Journal of Nuclear Cardiology最新文献

{"title":"Independent prognostic significance of myocardial flow reserve over coronary artery calcium, myocardial perfusion, and clinical variables in patients without known coronary artery disease, according to diabetes status.","authors":"Su Nam Lee, Pankaj Malhotra, Robert J H Miller, Heidi Gransar, Sean W Hayes, John D Friedman, Louise E J Thomson, Alan Rozanski, Piotr J Slomka, Donghee Han, Daniel S Berman","doi":"10.1016/j.nuclcard.2025.102165","DOIUrl":"10.1016/j.nuclcard.2025.102165","url":null,"abstract":"<p><strong>Objective: </strong>To explore differences in prevalence and prognosis associated with reduced myocardial flow reserve (MFR) in patients without known coronary artery disease (CAD) based on diabetes status.</p><p><strong>Methods: </strong>Of 2639 patients without known CAD who underwent rubidium positron emission tomography myocardial perfusion imaging (MPI), 818 patients (31%) had diabetes. Reduced MFR was defined as MFR <2.0. Coronary artery calcium (CAC) score was categorized as 0, 1-99, 100-399, and ≥400. Ischemic total perfusion deficit (TPD) was categorized as <1%, 1-<5%, and ≥5%. Outcome variables were all-cause death (ACD) and non-fatal myocardial infarction (MI).</p><p><strong>Results: </strong>During the median follow-up of 4.1 years, 574 (21.8%) ACD/MI occurred (204 [25.1%] diabetic patients, 370 [20.3%] nondiabetic patients). In multivariable Cox analysis, reduced MFR was associated with increased ACD/MI in patients with diabetes (per .1 decrease: HR: 1.04, 95% CI: 1.02-1.06, P < .001) and patients without diabetes (per .1 decrease: HR: 1.03, 95% CI: 1.02-1.04, P < .001). No interaction existed between diabetes and MFR for ACD/MI risk regardless of CAC or ischemic burden (all P > .05). Adding MFR to the risk prediction model of clinical, conventional MPI findings, and CAC improved the discrimination for clinical outcomes in both groups (DM: .003, non-DM: <.001, respectively).</p><p><strong>Conclusion: </strong>Reduced MFR was more common in patients with diabetes and an important independent prognostic marker over CAC and clinical variables. The association between MFR and ACD/MI risk did not differ between patients with and without diabetes who had no prior CAD, regardless of CAC and ischemic burden.</p>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":" ","pages":"102165"},"PeriodicalIF":3.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the effectiveness of tafamidis therapy in patients with transthyretin cardiac amyloidosis using 99mtechnetium pyrophosphate cardiac imaging","authors":"Tatsuro Tasaka MD ,&nbsp;Akiyoshi Ogimoto MD, PhD ,&nbsp;Makoto Saito MD, PhD ,&nbsp;Shota Koike MD ,&nbsp;Tamami Kono MD, PhD ,&nbsp;Kiyotaka Ohshima MD, PhD ,&nbsp;Mareomi Hamada MD, PhD","doi":"10.1016/j.nuclcard.2024.102075","DOIUrl":"10.1016/j.nuclcard.2024.102075","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"44 ","pages":"Article 102075"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current practices in amyloidosis imaging with bone-avid tracer cardiac scintigraphy","authors":"Sarah A.M. Cuddy MD, MPH ,&nbsp;Omar Abou-Ezzeddine MD, CM, MS ,&nbsp;Linda P. Giering ,&nbsp;Sharmila Dorbala MD, MPH ,&nbsp;Jamieson M. Bourque MD, MHS, FASNC","doi":"10.1016/j.nuclcard.2024.102078","DOIUrl":"10.1016/j.nuclcard.2024.102078","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"44 ","pages":"Article 102078"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A focus on women's heart health – Raising Awareness: Women's Heart Health Day","authors":"Panithaya Chareonthaitawee MD","doi":"10.1016/j.nuclcard.2025.102141","DOIUrl":"10.1016/j.nuclcard.2025.102141","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"44 ","pages":"Article 102141"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143403353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"‘TIDing’ over the uncertainty: Prognostic value of Transient Ischemic Dilation in Rubidium-82 PET myocardial perfusion imaging","authors":"Christoph Rischpler","doi":"10.1016/j.nuclcard.2025.102142","DOIUrl":"10.1016/j.nuclcard.2025.102142","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"44 ","pages":"Article 102142"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143403502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of transient ischemic dilation on Rubidium-82 positron emission tomography myocardial perfusion imaging","authors":"Krishna K. Patel MD, MSc ,&nbsp;Phillip Lim MD ,&nbsp;Poghni A. Peri-Okonny MD, MSc ,&nbsp;Annapoorna Singh MD ,&nbsp;A. Iain McGhie MD ,&nbsp;Basera Sabharwal MD ,&nbsp;Vikram Agarwal MD ,&nbsp;Leslee J. Shaw PhD ,&nbsp;Timothy M. Bateman MD","doi":"10.1016/j.nuclcard.2024.102084","DOIUrl":"10.1016/j.nuclcard.2024.102084","url":null,"abstract":"<div><h3>Background</h3><div>Transient ischemic dilation (TID) of the left ventricular (LV) cavity is considered a high-risk marker in patients with abnormal single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI). Stress image acquisition with rubidium-82 (⁸²Rb) PET occurs at peak stress compared to 30–60 minutes post-stress with SPECT. We aimed to evaluate the prognostic value of TID in patients undergoing ⁸²Rb PET MPI.</div></div><div><h3>Methods</h3><div>A total of 9878 consecutive patients with LVEF ≥40% undergoing rest/pharmacologic stress ⁸²Rb PET MPI from 2010 to 2016 were followed for a median of 3.2 years. The primary clinical outcome of cardiac death was assessed after adjusting for pre-test risk, known coronary artery disease (CAD), resting left ventricular ejection fraction (LVEF), summed stress score (SSS), LVEF reserve (LVEF-R), myocardial blood flow reserve (MBFR), and early (90-day) revascularization. Pre-specified interactions between TID and SSS were included to assess potential differences in the prognostic value of TID in patients based on perfusion.</div></div><div><h3>Results</h3><div>The mean age of the cohort was 69.0 (11.7) years with 56.1% being female, 49.8% having known CAD, and 27.9% having abnormal perfusion (SSS&gt;0). There were 451 cardiac deaths. Higher TID ratios were associated with higher risk of cardiac death, even after accounting for LVEF-R and MBFR (HR per .1 unit increase = 1.25 (1.11, 1.41), <em>P</em> &lt; .001). This was seen in patients with both normal (HR for TID per .1 unit increase = 1.24 (95% CI: 1.01, 1.52), <em>P</em> = .04) and abnormal perfusion (HR for TID per .1 unit increase = 1.14 (95% CI: 1.02, 1.28), <em>P</em> = .03).</div></div><div><h3>Conclusions</h3><div>TID on rest/stress ⁸²Rb PET MPI offers independent prognostic value in patients with both normal and abnormal perfusion independent of other risk factors in patients with LVEF ≥40%.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"44 ","pages":"Article 102084"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amyloidosis imaging in focus: The evolution of bone-avid cardiac scintigraphy in the era of disease-modifying therapies","authors":"Marcelo F. Di Carli MD, MASNC","doi":"10.1016/j.nuclcard.2025.102150","DOIUrl":"10.1016/j.nuclcard.2025.102150","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"44 ","pages":"Article 102150"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143402700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing motion in the estimation of myocardial blood flow with [F-18] flurpiridaz positron emission tomography","authors":"Jonathon A. Nye,&nbsp;Sameer