Journal of Nanomedicine & Nanotechnology最新文献

{"title":"Nanoparticles with Antitumoral Activity: An Integrative Literature Review","authors":"R. Nicolete, Ferreira Vpg, de Alencar Santos Júnior Jg, Rodrigues Jpv","doi":"10.35248/2157-7439.20.11.549","DOIUrl":"https://doi.org/10.35248/2157-7439.20.11.549","url":null,"abstract":"Nanotechnology is used to describe materials, devices and systems with structures and components, exhibiting new and/ or significantly improving physical, chemical and biological properties. In the biomedical area, these materials have unique nanoscale properties of 1 nanometers to 100 nanometers. Thus, the objective was to evidence the available scientific knowledge in the literature on some advances related to the use of nanoparticles with antitumor activity. The present study uses as an integrative literature review method, allowing to search, evaluate and synthesize the available evidence to contribute to the development of the discussion about the theme. Crossing the descriptors \"nanoparticles\" and \"antitumoral\", 62 studies were found, of which one was repeated in more than one place. Thus, of the 61 publications listed, 26 addressed the main theme proposed with emphasis on the use of nanoparticles/nanoemulsion against tumor cells, in this way were selected to compose this study. Nanotechnology can be considered a new technology in the oncology area. The major challenges are to gather information about the properties and risks of these nanomaterials, the in vivo application as well as specific clinical trials.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87014496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green Synthesis of Bio-polymer Composites of Iron for Pharmaceutical Applications","authors":"L. Gangadhar, K. Reddy, A. Garg, S. S. Sana","doi":"10.35248/2157-7439.20.11.551","DOIUrl":"https://doi.org/10.35248/2157-7439.20.11.551","url":null,"abstract":"Due to the capacity to moderate metals to their nanometer size, nanobiotechnology is gaining enormous popularity in this period, which effectively changes its chemical, physical and optical properties. Recent progress in nanoscience and technology has also managed to the growth of new nanomaterials (NMs), eventually increasing toxic and potential health effects. There has been growing attention in evolving eco-friendly methods for metal nanoparticles (NPs) synthesis. The main purpose of the study is to reduce the harmful influences of synthetic processes, associated substances alongside other derivatives. The use of diverse biomaterials (BMs) for NP synthesis is examined as a promising method in green nanotechnology. However, most of the techniques currently available are costly; utilizing the natural properties includes plants, bacteria, fungi and algae to manufacture low-cost, non-toxic and energy-efficient metallic NPs that are environmentally friendly. Besides, biologically synthesized NPs and their characterization are essential for their future utility in numerous deliveries of drugs and pharmaceutical utilizations. Here, the current analysis summarizes the synthesis and future use of iron nanoparticles (Fe NPs) by green nanobiotechnology in the arena of biomedical applications.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79279444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biogenic Silver Nanoparticles /Clusters Synthesis Characterization by Scanning Electron Microscopy and 2D-3D Topographical Analysis by Mountain -andreg;- graphical tool","authors":"Yuvaraj Sampath kumar, S. Elumalai, E. Manik, An, M. Priya","doi":"10.35248/2157-7439.20.11.556","DOIUrl":"https://doi.org/10.35248/2157-7439.20.11.556","url":null,"abstract":"The microalgae were exposed to Silver nitrate (AgNO3) solution and screened for their suitability for the production of nano-silver (nano-Ag).The intracellular and extracellular enzyme are secreted by microalgae(Phormidium sp.).The microalgae extract contain various active biomolecules such as superoxide dismutase, oxidoreductases, NADH-dependent enzymes, active bio-molecules (lipid, exopolymers, peptides), some protein and pigment phycobiliproteins play a major role in the formation of nanocluster and structures in the nanometer range, confirmed by change the brown colour indicates silver nanoparticle (Ag-NPs) synthesis. Extracted biogenic silver nanoparticles and its characterization studies which is applied on the Scanning Microscopic field to analysis the 2D, 3D topographical structure. The Mountain -®-expert graphical tool play an important role in structural prediction, stereoscopic configuration analysis, stereoscopic reconstruction, lateral analysis, Contour lines, Micro valley studies, Polynomial map, Partial, analysis, extract profile study, area of hole,fractal analysis, continuous wavelets decomposition, PSD, Abbott curve, Rk parameters, morphological envelop studies, R and w calculation, distance measurement, default mini-doc and 2D roughness analysis.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79014314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Research Trends and Growing Importance of Nanomedicine","authors":"A. Ostafin","doi":"10.35248/2157-7439.20.11.E539","DOIUrl":"https://doi.org/10.35248/2157-7439.20.11.E539","url":null,"abstract":"Copyright: ©2020 Ostafin A. