Journal of neurogenetics最新文献_第10页

Memory, anticipation, action - working with Troy D. Zars. 记忆、期待、行动——与特洛伊·d·扎尔斯合作。

IF 1.9 4区医学

Journal of neurogenetics Pub Date : 2020-03-01 DOI: 10.1080/01677063.2020.1715976

Reinhard Wolf, Martin Heisenberg, Björn Brembs, Scott Waddell, Aditi Mishra, Abigail Kehrer, Angelynn Simenson

引用次数: 0

Future perspectives of neurogenetics - in honor of Troy D. Zars (1967-2018). 神经遗传学的未来展望——纪念Troy D. Zars(1967-2018)。

IF 1.9 4区医学

Journal of neurogenetics Pub Date : 2020-03-01 DOI: 10.1080/01677063.2020.1715975

Bertram Gerber, Elizabeth G King, David Schulz, Hiromu Tanimoto, Scott Waddell, Chun-Fang Wu

引用次数: 1

Interactions between amyloid precursor protein-like (APPL) and MAGUK scaffolding proteins contribute to appetitive long-term memory in Drosophila melanogaster. 淀粉样前体蛋白样(APPL)和MAGUK支架蛋白之间的相互作用有助于黑腹果蝇的食欲长期记忆。

IF 1.9 4区医学

Journal of neurogenetics Pub Date : 2020-03-01 Epub Date: 2020-01-22 DOI: 10.1080/01677063.2020.1712597

Bryon Silva, Christian Niehage, Marta Maglione, Bernard Hoflack, Stephan J Sigrist, Thomas Wassmer, Alice Pavlowsky, Thomas Preat

{"title":"Interactions between amyloid precursor protein-like (APPL) and MAGUK scaffolding proteins contribute to appetitive long-term memory in Drosophila melanogaster.","authors":"Bryon Silva, Christian Niehage, Marta Maglione, Bernard Hoflack, Stephan J Sigrist, Thomas Wassmer, Alice Pavlowsky, Thomas Preat","doi":"10.1080/01677063.2020.1712597","DOIUrl":"https://doi.org/10.1080/01677063.2020.1712597","url":null,"abstract":"Amyloid precursor protein (APP), the precursor of amyloid beta peptide, plays a central role in Alzheimer's disease (AD), a pathology characterized by memory decline and synaptic loss upon aging. Understanding the physiological role of APP is fundamental in deciphering the progression of AD, and several studies suggest a synaptic function via protein-protein interactions. Nevertheless, it remains unclear whether and how these interactions contribute to memory. In Drosophila, we previously showed that APP-like (APPL), the fly APP homolog, is required for aversive associative memory in the olfactory memory center, the mushroom body (MB). In the present study, we show that APPL is required for appetitive long-term memory (LTM), another form of associative memory, in a specific neuronal subpopulation of the MB, the α'/β' Kenyon cells. Using a biochemical approach, we identify the synaptic MAGUK (membrane-associated guanylate kinase) proteins X11, CASK, Dlgh2 and Dlgh4 as interactants of the APP intracellular domain (AICD). Next, we show that the Drosophila homologs CASK and Dlg are also required for appetitive LTM in the α'/β' neurons. Finally, using a double RNAi approach, we demonstrate that genetic interactions between APPL and CASK, as well as between APPL and Dlg, are critical for appetitive LTM. In summary, our results suggest that APPL contributes to associative long-term memory through its interactions with the main synaptic scaffolding proteins CASK and Dlg. This function should be conserved across species.","PeriodicalId":16491,"journal":{"name":"Journal of neurogenetics","volume":"34 1","pages":"92-105"},"PeriodicalIF":1.9,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01677063.2020.1712597","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37565078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Towards a functional connectome in Drosophila. 果蝇的功能连接体研究。

IF 1.9 4区医学

Journal of neurogenetics Pub Date : 2020-03-01 Epub Date: 2020-01-17 DOI: 10.1080/01677063.2020.1712598

Katrin Vogt

{"title":"Towards a functional connectome in Drosophila.","authors":"Katrin Vogt","doi":"10.1080/01677063.2020.1712598","DOIUrl":"https://doi.org/10.1080/01677063.2020.1712598","url":null,"abstract":"The full functionality of the brain is determined by its molecular, cellular and circuit structure. Modern neuroscience now prioritizes the mapping of whole brain connectomes by detecting all direct neuron to neuron synaptic connections, a feat first accomplished for C. elegans, a full reconstruction of a 302-neuron nervous system. Efforts at Janelia Research Campus will soon reconstruct the whole brain connectomes of a larval and an adult Drosophila. These connectomes will provide a framework for incorporating detailed neural circuit information that Drosophila neuroscientists have gathered over decades. But when viewed in the context of a whole brain, it becomes difficult to isolate the contributions of distinct circuits, whether sensory systems or higher brain regions. The complete wiring diagram tells us that sensory information is not only processed in separate channels, but that even the earliest sensory layers are strongly synaptically interconnected. In the higher brain, long-range projections densely interconnect major brain regions and convergence centers that integrate input from different sensory systems. Furthermore, we also need to understand the impact of neuronal communication beyond direct synaptic modulation. Nevertheless, all of this can be pursued with Drosophila, combining connectomics with a diverse array of genetic tools and behavioral paradigms that provide effective approaches to entire brain function.","PeriodicalId":16491,"journal":{"name":"Journal of neurogenetics","volume":"34 1","pages":"156-161"},"PeriodicalIF":1.9,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01677063.2020.1712598","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37554031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Learning to collaborate: bringing together behavior and quantitative genomics. 学习合作:将行为和定量基因组学结合在一起。

