Journal of Nuclear Cardiology最新文献

{"title":"Communication of unexpected nuclear medicine and PET findings is a two-way street","authors":"Joseph C. Lee MBBS, FRACP, FAANMS , Jia Wen Chong B Med Sci, MBBS, Grad Dip Clin Ed , Bradley M. Hector B Med Rad Sci","doi":"10.1016/j.nuclcard.2024.102018","DOIUrl":"10.1016/j.nuclcard.2024.102018","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolution of cardiac amyloidosis imaging with bone-avid tracers: From qualification to quantification","authors":"Saurabh Malhotra MD, MPH, FASNC , Albert J. Sinusas MD, MASNC","doi":"10.1016/j.nuclcard.2024.102032","DOIUrl":"10.1016/j.nuclcard.2024.102032","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative 99mTc-pyrophosphate myocardial uptake: Changes on transthyretin stabilization therapy","authors":"Shilpa Vijayakumar MD, MPH ,&nbsp;Ardel Romero Pabon MD ,&nbsp;Olivier F. Clerc MD, MPH ,&nbsp;Sarah A.M. Cuddy MD ,&nbsp;Yuezhi Gu ,&nbsp;Caelan Watts ,&nbsp;Kyle Sullivan ,&nbsp;Benjamin Auer PhD ,&nbsp;Marie Foley Kijewski PhD ,&nbsp;Marcelo F. DiCarli MD ,&nbsp;Rodney H. Falk MD ,&nbsp;Sharmila Dorbala MD, MPH","doi":"10.1016/j.nuclcard.2024.102019","DOIUrl":"10.1016/j.nuclcard.2024.102019","url":null,"abstract":"<div><h3>Background</h3><div>Quantitative technetium-99m-pyrophosphate cardiac single-photon emission computed tomography (^99mTc-PYP SPECT/CT) is an emerging method for estimating myocardial burden of transthyretin cardiac amyloidosis (ATTR-CA), but its efficacy in monitoring longitudinal changes remains uncertain. We aimed to investigate longitudinal changes in cardiac ATTR amyloid burden following transthyretin stabilization therapy using visual and quantitative ^99mTc-PYP SPECT/CT and to relate these with changes in cardiac biomarkers and function.</div></div><div><h3>Methods</h3><div>This prospective longitudinal cohort study investigated changes in ^99mTc-PYP SPECT/CT in 23 participants with ATTR-CA on transthyretin stabilization therapy (median: 2.6 years). Quantitative analysis included left ventricular (LV) standardized uptake values (SUVs) (SUV_max, SUV_mean), cardiac amyloid activity (CAA; SUV_mean∗LV activity volume), and percent injected dose (%ID) (mean activity concentration∗LV activity volume/injected activity), calculated using a threshold of &gt;1.5 times left atrial blood pool activity concentration on SPECT/CT. Longitudinal changes of paired continuous and ordinal variables were analyzed using Wilcoxon signed-rank test.</div></div><div><h3>Results</h3><div>Following therapy, visual grade decreased significantly (<em>P</em> = 0.003). Several quantitative ^99mTc-PYP metrics also decreased significantly: SUV_max (median −0.75, <em>P</em> = 0.011), CAA (median: −406.6, <em>P</em> &lt; 0.001), and %ID (median: −0.45, <em>P</em> &lt; 0.001). Serum transthyretin levels improved (median: +6.5 mg/dL, <em>P</em> = 0.008). Echocardiographic parameters (global longitudinal strain, LV mass index, and LV wall thickness), N-terminal pro-B-type natriuretic peptide, and estimated glomerular filtration rate remained stable.</div></div><div><h3>Conclusions</h3><div>Favorable changes in ^99mTc-PYP myocardial uptake were observed in participants on transthyretin stabilization therapy, whereas echocardiographic parameters and biomarkers remained stable. These results likely signify myocardial ATTR amyloid stabilization rather than amyloid burden regression. Further investigation is needed to understand the implications of these findings.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in nuclear cardiology: From machine learning to human implementation","authors":"Lawrence M. Phillips MD, FASNC","doi":"10.1016/j.nuclcard.2024.102015","DOIUrl":"10.1016/j.nuclcard.2024.102015","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142424897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing the utility of radionuclide adrenergic imaging for assessing the risk of sudden arrhythmic cardiac death","authors":"Mark I. Travin MD, MASNC","doi":"10.1016/j.nuclcard.2024.102022","DOIUrl":"10.1016/j.nuclcard.2024.102022","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142004484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative assessment of cardiac 123iodo-metaiodobenzylguanidine SPECT/CT in patients with arrhythmogenic right ventricular cardiomyopathy: Novel insight in disease monitoring","authors":"Johannes M. Hagen ,&nbsp;Mathias J. Zacherl MD ,&nbsp;Matthias Brendel MD ,&nbsp;Sebastian Clauß MD ,&nbsp;Stefan Kääb MD ,&nbsp;Peter Bartenstein MD ,&nbsp;Andrei Todica MD ,&nbsp;Guido Böning PhD ,&nbsp;Maximilian Fischer MD","doi":"10.1016/j.nuclcard.2024.101911","DOIUrl":"10.1016/j.nuclcard.2024.101911","url":null,"abstract":"<div><h3>Background</h3><div>The heart-to-mediastinum ratio (H/M-Ratio) of ¹²³iodo-metaiodobenzylguanidine (¹²³I-MIBG) represents state-of-the-art assessment for sympathetic dysfunction in patients with arrhythmogenic right ventricular cardiomyopathy (ARVC). This study aims to evaluate quantitative reconstruction of ¹²³I-MIBG uptake and to demonstrate its correlation with echocardiographic parameters.