Journal of Neuroendocrinology最新文献

{"title":"The hindbrain-hypothalamic noradrenergic pathway controls homeostatic food intake but not cue-induced appetitive behaviors","authors":"Colin Vuong,&nbsp;Jo Ann Yap,&nbsp;Helen Yi Sha Gu,&nbsp;Hun Yee Lai,&nbsp;Zhi Yi Ong","doi":"10.1111/jne.70229","DOIUrl":"10.1111/jne.70229","url":null,"abstract":"<p>Nucleus of the solitary tract (NTS) A2 noradrenergic neurons are critical in regulating food intake. In addition to their well-established role in homeostatic feeding, there is also evidence indicating their contribution in non-homeostatic feeding behaviors. However, whether their control of homeostatic and non-homeostatic feeding behaviors is mediated via shared or separate neural circuits is not well understood. Given that NTS A2 neurons project to the lateral hypothalamus (LH), a brain region implicated in both homeostatic and non-homeostatic feeding, this study examined whether NTS A2 neurons project to LH (A2^NTS→LH) to control these feeding behaviors. We used chemogenetics to activate A2^NTS→LH neurons. To assess homeostatic feeding, we measured chow intake in the home cage for 24 h and to assess non-homeostatic feeding, we used the Pavlovian appetitive conditioning task to measure cue-induced appetitive behavior. Using anatomical tracing, we first showed that ~20% of NTS A2 neurons project to the LH and these LH-projecting NTS A2 neurons are activated by food intake. Chemogenetic activation of A2^NTS→LH neurons significantly suppressed home cage chow intake and body weight. However, while activation of all NTS A2 neurons suppressed cue-induced appetitive behavior, pathway specific stimulation of A2^NTS→LH neurons did not affect this cue-driven behavior. Together, these results indicate that the A2^NTS→LH neurons are involved in the control of homeostatic food intake but not cue-induced appetitive behaviors, and suggest the contribution of distinct NTS A2 pathways and LH neurons in the regulation of homeostatic and non-homeostatic feeding behaviors.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"38 7","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jne.70229","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148411555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-nuclei RNA sequencing reveals heterogeneity within developing GnRH3 neurons in zebrafish","authors":"Yalong Sun,&nbsp;Matan Golan,&nbsp;Yonathan Zohar,&nbsp;Xiaoxuan Fan,&nbsp;Nilli Zmora","doi":"10.1111/jne.70230","DOIUrl":"10.1111/jne.70230","url":null,"abstract":"<p>Gonadotropin-releasing hormone (GnRH) is a central regulator of vertebrate reproduction regulating pituitary gonadotropins. In zebrafish, GnRH3 serves as the hypophysiotropic isoform. Its neurons develop by migrating from the nasal placode to the hypothalamus, forming several distinct subpopulations along the migratory path. However, the molecular heterogeneity underlying this migration remains incompletely understood. To delineate the molecular and spatial heterogeneity, we employed single-nuclei RNA sequencing of nuclei enriched based on <i>gnrh3</i> promoter-driven EGFP fluorescence from 7 dpf <i>Tg(gnrh3:EGFP)</i> zebrafish. This was followed by GnRH3 neurons clustering, differentially expressed genes identification, trajectory inference as a hypothesis-generating framework, and functional analyses. Marker genes were selected and used for validation and to determine the distribution of each subcluster by in situ hybridization (ISH) and immunohistochemistry (IHC) in larval and adult zebrafish. Three subpopulations were identified featuring highly expressed marker genes: Gnrh3^cyp1a, Gnrh3^nrg1, and Gnrh3^npffl/prl2. Gnrh3^npffl/prl2 was further clustered into two subpopulations, Gnrh3^npffl/prl2 and Gnrh3^npffl, which localized in the olfactory bulbs/terminal nerve and telencephalon, whereas Gnrh3^cyp1a and Gnrh3^nrg1 were detected in distinct cells within the olfactory epithelium. Trajectory inference and gene ontology enrichment analyses were consistent with a putative transcriptomic continuum from Gnrh3^cyp1a to Gnrh3^npffl/prl2 states, with the latter subpopulation lacking canonical migratory gene signatures. Protein–protein interaction network analysis revealed interaction relationships among differentially expressed genes, with a GnRH3-associated interaction module further supporting the selection of the above marker genes. Our results support the notion of at least three distinct GnRH3 subpopulations with distinct transcriptomes and characteristics, providing a broader basis for deciphering the diverse roles of GnRH3 in migration and reproduction.