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The science behind the design and development of nano-scale materials has expanded tremendously over the past few decades owing to the improvement and sophistication of nanoscale level physicochemical characterization tools and techniques and has consequently enabled evolution and advancement of technological applications in diverse fields of practical utility. The applications of nanoscience and nanotechnology in the fields of medicine (both diagnostic and therapeutic) and in agriculture has had a great impact in the recent years.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74784599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theranostics: A Boon in Cancer Diagnosis and Therapy","authors":"R. Jain, Hardik P. Raisoni, P. S. Pawar","doi":"10.35248/2157-7439.20.11.555","DOIUrl":"https://doi.org/10.35248/2157-7439.20.11.555","url":null,"abstract":"Modern approaches in improvement of new nanomaterials have gained enormous attention due to various biomedical application, along with cancer theranostics. The characteristic physico-chemical feature of these materials, including their small size and wide-range surface-to-volume ratio provide potentiality for cancer theranostics that combine diagnosis , biosensing , imaging detection and immune therapy.Recent procurement for cancer immunotherapy have gained considerable attention in controlling the body’s immune system to fight against cancer.In this abstract , nanomedicine with inherent immunomodulatory properties presents interesting window(of opportunity) which can stimulate the function of immune cell. The goal is to cover broad range of information about the immunomodulation properties of nanomedicine in cancer theranostics i.e factors like pH, hypoxia, tumor angiogenesis, tumor extracellular matrix which have a huge role in the immunomodulation of nanomedicine and also strategies to enhance cancer theranostics applications. According to recent studies, cancer therapy can be potentially improved through nanoparticle based immunotherapy.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73315948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microelectronic Gas sensors for Non-invasive Analysis of Exhaled Gases","authors":"Aroutiounian Vm","doi":"10.35248/2157-7439.19.11.544","DOIUrl":"https://doi.org/10.35248/2157-7439.19.11.544","url":null,"abstract":"Interest in the research of small-sized gas sensors (especially semiconductor) for medical applications has sharply increased in recent years. Requirements for to such sensors are their high sensitivity, performance and stability to very low concentrations of gases, mainly exhaled by a living organism. Today the doctor not only polls, and examines the patient but also sends it to the lab-tests of blood, urine, perform an electrocardiogram, etc. But, for example, today’s periodic monitoring of glucose concentrations in the blood induces acute pain, risk of virus (e.g., hepatitis B) infection from needles, and other difficulties in frequent monitoring. Even in 1784, Antoine Lavoisier wrote that of all the phenomena of life, none is more striking and worthier for physicists and physiologists than phenomena accompanying the breath. Meanwhile, one of the most important directions of modern medicine is non-invasive diagnostics of the patient, based on the analysis of exhaled air in a special device.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74936944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metal Nanoparticles Based Electrochemical Biosensors for Cholesterol","authors":"S. Mehtab, M. Zaidi, Pragati S. Joshi","doi":"10.35248/2157-7439.19.10.540","DOIUrl":"https://doi.org/10.35248/2157-7439.19.10.540","url":null,"abstract":"Electrochemical biosensors (EBS) have recently gained much attention in the field of health care for the management of cholesterol (CHO). This review comprises a report on the modification of electrode surfaces with metal nanoparticles (MNP) for selective and sensitive sensing of CHO. Quantitative analysis of cholesterol is carried out with the use of the amperometric data of linear calibration plot. A good synergistic between MNP of working electrode (WE) and CHO give fast electron transfer and precised electrochemical detection of CHL.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85745310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Micromagnetic Manipulators - Ferromagnetic Microwire Systems for Diffusion and Separation of Para and Dia- magnetic Particles in GradientMagnetic Field","authors":"Beklemisheva Av, A. Gurevich, Pan-Long Lv, Suetina Ia, Mezentseva Mv, Zolotoreva Mg, Beklemishev Vn","doi":"10.35248/2157-7439.20.11.554","DOIUrl":"https://doi.org/10.35248/2157-7439.20.11.554","url":null,"abstract":"Micromagnetic manipulators to control and manage the dynamics of micro and nanoparticles are widely used in medicine, physics, and biology. In this paper, we proposed a number of concepts of targeted use of ferromagnetic microwires for para and dia-magnetic objects manipulation. The microwires are produced in a biocompatible glass shell by Taylor-Ulitovsky method and exhibit tunable magnetic properties. They have the ability to create high gradient magnetic fields due to specific composition of the ferromagnetic core, magnetic domain structure and micron dimensions. For various experimental tasks, the optimal configuration of ferromagnetic microwires in the system and the direction of the wire magnetization are selected. A point trap