Journal of Nuclear Cardiology最新文献

{"title":"Coronary Anatomy Matters: Dual LAD Presenting as Atypical Ischemia on Myocardial Perfusion Imaging.","authors":"Raza Abbas Mahdi, Harpreet Singh, Janarthanan Ilangovan, Neelam Dahiya, Bhagwant Rai Mittal","doi":"10.1016/j.nuclcard.2025.102205","DOIUrl":"https://doi.org/10.1016/j.nuclcard.2025.102205","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":" ","pages":"102205"},"PeriodicalIF":3.0,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can ChatGPT answer patients' questions about nuclear stress tests and ¹⁸F-Flurodeoxyglucose PET for myocardial inflammation?","authors":"Kaitlin Shinn, Cory S Henderson, Aldo L Schenone, Sascha N Goonewardena, Supriya Shore, Venkatesh L Murthy, Chaitanya Madamanchi","doi":"10.1016/j.nuclcard.2025.102174","DOIUrl":"https://doi.org/10.1016/j.nuclcard.2025.102174","url":null,"abstract":"<p><strong>Background: </strong>Several modalities are used for stress testing and require specific patient preparation. ¹⁸F-Flurodeoxyglucose positron emission tomography (FDG PET) is an important tool in the diagnosis and risk stratification of patients suspected of cardiac sarcoidosis and endocarditis[1-3]. There is a need for improved patient access to questions regarding cardiac testing to ensure proper adherence to instructions. We sought to evaluate the effectiveness of ChatGPT in answering questions about stress testing and cardiac FDG PET inflammation scans.</p><p><strong>Methods and results: </strong>We generated fifty-eight questions about stress testing and cardiac FDG PET inflammation scans. OpenAI ChatGPT 3.5 and 4o were used to answer the questions. The answers were graded by three nuclear cardiologists as: 1 = correct and complete, 2= somewhat correct/somewhat complete, 3 = incorrect: no benefit, or 4 = incorrect: harmful/misleading information (Table I). Of the 174 grades assigned to responses to the questions from ChatGPT 3.5, 62/174 (36%) were correct and complete, 93/174 (53%) were somewhat correct/somewhat complete, 12/174 (7%) were incorrect: no benefit, 7/174 (4%) were incorrect: harmful/misleading information. Of the grades assigned to responses to questions from ChatGPT-4o, 107/174 (61%) were correct and complete, 62/174 (36%) were somewhat correct/somewhat complete, 3/174 (2%) were incorrect: no benefit, 2/174 (1%) were incorrect: harmful/misleading information.</p><p><strong>Conclusions: </strong>ChatGPT can provide some accurate responses to patient questions regarding stress tests and cardiac FDG PET inflammation studies, and its accuracy has improved over time, however it is not suitable as a primary resource for clinical care at this stage of development.</p>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":" ","pages":"102174"},"PeriodicalIF":3.0,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caseous calcification as a cause of false positive FDG-PET/CT in native valve endocarditis","authors":"Yousef Kamel,&nbsp;Donato Terrone MD,&nbsp;Matthieu Pelletier-Galarneau MD, MSc","doi":"10.1016/j.nuclcard.2024.102058","DOIUrl":"10.1016/j.nuclcard.2024.102058","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"46 ","pages":"Article 102058"},"PeriodicalIF":3.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-walking exercise skeletal muscle perfusion and energetics in patients with symptomatic lower extremity peripheral artery disease","authors":"Sanjay Divakaran MD, MPH, FASNC ,&nbsp;Hendrik J. Harms PhD ,&nbsp;Matthew Robertson MD ,&nbsp;Sai K. Merugumala BS ,&nbsp;Mi-Ae Park PhD ,&nbsp;Marie F. Kijewski PhD ,&nbsp;Laurel B. Martell BS ,&nbsp;Victoria Morgan BS ,&nbsp;Leanne Barrett BS ,&nbsp;Anna Perillo BS ,&nbsp;David Yang BS ,&nbsp;Petr Jarolim MD, PhD ,&nbsp;Mark W. Feinberg MD ,&nbsp;Marie D. Gerhard-Herman MD ,&nbsp;Michael Belkin MD ,&nbsp;Alexander P. Lin PhD ,&nbsp;Mark A. Creager MD ,&nbsp;Marc P. Bonaca MD, MPH ,&nbsp;Marcelo F. Di Carli MD, MASNC","doi":"10.1016/j.nuclcard.2025.102143","DOIUrl":"10.1016/j.nuclcard.2025.102143","url":null,"abstract":"<div><h3>Background</h3><div>The pathophysiology of symptoms and reduced exercise capacity from peripheral artery disease (PAD) remains unclear. Additionally, there is limited information on blood flow and skeletal muscle energetics after walking exercise in patients with claudication in comparison to healthy individuals.