Journal of Nanomedicine & Nanotechnology最新文献_第6页

Remineralization Potential of a Novel Silver Nanoparticle Rinse on Severely Demineralized Enamel In-vitro: A 14-Day Trial 新型纳米银漂洗剂对体外严重脱矿牙釉质的再矿化潜力:14天试验

Journal of Nanomedicine & Nanotechnology Pub Date : 2020-01-01 DOI: 10.35248/2157-7439.20.11.542

C. Callister, M. Callister, M. Nolan, R. Nolan

引用次数: 3

Neutral Surfactant Enhanced Exon-skipping of Morpholino Oligonucleotides in vitro and in mdx Mice 中性表面活性剂增强体外和mdx小鼠的Morpholino寡核苷酸外显子跳变

Journal of Nanomedicine & Nanotechnology Pub Date : 2020-01-01 DOI: 10.35248/2157-7439.20.11.553

Mingxing Wang, B. Wu, Morgan Drains, Peijuan Lu, Q. Lu

{"title":"Neutral Surfactant Enhanced Exon-skipping of Morpholino Oligonucleotides in vitro and in mdx Mice","authors":"Mingxing Wang, B. Wu, Morgan Drains, Peijuan Lu, Q. Lu","doi":"10.35248/2157-7439.20.11.553","DOIUrl":"https://doi.org/10.35248/2157-7439.20.11.553","url":null,"abstract":"Antisense oligomers induced exon-skipping has been promising therapy for Duchenne muscular dystrophy in preclinical and clinical trials, but its therapeutic potential could be improved with enhanced delivery approach. A few neutral surfactants were investigated here in for their performance to improve exon-skipping of an antisense phosphorodiamidate morpholino oligomer (PMO) both in vitro and in vivo. This study showed that these surfactants, especially Bigchapand Deoxy Bigchap, improved the delivery efficiency of PMO to the levels comparable to Endoporter-mediated PMO delivery in vitro, and significant enhancement with Deoxy Bigchap-mediated PMO was further observed in mdx mice up to 7-fold compared with PMO alone. Cytotoxicity of the surfactants except for Mega10 was much lower than that by Endoporter in vitro and not clearly observed in vivo under the tested dosage. These results reveal that surfactant’s composition is key factor as delivery carrier to improve PMO exon-skipping efficiency, the efficacy and safety endow neutral surfactants as potential delivering enhancer for oligonucleotide in the treatment of muscular dystrophy or other diseases.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85319779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Remineralization Potential of a Novel Silver Nanoparticle Rinse on Severely Demineralized Enamel In-vitro: A 14-Day Trial 新型纳米银漂洗剂对体外严重脱矿牙釉质的再矿化潜力:14天试验

Journal of Nanomedicine & Nanotechnology Pub Date : 2020-01-01 DOI: 10.35248/2157-7439.19.10.542

C. C, Callister M, Nolan M, N. R

引用次数: 0

Tackling COVID-19 with Nanotechnology 利用纳米技术应对COVID-19

Journal of Nanomedicine & Nanotechnology Pub Date : 2020-01-01 DOI: 10.35248/2157-7439.20.10.544

Imran Moin

引用次数: 3

Nano-theragnostic Approach to Mitigate Covid-19 纳米诊断方法缓解Covid-19

Journal of Nanomedicine & Nanotechnology Pub Date : 2020-01-01 DOI: 10.35248/2157-7439.20.10.545

A. Verma

{"title":"Nano-theragnostic Approach to Mitigate Covid-19","authors":"A. Verma","doi":"10.35248/2157-7439.20.10.545","DOIUrl":"https://doi.org/10.35248/2157-7439.20.10.545","url":null,"abstract":"Global Coronavirus pandemic has to be strategically addressed. The initial preventive phase has been largely discussed. The gamut of disease is comprehensive as patients hospitalised with COVID-19 manifest respiratory failure, sepsis, pneumonia, and acute respiratory distress syndrome (ARDS). Nano-theragnostics might have the answer to the mightiest challenge of this century in the next phase of diagnostics and therapeutics. Coronavirus causes severe morbidity in the lower respiratory tract, where alveolar epithelial cells are the key targets for dysregulating their function and triggering immune responses. The intensity and continued production of cytokine rush leads to enhanced vascular hyperpermeability that often causes multiorgan failure, and finally death. Nanoparticles (NPs) are being envisaged to target the airway epithelial cells to repair the dysfunctions with therapy, drug repurposing to counter the imbalance caused by the cytokine storm. Because inflammation, according to the literature, induces thrombosis through a complex but well- known pathophysiological mechanism. The way to fight Covid-19 has to experiment not only antibiotics, antivirals, but also anti-inflammatories and anticoagulants.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79127377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of Nanotechnology in Tissue Engineering 纳米技术在组织工程中的应用

Journal of Nanomedicine & Nanotechnology Pub Date : 2020-01-01 DOI: 10.35248/2157-7439.20.10.E536

