Effect of High Dose of Selenium Nanoparticles on Alimentary Tract in Rodents

Salome Khubulava, Nino Chichiveishvili, Naili Shavshishvili, K. Mulkijanyan, N. Khodeli, M. Jangavadze, Z. Tsagareli, M. Dgebuadze, G. Phichkhaia
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引用次数: 5

Abstract

In recent years, application of nanoparticles in different fields of biomedical research, paves its way. Nanosized drugs are claimed to decrease toxicity and reduce the needed dose. Selenium is one of the essential trace element in the body that exhibits both anti-oxidative and pro-oxidative effects and is of great importance for nourishment and medicine. Like other nanoparticles, selenium nanoparticles (SeNPs) possess some unique mechanical, optical, electrical, biologic and chemical properties as compared with bulk materials. The aim of the study was to evaluate the possible effects of orally consumed high doses of SeNPs on rodents’ alimentary tract after single (1000 and 5000 mg/ kg) and repeated (500 mg/kg) 90 day administration.
大剂量纳米硒对啮齿动物消化道的影响
近年来,纳米颗粒在生物医学不同领域的应用研究,为其铺平了道路。纳米药物据称可以降低毒性并减少所需剂量。硒是人体必需的微量元素之一,具有抗氧化和促氧化双重作用,具有重要的营养和药用价值。与其他纳米粒子一样,硒纳米粒子与块状材料相比具有一些独特的机械、光学、电学、生物和化学性质。本研究的目的是评估高剂量口服SeNPs在单次(1000和5000 mg/kg)和多次(500 mg/kg)给药90天后对啮齿动物消化道可能产生的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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