IF 1.9 4区医学

Journal of neurogenetics Pub Date : 2020-03-01 Epub Date: 2020-01-10 DOI: 10.1080/01677063.2019.1710145

Patricka A Williams-Simon, Mathangi Ganesan, Elizabeth G King

引用次数: 0

Food restriction reconfigures naïve and learned choice behavior in Drosophila larvae. 食物限制重新配置naïve和果蝇幼虫的习得选择行为。

IF 1.9 4区医学

Journal of neurogenetics Pub Date : 2020-03-01 Epub Date: 2020-01-24 DOI: 10.1080/01677063.2020.1714612

Benita Brünner, Juliane Saumweber, Merve Samur, Denise Weber, Isabell Schumann, Deepthi Mahishi, Astrid Rohwedder, Andreas S Thum

{"title":"Food restriction reconfigures naïve and learned choice behavior in Drosophila larvae.","authors":"Benita Brünner, Juliane Saumweber, Merve Samur, Denise Weber, Isabell Schumann, Deepthi Mahishi, Astrid Rohwedder, Andreas S Thum","doi":"10.1080/01677063.2020.1714612","DOIUrl":"https://doi.org/10.1080/01677063.2020.1714612","url":null,"abstract":"In many animals, the establishment and expression of food-related memory is limited by the presence of food and promoted by its absence, implying that this behavior is driven by motivation. In the past, this has already been demonstrated in various insects including honeybees and adult Drosophila. For Drosophila larvae, which are characterized by an immense growth and the resulting need for constant food intake, however, knowledge is rather limited. Accordingly, we have analyzed whether starvation modulates larval memory formation or expression after appetitive classical olfactory conditioning, in which an odor is associated with a sugar reward. We show that odor-sugar memory of starved larvae lasts longer than in fed larvae, although the initial performance is comparable. 80 minutes after odor fructose conditioning, only starved but not fed larvae show a reliable odor-fructose memory. This is likely due to a specific increase in the stability of anesthesia-resistant memory (ARM). Furthermore, we observe that starved larvae, in contrast to fed ones, prefer sugars that offer a nutritional benefit in addition to their sweetness. Taken together our work shows that Drosophila larvae adjust the expression of learned and naïve choice behaviors in the absence of food. These effects are only short-lasting probably due to their lifestyle and their higher internal motivation to feed. In the future, the extensive use of established genetic tools will allow us to identify development-specific differences arising at the neuronal and molecular level.","PeriodicalId":16491,"journal":{"name":"Journal of neurogenetics","volume":"34 1","pages":"123-132"},"PeriodicalIF":1.9,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01677063.2020.1714612","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37574921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Sleep restores place learning to the adenylyl cyclase mutant rutabaga. 睡眠能恢复腺苷酸环化酶突变体芦柑的位置学习能力

IF 1.9 4区医学

Journal of neurogenetics Pub Date : 2020-03-01 Epub Date: 2020-01-30 DOI: 10.1080/01677063.2020.1720674

Stephane Dissel, Ellen Morgan, Vincent Duong, Dorothy Chan, Bruno van Swinderen, Paul Shaw, Troy Zars

{"title":"Sleep restores place learning to the adenylyl cyclase mutant rutabaga.","authors":"Stephane Dissel, Ellen Morgan, Vincent Duong, Dorothy Chan, Bruno van Swinderen, Paul Shaw, Troy Zars","doi":"10.1080/01677063.2020.1720674","DOIUrl":"10.1080/01677063.2020.1720674","url":null,"abstract":"Sleep plays an important role in regulating plasticity. In Drosophila, the relationship between sleep and learning and memory has primarily focused on mushroom body dependent operant-learning assays such as aversive phototaxic suppression and courtship conditioning. In this study, sleep was increased in the classic mutant rutabaga (rut2080) and dunce (dnc1) by feeding them the GABA-A agonist gaboxadol (Gab). Performance was evaluated in each mutant in response to social enrichment and place learning, tasks that do not require the mushroom body. Gab-induced sleep did not restore behavioral plasticity to either rut2080 or dnc1 mutants following social enrichment. However, increased sleep restored place learning to rut2080 mutants. These data extend the positive effects of enhanced sleep to place learning and highlight the utility of Gab for elucidating the beneficial effects of sleep on brain functioning.","PeriodicalId":16491,"journal":{"name":"Journal of neurogenetics","volume":"34 1","pages":"83-91"},"PeriodicalIF":1.9,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250152/pdf/nihms-1566917.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37591038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dopaminergic neurons can influence heat-box place learning in Drosophila. 多巴胺能神经元影响果蝇的热箱位置学习。

