Exploring the link between dopamine dysregulation and eating disorders: A narrative review

IF 4.1 4区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Neuroendocrinology Pub Date : 2025-07-23 DOI:10.1111/jne.70070

Zoaib Habib Tharwani, Sean Kaisser Shaeen, Komal Zahid, Shahzaib Ahmed, Rania Naqrashi, Amir Murtaza, Sanila Mughal, Muhammad Hasanain, Muhammad Umair Anjum, Mohammed Mahmmoud Fadelallah Eljack, Syeda Wardah Zaidi

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引用次数: 0

Abstract

The prevalence of eating disorders (ED), such as anorexia, bulimia, and binge-eating disorders, is on the rise, and it is imperative to explore the pathophysiological aspects and associations of these disorders to provide better and precise treatment. Dopamine is an essential hormone and a neurotransmitter involved in an array of processes and pathways. Disruption of any of the dopamine pathways can lead to diseases such as Parkinson's, Huntington's, schizophrenia, or anhedonia. The mesolimbic pathway of dopamine has a special association with the feeding behavior of a person, and disruption of this pathway has been shown to be associated with ED. In this article, we comprehensively assess the relation between dopamine and ED and discuss the clinical implications involving the pharmacological associations of drugs influencing dopamine levels and their impact on the treatment of ED.

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探索多巴胺失调与饮食失调之间的联系：叙述性回顾。

饮食失调（ED）的患病率，如厌食症、贪食症和暴食症，正在上升，探索这些疾病的病理生理方面和关联，以提供更好和精确的治疗是势在必行的。多巴胺是一种重要的激素和神经递质，参与一系列的过程和途径。任何多巴胺通路的破坏都可能导致帕金森症、亨廷顿氏症、精神分裂症或快感缺乏等疾病。多巴胺的中脑边缘通路与人的摄食行为有着特殊的联系，该通路的破坏已被证明与ED有关。在本文中，我们全面评估了多巴胺与ED之间的关系，并讨论了影响多巴胺水平的药物的药理关联及其对ED治疗的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Neuroendocrinology 医学-内分泌学与代谢

CiteScore

6.40

自引率

6.20%

发文量

137

审稿时长

4-8 weeks

期刊介绍： Journal of Neuroendocrinology provides the principal international focus for the newest ideas in classical neuroendocrinology and its expanding interface with the regulation of behavioural, cognitive, developmental, degenerative and metabolic processes. Through the rapid publication of original manuscripts and provocative review articles, it provides essential reading for basic scientists and clinicians researching in this rapidly expanding field. In determining content, the primary considerations are excellence, relevance and novelty. While Journal of Neuroendocrinology reflects the broad scientific and clinical interests of the BSN membership, the editorial team, led by Professor Julian Mercer, ensures that the journal’s ethos, authorship, content and purpose are those expected of a leading international publication.