Journal of Nuclear Cardiology最新文献

{"title":"Coronary Microvascular Dysfunction in Systemic Inflammatory Diseases: From Pathophysiology and Prevalence to Diagnosis and Management.","authors":"Helene DiGregorio, Kenneth Williams, Brittany Weber, Attila Feher","doi":"10.1016/j.nuclcard.2025.102504","DOIUrl":"https://doi.org/10.1016/j.nuclcard.2025.102504","url":null,"abstract":"<p><p>Coronary microvascular dysfunction (CMVD) significantly contributes to increased cardiovascular morbidity and mortality in patients with autoimmune systemic inflammatory diseases. Clinicians should maintain a high index of suspicion for CMVD when discussing cardiovascular symptoms in this patient population. In symptomatic patients without obstructive coronary artery disease, diagnostic evaluation of CMVD should be considered carefully. In this review, we will outline the pathophysiology of CMVD, with an emphasis on the role of inflammation in the development and progression of microvascular disease. We will also review available noninvasive and invasive diagnostic testing for the detection of microvascular disease and discuss evidence-based strategies for managing CMVD in these complex patients.</p>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":" ","pages":"102504"},"PeriodicalIF":2.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145206740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to manage patients receiving long-term suppressive antibiotic treatment for infective endocarditis: the role of [18F]-FDG-PET/CT imaging - An international multidisciplinary survey.","authors":"Renato Pascale, Núria Fernández-Hidalgo, Beatrice Tazza, Michele Bartoletti, Lorenzo Bertolino, Emanuele Durante-Mangoni, Albert Roque Pérez, María Nazarena Pizzi, Pierluigi Viale, Maddalena Giannella","doi":"10.1016/j.nuclcard.2025.102505","DOIUrl":"https://doi.org/10.1016/j.nuclcard.2025.102505","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":" ","pages":"102505"},"PeriodicalIF":2.7,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodality Imaging Training in 2025 and Beyond.","authors":"Richard Ferraro, Cory S Henderson, Chaitanya Madamanchi","doi":"10.1016/j.nuclcard.2025.102506","DOIUrl":"https://doi.org/10.1016/j.nuclcard.2025.102506","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":" ","pages":"102506"},"PeriodicalIF":2.7,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"National Trends in Radiopharmaceutical Use for the Diagnosis of Cardiac Amyloidosis from 2019-2024.","authors":"Mirza S Khan, Hima Sanjana Perumalla, Karnav Modi, Talal Asif, Randall C Thompson, Timothy M Bateman, Brett W Sperry","doi":"10.1016/j.nuclcard.2025.102502","DOIUrl":"https://doi.org/10.1016/j.nuclcard.2025.102502","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":" ","pages":"102502"},"PeriodicalIF":2.7,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of timing window and gating method for ¹⁸F-FDG PET/CT in patients with suspected prosthetic valve endocarditis: A prospective pilot study.","authors":"Eefje M Dalebout, Alexander Hirsch, Ties A Mulders, Marcel Segbers, Ali R Wahadat, Marina Muchnik Kurash, Jolanda Kluin, Jolien W Roos-Hesselink, Ricardo P J Budde","doi":"10.1016/j.nuclcard.2025.102501","DOIUrl":"https://doi.org/10.1016/j.nuclcard.2025.102501","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":" ","pages":"102501"},"PeriodicalIF":2.7,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical impact of Reverse Redistribution in Myocardial Perfusion Imaging.","authors":"Su Xingzhou, Yu Wenji, Xie Qifei, Song Xuhong, Wang Jianfeng, Zhang Feifei, Shao Xiaoliang, Wan Peng, Chen Yongjun, Liu Bao, Yang Xiaoyu, Wang Yuetao","doi":"10.1016/j.nuclcard.2025.102500","DOIUrl":"https://doi.org/10.1016/j.nuclcard.2025.102500","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":" ","pages":"102500"},"PeriodicalIF":2.7,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Perfusion with AI-derived Coronary Calcium on CT attenuation scans to improve selection of low-risk studies for stress-only SPECT MPI.","authors":"Robert J H Miller, Orit Barrett, Aakash Shanbhag, Alan Rozanski, Damini Dey, Mark Lemley, Serge D Van Kriekinge, Paul B Kavanagh, Attila Feher, Edward J Miller, Andrew J Einstein, Terrence D Ruddy, Timothy Bateman, Philip A Kaufmann, Joanna X Liang, Daniel S Berman, Piotr J Slomka","doi":"10.1016/j.nuclcard.2025.102482","DOIUrl":"https://doi.org/10.1016/j.nuclcard.2025.102482","url":null,"abstract":"<p><strong>Background: </strong>In many contemporary laboratories a completely normal stress perfusion SPECT-MPI is required for rest imaging cancelation. We hypothesized that an artificial intelligence (AI)-derived CAC score of 0 from computed tomography attenuation correction (CTAC) scans obtained during hybrid SPECT/CT, may identify additional patients at low risk of MACE who could be selected for stress-only imaging.</p><p><strong>Methods and results: </strong>Patients without known coronary artery disease who underwent SPECT/CT MPI and had stress total perfusion deficit (TPD) <5% were included. Stress TPD was categorized as no abnormality (stress TPD 0%) or minimal abnormality (stress TPD 1-4%). CAC was automatically quantified from the CTAC scans. We evaluated associations with major adverse cardiovascular events (MACE). In total, 6,884 patients (49.4% males and median age 63 years) were included. Of these, 9.7% experienced MACE (15% non-fatal MI, 2.7% unstable angina, 38.5% coronary revascularization and 43.8% deaths). Compared to patients with TPD 0%, those with TPD 1-4% and CAC 0 had lower MACE risk (hazard ratio [HR] 0.58; 95% confidence interval [CI] 0.45-0.76), while those with TPD 1-4% and CAC score>0 had a higher MACE risk (HR 1.90; 95%CI 1.56-2.30). Compared to canceling rest scans only in patients with normal perfusion (TPD 0%), by canceling rest scans in patients with CAC 0, more than twice as many rest scans (55% vs 25%) could be cancelled.