</div></div><div><h3>Methods</h3><div>Cardiac innervation was assessed in 23 patients diagnosed with definite ARVC or borderline ARVC and 12 patients with other cardiac disease presenting arrhythmia, using quantitative ¹²³I-MIBG Single Photon Emission Computed Tomography/Computed Tomography (SPECT/CT) imaging. Tracer uptake was evaluated in the left (LV) and right ventricle (RV) based on a CT scan after quantitative image reconstruction. The relationship between tracer uptake and echocardiographic parameter data was examined.</div></div><div><h3>Results</h3><div>Absolute quantification of ¹²³I-MIBG uptake in the LV and RV is feasible and correlates accurately with the gold standard H/M Ratio. When comparing sensitivity and specificity, the area under the curve (AUC) favors standardized uptake value (SUV) of the RV over the right-ventricle-to-mediastinum-ratio (RV/M-Ratio) for diagnosing ARVC. A reduced RV-SUV in patients with definite ARVC is associated with reduced RV function. RV polar maps revealed globally reduced ¹²³I-MIBG uptake without segment-specific reduction in the RV.</div></div><div><h3>Conclusions</h3><div>Quantitative ¹²³I-MIBG SPECT in ARCV patients offers robust potential for clinical reporting and demonstrates a significant correlation with RV function. Segmental RV analysis needs to be evaluated in larger samples. In summary, cardiac ¹²³I-MIBG imaging using SUV could facilitate image-guided therapy in patients diagnosed with ARVC.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141620141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of a dedicated cardiac protocol on diagnosis of infective endocarditis in patients undergoing [18F]-FDG-thoracic digital-PET/CT – Effects of expertise level","authors":"Susan Notohamiprodjo MD ,&nbsp;Klemens Scheidhauer MD ,&nbsp;Matthias Eiber MD ,&nbsp;Igor Yakushev MD ,&nbsp;Alberto Villagran Asiares MSc ,&nbsp;Julia Kraus-Deuringer MD ,&nbsp;Helge W.A. Krebs-Fleischmann MD ,&nbsp;Sebastian Kleiner MD ,&nbsp;Robert Eggerstedt MD ,&nbsp;Bettina Eglseder MD ,&nbsp;Wolfgang A. Weber MD ,&nbsp;Stephan G. Nekolla PhD","doi":"10.1016/j.nuclcard.2024.102010","DOIUrl":"10.1016/j.nuclcard.2024.102010","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to assess the impact of dedicated cardiac protocol (DCP) on diagnostic accuracy of state-of-the-art digital [¹⁸F]-FDG-PET/CT in infective endocarditis (IE) and the intra-individual comparison of the performance with that of conventional whole-body approach (WBA) and to analyze the effects of the expertise level of the investigators.</div></div><div><h3>Methods</h3><div>44 patients suspected for IE underwent digital-FDG-PET/CT after overnight fasting. Each three consultants and trainees reread PET images blinded to the examination approach and clinical information. Visual and semiquantitative analyses were performed.</div></div><div><h3>Results</h3><div>Digital-FDG-PET/CT with DCP revealed sensitivity, specificity, and accuracy of 89%, 93%, and 91% for native valve endocarditis (NVE) and 93%, 86%, and 91% for prosthetic valve endocarditis. Compared to WBA, substantial improvement of the diagnostic performance for NVE in DCP was evident, especially in trainees, but not as high compared to consultants. Digital-FDG-PET/CT enabled 79.5% reclassification of modified-Duke-Clinical-Criteria (mDC) with 34.1% upgrading and 45.4% downgrading.</div></div><div><h3>Conclusions</h3><div>This study provides new data using state-of-the-art digital-FDG-PET/CT with DCP improving the diagnostic accuracy in challenging cases of possible IE, particularly in NVE, provided that the investigators involved have the necessary expertise. These findings may have a significant impact on IE-related morbidity, mortality, and patient's management and might be meaningful for updates on the prevailing opinion regarding the value of FDG PET/CT in NVE.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary cardiac angiosarcoma confirmed by immunophenotype of pericardial fluid and multimodal imaging modalities","authors":"","doi":"10.1016/j.nuclcard.2024.101887","DOIUrl":"10.1016/j.nuclcard.2024.101887","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141235337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Letter to the Editor","authors":"Alexander Liu MBBS MRCP,&nbsp;Kshama Wechalekar MBBS, DRM, DNB","doi":"10.1016/j.nuclcard.2024.102033","DOIUrl":"10.1016/j.nuclcard.2024.102033","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In search of the answers to the viability questions","authors":"Mehmet Onur Omaygenc MD ,&nbsp;Holly Morgan PhD ,&nbsp;Lisa Mielniczuk MD, FRCPC, FCCS ,&nbsp;Divaka Perera MA, MD, FRCP ,&nbsp;Julio A. Panza MD","doi":"10.1016/j.nuclcard.2024.101912","DOIUrl":"10.1016/j.nuclcard.2024.101912","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}