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A perspective on C. elegans neurodevelopment: from early visionaries to a booming neuroscience research. 秀丽隐杆线虫的神经发育:从早期的空想家到蓬勃发展的神经科学研究。
IF 1.9 4区 医学
Journal of neurogenetics Pub Date : 2020-09-01 DOI: 10.1080/01677063.2020.1837799
Georgia Rapti
{"title":"A perspective on <i>C. elegans</i> neurodevelopment: from early visionaries to a booming neuroscience research.","authors":"Georgia Rapti","doi":"10.1080/01677063.2020.1837799","DOIUrl":"https://doi.org/10.1080/01677063.2020.1837799","url":null,"abstract":"<p><p>The formation of the nervous system and its striking complexity is a remarkable feat of development. <i>C. elegans</i> served as a unique model to dissect the molecular events in neurodevelopment, from its early visionaries to the current booming neuroscience community. Soon after being introduced as a model, <i>C. elegans</i> was mapped at the level of genes, cells, and synapses, providing the first metazoan with a complete cell lineage, sequenced genome, and connectome. Here, I summarize mechanisms underlying <i>C. elegans</i> neurodevelopment, from the generation and diversification of neural components to their navigation and connectivity. I point out recent noteworthy findings in the fields of glia biology, sex dimorphism and plasticity in neurodevelopment, highlighting how current research connects back to the pioneering studies by Brenner, Sulston and colleagues. Multifaceted investigations in model organisms, connecting genes to cell function and behavior, expand our mechanistic understanding of neurodevelopment while allowing us to formulate emerging questions for future discoveries.</p>","PeriodicalId":16491,"journal":{"name":"Journal of neurogenetics","volume":" ","pages":"259-272"},"PeriodicalIF":1.9,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01677063.2020.1837799","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38819739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Neuronal specification in C. elegans: combining lineage inheritance with intercellular signaling. 秀丽隐杆线虫的神经元分化:结合谱系遗传和细胞间信号传导。
IF 1.9 4区 医学
Journal of neurogenetics Pub Date : 2020-09-01 Epub Date: 2020-06-30 DOI: 10.1080/01677063.2020.1781850
Antoine Barrière, Vincent Bertrand
{"title":"Neuronal specification in <i>C. elegans</i>: combining lineage inheritance with intercellular signaling.","authors":"Antoine Barrière,&nbsp;Vincent Bertrand","doi":"10.1080/01677063.2020.1781850","DOIUrl":"https://doi.org/10.1080/01677063.2020.1781850","url":null,"abstract":"<p><p>The nervous system is composed of a high diversity of neuronal types. How this diversity is generated during development is a key question in neurobiology. Addressing this question is one of the reasons that led Sydney Brenner to develop the nematode <i>C. elegans</i> as a model organism. While there was initially a debate on whether the neuronal specification follows a 'European' model (determined by ancestry) or an 'American' model (determined by intercellular communication), several decades of research have established that the truth lies somewhere in between. Neurons are specified by the combination of transcription factors inherited from the ancestor cells and signaling between neighboring cells (especially Wnt and Notch signaling). This converges to the activation in newly generated postmitotic neurons of a specific set of terminal selector transcription factors that initiate and maintain the differentiation of the neuron. In this review, we also discuss the evolution of these specification mechanisms in other nematodes and beyond.</p>","PeriodicalId":16491,"journal":{"name":"Journal of neurogenetics","volume":" ","pages":"273-281"},"PeriodicalIF":1.9,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01677063.2020.1781850","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38105727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Neurogenetics of nictation, a dispersal strategy in nematodes. 线虫扩散策略的神经遗传学。
IF 1.9 4区 医学
Journal of neurogenetics Pub Date : 2020-09-01 Epub Date: 2020-07-10 DOI: 10.1080/01677063.2020.1788552
Heeseung Yang, Bo Yun Lee, Hyunsoo Yim, Junho Lee
