Journal of Nanomedicine & Nanotechnology最新文献

{"title":"Contributing to Vision 2030 with a Saudi Polymer Research Center","authors":"Ebtisam A. Aldaais","doi":"10.4172/2157-7439.1000527","DOIUrl":"https://doi.org/10.4172/2157-7439.1000527","url":null,"abstract":"","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85430399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of High Dose of Selenium Nanoparticles on Alimentary Tract in Rodents","authors":"Salome Khubulava, Nino Chichiveishvili, Naili Shavshishvili, K. Mulkijanyan, N. Khodeli, M. Jangavadze, Z. Tsagareli, M. Dgebuadze, G. Phichkhaia","doi":"10.35248/2157-7439.19.10.531","DOIUrl":"https://doi.org/10.35248/2157-7439.19.10.531","url":null,"abstract":"In recent years, application of nanoparticles in different fields of biomedical research, paves its way. Nanosized drugs are claimed to decrease toxicity and reduce the needed dose. Selenium is one of the essential trace element in the body that exhibits both anti-oxidative and pro-oxidative effects and is of great importance for nourishment and medicine. Like other nanoparticles, selenium nanoparticles (SeNPs) possess some unique mechanical, optical, electrical, biologic and chemical properties as compared with bulk materials. The aim of the study was to evaluate the possible effects of orally consumed high doses of SeNPs on rodents’ alimentary tract after single (1000 and 5000 mg/ kg) and repeated (500 mg/kg) 90 day administration.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81054276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanotechnology: Nanoparticle Characterization and Application in Pharmacology and Toxicology","authors":"A. Ostafin","doi":"10.35248/2157-7439.19.10.533","DOIUrl":"https://doi.org/10.35248/2157-7439.19.10.533","url":null,"abstract":"The past few decades have witnessed a great deal of exploration of nanomedicine and the potential application of nanoscience in biomedical science. Nanoparticles have the unique potential of both sensitivity and selectivity with customizability. These are fundamental requirements of medicine. Unlike macro scale features, the nanostructures’ properties and functions are very distinct and this elicits great deal of research. The present issue of the journal comprises of a research article on synthetic peptide for effective inhibition of viral infection; a review on nano-scale metal alloys and their fatigue resistance; a study on eco-friendly greensynthesized nanoparticles on reduction of haematological toxicity as well as a report on dosage response evaluation of nanoparticles having antioxidant effect.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87950890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chitosan Based Films Incorporated with Turmeric/Clove/Ginger Essential Oil for Food Packaging","authors":"M. Yashaswini, Iyer Pr","doi":"10.35248/2157-7439.19.10.537","DOIUrl":"https://doi.org/10.35248/2157-7439.19.10.537","url":null,"abstract":"The aim of this work was to produce chitosan based films which can be used as an effective packaging material. In order to produce a material like that chitosan was extracted from the crab shells by the process of demineralization, deproteinization and deacteylation and the obtained chitosan was made into a film with additives like Turmeric/ Clove/Ginger and gelatin. Plasticizer like glycerol was also added to obtain a transparent, stretchable, exquisite film which is a active packaging material and the film forming solution was used as a coating over the areca nut plates and cups to prevent the microbial spoilage and to increase the shelf life of them and then coating was also performed on fruits and vegetables to prevent spoilage and increase their shelf life. The film was checked for its thickness, transparency and stability. The physical, chemical and biological parameters were evaluated by performing the characterization studies like SEM, TG-DSC, TG-DTG, DSC and FTIR. The antioxidant, anticoagulant properties and cytotoxicity were tested to analyse and evaluate the quality of the film. The results state that the film has good thermal stability and through the results of FTIR it is proved that the film has functional groups of chitosan, gelatin, turmeric and other added components. And other results proved that the film is completely safe to be used as a food packaging material. Concerning/pertaining to the environmental issues and the effects of plastic films in human in terms of health and degradability conditions chitosan based films can bring about a change in the current packaging industry and the change could lead to better human and environmental health.