Journal of Nuclear Cardiology最新文献

{"title":"Post-Treatment Bias and the Prognostic Utility of Stress Myocardial Perfusion Imaging.","authors":"Alan Rozanski, Heidi Gransar, Robert Jh Miller, Donghee Han, Piotr Slomka, Sean W Hayes, John D Friedman, Daniel S Berman","doi":"10.1016/j.nuclcard.2025.102248","DOIUrl":"https://doi.org/10.1016/j.nuclcard.2025.102248","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":" ","pages":"102248"},"PeriodicalIF":3.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Attenuation Correction and Prone Positioning on Stress-Only Imaging in Cardiac SPECT: An Observational Study.","authors":"Maria Alwan, Ahmed Sayed, Ahmed Ibrahim Ahmed, Asim Shaikh, Ahmad El Yaman, Mahmoud Al Rifai, Mouaz H Al-Mallah","doi":"10.1016/j.nuclcard.2025.102249","DOIUrl":"https://doi.org/10.1016/j.nuclcard.2025.102249","url":null,"abstract":"<p><strong>Background: </strong>Current guidelines recommend stress-only single photon emission computed tomography myocardial perfusion imaging (SPECT MPI) in select patients to reduce time, cost, and radiation. However, stress-only imaging remains underutilized.</p><p><strong>Objectives: </strong>We assessed techniques to increase the adoption of stress-only SPECT MPI, specifically evaluating whether prone positioning and CT-based attenuation correction (AC) reduce the need for additional rest imaging.</p><p><strong>Methods: </strong>Consecutive patients with normal stress SPECT MPI scans were included. The need for additional rest imaging was assessed according to the use of prone-positioning and AC. Radiotracer dose was calculated per the institution's protocol and compared between groups. Survival analysis compared the safety of stress-only protocols compared to stress-rest protocols.</p><p><strong>Results: </strong>Between 2018 and 2024, 14,274 patients with no stress perfusion defects were included. The use of stress-only imaging increased from 43.6% among patients with neither AC nor prone to 63.4% with AC and 65.7% with prone to 76 % with both techniques. Using multivariable logistic regression, the simultaneous use of prone and AC techniques significantly increased stress-only imaging (OR: 5.0, 95% CI: 4.38-5.72). This was more pronounced among females, obese patients, patients >65 years, and patients with an EF ≥ 55%. Radiotracer dose dropped by 35.6% when both AC and prone were used. Patients with normal stress-only SPECT scans had similar prognoses to those with normal SPECT scans using both stress and rest images, regardless of AC or prone imaging use.</p><p><strong>Conclusion: </strong>Combined use of AC and prone reduces the need for rest imaging by nearly half and lowers radiotracer doses by a third. Benefits are more pronounced in women, the elderly, patients with obesity, non-diabetics and those with preserved ejection fraction.</p>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":" ","pages":"102249"},"PeriodicalIF":3.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"¹⁸F-FDG PET-CT in patients with prosthetic heart valves: variations in imaging findings: A review of the literature.","authors":"Eefje M Dalebout, Laurens E Swart, Jolanda Kluin, Annick C Weustink, Ties A Mulders, Jolien W Roos-Hesselink, Alexander Hirsch, Ricardo P J Budde","doi":"10.1016/j.nuclcard.2025.102247","DOIUrl":"https://doi.org/10.1016/j.nuclcard.2025.102247","url":null,"abstract":"<p><p>Imaging is a cornerstone of the diagnosis of prosthetic valve endocarditis. An abnormal ¹⁸F-FDG PET-CT was added as a major diagnostic criterion in the 2015 European Society of Cardiology guidelines for the management of endocarditis. However, interpretation of uptake around prosthetic heart valves (PHVs) can be difficult, because physiological factors and confounders may result in false-positive or false-negative results. This review provides a comprehensive overview of 'normal' uptake by reviewing the literature on uptake surrounding non-infected PHVs. We will elaborate on qualitative and quantitative measures of uptake. Then, differences in uptake between different valve types, implant positions and the natural course of uptake over time following PHV implantation will be discussed. Finally, factors possibly hampering assessment or mimicking infection are reviewed. We aim to support clinical implementation of ¹⁸F-FDG PET-CT in suspected prosthetic valve endocarditis and to provide practical guidance to the differentiation between physiological, postoperative and pathological uptake around PHVs.