{"title":"Neurogenetics of nictation, a dispersal strategy in nematodes.","authors":"Heeseung Yang,&nbsp;Bo Yun Lee,&nbsp;Hyunsoo Yim,&nbsp;Junho Lee","doi":"10.1080/01677063.2020.1788552","DOIUrl":"https://doi.org/10.1080/01677063.2020.1788552","url":null,"abstract":"<p><p>Nictation is a behaviour in which a nematode stands on its tail and waves its head in three dimensions. This activity promotes dispersal of dauer larvae by allowing them to attach to other organisms and travel on them to a new niche. In this review, we describe our understanding of nictation, including its diversity in nematode species, how it is induced by environmental factors, and neurogenetic factors that regulate nictation. We also highlight the known cellular and signalling factors that affect nictation, for example, IL2 neurons, insulin/IGF-1 signalling, TGF-β signalling, FLP neuropeptides and piRNAs. Elucidation of the mechanism of nictation will contribute to increased understanding of the conserved dispersal strategies in animals.</p>","PeriodicalId":16491,"journal":{"name":"Journal of neurogenetics","volume":" ","pages":"510-517"},"PeriodicalIF":1.9,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01677063.2020.1788552","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38139188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Plasticity of pheromone-mediated avoidance behavior in C. elegans. 线虫信息素介导的回避行为的可塑性。
IF 1.9 4区 医学
Journal of neurogenetics Pub Date : 2020-09-01 Epub Date: 2020-08-19 DOI: 10.1080/01677063.2020.1802723
YongJin Cheon, Hyeonjeong Hwang, Kyuhyung Kim
{"title":"Plasticity of pheromone-mediated avoidance behavior in <i>C. elegans</i>.","authors":"YongJin Cheon,&nbsp;Hyeonjeong Hwang,&nbsp;Kyuhyung Kim","doi":"10.1080/01677063.2020.1802723","DOIUrl":"https://doi.org/10.1080/01677063.2020.1802723","url":null,"abstract":"<p><p><i>Caenorhabditis elegans</i> secretes a complex cocktail of small chemicals collectively called ascaroside pheromones which serves as a chemical language for intra-species communication. Subsets of ascarosides have been shown to mediate a broad spectrum of <i>C. elegans</i> behavior and development, such as gender-specific attraction, repulsion, aggregation, olfactory plasticity, and dauer formation. Recent studies show that specific components of ascarosides elicit a rapid avoidance response that allows animals to avoid predators and escape from unfavorable conditions. Moreover, this avoidance behavior is modulated by external conditions, internal states, and previous experience, indicating that pheromone avoidance behavior is highly plastic. In this review, we describe molecular and circuit mechanisms underlying plasticity in pheromone avoidance behavior which pave a way to better understanding circuit mechanisms underlying behavioral plasticity in higher animals, including humans.</p>","PeriodicalId":16491,"journal":{"name":"Journal of neurogenetics","volume":" ","pages":"420-426"},"PeriodicalIF":1.9,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01677063.2020.1802723","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38276225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
C. elegans MAGU-2/Mpp5 homolog regulates epidermal phagocytosis and synapse density. 秀丽隐杆线虫MAGU-2/Mpp5同源调控表皮吞噬和突触密度。
IF 1.9 4区 医学
Journal of neurogenetics Pub Date : 2020-09-01 Epub Date: 2020-05-04 DOI: 10.1080/01677063.2020.1726915
Salvatore J Cherra, Alexandr Goncharov, Daniela Boassa, Mark Ellisman, Yishi Jin
{"title":"<i>C. elegans</i> MAGU-2/Mpp5 homolog regulates epidermal phagocytosis and synapse density.","authors":"Salvatore J Cherra,&nbsp;Alexandr Goncharov,&nbsp;Daniela Boassa,&nbsp;Mark Ellisman,&nbsp;Yishi Jin","doi":"10.1080/01677063.2020.1726915","DOIUrl":"https://doi.org/10.1080/01677063.2020.1726915","url":null,"abstract":"<p><p>Synapses are dynamic connections that underlie essential functions of the nervous system. The addition, removal, and maintenance of synapses govern the flow of information in neural circuits throughout the lifetime of an animal. While extensive studies have elucidated many intrinsic mechanisms that neurons employ to modulate their connections, increasing evidence supports the roles of non-neuronal cells, such as glia, in synapse maintenance and circuit function. We previously showed that <i>C. elegans</i> epidermis regulates synapses through ZIG-10, a cell-adhesion protein of the immunoglobulin domain superfamily. Here we identified a member of the Pals1/MPP5 family, MAGU-2, that functions in the epidermis to modulate phagocytosis and the number of synapses by regulating ZIG-10 localization. Furthermore, we used light and electron microscopy to show that this epidermal mechanism removes neuronal membranes from the neuromuscular junction, dependent on the conserved phagocytic receptor CED-1. Together, our study shows that <i>C. elegans</i> epidermis constrains synaptic connectivity, in a manner similar to astrocytes and microglia in mammals, allowing optimized output of neural circuits.