</div></div><div><h3>Methods</h3><div>We prospectively enrolled 19 patients with claudication from PAD and 12 healthy subjects. All participants underwent rest and post-exercise perfusion imaging of the lower leg muscles via PET/CT. Participants exercised on a treadmill following the Gardner-Skinner protocol. Skeletal muscle blood flow (SMBF) was quantified in each leg at rest and immediately after exercise. Phosphocreatine (PCr) recovery and NAD⁺/NADH concentrations were measured pre- and post-exercise by ³¹P magnetic resonance spectroscopy (MRS) in a subset of participants. Comparisons were made between the legs of healthy subjects and the asymptomatic and symptomatic legs of patients with PAD.</div></div><div><h3>Results</h3><div>SMBF increased post-exercise in all participants. Among patients with PAD, the post-exercise/rest SMBF ratio, was higher in the symptomatic (n = 25) than asymptomatic (n = 13) legs (8.03 ± 2.84 vs 6.03 ± 2.81, <em>P</em> = 0.046) and higher than the post-exercise/rest SMBF ratio measured in the legs of healthy subjects (4.40 ± 1.47, <em>P</em> &lt; 0.001). The post-exercise/rest PCr and NAD⁺/NADH ratios were lower in the legs of patients with PAD (n = 3) when compared with the legs of healthy subjects (n = 6) (0.79 ± 0.06 vs 1.00 ± 0.07 (<em>P</em> = 0.004) and 1.15 ± 0.43 vs 2.08 ± 0.30 (<em>P</em> = 0.007), respectively).</div></div><div><h3>Conclusions</h3><div>SMBF increased post-exercise to the greatest degree in the symptomatic legs of patients with PAD and post-exercise skeletal muscle mitochondrial function was abnormal in patients with PAD. These data suggest that the causes of symptoms and reduced exercise capacity from PAD are not limited to abnormal perfusion pressure in the legs.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"46 ","pages":"Article 102143"},"PeriodicalIF":3.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing cardiac care: The role of positron emission tomography myocardial perfusion imaging and the introduction of F-18 flurpiridaz","authors":"Panithaya Chareonthaitawee MD","doi":"10.1016/j.nuclcard.2025.102177","DOIUrl":"10.1016/j.nuclcard.2025.102177","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"46 ","pages":"Article 102177"},"PeriodicalIF":3.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"XTR003, a fatty acid metabolism PET tracer: A phase I study to evaluate the safety, biodistribution, radiation dosimetry, and pharmacokinetics in healthy volunteers","authors":"Tiantian Mou PhD ,&nbsp;Jingjing Meng MD, PhD ,&nbsp;Chengyu Lin MD ,&nbsp;Xiaofen Xie BS ,&nbsp;Bailing Hsu PhD ,&nbsp;Xiaoli Zhang MD, PhD","doi":"10.1016/j.nuclcard.2025.102144","DOIUrl":"10.1016/j.nuclcard.2025.102144","url":null,"abstract":"<div><h3>Purpose</h3><div>XTR003 is a novel ¹⁸F-labeled fatty acid PET tracer to image myocardial fatty acid metabolism that can be potentially used to assess myocardial viability for ischemic heart disease. This Phase I study evaluated its safety, biodistribution, radiation dosimetry, and pharmacokinetics.</div></div><div><h3>Methods</h3><div>Ten healthy Chinese volunteers (mean age of 28.4 ± 4.6 years, 3 females) were intravenously injected with XTR003 (296-370 MBq) at rest and monitored for adverse events on the day of injection and follow-up days. Multiple whole-body PET images were acquired within 290 minutes and processed to investigate the biodistribution and radiation dosimetry. Whole blood, plasma, and urine were collected simultaneously for 420 minutes to evaluate the pharmacokinetics with the measurement of radioactivity.