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79902389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accumulation of Silver Nanoparticles in Mice Brain Parts and the Harmful Effects","authors":"A. Antsiferova, M. Kopaeva, Vyacheslav N Kochkin, P. Kashkarov, M. Kovalchuk","doi":"10.4172/2157-7439.1000524","DOIUrl":"https://doi.org/10.4172/2157-7439.1000524","url":null,"abstract":"The influence of the daily prolonged administration of silver nanoparticles on cognitive functions of model mammals was studied. The accumulation of silver in whole brain, hippocampus, cerebellum, cortex and residual part of mice brain was investigated by highly precise and representative Neutron Activation Analysis and the histological studies were conducted in the present research. Some of the main results of the comprehensive study are the description of the biokinetics of silver in the hippocampus, cerebellum and cortex, the finding of the jump increase of silver in the hippocampus and cerebellum after the period of administration of 120 days. Accumulation of silver in the mice brain and hippocampus itself as well as the integrity violation of the CA2 subregion caused long-term contextual memory impairment at 180 days of silver nanoparticle exposure. However, destruction of CA2 had started 60 days before the visible changes in behavior appeared. Complex of the three types of the approach let us find the cognitive impairment and understand the reasons of it.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79160610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibodies can be Spontaneously Loaded onto Monosialoganglioside Micelles Containing Oncological Drugs","authors":"A. G. Garro, R. Alasino, V. Leonhard, V. Heredia, D. Beltramo","doi":"10.35248/2157-7439.19.10.532","DOIUrl":"https://doi.org/10.35248/2157-7439.19.10.532","url":null,"abstract":"Recently, we demonstrated that GM1 micelles transport paclitaxel and doxorubicin with high efficiency. When this GM1-drugs complex is incubated with whole serum, albumin was the only one protein that binds spontaneously to form GM1-drug-albumin complex. Here, we show that, under specific physicochemical conditions, these micelles interact with antibodies forming GM1-IgG complexes. The load of IgG in GM1 reaches a maximum at ratios of 1/4 (w / w) incubating to 4.5 and preheating the micelles of GM1 at 55-60°C. The IgG of the GM1-IgG complex obtained under these experimental conditions retains the biological activity against the soluble and cellular antigens and is not displaced from the micelles in the presence of albumin, the main competitive binding protein. Treatment of GM1-IgG with pepsin, does not show the breakage of the IgG like control of free IgG, suggesting that IgG is deeply bound into GM1, probably via Fc. Moreover, the presence of 1 M NaCl does not prevent neither dissociate the complex, suggesting the hydrophobic nature of the interaction. The DLS and TEM results shows that GM1-IgG complexes have sizes significantly higher than those of GM1 micelles; this is directly related to the amount of IgG loaded. On the other hand GM1-IgG complex also retain the ability to encapsulate oncological drugs, but, an adequate sequence must be followed during the preparation, in order to obtain efficient GM1-drug-IgG ternary complexes. Moreover, the presence of IgG into GM1-oncological drugs complex do not affect the release or the cytotoxic activity of the encapsulated molecules such as Ptx or Doxo.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79383855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a Refractive Index Sensor Based on the Deposition of Gold and Silver Nanowires on ITO Glass for CA15-3 Detection","authors":"H. Zeng","doi":"10.4172/2157-7439.1000523","DOIUrl":"https://doi.org/10.4172/2157-7439.1000523","url":null,"abstract":"As a step towards the development of highly sensitive and accurate biosensors for the early detection and monitoring of breast cancer, we have developed a refractive index sensor for the detection of CA15-3 breast cancer biomarker based on the deposition of gold and silver nanowires on ITO glass. 1 cm × 1 cm ITO glass was washed and vacuum dried. Gold films were sputtered on the clean dried ITO glass using an ion sputtering machine and labelled ITO/ Au electrode. Silver nanowires solution were deposited on the ITO/Au electrode and labelled ITO/AU/AgNWs electrode. The ITO/Au/AgNWs electrode was then embedded in a 12 well-plate containing CA15-3 antibody and labelled ITO/Au/ AgNWS/CA15-3 antibody electrode, which was used to detect CA15-3 antigen. The UV absorption wavelength of the sensor was found to be within the range of 320 nm to 350 nm. The sensor has a linear response to CA 15-3 antigen at concentrations ranging from 3 IU/mL to 32 IU/mL, and showed good CA15-3 detection properties with significant linear relationships between the wavelength change and the CA15-3 antigen concentration, the wavelength change and the refractive index, and the CA15-3 antigen concentration and refractive index. Our study provides a new and sure way towards the development of highly sensitive, accurate and efficient biosensors for the early detection and monitoring of breast cancer during therapy because Localized Surface Plasmon Resonance (LSPR) based detection techniques has an advantage over other detection techniques. Moreover, LSPR is superior to conventional methods when it comes to long term monitoring applications since LSPR of metallic nanoparticles do not bleach or blink. Also, the binding of nanoparticles to organic molecules increases the local refractive index since the index of refraction of typical buffer solutions are smaller than that of organic molecules.