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"38 7","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jne.70230","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148404949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping of oxytocin- and arginine vasopressin-expressing neurons with calbindin 1 or reelin in the male mouse brain","authors":"Naranbat Nasanbuyan,&nbsp;Masahide Yoshida,&nbsp;Yuki Takayanagi,&nbsp;Keiichi Itoi,&nbsp;Tatsushi Onaka","doi":"10.1111/jne.70228","DOIUrl":"10.1111/jne.70228","url":null,"abstract":"<p>Oxytocin (OXT)- and arginine vasopressin (AVP)-synthesizing neurons are traditionally classified into magnocellular and parvocellular types based on their projection targets. However, molecular markers that reliably distinguish these neuronal subtypes across hypothalamic regions remain undefined. Recent single-cell transcriptomic studies suggest that <i>Calb1</i> and <i>Reln</i> are differentially expressed in magnocellular and parvocellular OXT-synthesizing neurons in the hypothalamic paraventricular nucleus (PVN). Whether this molecular distinction extends to OXT neurons beyond the PVN or to AVP neurons has remained unclear. Fluorogold (FG) was administered to adult male C57BL/6J mice via tail vein injection. Calbindin 1 and reelin expression in OXT- and AVP-synthesizing neurons in the bed nucleus of the stria terminalis (BNST), PVN, supraoptic nucleus (SON), and retrochiasmatic supraoptic nucleus (SOR) was examined by immunocytochemistry. FG-labeled neurons were distributed in the PVN, SON, and SOR. Most OXT-immunoreactive (ir) neurons in the anterior PVN, SON, and SOR were FG-positive, whereas many OXT-ir neurons in the posterior PVN were FG-negative. Most FG-positive OXT-ir neurons showed calbindin 1 immunoreactivity. Two-thirds of FG-negative OXT-ir neurons in the posterior PVN expressed reelin. Almost all Reln-positive OXT-ir neurons were FG-negative. Nearly all AVP-ir neurons were FG-positive, and more than half expressed calbindin 1, whereas reelin expression was not detected. In corticotropin-releasing hormone (CRH)-Venus knock-in mice, AVP-ir neurons and CRH-positive neurons were not colocalized within the PVN, and AVP-ir and CRH-positive fibers were localized to distinct layers of the median eminence. These findings indicate that AVP expression in parvocellular CRH neurons was below the detection threshold of the methods used in this study. Calbindin 1 serves as a marker for magnocellular OXT neurons, whereas reelin identifies a subset of parvocellular OXT neurons. Given that the detected AVP-ir neurons were predominantly magnocellular, calbindin 1 labels a subset of this magnocellular AVP population. This molecular distinction provides a framework for distinguishing OXT- and AVP-expressing neuronal populations and for examining their respective roles in endocrine and behavioral regulation.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"38 7","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jne.70228","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148396958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isosmotic hypovolemia preserves inverse neurovascular coupling in the supraoptic nucleus during heart failure","authors":"Ranjan K. Roy,&nbsp;Paramita P. Juardar,&nbsp;Jessica A. Filosa,&nbsp;Javier E. Stern","doi":"10.1111/jne.70227","DOIUrl":"10.1111/jne.70227","url":null,"abstract":"<p>Vasopressin (AVP) neurons in the hypothalamic supraoptic nucleus (SON) are activated by systemic challenges that threaten fluid balance. We previously showed that a systemic salt challenge triggers inverse neurovascular coupling (iNVC) in the SON, in which activity-dependent dendritic AVP release induces parenchymal arteriole (PA) vasoconstriction and local hypoxia. In heart failure (HF), however, the polarity of this salt-evoked response is reversed: microglia-derived adenosine acting on A2A receptors overrides an enhanced AVP-mediated