</p>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":" ","pages":"102247"},"PeriodicalIF":3.0,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac positron emission tomography/Computed tomography (PET/CT) in current cardiology guidelines.","authors":"Maria Alwan, Ahmad El Yaman, Ahmed Sayed, Asim Shaikh, Mahmoud Al Rifai, Mouaz H Al-Mallah","doi":"10.1016/j.nuclcard.2025.102231","DOIUrl":"10.1016/j.nuclcard.2025.102231","url":null,"abstract":"<p><p>Cardiac positron emission tomography (PET) is increasingly utilized in clinical practice. This review examines the latest clinical practice guidelines from the American College of Cardiology/American Heart Association (ACC/AHA), the European Society of Cardiology (ESC), the International Society for Heart and Lung Transplantation (ISHLT), and multisocietal consensus statements as of December 2024, to assess the extent to which cardiac PET is incorporated into their recommendations.</p>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":" ","pages":"102231"},"PeriodicalIF":3.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of medical therapies with survival according to SPECT MPI findings.","authors":"Waseem Hijazi, Yuanchao Feng, Danielle A Southern, Derek Chew, Neil Filipchuk, Ilias Mylonas, Mustapha Kazmi, Hamid Banijamali, Bryan Har, Matthew James, Stephen Wilton, Piotr J Slomka, Daniel Berman, Robert Jh Miller","doi":"10.1016/j.nuclcard.2025.102229","DOIUrl":"10.1016/j.nuclcard.2025.102229","url":null,"abstract":"<p><strong>Background: </strong>Myocardial perfusion imaging (MPI) results in downstream changes to medication prescription. While the benefits of medical therapy for coronary artery disease (CAD) are established, how this varies with MPI findings is unknown. Our goal was to evaluate the association of medical therapy with survival among patients undergoing MPI, including differential associations as a function of imaging findings.</p><p><strong>Methods: </strong>Consecutive patients who underwent single-photon emission computed tomography MPI for suspected CAD between January 2015 and December 2021 were identified. Multivariable Cox regression modeling was used to assess the associations between medical therapy and all-cause mortality.</p><p><strong>Results: </strong>In total, 7802 patients were included with a mean age of 66.1 ± 12.0 years and 3841 (49.2 %) male patients. Angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACE inhibitors/ARBs) were associated with lower mortality (adjusted hazard ratio [HR] .66, 95 % confidence interval [CI]: .57-.77, P < .001). Beta-blockers were not associated with mortality overall (adjusted HR .95, 95 % CI: .83-1.10, P = .506) but were associated with lower mortality among patients with more ischemia (HR .94 per summed difference score point, 95 % CI: .90-.97, P-value <.001). Statins were associated with greater survival in patients with coronary calcium (adjusted HR .67, 95 % CI .56-.81, P = <0.001) but not in patients without assessment of coronary calcium (adjusted HR: 1.16, 95 % CI: .91-1.49 P = .236).</p><p><strong>Conclusion: </strong>ACE/ARB prescription was significantly associated with improved survival. Beta-blocker prescription was associated with greater survival in patients with ischemia and statins were in patients with coronary calcification. Findings from MPI may identify patients more likely to benefit from specific therapies, suggesting a role for hybrid MPI in guiding medical therapy for CAD.