Journal of Nuclear Cardiology最新文献

{"title":"Cardiac sympathetic activity in patients suffering from heart failure with improved ejection fraction","authors":"Yohei Ishibashi MD, PhD ,&nbsp;Shu Kasama MD, PhD ,&nbsp;Hideki Ishii MD, PhD","doi":"10.1016/j.nuclcard.2025.102196","DOIUrl":"10.1016/j.nuclcard.2025.102196","url":null,"abstract":"<div><h3>Background</h3><div>The characteristics of cardiac sympathetic nerve activity among patients suffering from heart failure (HF) with improved ejection fraction (EF) (HFimpEF) remain unclear.</div></div><div><h3>Methods</h3><div>Patients admitted for HF with an EF ≤ 40% who underwent echocardiography and ¹²³I-metaiodobenzylguanidine scintigraphy before and 6 months after discharge were followed for 5.2 (2.8–6.1) years. At 6 months, patients with an EF ≤ 40% were classified into the HF with reduced EF (HFrEF) group. Meanwhile, patients with an EF of &gt;40% were classified under the HFimpEF group.</div></div><div><h3>Results</h3><div>Among the 188 patients analyzed, 78 (41.5%) and 110 (58.5%) were categorized into the HFimpEF and HFrEF groups, respectively. The HFimpEF group had a better heart-to-mediastinal (H/M) ratio at baseline than did the HFrEF group (1.76 [1.59–1.85] vs 1.64 [1.48–1.81], respectively; <em>P</em> = .011). The predictive factors of HFimpEF included ischemic heart disease (odds ratio [OR]: .45, 95% confidence interval [CI]: .21–.94, <em>P</em> = .034), H/M ratio (OR: 1.02, 95% CI: 1.00–1.04, <em>P</em> = .032), and EF (OR: 1.14, 95% CI: 1.08–1.21, <em>P</em> &lt; .001).</div></div><div><h3>Conclusions</h3><div>The HFimpEF group had a higher H/M ratio than did the HFrEF group, suggesting lower cardiac sympathetic hyperactivity. The H/M ratio was identified as an independent predictor of HFimpEF.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"48 ","pages":"Article 102196"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laboratory considerations on the use of F-18 myocardial perfusion imaging radiotracers: An Information Statement from the American Society of Nuclear Cardiology","authors":"Rupa Sanghani MD (Co-chair) ,&nbsp;Robert deKemp PhD (Co-chair) ,&nbsp;Stephen Horgan MB, BCh, PhD (Co-chair) ,&nbsp;Mouaz Al-Mallah MD ,&nbsp;Timothy Bateman MD ,&nbsp;James Case PhD ,&nbsp;Panithaya Chareonthaitawee MD ,&nbsp;Sharmila Dorbala MD, MPH ,&nbsp;Gary Heller MD, PhD ,&nbsp;Mark Hyun CNMT ,&nbsp;Lawrence M. Phillips MD","doi":"10.1016/j.nuclcard.2025.102230","DOIUrl":"10.1016/j.nuclcard.2025.102230","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"48 ","pages":"Article 102230"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144239417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The enduring value of single-photon emission computed tomography myocardial perfusion imaging","authors":"Panithaya Chareonthaitawee MD","doi":"10.1016/j.nuclcard.2025.102233","DOIUrl":"10.1016/j.nuclcard.2025.102233","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"48 ","pages":"Article 102233"},"PeriodicalIF":3.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144241394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of attenuation correction and prone positioning on stress-only imaging in cardiac SPECT: An observational study.","authors":"Maria Alwan, Ahmed Sayed, Ahmed Ibrahim Ahmed, Asim Shaikh, Ahmad El Yaman, Mahmoud Al Rifai, Mouaz H Al-Mallah","doi":"10.1016/j.nuclcard.2025.102249","DOIUrl":"10.1016/j.nuclcard.2025.102249","url":null,"abstract":"<p><strong>Background: </strong>Current guidelines recommend stress-only single photon emission computed tomography myocardial perfusion imaging (SPECT MPI) in select patients to reduce time, cost, and radiation. However, stress-only imaging remains underutilized.</p><p><strong>Objectives: </strong>We assessed techniques to increase the adoption of stress-only SPECT MPI, specifically evaluating whether prone positioning and CT-based attenuation correction (AC) reduce the need for additional rest imaging.</p><p><strong>Methods: </strong>Consecutive patients with normal stress SPECT MPI scans were included. The need for additional rest imaging was assessed according to the use of prone positioning and AC. Radiotracer dose was calculated per the institution's protocol and compared between groups. Survival analysis compared the safety of stress-only protocols to stress-rest protocols.</p><p><strong>Results: </strong>Between 2018 and 2024, 14,274 patients with no stress perfusion defects were included. The use of stress-only imaging increased from 43.6% among patients with neither AC nor prone to 63.4% with AC and 65.7% with prone to 76 % with both techniques. Using multivariable logistic regression, the simultaneous use of prone and AC techniques significantly increased stress-only imaging (OR: 5.0, 95% CI: 4.38-5.72). This was more pronounced among females, obese patients, patients >65 years, and patients with an EF ≥ 55%. Radiotracer dose dropped by 35.6% when both AC and prone were used. Patients with normal stress-only SPECT scans had similar prognoses to those with normal SPECT scans using both stress and rest images, regardless of AC or prone imaging use.