Journal of Neuroendocrinology最新文献

{"title":"Exploring the link between dopamine dysregulation and eating disorders: A narrative review","authors":"Zoaib Habib Tharwani,&nbsp;Sean Kaisser Shaeen,&nbsp;Komal Zahid,&nbsp;Shahzaib Ahmed,&nbsp;Rania Naqrashi,&nbsp;Amir Murtaza,&nbsp;Sanila Mughal,&nbsp;Muhammad Hasanain,&nbsp;Muhammad Umair Anjum,&nbsp;Mohammed Mahmmoud Fadelallah Eljack,&nbsp;Syeda Wardah Zaidi","doi":"10.1111/jne.70070","DOIUrl":"10.1111/jne.70070","url":null,"abstract":"<p>The prevalence of eating disorders (ED), such as anorexia, bulimia, and binge-eating disorders, is on the rise, and it is imperative to explore the pathophysiological aspects and associations of these disorders to provide better and precise treatment. Dopamine is an essential hormone and a neurotransmitter involved in an array of processes and pathways. Disruption of any of the dopamine pathways can lead to diseases such as Parkinson's, Huntington's, schizophrenia, or anhedonia. The mesolimbic pathway of dopamine has a special association with the feeding behavior of a person, and disruption of this pathway has been shown to be associated with ED. In this article, we comprehensively assess the relation between dopamine and ED and discuss the clinical implications involving the pharmacological associations of drugs influencing dopamine levels and their impact on the treatment of ED.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"37 10","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproductive experience influences the effects of Lactocaseibacillus rhamnosus HN001 on gut microbiota and hippocampal plasticity in female rats.","authors":"Jodi L Pawluski, Khadidja Kacimi, Cai Zhang, Laetitia Guillot, Aliocha Lo Guidice, Thierry D Charlier, Joseph S Lonstein","doi":"10.1111/jne.70068","DOIUrl":"https://doi.org/10.1111/jne.70068","url":null,"abstract":"<p><p>There is increasing interest in the role of probiotics in supporting maternal well-being throughout female reproduction. However, it remains largely unknown whether the brain of a female with reproductive experience responds differently to probiotics compared to females without reproductive experience. Reproduction involves remarkable neuroplasticity; therefore, we hypothesized that reproducing females are particularly susceptible to the effects of probiotic treatment. Groups of early pregnant or age-matched virgin female Long-Evans rats were administered the probiotic, Lactocaseibacillus rhamnosus HN001 (HN001), in their drinking water or given untreated water for 30 days. To measure changes in gut microbiota, fecal samples were taken regularly. Brains were analyzed at the end of treatment to quantify hippocampal cells containing the neurogenesis marker doublecortin, the synaptic marker synaptophysin, and the microglial activation marker Iba1. For dams, an offspring retrieval test was performed. Main findings show that HN001 administration lowers Bacteroidota abundance in the gut regardless of reproductive experience. In HN001-treated dams there was an increase in the number of times offspring were carried and this was negatively correlated with Bacteroidota abundance in the dam's gut. HN001-treated dams also had more immature neurons in the hippocampus and more thick-type microglial cells in the dorsal hippocampus compared to control dams. HN001-treated females, regardless of reproductive experience, had lower density of synaptophysin immunoreactivity in the CA1, and more thick-type microglia cells in the ventral hippocampus, compared to control females. These results indicate that the probiotic, HN001, alters female rat maternal behavior, plasticity in the hippocampus, and the gut microbiota abundance, with some effects being influenced by reproductive experience.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":" ","pages":"e70068"},"PeriodicalIF":3.3,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress alters hypothalamic gene expression in adolescent male Golden hamsters","authors":"Kevin M. Moran,&nbsp;Tyler M. Milewski,&nbsp;James P. Curley,&nbsp;Yvon Delville","doi":"10.1111/jne.70067","DOIUrl":"10.1111/jne.70067","url":null,"abstract":"<p>In Golden hamsters (<i>Mesocricetus auratus</i>), a two-week exposure to chronic social stress in adolescence causes acceleration of agonistic behavior, enhanced adult aggression, impaired waiting impulsivity, and higher food intake, body fat, and long-term increased body weight. In adult rodents, stress is accompanied by widespread alterations