{"title":"March: Time to spotlight amyloidosis","authors":"Panithaya Chareonthaitawee MD","doi":"10.1016/j.nuclcard.2025.102164","DOIUrl":"10.1016/j.nuclcard.2025.102164","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"45 ","pages":"Article 102164"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143642469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Juan P. Suarez MD, Maria L. Dominguez MD, PhD, Carmen Vigil MD, PhD, Belen Fernandez MD, PhD, Sara Naranjo MD, Laura Rodriguez MD, Noelia Martin PhD, Francisco M. Gonzalez MD, PhD
{"title":"Detection of small vegetations in native bi-valvular (aortic + mitral) infective endocarditis with 4D ECG-gated cardiac [18F]FDG PET/CT","authors":"Juan P. Suarez MD, Maria L. Dominguez MD, PhD, Carmen Vigil MD, PhD, Belen Fernandez MD, PhD, Sara Naranjo MD, Laura Rodriguez MD, Noelia Martin PhD, Francisco M. Gonzalez MD, PhD","doi":"10.1016/j.nuclcard.2024.102043","DOIUrl":"10.1016/j.nuclcard.2024.102043","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"45 ","pages":"Article 102043"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cardiac denervation and morpho-functional changes, two sides of the same coin in wild-type transthyretin amyloid cardiomyopathy?","authors":"Albert Flotats","doi":"10.1016/j.nuclcard.2025.102145","DOIUrl":"10.1016/j.nuclcard.2025.102145","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"45 ","pages":"Article 102145"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"CME INSTRUCTIONS: Infection vs inflammation in prosthetic heart valves by [18F]FDG-PET/CT: A practical tutorial for proper interpretation","authors":"","doi":"10.1016/j.nuclcard.2025.102173","DOIUrl":"10.1016/j.nuclcard.2025.102173","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"45 ","pages":"Article 102173"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143642351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"More than pictures: The science and promise of nuclear imaging","authors":"Marcelo F. Di Carli MD, MASNC","doi":"10.1016/j.nuclcard.2025.102178","DOIUrl":"10.1016/j.nuclcard.2025.102178","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"45 ","pages":"Article 102178"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143642468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Albert Roque MD, PhD , María Nazarena Pizzi MD, PhD
{"title":"Infection vs inflammation in prosthetic heart valves by [18F]FDG-PET/CT: A practical tutorial for accurate interpretation","authors":"Albert Roque MD, PhD , María Nazarena Pizzi MD, PhD","doi":"10.1016/j.nuclcard.2024.102053","DOIUrl":"10.1016/j.nuclcard.2024.102053","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"45 ","pages":"Article 102053"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
René R. Sevag Packard , Robert A. deKemp , Juhani Knuuti , Jonathan B. Moody , Jennifer M. Renaud , Antti Saraste , Piotr J. Slomka
{"title":"Quantitative approaches to 18F-flurpiridaz positron emission tomography image analysis","authors":"René R. Sevag Packard , Robert A. deKemp , Juhani Knuuti , Jonathan B. Moody , Jennifer M. Renaud , Antti Saraste , Piotr J. Slomka","doi":"10.1016/j.nuclcard.2025.102180","DOIUrl":"10.1016/j.nuclcard.2025.102180","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"45 ","pages":"Article 102180"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143743237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alwin Tubben MD , Niek H.J. Prakken MD, PhD , Oleksandra V. Ivashchenko PhD , Hendrea S.A. Tingen MD , Andor W.J.M. Glaudemans MD, PhD , Walter Noordzij MD, PhD , Hans L.A. Nienhuis MD, PhD , Peter van der Meer MD, PhD , Riemer H.J.A. Slart MD, PhD
{"title":"Feasibility of the absolute quantification and left ventricular segmentation of cardiac sympathetic innervation in wild-type transthyretin amyloidosis cardiomyopathy with [123I]-MIBG SPECT/CT: The I-NERVE study","authors":"Alwin Tubben MD , Niek H.J. Prakken MD, PhD , Oleksandra V. Ivashchenko PhD , Hendrea S.A. Tingen MD , Andor W.J.M. Glaudemans MD, PhD , Walter Noordzij MD, PhD , Hans L.A. Nienhuis MD, PhD , Peter van der Meer MD, PhD , Riemer H.J.A. Slart MD, PhD","doi":"10.1016/j.nuclcard.2025.102146","DOIUrl":"10.1016/j.nuclcard.2025.102146","url":null,"abstract":"<div><h3>Background</h3><div>Cardiac sympathetic neuronal dysfunction is an early marker in wild-type transthyretin amyloidosis cardiomyopathy (ATTRwt-CM). Iodine-123-labeled norepinephrine analog meta-iodobenzylguanidine ([<sup>123</sup>I]-MIBG) imaging evaluates cardiac sympathetic innervation but lacks volumetric activity quantification in current methods. This study aims to quantify cardiac sympathetic neuronal dysfunction in ATTRwt-CM using [<sup>123</sup>I]-MIBG single-photon emission computed tomography/ computed tomography (SPECT/CT) and correlate findings with functional and structural cardiac parameters from echocardiogram and cardiac magnetic resonance imaging (CMR).</div></div><div><h3>Methods</h3><div>We conducted a single-center, descriptive, cross-sectional study to quantify absolute myocardial sympathetic function in ATTRwt-CM using [<sup>123</sup>I]-MIBG SPECT/CT. Retrospective reconstruction allowed for absolute tracer-uptake quantification of the left ventricle, overall and segmented, in kBq/mL, standard uptake value (SUV), and percentage of the injected dose (%ID). Echocardiography, CMR, and bone scintigraphy were performed according to clinical standards. Segmented [<sup>123</sup>I]-MIBG SPECT/CT values were correlated with global longitudinal systolic strain (GLSS) on echocardiography, native-T1, and extracellular volume (ECV) on CMR using SPECT/CT fused with CMR.</div></div><div><h3>Results</h3><div>Twenty-nine ATTRwt-CM patients (75.8 ± 6.6 years, 90% male) were prospectively included. All exhibited cardiac sympathetic neuronal dysfunction, with a median late heart-to-mediastinum ratio of 1.69 (1.45–1.89) and a washout rate of 22.7% (16.4%–27.3%). SUV<sub>mean</sub>, SUV<sub>peak</sub>, SUV<sub>max</sub>, and %ID were 1.80 ± .78, 3.84 ± 1.41, 4.46 ± 1.68, and .46 ± .18, respectively, correlating with semiquantitative [<sup>123</sup>I]-MIBG measures. No correlations were found with GLSS on echocardiography or native T1 and ECV on CMR.</div></div><div><h3>Conclusions</h3><div>The current study demonstrates the feasibility of volumetric quantification of [<sup>123</sup>I]–MIBG SPECT/CT in ATTRwt-CM. SUV<sub>mean</sub>, SUV<sub>peak</sub>, SUV<sub>max</sub>, and %ID correlate with semi-quantitative measures but not with key cardiac parameters on echocardiography or CMR. This confirms the sensitivity of [<sup>123</sup>I]-MIBG SPECT/CT to different aspects of cardiac function or pathology.</div></div><div><h3>Trial registration</h3><div>EudraCT ref. 2020-003350-72, retrospectively registered March 20, 2023. <span><span>https://classic.clinicaltrials.gov/ct2/show/NCT05776212</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"45 ","pages":"Article 102146"},"PeriodicalIF":3.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}