</p><p><strong>Conclusion: </strong>Combined use of AC and prone reduces the need for rest imaging by nearly half and lowers radiotracer doses by a third. Benefits are more pronounced in women, the elderly, patients with obesity, non-diabetics, and those with preserved ejection fraction.</p>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":" ","pages":"102249"},"PeriodicalIF":3.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-treatment bias and the prognostic utility of stress myocardial perfusion imaging.","authors":"Alan Rozanski, Heidi Gransar, Robert Jh Miller, Donghee Han, Piotr Slomka, Sean W Hayes, John D Friedman, Daniel S Berman","doi":"10.1016/j.nuclcard.2025.102248","DOIUrl":"10.1016/j.nuclcard.2025.102248","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":" ","pages":"102248"},"PeriodicalIF":3.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Independent prognostic significance of myocardial flow reserve over coronary artery calcium, myocardial perfusion, and clinical variables in patients without known coronary artery disease, according to diabetes status","authors":"Su Nam Lee MD, PhD ,&nbsp;Pankaj Malhotra MD ,&nbsp;Robert J.H. Miller MD ,&nbsp;Heidi Gransar MS ,&nbsp;Sean W. Hayes MD ,&nbsp;John D. Friedman MD ,&nbsp;Louise E.J. Thomson MBChB ,&nbsp;Alan Rozanski MD ,&nbsp;Piotr J. Slomka PhD ,&nbsp;Donghee Han MD ,&nbsp;Daniel S. Berman MD","doi":"10.1016/j.nuclcard.2025.102165","DOIUrl":"10.1016/j.nuclcard.2025.102165","url":null,"abstract":"<div><h3>Objective</h3><div>To explore differences in prevalence and prognosis associated with reduced myocardial flow reserve (MFR) in patients without known coronary artery disease (CAD) based on diabetes status.</div></div><div><h3>Methods</h3><div>Of 2639 patients without known CAD who underwent rubidium positron emission tomography myocardial perfusion imaging (MPI), 818 patients (31%) had diabetes. Reduced MFR was defined as MFR &lt;2.0. Coronary artery calcium (CAC) score was categorized as 0, 1-99, 100-399, and ≥400. Ischemic total perfusion deficit (TPD) was categorized as &lt;1%, 1-&lt;5%, and ≥5%. Outcome variables were all-cause death (ACD) and non-fatal myocardial infarction (MI).</div></div><div><h3>Results</h3><div>During the median follow-up of 4.1 years, 574 (21.8%) ACD/MI occurred (204 [25.1%] diabetic patients, 370 [20.3%] nondiabetic patients). In multivariable Cox analysis, reduced MFR was associated with increased ACD/MI in patients with diabetes (per .1 decrease: HR: 1.04, 95% CI: 1.02-1.06, <em>P</em> &lt; .001) and patients without diabetes (per .1 decrease: HR: 1.03, 95% CI: 1.02-1.04, <em>P</em> &lt; .001). No interaction existed between diabetes and MFR for ACD/MI risk regardless of CAC or ischemic burden (all <em>P</em> &gt; .05). Adding MFR to the risk prediction model of clinical, conventional MPI findings, and CAC improved the discrimination for clinical outcomes in both groups (DM: .003, non-DM: &lt;.001, respectively).</div></div><div><h3>Conclusion</h3><div>Reduced MFR was more common in patients with diabetes and an important independent prognostic marker over CAC and clinical variables. The association between MFR and ACD/MI risk did not differ between patients with and without diabetes who had no prior CAD, regardless of CAC and ischemic burden.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"47 ","pages":"Article 102165"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probing the shadows of myocardial scar: Can PET MPI see what MRI sees?","authors":"Michael T. Osborne MD ,&nbsp;Mouaz H. Al-Mallah MD, MSc","doi":"10.1016/j.nuclcard.2025.102221","DOIUrl":"10.1016/j.nuclcard.2025.102221","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"47 ","pages":"Article 102221"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative radionuclide imaging – An opportunity to optimize and personalize care of ATTR cardiomyopathy","authors":"Dominik C. Benz MD ,&nbsp;Sarah A.M. Cuddy MD","doi":"10.1016/j.nuclcard.2025.102225","DOIUrl":"10.1016/j.nuclcard.2025.102225","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"47 ","pages":"Article 102225"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliable answers to patients’ questions: A fundamental need in any patient education tool, especially generative artificial intelligence","authors":"Alfonso H. Waller MD, FASNC ,&nbsp;Baoqiong Liu MD","doi":"10.1016/j.nuclcard.2025.102227","DOIUrl":"10.1016/j.nuclcard.2025.102227","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"47 ","pages":"Article 102227"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring time in the arteries: Imaging biomarkers of vascular aging in focus","authors":"Marcelo F. Di Carli MD, MASNC","doi":"10.1016/j.nuclcard.2025.102234","DOIUrl":"10.1016/j.nuclcard.2025.102234","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"47 ","pages":"Article 102234"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}