Journal of Nuclear Cardiology最新文献

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Cardiovascular positron emission tomography imaging of fibroblast activation: A review of the current literature 心血管成纤维细胞激活的PET显像综述。
IF 3 4区 医学
Journal of Nuclear Cardiology Pub Date : 2025-05-01 DOI: 10.1016/j.nuclcard.2024.102106
Krithika Loganath MD , Neil Craig MD , Anna Barton MD , Shruti Joshi MD , Constantinos Anagnostopoulos MD , Paola Anna Erba MD, PhD , Andor W.J.M. Glaudemans MD, PhD , Antti Saraste MD, PhD , Jan Bucerius MD , Mark Lubberink PhD , Olivier Gheysens MD, PhD , Ronny R. Buechel MD , Gilbert Habib MD , Oliver Gaemperli MD, FESC , Alessia Gimelli MD, FESC , Fabien Hyafil MD, PhD, FESC , David E. Newby MD, DSc , Riemer H.J.A. Slart MD, PhD , Marc R. Dweck MD, PhD
{"title":"Cardiovascular positron emission tomography imaging of fibroblast activation: A review of the current literature","authors":"Krithika Loganath MD ,&nbsp;Neil Craig MD ,&nbsp;Anna Barton MD ,&nbsp;Shruti Joshi MD ,&nbsp;Constantinos Anagnostopoulos MD ,&nbsp;Paola Anna Erba MD, PhD ,&nbsp;Andor W.J.M. Glaudemans MD, PhD ,&nbsp;Antti Saraste MD, PhD ,&nbsp;Jan Bucerius MD ,&nbsp;Mark Lubberink PhD ,&nbsp;Olivier Gheysens MD, PhD ,&nbsp;Ronny R. Buechel MD ,&nbsp;Gilbert Habib MD ,&nbsp;Oliver Gaemperli MD, FESC ,&nbsp;Alessia Gimelli MD, FESC ,&nbsp;Fabien Hyafil MD, PhD, FESC ,&nbsp;David E. Newby MD, DSc ,&nbsp;Riemer H.J.A. Slart MD, PhD ,&nbsp;Marc R. Dweck MD, PhD","doi":"10.1016/j.nuclcard.2024.102106","DOIUrl":"10.1016/j.nuclcard.2024.102106","url":null,"abstract":"<div><div>Fibrosis is one of the key healing responses to injury, especially within the heart, where it helps to maintain structural integrity following acute insults such as myocardial infarction. However, if it becomes dysregulated, then fibrosis can become maladaptive, leading to adverse remodelling, impaired cardiac function and heart failure. Fibroblast activation protein is exclusively expressed by activated fibroblasts, the key effector cells of fibrogenesis, and has a unique extracellular domain that is an ideal ligand for novel molecular imaging probes. Fibroblast activation protein inhibitor (FAPI) radiotracers have been developed for positron emission tomography (PET) imaging, demonstrating high selectivity for activated fibroblasts across a range of different pathologies and disparate organ systems. In this review, we will summarise the role of fibroblast activation protein in cardiovascular disease and how FAPI radiotracers might improve the assessment and treatment of patients with cardiovascular diseases.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"47 ","pages":"Article 102106"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
To screen or not to screen for transthyretin cardiac amyloidosis 筛查或不筛查转甲状腺素型心脏淀粉样变性
IF 3 4区 医学
Journal of Nuclear Cardiology Pub Date : 2025-05-01 DOI: 10.1016/j.nuclcard.2024.102122
Mallika Lal MD , Ahmad Masri MD, MS , Adam Ioannou MBBS, BSc, PhD , Marianna Fontana MD, PhD , Yevgeniy Brailovsky DO , Mathew S. Maurer MD
{"title":"To screen or not to screen for transthyretin cardiac amyloidosis","authors":"Mallika Lal MD ,&nbsp;Ahmad Masri MD, MS ,&nbsp;Adam Ioannou MBBS, BSc, PhD ,&nbsp;Marianna Fontana MD, PhD ,&nbsp;Yevgeniy Brailovsky DO ,&nbsp;Mathew S. Maurer MD","doi":"10.1016/j.nuclcard.2024.102122","DOIUrl":"10.1016/j.nuclcard.2024.102122","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"47 ","pages":"Article 102122"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AHL amyloidosis mimicking transthyretin amyloidosis on cardiac Tc-99 m pyrophosphate scan: A diagnostic challenge 心脏PYP扫描中模拟ATTR的AHL淀粉样变性:诊断难题。
