Journal of Nanomedicine & Nanotechnology最新文献_第4页

Applications of Polymeric Nanomaterials 高分子纳米材料的应用

Journal of Nanomedicine & Nanotechnology Pub Date : 2021-01-01 DOI: 10.35248/2157-7439.21.12.571

Amedeo Xu

引用次数: 0

Plasma and Serum Proteins Bound to Nanoceria: Insights into Pathways by which Nanoceria may Exert Its Beneficial and Deleterious Effects In Vivo 血浆和血清蛋白结合纳米微球:纳米微球在体内发挥其有益和有害作用的途径

Journal of Nanomedicine & Nanotechnology Pub Date : 2020-07-17 DOI: 10.35248/2157-7439.20.11.546

A. Butterfield, Binghui Wang, Peng Wu, Sarita S. Hardas, J. Unrine, E. Grulke, Jian Cai, J. Klein, W. Pierce, R. Yokel, R. Sultana

{"title":"Plasma and Serum Proteins Bound to Nanoceria: Insights into Pathways by which Nanoceria may Exert Its Beneficial and Deleterious Effects In Vivo","authors":"A. Butterfield, Binghui Wang, Peng Wu, Sarita S. Hardas, J. Unrine, E. Grulke, Jian Cai, J. Klein, W. Pierce, R. Yokel, R. Sultana","doi":"10.35248/2157-7439.20.11.546","DOIUrl":"https://doi.org/10.35248/2157-7439.20.11.546","url":null,"abstract":"Nanoceria (CeO2, cerium oxide nanoparticles) is proposed as a therapeutic for multiple disorders. In blood, nanoceria becomes protein-coated, changing its surface properties to yield a different presentation to cells. There is little information on the interaction of nanoceria with blood proteins. The current study is the first to report the proteomics identification of plasma and serum proteins adsorbed to nanoceria. The results identify a number of plasma and serum proteins interacting with nanoceria, proteins whose normal activities regulate numerous cell functions: antioxidant/detoxification, energy regulation, lipoproteins, signaling, complement, immune function, coagulation, iron homeostasis, proteolysis, inflammation, protein folding, protease inhibition, adhesion, protein/RNA degradation, and hormonal. The principal implications of this study are: 1) The protein corona may positively or negatively affect nanoceria cellular uptake, subsequent organ bioprocessing, and effects; and 2) Nanoceria adsorption may alter protein structure and function, including pro- and inflammatory effects. Consequently, prior to their use as therapeutic agents, better understanding of the effects of nanoceria protein coating is warranted.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77765019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

On The Short Delay in Neighboring Neural Pulses 相邻神经脉冲的短延迟

Journal of Nanomedicine & Nanotechnology Pub Date : 2020-02-01 DOI: 10.26420/austinjnanomednanotechnol.2020.1058

J. Xu, S. Xu

引用次数: 0

Zirconium interferences on the detection of silver nanoparticles by single particle ICP-MS: implications on natural water analysis 用单粒子ICP-MS检测纳米银的锆干扰:对天然水分析的意义

Journal of Nanomedicine & Nanotechnology Pub Date : 2020-01-30 DOI: 10.21203/rs.2.22297/v1

P. Turcotte, C. Gagnon

{"title":"Zirconium interferences on the detection of silver nanoparticles by single particle ICP-MS: implications on natural water analysis","authors":"P. Turcotte, C. Gagnon","doi":"10.21203/rs.2.22297/v1","DOIUrl":"https://doi.org/10.21203/rs.2.22297/v1","url":null,"abstract":"\u0000 Background: The analysis of silver nanoparticle (NP-Ag) by the single particle technique with argon plasma-coupled mass spectrometry (SP-ICP-MS) is an increasingly used analytical approach. The sensitive technique, distinguishing particle size distribution, allows working at concentrations similar to those found in environmental samples. The two natural Ag isotopes 107 and 109, with abundances of 52 and 48% respectively, have similar sensitivity in ICP-MS detection. However, it is common to encounter isobaric interferences in mass spectrometry, and the element silver is not an exception, as much with the 107 isotope as 109. For both isotopes, zirconium oxides present isobaric interferences, either 91Zr16O, 90Zr16O1H for the isotope 107 and the 92Zr16O1H for the 109. Results: For surface water analysis by ICP-MS in regular technique, these interferences do not generally impact the analysis of total Ag concentrations (mainly dissolved) as they can be then simply subtracted like background signal. On the other hand, detection of NPAg was impacted by the interfering colloidal Zr. The analysis of Zr by the SP-ICP-MS technique of surface waters showed the presence of colloidal Zr, a random signal that cannot be simply subtracted from NP Ag signal. Our results show that, Zr colloids are effectively interfering with the NP-Ag assays by SP-ICP-MS technique where interferences translated into a false positive. Conclusion: The analytical issue related isobaric interferences from the naturally occurring colloidal Zr was attenuated (up to 250% in this assay) by the use of the 109 isotope in the Ag detection, limiting false positive detections and improving the reliability of NP-Ag measurements in natural waters. Therefore , more specific detection of NP Ag in surface waters that naturally contain Zr colloids can be accomplished.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90635177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Plasma and Serum Proteins Bound to Nanoceria: Insights into Pathways by which Nanoceria may Exert Its Beneficial and Deleterious Effects In Vivo. 血浆和血清蛋白结合纳米微球:纳米微球在体内发挥其有益和有害作用的途径。