V. Tipnis","doi":"10.1016/j.nuclcard.2024.102123","DOIUrl":"10.1016/j.nuclcard.2024.102123","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"44 ","pages":"Article 102123"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143403501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automatic motion correction for myocardial blood flow estimation improves diagnostic performance for coronary artery disease in 18F-flurpiridaz positron emission tomography-myocardial perfusion imaging","authors":"Valerie Builoff BS ,&nbsp;Cathleen Huang BA ,&nbsp;Keiichiro Kuronuma MD, PhD ,&nbsp;Chih-Chun Wei MS ,&nbsp;Hidesato Fujito MD, PhD ,&nbsp;Yuka Otaki MD, PhD ,&nbsp;Serge D. Van Kriekinge PhD ,&nbsp;Paul Kavanagh MS ,&nbsp;Mark Lemley BS ,&nbsp;Mark C. Hyun CNMT ,&nbsp;Marcelo Di Carli MD ,&nbsp;Daniel S. Berman MD ,&nbsp;Piotr J. Slomka PhD","doi":"10.1016/j.nuclcard.2024.102072","DOIUrl":"10.1016/j.nuclcard.2024.102072","url":null,"abstract":"<div><h3>Background</h3><div>Motion correction (MC) is critical for accurate quantification of myocardial blood flow (MBF) and flow reserve (MFR) from ¹⁸F-flurpiridaz positron emission tomography (PET) myocardial perfusion imaging (MPI). However, manual correction is time consuming and introduces inter-observer variability. We aimed to validate an automatic MC algorithm for ¹⁸F-flurpiridaz PET-MPI in terms of diagnostic performance for predicting coronary artery disease (CAD).</div></div><div><h3>Methods</h3><div>In total, 231 patients who underwent invasive coronary angiography and rest/pharmacologic stress ¹⁸F-flurpiridaz PET-MPI from the phase III Flurpiridaz trial (NCT01347710) were enrolled. For manual MC, two operators (Reader 1 and Reader 2) shifted each frame's images in three directions. The automatic MC algorithm, initially developed for ⁸²Rb-chloride PET-MPI, was optimized for ¹⁸F-flurpiridaz. Diagnostic performance was compared using minimal segmental MBF/MFR with and without MC to predict obstructive CAD by invasive coronary angiography.</div></div><div><h3>Results</h3><div>Manual MC took 10 minutes per case (both stress and rest) on average, while automatic MC required &lt;10 seconds. The area under the receiver operating characteristic curves (AUCs) for significant CAD using minimal segmental MBF were comparable between automatic and manual MC (AUC = 0.877 automatic, AUC = 0.888 Reader 1 and AUC = 0.892 Reader 2; all <em>P</em> &gt; 0.05). AUCs of minimal segmental MBF with manual and automatic MC were significantly higher than without MC (<em>P</em> &lt; 0.05 for both). Similar findings were observed with minimal segmental MFR.</div></div><div><h3>Conclusions</h3><div>Automatic MC can be performed rapidly, with diagnostic performance for predicting obstructive CAD comparable to manual MC. This method could be utilized for analysis of MBF/MFR in patients undergoing ¹⁸F-flurpiridaz PET-MPI.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"44 ","pages":"Article 102072"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between technetium-99m pyrophosphate myocardial uptake and extracellular volume on cardiac magnetic resonance imaging in patients with transthyretin cardiac amyloidosis","authors":"Chun-Yuan Khoo MBBS ,&nbsp;Jennifer Maning DO ,&nbsp;Richard Weinberg MD, PhD ,&nbsp;Ryan Avery MD ,&nbsp;Vinesh Appadurai MD ,&nbsp;Sanjiv Shah MD ,&nbsp;Korosh Sharain MD ,&nbsp;Scott M. Leonard BSc ,&nbsp;Logan Robert Linscheid BSc ,&nbsp;Chen Chen MD ,&nbsp;Anahita Iyer BSc ,&nbsp;Susan Lehrer BSc ,&nbsp;Ike S. Okwuosa MD ,&nbsp;Paul C. Cremer MD, MS","doi":"10.1016/j.nuclcard.2024.102083","DOIUrl":"10.1016/j.nuclcard.2024.102083","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"44 ","pages":"Article 102083"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}