vasoconstriction, producing net vasodilation. Still, whether AVP activation by non-osmotic stimuli engages similar neurovascular mechanisms is unknown. Here, we examined whether hypovolemia induced by intraperitoneal polyethylene glycol (PEG) evokes comparable vascular responses in control and HF rats. In vivo two-photon imaging was used to assess PA diameter in response to PEG in HF rats. Plasma protein and osmolarity were measured using the nanodrop ultra spectrophotometer and osmometer respectively. PEG produced a sustained rise in plasma protein concentration without altering plasma osmolality, confirming induction of isosmotic hypovolemia, and evoked vasoconstriction of SON PA in both control and sham rats. In HF rats, PEG still induced vasoconstriction at 60 min, but this response was attenuated by 90 min despite persistent hypovolemia. These findings indicate that hypovolemia engages a vasoconstrictive neurovascular response consistent with the iNVC previously shown to be AVP-mediated during osmotic stimulation, and that this response remains largely intact in HF. The polarity and temporal dynamics of NVC in HF appear to be stimulus-dependent, shaped both by osmotic-specific recruitment of purinergic pathways and by the altered physiological milieu imposed by HF.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"38 7","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148396971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations in cognitive function among reproductive-age women with polyendocrine metabolic ovarian syndrome: A systematic review and meta-analysis","authors":"Samantha Rogers,&nbsp;Bailey Milne,&nbsp;Jennifer Carpenter","doi":"10.1111/jne.70225","DOIUrl":"10.1111/jne.70225","url":null,"abstract":"<p>Polyendocrine metabolic ovarian syndrome (PMOS) is a common endocrine disorder affecting 1.55 million women of reproductive age worldwide. While its physical and reproductive impacts are well-documented, the cognitive effects of PMOS remain under-researched and poorly understood. This systematic review aims to investigate existing literature on cognitive function in women with PMOS. The objective of this review is to identify specific cognitive differences between women with PMOS and those without, highlight gaps in current research and clinical care, and inform the development of more comprehensive care frameworks for individuals with PMOS. A systematic search was conducted using Ovid MEDLINE, Ovid EMBASE, and CINAHL (Cumulative Index to Nursing and Allied Health Literature) for studies published up to June 23, 2025. Eligible studies underwent data extraction and risk of bias assessment in accordance with standard systematic review protocols. Out of 2887 articles screened, 22 studies met the inclusion criteria. Twenty-two studies involving 136,008 women with PMOS and 333,895 without PMOS were included. Across cognitive domains, pooled correlations generally indicated small, non-significant negative associations, including executive function (<i>r</i> = −0.12, 95% confidence interval [CI] –0.26 to 0.02), attention (<i>r</i> = −0.13, 95% CI –0.38 to 0.14), and working memory (<i>r</i> = −0.14, 95% CI –0.31 to 0.05). Substantial heterogeneity was observed in several domains, often driven by individual outlying studies. Risk of bias was generally low, and funnel plots with Egger's regression provided no evidence of publication bias. This review underscores the need for further research into the cognitive aspects of PMOS. Addressing this gap is essential for developing a more comprehensive approach to PMOS treatment and support beyond its traditional focus on physical and reproductive health.