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86372508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formation of Protein Corona on Rhodium Citrate-Functionalized Magnetic Nanoparticles and Their Interaction with Human Macrophages","authors":"Weskly F Lago, N. V. Carvalho, N. Chaves, M. A. Radicchi, M. H. Sousa, W. Fontes, M. Sousa, S. Báo","doi":"10.35248/2157-7439.19.10.534","DOIUrl":"https://doi.org/10.35248/2157-7439.19.10.534","url":null,"abstract":"Nanoscience and Nanotechnology enable innovations for Medicine and for Biomedical Science. Among the current nanoparticles, maghemite associated with rhodium citrate (Magh-RhCit) has been shown to be promising, because it reduces side effects of drugs while maintaining cytotoxicity for tumor cells. However, NPs in contact with biological fluids are immediately coated by proteins (protein corona) that are unique to each nanomaterial. In this study, the adsorption of the most abundant binding proteins was studied in vitro using a three-step analysis: (1) characterization of the magnetic fluid (Magh-RhCit) before and after incubation with serum; (2) identification and physical and biochemical analysis of protein corona; and (3) the cellular internalization of these nanoparticles in human macrophages. Magh-RhCit was initially obtained in the magnetite phase (Fe3O4) via alkaline coprecipitation of Fe2+ and Fe3+ ions and subsequently oxidized to maghemite by the bubbling of oxygen gas in the suspension. Later, rhodium citrate was associated with nanoparticles. Dynamic Light Scattering data were used for characterization of the hydrodynamic diameter and zeta potential. The morphological characterization and measurement of the particles were obtained from Scanning and Transmission Electron Microscopy, and the X-ray Diffraction technique. The identification of the proteins was performed by Liquid Chromatograph coupled to Mass Spectrometry. Human blood serum altered the characteristics of the nanoparticle, making it less polydisperse, larger and with less negative zeta potential, indicating the formation of the protein corona. Forty-nine proteins (which mostly promote opsonization, phagocytosis and endocytosis in cells of the immune system) were identified and characterized: albumin, IgGs, apoliproteins, serpins, complement (C5), kinases, haptoglobin, glycoproteins and transferrin. Nanoparticle characterization and mass spectrometric data of the digested protein corona suggest improved biocompatibility. Moreover, results regarding nanoparticles’ interaction with macrophages suggest that the corona may have profoun implications for in vitro and in vivo extrapolations and will require some consideration in the future.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74725890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laser Auto Fluorescence and Dye-enhanced Spectroscopic Detection of Normal and Cancerous Human Lung Cell Lines and Plasmonic Photothermal Heating","authors":"M. E. Khosroshahi, M. Asemani, Payam Khoshkenar","doi":"10.4172/2157-7439.1000525","DOIUrl":"https://doi.org/10.4172/2157-7439.1000525","url":null,"abstract":"This work describes the results of laser autofluorescence, dye-enhanced fluorescence spectroscopy of normal MRC-5 and cancerous QU-DB human lung cell lines and the effect of gold nanoshells heating on the cells. It was shown that the intensity ratio of MRC-5 to QU-DB 80 (ΔR) and the shape factor (RP) can be appropriate indicators of normal and cancerous cells for primary and secondary peaks at 500 nm and 590 nm respectively. About 5 nm red shift was observed in the case of cancerous cells. Highest temperatures of about 51 and 39.5?C were achieved for (S3, S4) and (S5, S6) respectively. The percentage of damaged cells and nanoshells density are expected to decrease with radial distance from the center of the beam. The results also indicated an increasing degree of apoptosis with increasing the laser power, which critically governs the quality and the degree of laser-hyperthermia. The matrix temperature is thought to vary due to possible thermal overlapping of a larger fraction of NSs, agglomeration and clustering.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85570167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the Fatigue Behavior of Nanocrystalline NiTi Shape Memory Alloys: A Review","authors":"Sulaiman Ashbli, C. Menzemer","doi":"10.4172/2157-7439.1000529","DOIUrl":"https://doi.org/10.4172/2157-7439.1000529","url":null,"abstract":"This paper presents a review of the research on the fatigue performance of superelastic polycrystalline nanocrystalline NiTi shape memory alloys (nc NiTi SMAs). A brief introduction to some focal definitions and basic concepts of fatigue measurement and response in NiTi SMAs were given. Results found in the literature on fatigue in nc NiTi SMAs are discussed. Mechanical behavior and energy dissipation capacity of nc NiTi SMAs are explored and collectively compared with coarse-grained NiTi SMAs, along with an assessment of the influence of grain size refinement and thermomechanical treatments. Several conclusions and suggestions are made, including that nc NiTi SMAs exhibit larger functional fatigue resistance, lower crack tolerance, higher superelasticity, and smaller hysteresis loss.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76751286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}