IF 1.9 4区医学

Journal of neurogenetics Pub Date : 2020-03-01 Epub Date: 2020-01-30 DOI: 10.1080/01677063.2020.1715974

Aditi Mishra, Patrick Cronley, Mathangi Ganesan, David J Schulz, Troy Zars

引用次数: 2

Troy D. Zars: a personal tribute to a scientist, colleague, and friend. 特洛伊·d·扎尔斯:向一位科学家、同事和朋友致敬。

IF 1.9 4区医学

Journal of neurogenetics Pub Date : 2020-03-01 DOI: 10.1080/01677063.2020.1713118

David J Schulz

{"title":"Troy D. Zars: a personal tribute to a scientist, colleague, and friend.","authors":"David J Schulz","doi":"10.1080/01677063.2020.1713118","DOIUrl":"https://doi.org/10.1080/01677063.2020.1713118","url":null,"abstract":"I knew Troy for nearly 15 years, and in that time I don't recall hearing any childhood stories like those in seemingly every personal statement I've read from aspiring scientists or medical students. No stories about hours spent gazing at an anthill. I don't recall hearing about shelves crowded with insects collected on Styrofoam, or animal skulls kept in a shoebox under his bed. If these collected crania existed, it was more likely because Troy was a crack shot with a pellet gun than a need to know adaptations in the dentition of local squirrel populations. I don't recall hearing about science projects taken to the Iowa State Capitol to share with politely interested legislators. But I do recall hearing about spending the entirety of the daylight hours in the summer, with his brother Doug, finding where the crappie were biting. About crystal clear water on a lake in Minnesota that you didn't quite need to know the exact location of, just in case you were thinking of going and plundering the walleye within. I definitely heard about triumphs as a starting lineman not only for his high school football team, but the mighty Norse of Luther College. I heard about summer warehouse jobs in sweltering Iowa Julys. And I saw, firsthand, love and commitment and family. Troy's story demonstrates that the finest scientists are not just cultivated in narrow STEM curricula that begin at age 5. They are just as likely to be football-playing fishermen, fathers, husbands, and friends who can navigate an operant conditioning paradigm during the week, and dance a polka and produce a magnificent smoked pork shoulder on Saturday. Nature and an independent spirit and a little bit of mischief is a different kind of Magnet school. And it gave us truly one of the best.","PeriodicalId":16491,"journal":{"name":"Journal of neurogenetics","volume":"34 1","pages":"5-8"},"PeriodicalIF":1.9,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01677063.2020.1713118","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37789437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Playing the genome card. 打基因组牌。

IF 1.9 4区医学

Journal of neurogenetics Pub Date : 2020-03-01 Epub Date: 2019-12-24 DOI: 10.1080/01677063.2019.1706093

Ari Berkowitz

{"title":"Playing the genome card.","authors":"Ari Berkowitz","doi":"10.1080/01677063.2019.1706093","DOIUrl":"https://doi.org/10.1080/01677063.2019.1706093","url":null,"abstract":"In the 1990s, prominent biologists and journalists predicted that by 2020 each of us would carry a genome card, which would allow physicians to access our entire genome sequence and routinely use this information to diagnose and treat common and debilitating conditions. This is not yet the case. Why not? Common and debilitating diseases are rarely caused by single-gene mutations, and this was recognized before these genome card predictions had been made. Debilitating conditions, including common psychiatric disorders, are typically caused either by rare mutations or by complex interactions of many genes, each having a small effect, and epigenetic, environmental, and microbial factors. In such cases, having a complete genome sequence may have limited utility in diagnosis and treatment. Genome sequencing technologies have transformed biological research in many ways, but had a much smaller effect than expected on treatments of common diseases. Thus, early proponents of genome sequencing effectively \"mis-promised\" its benefits. One reason may be that there are incentives for both biologists and journalists to tell simple stories, including the idea of relatively simple genetic causation of common, debilitating diseases. These incentives may have led to misleading predictions, which to some extent continue today. Although the Human Genome Project has facilitated biological research generally, the mis-promising of medical benefits, at least for treating common and debilitating disorders, could undermine support for scientific research over the long term.","PeriodicalId":16491,"journal":{"name":"Journal of neurogenetics","volume":"34 1","pages":"189-197"},"PeriodicalIF":1.9,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01677063.2019.1706093","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37488060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0