</p>","PeriodicalId":16491,"journal":{"name":"Journal of neurogenetics","volume":" ","pages":"298-306"},"PeriodicalIF":1.9,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01677063.2020.1726915","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37898950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Nature's gift to neuroscience. 大自然给神经科学的礼物
IF 1.9 4区 医学
Journal of neurogenetics Pub Date : 2020-09-01 DOI: 10.1080/01677063.2020.1841760
Joy Alcedo, Yishi Jin, Douglas S Portman, Veena Prahlad, David Raizen, Georgia Rapti, X Z Shawn Xu, Yun Zhang, Chun-Fang Wu
{"title":"Nature's gift to neuroscience.","authors":"Joy Alcedo, Yishi Jin, Douglas S Portman, Veena Prahlad, David Raizen, Georgia Rapti, X Z Shawn Xu, Yun Zhang, Chun-Fang Wu","doi":"10.1080/01677063.2020.1841760","DOIUrl":"10.1080/01677063.2020.1841760","url":null,"abstract":"","PeriodicalId":16491,"journal":{"name":"Journal of neurogenetics","volume":"34 3-4","pages":"223-224"},"PeriodicalIF":1.9,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01677063.2020.1841760","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9762051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A touching story. 一个感人的故事。
IF 1.9 4区 医学
Journal of neurogenetics Pub Date : 2020-09-01 DOI: 10.1080/01677063.2020.1833879
Martin Chalfie
{"title":"A touching story.","authors":"Martin Chalfie","doi":"10.1080/01677063.2020.1833879","DOIUrl":"https://doi.org/10.1080/01677063.2020.1833879","url":null,"abstract":"<p><p>A slide taped to a window at the Woods Hole Marine Biology Laboratory was my first introduction to the touch receptor neurons of the nematode <i>Caenorhabditis elegans</i>. Studying these cells as a postdoc with Sydney Brenner gave me a chance to work with John Sulston on a fascinating set of neurons. I would never have guessed then that 43 years later I would still be excited about learning their secrets.</p>","PeriodicalId":16491,"journal":{"name":"Journal of neurogenetics","volume":" ","pages":"247-250"},"PeriodicalIF":1.9,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01677063.2020.1833879","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38819735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discriminating between sleep and exercise-induced fatigue using computer vision and behavioral genetics. 使用计算机视觉和行为遗传学区分睡眠和运动引起的疲劳。
IF 1.9 4区 医学
Journal of neurogenetics Pub Date : 2020-09-01 Epub Date: 2020-08-19 DOI: 10.1080/01677063.2020.1804565
Kelsey N Schuch, Lakshmi Narasimhan Govindarajan, Yuliang Guo, Saba N Baskoylu, Sarah Kim, Benjamin Kimia, Thomas Serre, Anne C Hart
{"title":"Discriminating between sleep and exercise-induced fatigue using computer vision and behavioral genetics.","authors":"Kelsey N Schuch,&nbsp;Lakshmi Narasimhan Govindarajan,&nbsp;Yuliang Guo,&nbsp;Saba N Baskoylu,&nbsp;Sarah Kim,&nbsp;Benjamin Kimia,&nbsp;Thomas Serre,&nbsp;Anne C Hart","doi":"10.1080/01677063.2020.1804565","DOIUrl":"https://doi.org/10.1080/01677063.2020.1804565","url":null,"abstract":"<p><p>Following prolonged swimming, <i>Caenorhabditis elegans</i> cycle between active swimming bouts and inactive quiescent bouts. Swimming is exercise for <i>C. elegans</i> and here we suggest that inactive bouts are a recovery state akin to fatigue. It is known that cGMP-dependent kinase (PKG) activity plays a conserved role in sleep, rest, and arousal. Using <i>C. elegans</i> EGL-4 PKG, we first validate a novel learning-based computer vision approach to automatically analyze <i>C. elegans</i> locomotory behavior and an edge detection program that is able to distinguish between activity and inactivity during swimming for long periods of time. We find that <i>C. elegans</i> EGL-4 PKG function impacts timing of exercise-induced quiescent (EIQ) bout onset, fractional quiescence, bout number, and bout duration, suggesting that previously described pathways are engaged during EIQ bouts. However, EIQ bouts are likely not sleep as animals are feeding during the majority of EIQ bouts. We find that genetic perturbation of neurons required for other <i>C. elegans</i> sleep states also does not alter EIQ dynamics. Additionally, we find that EIQ onset is sensitive to age and DAF-16 FOXO function. In summary, we have validated behavioral analysis software that enables a quantitative and detailed assessment of swimming behavior, including EIQ. We found novel EIQ defects in aged animals and animals with mutations in a gene involved in stress tolerance. We anticipate that further use of this software will facilitate the analysis of genes and pathways critical for fatigue and other <i>C. elegans</i> behaviors.