down-regulation of contractile protein expression were observed in the distal loop, number of PDGFRα⁺ cells, ICCs, and neuronal cells were preserved. These results may explain restoration of the bowel motility after ileostomy take-down with low incidence of ileus.</p>","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":"32 3","pages":"438-448"},"PeriodicalIF":3.7,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13425082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148592031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical Activity as a Therapeutic Strategy for Functional Dyspepsia.","authors":"Yeon Ji Kim","doi":"10.5056/jnm26125","DOIUrl":"10.5056/jnm26125","url":null,"abstract":"","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":"32 3","pages":"305-306"},"PeriodicalIF":3.7,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13424848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148592094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disorders of Gut-Brain Interaction and Psychological Comorbidity in Singapore: Insights From the Rome IV Global Epidemiology Study.","authors":"Kewin T H Siah, Tamar Freud, Valencia R Y Zhang, Ami D Sperber, Olafur S Palsson, Shrikant I Bangdiwala, Reuben K Wong","doi":"10.5056/jnm25190","DOIUrl":"10.5056/jnm25190","url":null,"abstract":"<p><strong>Background/aims: </strong>: Disorders of gut-brain interaction (DGBI) affect ~40% of the global population, yet data from Asia, including urbanized Singapore, remain limited. We aim to estimate prevalence, characterize psychological comorbidities, and assess burden using Rome IV criteria.</p><p><strong>Methods: </strong>: As part of the Rome Foundation Global Epidemiology Study, we conducted a cross-sectional, internet-based survey of 2047 nationally representative Singaporean adults (January-March 2018). The Rome IV Diagnostic Questionnaire identified 22 DGBI; participants with physician-diagnosed organic disease were excluded. Psychological comorbidities were assessed with Patient Health Questionnaire-4 (PHQ-4 [anxiety/depression]) and Patient Health Questionnaire-12 (PHQ-12 [somatization]), and quality of life with Patient-Reported Outcomes Measurement Information System Global-10. Multivariable logistic regression identified factors associated with DGBI and psychological comorbidity.</p><p><strong>Results: </strong>: DGBI prevalence was 31.1% (95% CI, 29.1-33.2), lower than the pooled global prevalence (~40%). Functional bowel disorders predominated (25.3%), with constipation-related conditions (irritable bowel syndrome with constipation and functional constipation) affecting 9.9%. DGBI were more common in younger adults and women, but not education-related. Participants with multi-region DGBI reported higher somatization and anxiety/depression scores, poorer physical and mental health, and greater healthcare use. Regression showed younger age (per-year OR, 0.978; 95% CI, 0.970-0.986), female sex (OR, 0.667; 95% CI, 0.546-0.813), and higher somatization and anxiety scores independently associated with DGBI. Among those with DGBI, psychological comorbidity was independently associated with female sex, polypharmacy, and multi-region involvement.</p><p><strong>Conclusions: </strong>: In Singapore, DGBI are common but less prevalent than global estimates. Constipation-related disorders and psychological comorbidities contribute substantially to symptom burden and healthcare use, particularly in women and younger adults. Findings support integrated, culturally tailored care pathways to guide regional practice and public health policy.</p>","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":"32 3","pages":"372-386"},"PeriodicalIF":3.7,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13425139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148591562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Belching and Reflux: The Relationship and the Underlying Mechanism.","authors":"","doi":"10.5056/jnm25189E","DOIUrl":"10.5056/jnm25189E","url":null,"abstract":"","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":"32 3","pages":"470"},"PeriodicalIF":3.7,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13424626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148592242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptomatic Inlet Patch as a Cause of Chronic Cough and Dysphagia: A Case Report.","authors":"Elena Aznar Ruiz, Ana Zataraín Vallés, Marta Aparicio Cabezudo, Laura García Pravia, Marina Arroyo Cadenas, Constanza Ciriza de Los Ríos","doi":"10.5056/jnm25178","DOIUrl":"10.5056/jnm25178","url":null,"abstract":"","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":"32 3","pages":"464-465"},"PeriodicalIF":3.7,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13424627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148592047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Substrate-dependent Differences of Colonic Hydrogen Production in a Patient With Fructose Malabsorption.","authors":"Gernot Kriegshäuser","doi":"10.5056/jnm25163","DOIUrl":"10.5056/jnm25163","url":null,"abstract":"","PeriodicalId":16543,"journal":{"name":"Journal of Neurogastroenterology and Motility","volume":"32 2","pages":"300-301"},"PeriodicalIF":3.7,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13071413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147639273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}