</div></div><div><h3>Results</h3><div>Only two treatment-related adverse events occurred with no severe adverse effects. After tracer injection, XTR003 in the plasma peaked at 2.883 minutes as .0108235% of injected dose per gram (%ID/g) and reduced to the minimum at 30 minutes. The 0-20 minutes whole-body PET images indicated that both heart and liver were two critical organs with the highest percentage of injected dose (%ID) (4.37 ± .66 and 48.76 ± 4.17 %ID). Specifically, XTR003 demonstrated high initial uptake in the heart, with sustained retention for up to 290 minutes (standardized uptake value: 6.50 ± 2.54 at 0-20 minutes and 5.89 ± 2.18 at 270-290 minutes). The whole-body effective radiation dose was 17 μSv/MBq. The cumulative urinary excretion was 9.009%.</div></div><div><h3>Conclusions</h3><div>XTR003, as an¹⁸F-labeled radiotracer, was safe and well-tolerated. The rapid uptake and prolonged retention of XTR003 in the heart show promise for evaluating myocardial fatty acid metabolism. The Phase II clinical trial to explore the efficacy of XTR003 for detecting myocardial viability should be warranted.</div></div><div><h3>Trail registration number</h3><div><span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> Identifier: NCT05136391.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"46 ","pages":"Article 102144"},"PeriodicalIF":3.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcoid imaging on the quantitative spectrum?","authors":"Robert A. deKemp ,&nbsp;Christiane Wiefels","doi":"10.1016/j.nuclcard.2025.102149","DOIUrl":"10.1016/j.nuclcard.2025.102149","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"46 ","pages":"Article 102149"},"PeriodicalIF":3.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New horizons in nuclear cardiology: Imaging of peripheral arterial disease","authors":"Santiago Callegari ,&nbsp;Carlos Mena-Hurtado ,&nbsp;Kim G. Smolderen ,&nbsp;Stephanie Thorn ,&nbsp;Albert J. Sinusas","doi":"10.1016/j.nuclcard.2024.102079","DOIUrl":"10.1016/j.nuclcard.2024.102079","url":null,"abstract":"<div><div>Lower extremity peripheral artery disease (PAD) is characterized by impairment of blood flow associated with arterial stenosis and frequently coexisting microvascular disease and is associated with high rates of morbidity and mortality. Current diagnostic modalities have limited accuracy in early diagnosis, risk stratification, preprocedural assessment, and evaluation of therapy and are focused on the detection of obstructive atherosclerotic disease. Early diagnosis and assessment of both large vessels and microcirculation may improve risk stratification and guide therapeutic interventions. Single-photon emission computed tomography and positron emission tomography imaging have been shown to be accurate to detect changes in perfusion in preclinical models and clinical disease, and have the potential to overcome limitations of existing diagnostic modalities, while offering novel information about perfusion, metabolic, and molecular processes. This review provides a comprehensive reassessment of radiotracer-based imaging of PAD in preclinical and clinical studies, emphasizing the challenges that arise due to the complex physiology in the peripheral vasculature. We will also highlight the latest advancements, underscoring emerging artificial intelligence and big data analysis, as well as clinically relevant areas where the field could advance in the next decade.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"46 ","pages":"Article 102079"},"PeriodicalIF":3.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disrupting the default: The innovation pipeline in nuclear cardiology","authors":"Marcelo F. Di Carli MD, MASNC","doi":"10.1016/j.nuclcard.2025.102206","DOIUrl":"10.1016/j.nuclcard.2025.102206","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"46 ","pages":"Article 102206"},"PeriodicalIF":3.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-walking exercise skeletal muscle perfusion and energetics in patients with symptomatic lower extremity peripheral artery disease","authors":"Neela D. Thangada MD","doi":"10.1016/j.nuclcard.2025.102204","DOIUrl":"10.1016/j.nuclcard.2025.102204","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"46 ","pages":"Article 102204"},"PeriodicalIF":3.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}