</p>","PeriodicalId":16491,"journal":{"name":"Journal of neurogenetics","volume":" ","pages":"453-465"},"PeriodicalIF":1.9,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01677063.2020.1804565","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38277547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Molecular mechanisms governing axonal transport: a C. elegans perspective. 控制轴突运输的分子机制:秀丽隐杆线虫的观点。
IF 1.9 4区 医学
Journal of neurogenetics Pub Date : 2020-09-01 Epub Date: 2020-10-08 DOI: 10.1080/01677063.2020.1823385
Amruta Vasudevan, Sandhya P Koushika
{"title":"Molecular mechanisms governing axonal transport: a <i>C. elegans</i> perspective.","authors":"Amruta Vasudevan,&nbsp;Sandhya P Koushika","doi":"10.1080/01677063.2020.1823385","DOIUrl":"https://doi.org/10.1080/01677063.2020.1823385","url":null,"abstract":"<p><p>Axonal transport is integral for maintaining neuronal form and function, and defects in axonal transport have been correlated with several neurological diseases, making it a subject of extensive research over the past several years. The anterograde and retrograde transport machineries are crucial for the delivery and distribution of several cytoskeletal elements, growth factors, organelles and other synaptic cargo. Molecular motors and the neuronal cytoskeleton function as effectors for multiple neuronal processes such as axon outgrowth and synapse formation. This review examines the molecular mechanisms governing axonal transport, specifically highlighting the contribution of studies conducted in <i>C. elegans</i>, which has proved to be a tractable model system in which to identify both novel and conserved regulatory mechanisms of axonal transport.</p>","PeriodicalId":16491,"journal":{"name":"Journal of neurogenetics","volume":" ","pages":"282-297"},"PeriodicalIF":1.9,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01677063.2020.1823385","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38465958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
What can a worm learn in a bacteria-rich habitat? 蠕虫在细菌丰富的栖息地能学到什么?
IF 1.9 4区 医学
Journal of neurogenetics Pub Date : 2020-09-01 Epub Date: 2020-10-15 DOI: 10.1080/01677063.2020.1829614
He Liu, Yun Zhang
{"title":"What can a worm learn in a bacteria-rich habitat?","authors":"He Liu,&nbsp;Yun Zhang","doi":"10.1080/01677063.2020.1829614","DOIUrl":"https://doi.org/10.1080/01677063.2020.1829614","url":null,"abstract":"<p><p>With a nervous system that has only a few hundred neurons, <i>Caenorhabditis elegans</i> was initially not regarded as a model for studies on learning. However, the collective effort of the <i>C. elegans</i> field in the past several decades has shown that the worm displays plasticity in its behavioral response to a wide range of sensory cues in the environment. As a bacteria-feeding worm, <i>C. elegans</i> is highly adaptive to the bacteria enriched in its habitat, especially those that are pathogenic and pose a threat to survival. It uses several common forms of behavioral plasticity that last for different amounts of time, including imprinting and adult-stage associative learning, to modulate its interactions with pathogenic bacteria. Probing the molecular, cellular and circuit mechanisms underlying these forms of experience-dependent plasticity has identified signaling pathways and regulatory insights that are conserved in more complex animals.</p>","PeriodicalId":16491,"journal":{"name":"Journal of neurogenetics","volume":" ","pages":"369-377"},"PeriodicalIF":1.9,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/01677063.2020.1829614","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38487044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
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