in gene expression in the brain. As stress is a potent modulator of both gene expression and behavior, the present research investigated possible mechanistic-related transcriptomic changes in the lateral, dorsomedial, and arcuate nucleus of the hypothalamus caused by adolescent stress using RNA Tag-sequencing, as these areas are involved in the regulation of metabolic and motivated behaviors. In each region, there were approximately 250 genes with higher expression compared to controls and 250 genes with lower expression. Many of the most significantly affected genes have been associated with metabolism and sex hormone function. For example, in the lateral hypothalamus, melanocortin 3 receptor, growth hormone releasing factor, both involved in metabolic processes, and neuropeptide VF precursor, involved in growth hormone inhibitory hormone production, were among the most increased in expression in stressed subjects. In the dorsomedial hypothalamus, neuropeptide W, involved in feeding cessation, was significantly decreased in expression in stressed animals. Across both regions, G-protein coupled receptor 50, involved in thermoregulation, sleep, and sex-related mood disorders, was significantly altered, but in opposite directions. In the arcuate nucleus, a number of blood brain barrier- and inflammation-related genes were altered as well. Furthermore, there were consistent patterns of genetic ensembles identified through gene ontology analysis and weighted gene correlation network analysis that were altered across each region. Many of these involved roles in RNA processing, DNA methylation, myelination, and synaptic organization. These findings reinforce prior behavioral, hormonal, and metabolic changes observed in this developmental model, and help guide future directions of research related to the negative consequences of early life stress.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"37 9","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jne.70067","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disrupted circadian rhythms and opioid-mediated adverse effects: Bidirectional relationship and putative mechanisms","authors":"Nasrin Mehranfard,&nbsp;Maedeh Ghasemi,&nbsp;Ehsan Saboory","doi":"10.1111/jne.70065","DOIUrl":"10.1111/jne.70065","url":null,"abstract":"<p>Recent studies have shown a link between disrupted circadian rhythms and the development of chronic opioid-induced negative effects. Both animal and human studies show a significant bidirectional relationship between the circadian system and opioid effects. Opioids can perturb circadian rhythms, and perturbation of the circadian rhythms can aggravate opioid-mediated adverse effects. These bidirectional interactions may attenuate the outcomes of long-term opioid therapy when not considered. A better understanding of the potential mechanisms underlying these interactions may be essential for more effective management of opioid-induced adverse effects. This review highlights the association between circadian rhythms and opioid-induced hyperalgesia, dependence, and withdrawal, and the possible role of the dopaminergic, serotoninergic, and noradrenergic systems, redox state, and stress in this association. We also highlight the existence of an interaction between other rhythmic biological processes, including the sleep–wake cycle as well as melatonin and glucocorticoid rhythms on the circadian and opioid systems and their possible effects on opioid-related negative effects.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"37 9","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jne.70065","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic submucosal dissection for gastric neuroendocrine neoplasms: A multicenter retrospective study","authors":"Nikolaos Lazaridis,&nbsp;Alessandro Rimondi,&nbsp;Rocio Chacchi-Cahuin,&nbsp;Arnaud Lemmers,&nbsp;Deborah Costa,&nbsp;Ana-Maria Bucalau,&nbsp;Dalvinder Mandair,&nbsp;Sunil Gupta,&nbsp;Marcel Tantau,&nbsp;Mathieu Pioche,&nbsp;Jérôme Rivory,&nbsp;João Santos-Antunes,&nbsp;Margarida Marques,&nbsp;Felipe Ramos Zabala,&nbsp;Federico Barbaro,&nbsp;Pedro Pimentel-Nunes,&nbsp;Hugo Uchima,&nbsp;Eduardo Albeniz,&nbsp;Mario Dinis-Ribeiro,&nbsp;Guido Costamagna,&nbsp;Cristiano Spada,&nbsp;Michael Bourke,&nbsp;Martyn Caplin,&nbsp;Christos Toumpanakis,&nbsp;Edward J. Despott,&nbsp;Alberto Murino","doi":"10.1111/jne.70064","DOIUrl":"10.1111/jne.70064","url":null,"abstract":"<p>Endoscopic submucosal dissection (ESD) has been