Journal of Nanomedicine & Nanotechnology Pub Date : 2020-01-01 Epub Date: 2020-07-17

Allan D Butterfield, Binghui Wang, Peng Wu, Sarita S Hardas, Jason M Unrine, Eric A Grulke, Jian Cai, Jon B Klein, William M Pierce, Robert A Yokel, Rukhsana Sultana

{"title":"Plasma and Serum Proteins Bound to Nanoceria: Insights into Pathways by which Nanoceria may Exert Its Beneficial and Deleterious Effects In Vivo.","authors":"Allan D Butterfield, Binghui Wang, Peng Wu, Sarita S Hardas, Jason M Unrine, Eric A Grulke, Jian Cai, Jon B Klein, William M Pierce, Robert A Yokel, Rukhsana Sultana","doi":"","DOIUrl":"","url":null,"abstract":"Nanoceria (CeO2, cerium oxide nanoparticles) is proposed as a therapeutic for multiple disorders. In blood, nanoceria becomes protein-coated, changing its surface properties to yield a different presentation to cells. There is little information on the interaction of nanoceria with blood proteins. The current study is the first to report the proteomics identification of plasma and serum proteins adsorbed to nanoceria. The results identify a number of plasma and serum proteins interacting with nanoceria, proteins whose normal activities regulate numerous cell functions: antioxidant/detoxification, energy regulation, lipoproteins, signaling, complement, immune function, coagulation, iron homeostasis, proteolysis, inflammation, protein folding, protease inhibition, adhesion, protein/RNA degradation, and hormonal. The principal implications of this study are: 1) The protein corona may positively or negatively affect nanoceria cellular uptake, subsequent organ bioprocessing, and effects; and 2) Nanoceria adsorption may alter protein structure and function, including pro- and inflammatory effects. Consequently, prior to their use as therapeutic agents, better understanding of the effects of nanoceria protein coating is warranted.","PeriodicalId":16532,"journal":{"name":"Journal of Nanomedicine & Nanotechnology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8478346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39471217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Highlights of Contemporary Nanoscience and Nanotechnology with Biomedical Applications 当代纳米科学和纳米技术与生物医学应用的研究重点

Journal of Nanomedicine & Nanotechnology Pub Date : 2020-01-01 DOI: 10.35248/2157-7439.20.11.E537

A. Ostafin

引用次数: 0

Novel Nanotechnology based Approaches for Targeted Drug Delivery and Effective Therapy 基于纳米技术的靶向药物传递和有效治疗新方法

Journal of Nanomedicine & Nanotechnology Pub Date : 2020-01-01 DOI: 10.35248/2157-7439.20.11.E538

A. Ostafin

引用次数: 0

Targeted Site-Specific Therapeutics for COVID-19 针对COVID-19的靶向部位特异性治疗

Journal of Nanomedicine & Nanotechnology Pub Date : 2020-01-01 DOI: 10.35248/2157-7439.20.11.548

P. Iversen, T. Porter, N. Kipshidze, N. Kipshidze

引用次数: 0

A Review: The Uses of Various Nanoparticles in Organic Synthesis 各种纳米颗粒在有机合成中的应用综述

Journal of Nanomedicine & Nanotechnology Pub Date : 2020-01-01 DOI: 10.35248/2157-7439.19.10.543

S. Khaturia, M. Chahar, H. Sachdeva, Sangeeta, Mahto Cb

引用次数: 4

Current Relevance of Nanotechnology to Medicine and Industry 纳米技术与医学和工业的当前相关性

Journal of Nanomedicine & Nanotechnology Pub Date : 2020-01-01 DOI: 10.35248/2157-7439.20.10.E535

A. Ostafin

引用次数: 0