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"38 7","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jne.70225","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148376085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopic resection of small bowel neuroendocrine tumors: A long-term survival analysis","authors":"Michal Perets,&nbsp;Ofra Carmel,&nbsp;Anoushka Adler,&nbsp;Nir Horesh,&nbsp;Simona Grozinsky-Glasberg,&nbsp;Petachia Reissman,&nbsp;Michael R. Freund","doi":"10.1111/jne.70224","DOIUrl":"10.1111/jne.70224","url":null,"abstract":"<p>Small bowel neuroendocrine tumors (SBNET) are rare neoplasms that often present insidiously and may be associated with mesenteric fibrosis and advanced disease at diagnosis. While open surgery has traditionally been the standard of care, the role of laparoscopic resection in patients with complex SBNET remains under evaluation. We performed a retrospective analysis of all patients who underwent laparoscopic resection for SBNET at a tertiary referral center between 2002 and 2022. Clinical, operative, and oncologic data were extracted from a prospectively maintained database and reviewed for perioperative outcomes and long-term survival. Forty patients (mean age 62.2 years; 55% male) underwent laparoscopic resection, with a conversion rate of 7.5%. The ileum was the most common primary site (85%), and 75% of patients harbored a mesenteric mass. Postoperative morbidity was low (10%, all minor), with no perioperative mortality. The mean hospital stay was 7 days. Most tumors were low-grade (72.5% grade 1), yet 62.5% of patients presented with stage IV disease. With a mean follow-up of 7 years, overall survival reached 95 months, and progression-free survival 61 months. Age at surgery was the only independent predictor of outcome. Laparoscopic resection of SBNET is feasible and safe in selected patients, including those with advanced disease and mesenteric involvement, providing favorable long-term oncologic outcomes. These findings support the important role of minimally invasive surgery as part of the management of SBNET.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"38 7","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jne.70224","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148368756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controversies in NEN: An ENETS position statement on the interchangeability of somatostatin receptor PET tracers","authors":"Christophe M. Deroose,&nbsp;Valentina Ambrosini,&nbsp;Johanes Hofland,&nbsp;Gregory Kaltsas,&nbsp;Andreas Kjaer,&nbsp;Angela Lamarca,&nbsp;Anna Sowa-Staszczak,&nbsp;Eva Tiensuu Janson,&nbsp;Nicola Fazio","doi":"10.1111/jne.70220","DOIUrl":"10.1111/jne.70220","url":null,"abstract":"<p>Molecular imaging of the somatostatin receptor (SSTR) plays a key role in the management of patients with neuroendocrine neoplasms in general, and neuroendocrine tumours in particular. Over the last 2 decades, gallium-68 labelled somatostatin analogues have revolutionised SSTR imaging through the advent of SSTR positron emission tomography (PET), leading to better staging and theranostic imaging. Recent advances in the development of PET SSTR tracers continue to change the field, with novel tracers labelled with different radionuclides such as fluorine-18 and copper-64, or based on new antagonist vector molecules. The advent of these innovations generates questions, such as which tracers can be used in clinical practice, how to compare scans performed with different tracers, or can antagonists be used to select patients for peptide receptor radionuclide therapy? This ‘controversy paper’ from the <i>European Neuroendocrine Tumor Society</i> provides an overview of the relevant evidence to answer these questions, and provides guidance to clinicians and nuclear medicine physicians for contemporary use of SSTR PET.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"38 7","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148361273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of liver resections for neuroendocrine tumor liver metastases in carcinoid heart disease","authors":"Markus Ammann,&nbsp;Hallbera Gudmundsdottir,&nbsp;Vanja Podrascanin,&nbsp;Jonas Santol,&nbsp;David Pereyra,&nbsp;Yawen Dong,&nbsp;Heidi M. Connolly,&nbsp;Patricia A. Pellikka,&nbsp;Hartzell V. Schaff,&nbsp;Juan A. Crestanello,&nbsp;Cornelius A. Thiels,&nbsp;Susanne G. Warner,&nbsp;Mark J. Truty,&nbsp;Michael L. Kendrick,&nbsp;Rory L. Smoot,&nbsp;Thorvardur R. Halfdanarson,&nbsp;David M. Nagorney,&nbsp;Patrick P. Starlinger","doi":"10.1111/jne.70226","DOIUrl":"10.1111/jne.70226","url":null,"abstract":"<p>Carcinoid heart disease (CHD) is associated with advanced neuroendocrine tumor liver metastases (NETLM) and may preclude surgical cytoreduction. We assessed perioperative and long-term outcomes of hepatectomy in patients with CHD. We retrospectively