</p>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":" ","pages":"102229"},"PeriodicalIF":3.0,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Independent prognostic significance of myocardial flow reserve over coronary artery calcium, myocardial perfusion, and clinical variables in patients without known coronary artery disease, according to diabetes status","authors":"Su Nam Lee MD, PhD ,&nbsp;Pankaj Malhotra MD ,&nbsp;Robert J.H. Miller MD ,&nbsp;Heidi Gransar MS ,&nbsp;Sean W. Hayes MD ,&nbsp;John D. Friedman MD ,&nbsp;Louise E.J. Thomson MBChB ,&nbsp;Alan Rozanski MD ,&nbsp;Piotr J. Slomka PhD ,&nbsp;Donghee Han MD ,&nbsp;Daniel S. Berman MD","doi":"10.1016/j.nuclcard.2025.102165","DOIUrl":"10.1016/j.nuclcard.2025.102165","url":null,"abstract":"<div><h3>Objective</h3><div>To explore differences in prevalence and prognosis associated with reduced myocardial flow reserve (MFR) in patients without known coronary artery disease (CAD) based on diabetes status.</div></div><div><h3>Methods</h3><div>Of 2639 patients without known CAD who underwent rubidium positron emission tomography myocardial perfusion imaging (MPI), 818 patients (31%) had diabetes. Reduced MFR was defined as MFR &lt;2.0. Coronary artery calcium (CAC) score was categorized as 0, 1-99, 100-399, and ≥400. Ischemic total perfusion deficit (TPD) was categorized as &lt;1%, 1-&lt;5%, and ≥5%. Outcome variables were all-cause death (ACD) and non-fatal myocardial infarction (MI).</div></div><div><h3>Results</h3><div>During the median follow-up of 4.1 years, 574 (21.8%) ACD/MI occurred (204 [25.1%] diabetic patients, 370 [20.3%] nondiabetic patients). In multivariable Cox analysis, reduced MFR was associated with increased ACD/MI in patients with diabetes (per .1 decrease: HR: 1.04, 95% CI: 1.02-1.06, <em>P</em> &lt; .001) and patients without diabetes (per .1 decrease: HR: 1.03, 95% CI: 1.02-1.04, <em>P</em> &lt; .001). No interaction existed between diabetes and MFR for ACD/MI risk regardless of CAC or ischemic burden (all <em>P</em> &gt; .05). Adding MFR to the risk prediction model of clinical, conventional MPI findings, and CAC improved the discrimination for clinical outcomes in both groups (DM: .003, non-DM: &lt;.001, respectively).</div></div><div><h3>Conclusion</h3><div>Reduced MFR was more common in patients with diabetes and an important independent prognostic marker over CAC and clinical variables. The association between MFR and ACD/MI risk did not differ between patients with and without diabetes who had no prior CAD, regardless of CAC and ischemic burden.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"47 ","pages":"Article 102165"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probing the shadows of myocardial scar: Can PET MPI see what MRI sees?","authors":"Michael T. Osborne MD ,&nbsp;Mouaz H. Al-Mallah MD, MSc","doi":"10.1016/j.nuclcard.2025.102221","DOIUrl":"10.1016/j.nuclcard.2025.102221","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"47 ","pages":"Article 102221"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative radionuclide imaging – An opportunity to optimize and personalize care of ATTR cardiomyopathy","authors":"Dominik C. Benz MD ,&nbsp;Sarah A.M. Cuddy MD","doi":"10.1016/j.nuclcard.2025.102225","DOIUrl":"10.1016/j.nuclcard.2025.102225","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"47 ","pages":"Article 102225"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliable answers to patients’ questions: A fundamental need in any patient education tool, especially generative artificial intelligence","authors":"Alfonso H. Waller MD, FASNC ,&nbsp;Baoqiong Liu MD","doi":"10.1016/j.nuclcard.2025.102227","DOIUrl":"10.1016/j.nuclcard.2025.102227","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"47 ","pages":"Article 102227"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring time in the arteries: Imaging biomarkers of vascular aging in focus","authors":"Marcelo F. Di Carli MD, MASNC","doi":"10.1016/j.nuclcard.2025.102234","DOIUrl":"10.1016/j.nuclcard.2025.102234","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"47 ","pages":"Article 102234"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}