reported as a feasible and effective treatment for Gastric Neuroendocrine Tumors (G-NETs). However, most of the experience comes from retrospective tertiary centers in Eastern Asia. Data coming from western centers are lacking. This is a retrospective study, including patients who underwent endoscopic resection of G-NETs by ESD between 2010 and 2020 in Western Centers. Important clinical variables such as demographic, size, type, presence of lymphovascular invasion or distant metastasis, completeness of the endoscopic resection, recurrence, and procedure-related complications were recorded. Seventy-three ESD procedures on G-NETs from 69 patients from 11 centers were included. Median G-NETs size on endoscopy was 12 mm (IQR 10–15). Case mix accounted for 83.6% type 1, 15.1% type 3, and 1.4% type 2. En-bloc resection was possible in 69 procedure 94.5%, R0 resection rate stood at 79.5%. Five patients (7.2%) were referred for additional surgical intervention. One case of perforation was reported (1.4%), treated endoscopically. Three patients (4.4%) had evidence of recurrence during follow-up. ESD is an effective and safe treatment for G-NETs in western centers.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"37 9","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controversies in NEN: An ENETS Position Statement on nutritional support in neuroendocrine neoplasms.","authors":"Simona Grozinsky-Glasberg, Johannes Hofland, Stephanie Alband, Yasmin Chotai de Lima, Adina Croitoru, Wanda Geilvoet, Peter Igaz, Beata Kos-Kudła, Guenter J Krejs, Alessandro Laviano, Francesco Panzuto, Anguraj Sadanandam, Ana Paula Santos, Staffan Welin, Rajaventhan Srirajaskanthan","doi":"10.1111/jne.70062","DOIUrl":"https://doi.org/10.1111/jne.70062","url":null,"abstract":"<p><p>Neuroendocrine neoplasms (NEN) themselves and also their treatment may cause malnutrition, inducing changes in physiological behaviour and eventually leading to increased rates of morbidity and mortality. Malnutrition is a common, under-recognised and under-treated condition in patients with NEN, and there are limited data available on the role of optimising nutrition in this setting. There are no formal evidence-based European Neuroendocrine Tumor Society (ENETS) guidelines on nutrition evaluation and management in patients with NEN to date. This manuscript was initiated during the 2024 ENETS Advisory Board meeting by using an expert panel consensus methodology and specific structured questions, which were identified and addressed through a structured review of the literature. The manuscript aims to identify the presence of specific nutrient deficits and define unmet needs and controversies regarding nutrition and NEN in a succinct manner, to promote collaborative and multidisciplinary research in the field, and to offer practical guidance in terms of how to assess malnutrition and dietary interventions by means of formulating a structured questionnaire.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":" ","pages":"e70062"},"PeriodicalIF":3.3,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroid lesions of neuroendocrine origin? Thinking of a “polka-dotted” zebra! Case series from three Italian referral centers and review of the literature","authors":"Tiziana Feola,&nbsp;Alessia Cozzolino,&nbsp;Federica Grillo,&nbsp;Maria Francesca Birtolo,&nbsp;Irene Aini,&nbsp;Erika Messina,&nbsp;Roberto Minotta,&nbsp;Alessia Filice,&nbsp;Isabella Zanata,&nbsp;Paola Razzore,&nbsp;Manila Rubino,&nbsp;Andrea M. Isidori,&nbsp;Annamaria Colao,&nbsp;Antongiulio Faggiano,&nbsp;Elisa Giannetta,&nbsp;NIKE group","doi":"10.1111/jne.70061","DOIUrl":"10.1111/jne.70061","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Neuroendocrine neoplasms (NENs) may metastasize very rarely to the thyroid. The current paper aims at identifying peculiar thyroid nodule's features that could prompt their diagnosis and analyzing therapeutic approach and patient's outcome.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A case series of three patients have been collected from three Italian referral centers. Moreover, we performed a keyword based PUBMED search, using relevant keywords.