analyzed 311 patients undergoing cytoreductive hepatectomy for intestinal NETLM: non-functional (<i>n</i> = 163), carcinoid syndrome (CS) without CHD (<i>n</i> = 110), and CHD (<i>n</i> = 38), including patients undergoing pre-hepatectomy valve replacement. CHD patients more frequently had &gt;10 liver metastases (78%) and larger lesions (median 9.5 cm) and required major hepatectomy more often (58%). Major morbidity was higher in CHD (up to 47%), yet 90-day mortality remained low (≤4%). Median overall survival after hepatectomy was comparable across groups (12.5 vs. 9.1 vs. 11.4 years; <i>p</i> = .19), including matched analyses. With optimal cardiac management, cytoreductive hepatectomy in CHD is feasible and provides long-term survival comparable to patients without CHD.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"38 7","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148360764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pubertal development and hypothalamic–pituitary–gonadal axis are altered in male mice lacking Mecp2","authors":"Ana Martín-Sánchez,&nbsp;Daniela Jiménez-Díaz,&nbsp;Rafael Esteve-Pérez,&nbsp;Alexandru Vasile-Tudorache,&nbsp;Jordan E. Read,&nbsp;Sasha R. Howard,&nbsp;Carmen Agustín-Pavón","doi":"10.1111/jne.70221","DOIUrl":"https://doi.org/10.1111/jne.70221","url":null,"abstract":"<p>Mutations in the <i>MECP2</i> gene, encoding the epigenetic reader Methyl-CpG binding protein 2, are the main cause of Rett syndrome, a rare neurodevelopmental disorder. Besides severe symptoms such as profound intellectual disability, loss of speech and motor skills, and epilepsy, loss of function of <i>MECP2</i> has been associated with pubertal dysregulation, but the biological mechanisms leading to this remain unclear. Using a mouse model of Rett, in which males are hemizygous and females heterozygous for <i>Mecp2</i> loss of function mutation, we assessed the onset and progression of puberty, together with increase in body weight and onset of neurological symptoms in post-weaning mice until puberty. In brain samples of young adult mice, we analysed hypothalamic Gonadotropin releasing hormone (GnRH) neurons by immunofluorescent labelling, and in plasma samples we measured circulating GnRH, LH, and testosterone concentrations. Finally, we analysed testosterone-dependent arginine-vasopressin circuits. In our mouse model we found delayed puberty in <i>Mecp2</i> ^<i>CD1</i>-null males, associated with a reduced rate of weight gain, but with puberty onset occurring at a lower body weight than in wildtype controls. Despite later puberty onset, <i>Mecp2</i>^<i>CD1</i>-null male mice were found to have an increased number of GnRH neurons, but displayed lower levels of circulating reproductive hormones. Consequently, <i>Mecp2</i>^<i>CD1</i>-null males have deficient testosterone-dependent arginine-vasopressin innervation. In female <i>Mecp2</i>^<i>CD1</i>-heterozygous mice, we found no overall significant differences in pubertal development or GnRH neurons. The lack of significant alterations in females might be related to a later onset of neurological symptoms due to heterozygosity. Our data supports that <i>MECP2</i> is essential for typical pubertal development, with complete loss of <i>Mecp2</i> in a male murine model resulting in abnormalities of pubertal timing related to lower body weight, with an observed increase in hypothalamic GnRH neurons.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"38 7","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jne.70221","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148324599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to “Methodological and inferential limits before abandoning follow-up in node-negative typical lung carcinoids”","authors":"Tobias Stemann Lau,&nbsp;Patrick Soldath,&nbsp;Karina Stubkjær Rewitz,&nbsp;Peter Jepsen,&nbsp;Ulrich Knigge,&nbsp;Seppo W. Langer,&nbsp;René Horsleben Petersen,&nbsp;Mikkel Andreasen,&nbsp;Gitte Dam","doi":"10.1111/jne.70223","DOIUrl":"https://doi.org/10.1111/jne.70223","url":null,"abstract":"","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"38 7","pages":""},"PeriodicalIF":5.0,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148324600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}