Journal of Nuclear Cardiology最新文献

{"title":"XTR003, a fatty acid metabolism PET tracer: A phase I study to evaluate the safety, biodistribution, radiation dosimetry, and pharmacokinetics in healthy volunteers.","authors":"Tiantian Mou, Jingjing Meng, Chengyu Lin, Xiaofen Xie, Bailing Hsu, Xiaoli Zhang","doi":"10.1016/j.nuclcard.2025.102144","DOIUrl":"10.1016/j.nuclcard.2025.102144","url":null,"abstract":"<p><strong>Purpose: </strong>XTR003 is a novel ¹⁸F-labeled fatty acid PET tracer to image myocardial fatty acid metabolism that can be potentially used to assess myocardial viability for ischemic heart disease. This Phase I study evaluated its safety, biodistribution, radiation dosimetry, and pharmacokinetics.</p><p><strong>Methods: </strong>Ten healthy Chinese volunteers (mean age of 28.4 ± 4.6 years, 3 females) were intravenously injected with XTR003 (296-370 MBq) at rest and monitored for adverse events on the day of injection and follow-up days. Multiple whole-body PET images were acquired within 290 minutes and processed to investigate the biodistribution and radiation dosimetry. Whole blood, plasma, and urine were collected simultaneously for 420 minutes to evaluate the pharmacokinetics with the measurement of radioactivity.</p><p><strong>Results: </strong>Only two treatment-related adverse events occurred with no severe adverse effects. After tracer injection, XTR003 in the plasma peaked at 2.883 minutes as .0108235% of injected dose per gram (%ID/g) and reduced to the minimum at 30 minutes. The 0-20 minutes whole-body PET images indicated that both heart and liver were two critical organs with the highest percentage of injected dose (%ID) (4.37 ± .66 and 48.76 ± 4.17 %ID). Specifically, XTR003 demonstrated high initial uptake in the heart, with sustained retention for up to 290 minutes (standardized uptake value: 6.50 ± 2.54 at 0-20 minutes and 5.89 ± 2.18 at 270-290 minutes). The whole-body effective radiation dose was 17 μSv/MBq. The cumulative urinary excretion was 9.009%.</p><p><strong>Conclusions: </strong>XTR003, as an¹⁸F-labeled radiotracer, was safe and well-tolerated. The rapid uptake and prolonged retention of XTR003 in the heart show promise for evaluating myocardial fatty acid metabolism. The Phase II clinical trial to explore the efficacy of XTR003 for detecting myocardial viability should be warranted.</p><p><strong>Trail registration number: </strong>ClinicalTrials.gov Identifier: NCT05136391.</p>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":" ","pages":"102144"},"PeriodicalIF":3.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A focus on women's heart health – Raising Awareness: Women's Heart Health Day","authors":"Panithaya Chareonthaitawee MD","doi":"10.1016/j.nuclcard.2025.102141","DOIUrl":"10.1016/j.nuclcard.2025.102141","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"44 ","pages":"Article 102141"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143403353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"‘TIDing’ over the uncertainty: Prognostic value of Transient Ischemic Dilation in Rubidium-82 PET myocardial perfusion imaging","authors":"Christoph Rischpler","doi":"10.1016/j.nuclcard.2025.102142","DOIUrl":"10.1016/j.nuclcard.2025.102142","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"44 ","pages":"Article 102142"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143403502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the effectiveness of tafamidis therapy in patients with transthyretin cardiac amyloidosis using 99mtechnetium pyrophosphate cardiac imaging","authors":"Tatsuro Tasaka MD ,&nbsp;Akiyoshi Ogimoto MD, PhD ,&nbsp;Makoto Saito MD, PhD ,&nbsp;Shota Koike MD ,&nbsp;Tamami Kono MD, PhD ,&nbsp;Kiyotaka Ohshima MD, PhD ,&nbsp;Mareomi Hamada MD, PhD","doi":"10.1016/j.nuclcard.2024.102075","DOIUrl":"10.1016/j.nuclcard.2024.102075","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"44 ","pages":"Article 102075"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142622248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current practices in amyloidosis imaging with bone-avid tracer cardiac scintigraphy","authors":"Sarah A.M. Cuddy MD, MPH ,&nbsp;Omar Abou-Ezzeddine MD, CM, MS ,&nbsp;Linda P. Giering ,&nbsp;Sharmila Dorbala MD, MPH ,&nbsp;Jamieson M. Bourque MD, MHS, FASNC","doi":"10.1016/j.nuclcard.2024.102078","DOIUrl":"10.1016/j.nuclcard.2024.102078","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"44 ","pages":"Article 102078"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of transient ischemic dilation on Rubidium-82 positron emission tomography myocardial perfusion imaging","authors":"Krishna K. Patel MD, MSc ,&nbsp;Phillip Lim MD ,&nbsp;Poghni A. Peri-Okonny MD, MSc ,&nbsp;Annapoorna Singh MD ,&nbsp;A. Iain McGhie MD ,&nbsp;Basera Sabharwal MD ,&nbsp;Vikram Agarwal MD ,&nbsp;Leslee J. Shaw PhD ,&nbsp;Timothy M. Bateman MD","doi":"10.1016/j.nuclcard.2024.102084","DOIUrl":"10.1016/j.nuclcard.2024.102084","url":null,"abstract":"<div><h3>Background</h3><div>Transient ischemic dilation (TID) of the left ventricular (LV) cavity is considered a high-risk marker in patients with abnormal single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI). Stress image acquisition with rubidium-82 (⁸²Rb) PET occurs at peak stress compared to 30–60 minutes post-stress with SPECT. We aimed to evaluate the prognostic value of TID in patients undergoing ⁸²Rb PET MPI.</div></div><div><h3>Methods</h3><div>A total of 9878 consecutive patients with LVEF ≥40% undergoing rest/pharmacologic stress ⁸²Rb PET MPI from 2010 to 2016 were followed for a median of 3.2 years. The primary clinical outcome of cardiac death was assessed after adjusting for pre-test risk, known coronary artery disease (CAD), resting left ventricular ejection fraction (LVEF), summed stress score (SSS), LVEF reserve (LVEF-R), myocardial blood flow reserve (MBFR), and early (90-day) revascularization. Pre-specified interactions between TID and SSS were included to assess potential differences in the prognostic value of TID in patients based on perfusion.</div></div><div><h3>Results</h3><div>The mean age of the cohort was 69.0 (11.7) years with 56.1% being female, 49.8% having known CAD, and 27.9% having abnormal perfusion (SSS&gt;0). There were 451 cardiac deaths. Higher TID ratios were associated with higher risk of cardiac death, even after accounting for LVEF-R and MBFR (HR per .1 unit increase = 1.25 (1.11, 1.41), <em>P</em> &lt; .001). This was seen in patients with both normal (HR for TID per .1 unit increase = 1.24 (95% CI: 1.01, 1.52), <em>P</em> = .04) and abnormal perfusion (HR for TID per .1 unit increase = 1.14 (95% CI: 1.02, 1.28), <em>P</em> = .03).</div></div><div><h3>Conclusions</h3><div>TID on rest/stress ⁸²Rb PET MPI offers independent prognostic value in patients with both normal and abnormal perfusion independent of other risk factors in patients with LVEF ≥40%.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"44 ","pages":"Article 102084"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amyloidosis imaging in focus: The evolution of bone-avid cardiac scintigraphy in the era of disease-modifying therapies","authors":"Marcelo F. Di Carli MD, MASNC","doi":"10.1016/j.nuclcard.2025.102150","DOIUrl":"10.1016/j.nuclcard.2025.102150","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"44 ","pages":"Article 102150"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143402700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing motion in the estimation of myocardial blood flow with [F-18] flurpiridaz positron emission tomography","authors":"Jonathon A. Nye,&nbsp;Sameer V. Tipnis","doi":"10.1016/j.nuclcard.2024.102123","DOIUrl":"10.1016/j.nuclcard.2024.102123","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"44 ","pages":"Article 102123"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143403501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automatic motion correction for myocardial blood flow estimation improves diagnostic performance for coronary artery disease in 18F-flurpiridaz positron emission tomography-myocardial perfusion imaging","authors":"Valerie Builoff BS ,&nbsp;Cathleen Huang BA ,&nbsp;Keiichiro Kuronuma MD, PhD ,&nbsp;Chih-Chun Wei MS ,&nbsp;Hidesato Fujito MD, PhD ,&nbsp;Yuka Otaki MD, PhD ,&nbsp;Serge D. Van Kriekinge PhD ,&nbsp;Paul Kavanagh MS ,&nbsp;Mark Lemley BS ,&nbsp;Mark C. Hyun CNMT ,&nbsp;Marcelo Di Carli MD ,&nbsp;Daniel S. Berman MD ,&nbsp;Piotr J. Slomka PhD","doi":"10.1016/j.nuclcard.2024.102072","DOIUrl":"10.1016/j.nuclcard.2024.102072","url":null,"abstract":"<div><h3>Background</h3><div>Motion correction (MC) is critical for accurate quantification of myocardial blood flow (MBF) and flow reserve (MFR) from ¹⁸F-flurpiridaz positron emission tomography (PET) myocardial perfusion imaging (MPI). However, manual correction is time consuming and introduces inter-observer variability. We aimed to validate an automatic MC algorithm for ¹⁸F-flurpiridaz PET-MPI in terms of diagnostic performance for predicting coronary artery disease (CAD).</div></div><div><h3>Methods</h3><div>In total, 231 patients who underwent invasive coronary angiography and rest/pharmacologic stress ¹⁸F-flurpiridaz PET-MPI from the phase III Flurpiridaz trial (NCT01347710) were enrolled. For manual MC, two operators (Reader 1 and Reader 2) shifted each frame's images in three directions. The automatic MC algorithm, initially developed for ⁸²Rb-chloride PET-MPI, was optimized for ¹⁸F-flurpiridaz. Diagnostic performance was compared using minimal segmental MBF/MFR with and without MC to predict obstructive CAD by invasive coronary angiography.</div></div><div><h3>Results</h3><div>Manual MC took 10 minutes per case (both stress and rest) on average, while automatic MC required &lt;10 seconds. The area under the receiver operating characteristic curves (AUCs) for significant CAD using minimal segmental MBF were comparable between automatic and manual MC (AUC = 0.877 automatic, AUC = 0.888 Reader 1 and AUC = 0.892 Reader 2; all <em>P</em> &gt; 0.05). AUCs of minimal segmental MBF with manual and automatic MC were significantly higher than without MC (<em>P</em> &lt; 0.05 for both). Similar findings were observed with minimal segmental MFR.</div></div><div><h3>Conclusions</h3><div>Automatic MC can be performed rapidly, with diagnostic performance for predicting obstructive CAD comparable to manual MC. This method could be utilized for analysis of MBF/MFR in patients undergoing ¹⁸F-flurpiridaz PET-MPI.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"44 ","pages":"Article 102072"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transient ischemic dilatation in cardiac amyloidosis","authors":"Bethlehem Mengesha MD,&nbsp;Gary Small MD,&nbsp;David Ian Paterson MD,&nbsp;Benjamin Chow MD","doi":"10.1016/j.nuclcard.2024.102042","DOIUrl":"10.1016/j.nuclcard.2024.102042","url":null,"abstract":"<div><div>Myocardial perfusion abnormalities and altered myocardial blood flow have been described in cardiac amyloidosis. Transient ischemic dilatation (TID) on perfusion imaging has been seen in the presence of multivessel coronary artery disease (CAD), hypertrophic cardiomyopathy, significant LV systolic dysfunction and hypertensive cardiomyopathy. But to our knowledge this phenomenon has not been described in cardiac amyloidosis. We present a case of cardiac amyloidosis presenting with transient ischemic dilatation on myocardial perfusion imaging.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"44 ","pages":"Article 102042"},"PeriodicalIF":3.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}