Bharti Sn, G. Swetha

{"title":"Application of Nanotechnology in Tissue Engineering","authors":"Bharti Sn, G. Swetha","doi":"10.35248/2157-7439.20.10.E536","DOIUrl":"https://doi.org/10.35248/2157-7439.20.10.E536","url":null,"abstract":"Nanomaterials display altered compound and physical properties that enable them to collaborate with the natural frameworks at the cell and atomic levels. This cooperation improves the biomedical uses of nanotechnology in the field of tissue recovery. A wide scope of nanomaterials made of natural and inorganic composites could act naturally amassed in nano scale size that reproduces all the more precisely the elements of the common human tissues, for example, nanoparticles, nanosurfaces and nanoscaffolds. These tale nanomaterials essentially impact the conduct and improvement of undeveloped cells. The utilizations of nanotechnology in explicit tissue recovery, for example, bone, ligament, cardiovascular and neural tissues were explored by a few analysts. Nanostructures have been utilized to advance undifferentiated organism suitability, expansion and separation. Nanotechnology gives biodegradable and biocompatible biomimetic creates that reestablish and improve the tissue capacities. Nanocomposition and nanotopography of a tissue designed material decide the embed destiny giving 3 dimentional tissue culture frameworks that advance typical cell development and separation without antagonistic tissue response. Late advancement in the combination permits the refined cells to respond to the inward and outside boosts and to trade the flagging elements between those cells and the outer condition. In any case, further comprehension to the collaborations of nanomaterials with the natural framework and more examinations of the security of these nanostructures are yet required before their full application in human tissue fixation.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86544381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Terahertz Reflectometry Imaging of Carbon Nanomaterials for Biological Application 生物应用碳纳米材料的太赫兹反射成像

Journal of Nanomedicine & Nanotechnology Pub Date : 2019-08-26 DOI: 10.35248/2157-7439.19.10.535

William Ghann, Hyeonggon Kang, Aunik K. Rahman, A. Rahman, Meser M. Ali, J. Uddin

引用次数: 4

Light controlled dynamics of charge carriers 载流子的光控动力学

Journal of Nanomedicine & Nanotechnology Pub Date : 2019-02-11 DOI: 10.4172/2157-7439-C10-095

pIstvan Magashegyip

引用次数: 0

Preparation and Evaluation of Hydrogel Nanoparticles as Drug Delivery System 水凝胶纳米颗粒给药系统的制备与评价

Journal of Nanomedicine & Nanotechnology Pub Date : 2019-01-01 DOI: 10.4172/2157-7439.1000526

R. Kaur, Vishal K. Gupta, S. Ch, P. ra, ey

{"title":"Preparation and Evaluation of Hydrogel Nanoparticles as Drug Delivery System","authors":"R. Kaur, Vishal K. Gupta, S. Ch, P. ra, ey","doi":"10.4172/2157-7439.1000526","DOIUrl":"https://doi.org/10.4172/2157-7439.1000526","url":null,"abstract":"Hydrogel nanoparticles (NPs) can be used for colon drug delivery, utilizing Methotrexate (MTX) as a model drug. MTX loaded hydrogel NPs were prepared using Poly-acrylamide-grafted- gum ghatti (PAAm-g-Gg), which is pH sensitive. PAAm-g-Gg was synthesized by free radical polymerization. MTX loaded hydrogel NPs was prepared from PAAm-g-Gg by using nanoemulsification polymer crosslinking method. FT-IR and DSC studies of the prepared NPs indicated no chemical change of MTX in the hydrogel NPs. The prepared hydrogel NPs showed mean diameters in the range of 238 ± 0.57 nm to 1064 ± 0.99 nm. The encapsulation efficiency of the drug was found to be 39.11% to 48.84%. The suitability of the polyacrylamide grafted gum ghatti hydrogel NPs for the release of Methotrexate was studied by in vitro release at pH 1.2 and 7.4. It was observed that, there was no significant amount of drug release in gastric pH and 97.28% of drug release at pH 7.4 for formulation F6 at the end of 12 hrs. Based on result formulation F6 was considered as the best formulation and further evaluated for stability studies and characterized for surface morphology using SEM. SEM photographs have shown that the hydrogel NPs are spherical in shape and the stability study data indicated no significant change in the drug content.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87115474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Photophysical Studies of Ruthenium-Based Complexes and the Performance of Nanostructured TiO₂ Based Dye Sensitized Solar Cells. 钌基配合物的光物理研究及纳米结构TiO2基染料敏化太阳能电池的性能。

Journal of Nanomedicine & Nanotechnology Pub Date : 2019-01-01 Epub Date: 2019-12-07 DOI: 10.35248/2157-7439.19.10.538

Meser M Ali, Wasif Pervez, William Ghann, Jamal Uddin

{"title":"Photophysical Studies of Ruthenium-Based Complexes and the Performance of Nanostructured TiO2 Based Dye Sensitized Solar Cells.","authors":"Meser M Ali, Wasif Pervez, William Ghann, Jamal Uddin","doi":"10.35248/2157-7439.19.10.538","DOIUrl":"10.35248/2157-7439.19.10.538","url":null,"abstract":"Dye-sensitized solar cells (DSSCs) have attracted enormous attention in the last couple of decades due to their relatively small size, low cost and minimal environmental impact. DSSCs convert solar energy to electrical energy with the aid of a sensitizing dye. In this work, two ruthenium-based dyes, tris(bipyridine)ruthenium(II) chloride (Rubpy) and ruthenium(II)2,2'-bis(benzimidazol-2-yl)-4,4'-bipyridine (RubbbpyH2), were synthesized, characterized, and investigated for use as dye sensitizers in the fabrication of DSSCs. The photovoltaic performance of the ruthenium-based DSSCs was assessed. The solar-to-electric power efficiency of the RubbbpyH2 DSSC was 0.2% and that of the Rubpy was 0.03%. The RubbbpyH2 was also deprotonated and analyzed to study the effect of deprotonation on the efficiency of the solar cell. The deprotonated species, Rubbbpy, recorded an average efficiency of 0.12%. Thus, a change in pH did not enhance the efficiency of the solar cell. The cells were further characterized by impedance measurements. The photocurrent-photovoltage results were not consistent with the absorption spectra since Rubbbpy showed a more prominent band than RubbbpyH2 but had a lower efficiency.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986734/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37587417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6