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We included in the review 27 papers and 33 cases have been identified. Patients’ age ranged from 17 to 85 years (mean age: 55.8 ± 14.2 years), 14 males, 42.4%. The majority of cases (48.5%) originated from a thoracic NEN. Median time to diagnosis from the primary tumor was 48 months (range 1–252 months). At ultrasound, they were generally hypoechoic nodules with irregular margins. The diagnosis was made by fine-niddle aspiration in the majority of cases, followed by nuclear medicine imaging. At immunohistochemistry, chromogranin A and synaptophysin were expressed in almost all of them, with negative calcitonin and thyroid transcription factor-1. Surgery or systemic treatment were needed according to primary tumor, disease stage, and patients’ general condition. Prognosis was variable, better if primary tumor origin was thoracic.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Thyroid metastases from NENs should be considered in the diagnostic work-up of suspicious thyroid nodules in patients with a positive medical history of previous NEN, mainly of thoracic origin. Immunohistochemistry is the key diagnostic tool for their identification. A prompt and correct diagnosis is mandatory because of its crucial prognostic and therapeutic implications.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"37 9","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jne.70061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical/pathological features and survival outcomes of extra-pulmonary neuroendocrine carcinomas: A retrospective single-center series","authors":"L. Benini,&nbsp;L. Gervaso,&nbsp;S. Frassoni,&nbsp;V. Bagnardi,&nbsp;C. A. Cella,&nbsp;L. Algeri,&nbsp;D. Ciardiello,&nbsp;M. G. Zampino,&nbsp;C. Winchler,&nbsp;S. Boselli,&nbsp;D. Tamayo,&nbsp;F. Spada,&nbsp;N. Fazio","doi":"10.1111/jne.70057","DOIUrl":"10.1111/jne.70057","url":null,"abstract":"<p>Poorly differentiated neuroendocrine carcinomas (NECs) are rare malignancies with a dismal prognosis, few therapeutic options, and a lack of predictive factors. We describe a large series of extra-pulmonary (EP) NEC patients from a neuroendocrine neoplasm (NEN) referral center, aiming to improve the clinical management of these diseases. Medical records of patients with histological diagnosis of pure histology EP-NEC, discussed at the NEN-dedicated multidisciplinary team (MDT) between October 2018 and August 2022, were included. Demographic features, tumor characteristics, molecular profile, treatments, and responses to treatments were collected. Among 1594 NEN diagnoses discussed at the MDT during the study period, 377 were NECs; the final population consisted of 173 patients, mostly presenting with advanced disease and often with a gastroenteropancreatic tract primary tumor. Molecular profiling was available for 52 patients (30%). The most frequent alterations occurred in <i>TP53</i> and <i>KRAS</i>. One of 25 patients tested for microsatellite instability was confirmed MSI-h; one of 52 patients tested had a high tumor mutational burden (TMB = 19). Median overall survival (OS) was 15.4 months (95% confidence interval [CI]: 13.2–18.5). Most patients with advanced disease received a first-line chemotherapy (136/153 [88.9%]), often platinum plus etoposide (111/136 patients [82%]). The overall response rate (ORR) to first-line was 40%. Median progression-free survival (PFS) was 5.7 months (95% CI: 4.4–6.4). Forty-two percent and 18% of patients received second- and third-line therapy, respectively. No significant difference was seen when stratifying OS and PFS by Ki-67 groups and tumor cell morphology, whereas performance status and presence of metastases were significantly related to OS. In this single-center retrospective large series of EP-NECs, almost half of the patients showed a tumor response to first-line chemotherapy. No relevant correlation was found with primary site, tumor cell morphology, or Ki-67. The proportion of patients receiving subsequent lines, along with the mOS, confirms the aggressiveness of this disease. Molecular profiling was performed only fragmentarily, with limited practical applicability. Efforts shall be made in the future to implement these investigations.