</p><p><strong>Conclusion: </strong>Using AI-derived CAC 0 on CT scans with hybrid SPECT/CT in patients with a stress TPD<5% can double the proportion of patients in whom stress-only procedures could be safely performed.</p>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":" ","pages":"102482"},"PeriodicalIF":2.7,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145054242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to prepare patients for fluorine-18 fluorodeoxyglucose positron emission tomography myocardial viability assessment.","authors":"Bruno B Lima, Marvin W Kronenberg, Chloe M Carr, Jessica Duran, Panithaya Chareonthaitawee","doi":"10.1016/j.nuclcard.2025.102480","DOIUrl":"10.1016/j.nuclcard.2025.102480","url":null,"abstract":"<p><p>Myocardial viability assessment can be valuable in the management of selected patients with moderate-to-severe ischemic cardiomyopathy. Among the viability imaging modalities, 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) is a key tool for evaluating myocardial metabolic activity, helping to distinguish viable myocardium from scar tissue. Optimal metabolic preparation is crucial to enhance myocardial glucose uptake and ensure accurate imaging, particularly in diabetic patients with variable insulin resistance. This review presents a clinical case illustrating the role of 18F-FDG PET in myocardial viability assessment, explores different metabolic preparation protocols, and examines their clinical implications. The hyperinsulinemic euglycemic clamp (HEC) remains the most effective technique; however,alternative protocols, such as intravenous glucose loading with insulin, are increasingly utilized for their efficiency and practicality. A comparative analysis of these methods provides insight into their suitability for different patient populations. This review also emphasizes the importance of a standardized yet adaptable approach to metabolic preparation,considering individual patient factors and institutional resources. Emerging literature supporting optimized PET imaging protocols is highlighted to help guide clinical decision-making for revascularization in patients with moderate-to-severe ischemic cardiomyopathy.</p>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":" ","pages":"102480"},"PeriodicalIF":2.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theranostics in nuclear cardiology: Approaching harbour or boundless horizon?","authors":"James T Thackeray","doi":"10.1016/j.nuclcard.2025.102481","DOIUrl":"10.1016/j.nuclcard.2025.102481","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":" ","pages":"102481"},"PeriodicalIF":2.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac nuclear imaging workforce: Trends from Medicare Part B (2013-2022).","authors":"Maria Alwan, Ahmad El Yaman, Ahmed Sayed, Asim Shaikh, Phillips M Lawrence, Mahmoud Al Rifai, Mouaz H Al-Mallah","doi":"10.1016/j.nuclcard.2025.102472","DOIUrl":"https://doi.org/10.1016/j.nuclcard.2025.102472","url":null,"abstract":"<p><strong>Background: </strong>Cardiac positron emission tomography (PET) and single-photon emission computed tomography (SPECT) are widely used for the assessment of coronary artery disease. While SPECT remains more available, workforce shortages and training demands contribute to geographic disparities in PET availability, impacting patient access to advanced imaging. Therefore, we assessed trends in the U.S. cardiac nuclear imaging workforce.</p><p><strong>Methods: </strong>Data from Medicare Part B (2013-2022), provided by the Centers for Medicare & Medicaid Services, were analyzed to assess trends in cardiac nuclear imaging services billed by physicians. The analysis focused on the number of readers, their gender, specialty, geographic distribution, and workload.</p><p><strong>Results: </strong>From 2013 to 2022, the proportion of SPECT procedures declined from 95.8% (2,303,194 scans; 4393 per 100,000 Medicare beneficiaries) to 86.3% (1,386,358 scans; 2130 per 100,000 Medicare beneficiaries) of total nuclear cardiology procedures, while the proportion of PET procedures increased from 4.2% (99,861 scans; 190 per 100,000 Medicare beneficiaries) to 13.7% (220,366 scans; 339 per 100,000 Medicare beneficiaries). The majority of studies were interpreted by readers performing 50 or more studies annually. From 2013 to 2022, the number of SPECT-only readers declined from 17,013 to 13,491, while PET-only readers increased from 66 to 386. Readers interpreting both SPECT and PET doubled from 822 to 1643. Only 1 in 10 nuclear imaging readers were women and the majority were cardiologists. The median (interquartile range) number of studies per reader was higher for cardiologists compared to those of other specialties. Geographic disparities were evident, with most nuclear imaging readers practicing in Texas, Florida, and California, while the fewest were in Wyoming, Alaska, Vermont, and Washington, D.C.</p><p><strong>Conclusions: </strong>While SPECT remained the most commonly used modality in 2022, its use has declined, whereas PET use has increased, accompanied by similar trends in the number of readers. Gender and geographic disparities persist in the distribution of nuclear cardiology imaging specialists. Addressing these gaps is essential to ensuring equitable access to nuclear imaging expertise.</p>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":" ","pages":"102472"},"PeriodicalIF":2.7,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}