for paramagnetic particles is formed by an individual wire with an axial magnetization. The wires magnetized along diameter are a source of linearly situated magnetic poles and help to realize a fast redistribution of even weakly paramagnetic particles. Due to a camel-back profile of the magnetic potential, created by a pair of closely spaced wires with orthogonal magnetization they act as effective diamagnetic trapping system. There is also an interesting opportunity to realize a magnetic ratchet using a microwire with a circular domain structure. Thus, the magnetic manipulators based on systems of ferromagnetic microwires make it possible to organize fixation, redistribution and analysis of cell suspensions and magnetic nanoparticles. The biocompatibility of the glass shell of the microwires was demonstrated, hence, the possibility of their further using when working with living objects.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90036162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PPARγ Deficiency in Carbon Nanotube-elicited Granulomatous Inflammation Promotes a Th17 Response to a Microbial Antigen.","authors":"Victoria Sanderford, Barbara P Barna, Robert A Barrington, Anagha Malur, Arjun Mohan, Nancy Leffler, Eman Soliman, Mary Jane Thomassen","doi":"10.35248/2157-7439.20.11.541","DOIUrl":"10.35248/2157-7439.20.11.541","url":null,"abstract":"<p><strong>Background: </strong>The pathological consequences of interaction between environmental carbon pollutants and microbial antigens have not been fully explored. We developed a murine model of multi-wall carbon nanotube (MWCNT)-elicited granulomatous disease which bears a striking resemblance to sarcoidosis, a human granulomatous disease. Because of reports describing lymphocyte reactivity to mycobacterial antigens in sarcoidosis patients, we hypothesized that addition of mycobacterial antigen (ESAT-6) to MWCNT might elicit activation in T cells.</p><p><strong>Methods: </strong>Macrophage-specific peroxisome-proliferator-activated receptor gamma (PPARγ) knock out (KO) mice were studied along with wild-type mice because our previous report indicated PPARγ deficiency in sarcoidosis alveolar macrophages. MWCNT+ESAT-6 were instilled into mice. Controls received vehicle (surfactant-PBS) or ESAT-6 and were evaluated 60 days post-instillation. As noted in our recent publication, lung tissues from PPARγ KO mice instilled with MWCNT+ESAT-6 yielded more intensive pathophysiology, with elevated fibrosis.</p><p><strong>Results: </strong>Inspection of mediastinal lymph nodes (MLN) revealed no granulomas but deposition of MWCNT. MLN cell counts were higher in PPARγ KO than in wild-type instilled with MWCNT+ESAT-6. Moreover, the CD4:CD8 T cell ratio, a major clinical metric for human disease, was increased in PPARγ KO mice. Bronchoalveolar lavage (BAL) cells from PPARγ KO mice instilled with MWCNT+ESAT-6 displayed increased Th17 cell markers (RORγt, IL-17A, CCR6) which associate with elevated fibrosis.</p><p><strong>Conclusion: </strong>These findings suggest that PPARγ deficiency in macrophages may promote ESAT-6-associated T cell activation in the lung, and that the MWCNT+ESAT-6 model may offer new insights into pathways of lymphocyte-mediated sarcoidosis histopathology.</p>","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37934661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted Delivery of CBD-Loaded Poly (RGD) Proteinoid Nanoparticles for Antitumor Therapy","authors":"L. Lugasi, I. Grinberg, S. Margel","doi":"10.35248/2157-7439.20.11.552","DOIUrl":"https://doi.org/10.35248/2157-7439.20.11.552","url":null,"abstract":"Background: Targeted nanoparticle (NP)-based drug delivery systems enable administration of non-soluble drugs and enhance their efficacy. The arginine-glycine-aspartic acid (RGD) motif is a known recognition site of integrins, and RGD receptors are overexpressed in tumors and their neovasculature and can be used as targets for tumor treatment. Cannabidiol (CBD), the main non-psychotropic phytocannabinoid of Cannabis sativa, exhibits various therapeutic effects and has antitumor properties. Encapsulation of CBD within poly(RGD) (P(RGD)) proteinoid NPs can overcome the poor solubility and bioavailability of CBD and target it to tumors in vivo. Methods: P(RGD) proteinoid polymer was synthesized from D- and L-amino acids by thermal step-growth polymerization. CBD was encapsulated within the proteinoid NPs by self-assembly process. CBD-loaded proteinoid NPs were characterized in terms of particle diameter and size distribution, drug loading, ζ-potential, cytotoxicity, drug release, and biodistribution as well as antitumor effect. Results: P(RGD) proteinoid polymer was obtained with high molecular weight and low polydispersity. CBD was successfully encapsulated in the proteinoid NPs. The results demonstrate significant tumor growth inhibition by CBD-loaded P(RGD) proteinoid NPs compared to free CBD solution. The targeted delivery of P(RGD) NPs to tumors in a xenograft mouse model significantly increases (p<0.05) the anticancer activity of CBD with respect to the free compound. Conclusions: CBD-loaded P(RGD) NPs can potentially be used for anticancer therapy owing to their in vivo targeting ability, suggesting a good strategy for colorectal and breast cancers.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87110846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}