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":"37 9","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jne.70057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The 20 kDa isoform of the human growth hormone variant alters adipose and muscle gene expression differently than human growth hormone.","authors":"Jonathan A Young, Jolie Bogart, Mat Buchman, Silvana Duran-Ortiz, Stephen Bell, John J Kopchick, Darlene E Berryman, Edward O List","doi":"10.1111/jne.70059","DOIUrl":"10.1111/jne.70059","url":null,"abstract":"<p><p>The 20 kDa isoform of human growth hormone variant (20K hGH-V) (derived from the GH2 gene) has previously been shown to promote growth but lacks the diabetogenic and lactogenic activities of human GH (derived from the GH1 gene). That is, 20K hGH-V-treated mice have similar body size and composition to hGH-treated mice, as well as improved insulin sensitivity despite having similar adipose tissue mass. Furthermore, 20K hGH-V-treated prolactin receptor-positive cancer cells exhibited significantly less growth compared to hGH treatment. The aim of this study was to use transcriptomics to compare the effects of 20K hGH-V injection to that of hGH injection on adipose and muscle tissue. GH knockout (GHKO) mice, which do not produce endogenous GH, were injected with hGH or 20K hGH-V daily for 5 days and dissected 4 h after the final injection. RNA was extracted from inguinal subcutaneous adipose tissue and quadriceps muscle and subjected to RNA sequencing. When comparing hGH to 20K hGH-V, there were 73 genes that were significantly altered (q value <.05 and log₂ fold change >1 or < -1) in adipose and 32 in muscle, with two genes (Cish and Sv2b) common to both tissues. Gene set enrichment analysis (GSEA) indicated that the adipose tissue of the 20K hGH-V-treated mice had decreased enrichment of genes associated with T and B lymphocytes compared to hGH-treated adipose tissue. Furthermore, 20K hGH-V treatment resulted in increased enrichment of genes associated with adipogenesis and carbon metabolism compared to hGH treatment. In muscle tissue, the electron transport chain and muscle contraction pathways were upregulated in 20K hGH-V-treatment, while cell cycle, extracellular matrix organization, and xenobiotic metabolism pathways were negatively enriched. While most genes and signalling pathways were similar between the two hormone treatments, the differentially expressed genes identified may help explain some of the phenotypic differences between 20K hGH-V and hGH treatment and also suggest additional novel differences, notably muscle fibre type, immune cell infiltration, and fibrosis.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":" ","pages":"e70059"},"PeriodicalIF":3.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12272731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controversies in NEN: An ENETS position statement on the endoscopic management of localised gastric, duodenal and rectal neuroendocrine neoplasms.","authors":"Francesco Panzuto, Dermot O'Toole, Günter Klöppel, Ulrich Peter Knigge, Günter Josef Krejs, Marina Tsoli, Marco Volante, Tu Vinh Luong","doi":"10.1111/jne.70060","DOIUrl":"https://doi.org/10.1111/jne.70060","url":null,"abstract":"<p><p>Gastric, duodenal and rectal neuroendocrine tumours (NETs) are increasingly detected due to advances in endoscopic imaging. While international guidelines provide criteria for endoscopic management, several aspects remain controversial due to limited high-quality evidence. This position paper, developed by an expert panel, aims to clarify these unresolved issues and provide consensus-based recommendations. The primary objective of this position paper is to critically analyse and address key controversies in the endoscopic management of gastro-duodenal-rectal NETs. These include the optimal selection of endoscopic resection techniques, the significance of R1 resections, pathological assessment and surveillance strategies. Special attention is given to site-specific challenges, including the role of Ki-67 in type 1 gastric NETs, the management of multiple gastric lesions, the feasibility of endoscopic resection for type 3 gastric NETs and the limitations of advanced endoscopic techniques in the duodenum. This position paper was developed using an Expert Panel Consensus methodology. Topics were identified during the 2024 ENETS Advisory Board meeting and addressed through a structured literature review. Evidence was critically appraised, and expert discussions were conducted to identify key points. By reviewing controversial aspects of endoscopic management, this position paper will provide practical guidance to optimise decision-making and improve outcomes for patients with gastro-duodenal-rectal NETs. Multidisciplinary evaluation remains crucial to tailoring treatment strategies based on tumour characteristics, patient factors and procedural risks.</p>","PeriodicalId":16535,"journal":{"name":"Journal of Neuroendocrinology","volume":" ","pages":"e70060"},"PeriodicalIF":3.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}