IF 3 4区 医学
Journal of Nuclear Cardiology Pub Date : 2025-05-01 DOI: 10.1016/j.nuclcard.2025.102147
Ting-Jui Hsu MD , Chin-Te Tseng MD , Ling Kuo MD , Chih-Yu Yang MD, PhD , Yao-Ping Lin MD, PhD , Wen-Chung Yu MD, PhD , Der-Cherng Tarng MD, PhD
{"title":"AHL amyloidosis mimicking transthyretin amyloidosis on cardiac Tc-99 m pyrophosphate scan: A diagnostic challenge","authors":"Ting-Jui Hsu MD ,&nbsp;Chin-Te Tseng MD ,&nbsp;Ling Kuo MD ,&nbsp;Chih-Yu Yang MD, PhD ,&nbsp;Yao-Ping Lin MD, PhD ,&nbsp;Wen-Chung Yu MD, PhD ,&nbsp;Der-Cherng Tarng MD, PhD","doi":"10.1016/j.nuclcard.2025.102147","DOIUrl":"10.1016/j.nuclcard.2025.102147","url":null,"abstract":"<div><h3>Background</h3><div>Amyloidosis is a multisystem disease characterized by the deposition of amyloid fibrils, leading to organ dysfunction. When cardiac amyloidosis is suspected, it is essential to screen for light chain amyloidosis (AL) and transthyretin amyloidosis (ATTR), the two most common subtypes.</div></div><div><h3>Case presentation</h3><div>We report a patient with advanced heart failure and mild kidney dysfunction as initial symptoms. Preliminary testing revealed a slightly abnormal light chain ratio and a strong positive Tc-99 m pyrophosphate (PYP) scan. Biopsies of the heart, bone marrow, and kidney confirmed amyloidosis. Further immunofluorescence and mass spectrometry analysis identified immunoglobulin G and lambda light chain deposits. The patient was diagnosed with multiple myeloma and heavy and light chain amyloidosis (AHL) and initiated treatment with cyclophosphamide, bortezomib, and dexamethasone, rather than tafamidis, an oral transthyretin kinetic stabilizer used for ATTR.</div></div><div><h3>Conclusions</h3><div>AHL amyloidosis is a rare subtype. This case demonstrates that a positive PYP scan, even with intense uptake, is not entirely specific for ATTR. Tissue confirmation is essential for a definitive diagnosis, particularly when light chain disease or other rare forms are suspected, because AL/AHL and ATTR have distinct treatments and prognoses and may coexist.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"47 ","pages":"Article 102147"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validation of [99mTc]Tc-HMDP SPECT/CT myocardium-to-blood ratio for the detection of ATTR cardiomyopathy [99mTc]Tc-HMDP SPECT/CT心肌血比检测ATTR型心肌病的验证
IF 3 4区 医学
Journal of Nuclear Cardiology Pub Date : 2025-05-01 DOI: 10.1016/j.nuclcard.2025.102199
Olli Suomalainen MD , Tommi Ahokas MD , Eero Hippeläinen PhD , Tiina Heliö MD, PhD , Valtteri Uusitalo MD, PhD
{"title":"Validation of [99mTc]Tc-HMDP SPECT/CT myocardium-to-blood ratio for the detection of ATTR cardiomyopathy","authors":"Olli Suomalainen MD ,&nbsp;Tommi Ahokas MD ,&nbsp;Eero Hippeläinen PhD ,&nbsp;Tiina Heliö MD, PhD ,&nbsp;Valtteri Uusitalo MD, PhD","doi":"10.1016/j.nuclcard.2025.102199","DOIUrl":"10.1016/j.nuclcard.2025.102199","url":null,"abstract":"<div><h3>Background</h3><div>This study validates the accuracy of <sup>99m</sup>Tc-hydroxymethylene diphosphonate ([<sup>99m</sup>Tc]Tc-HMDP) single-photon emission tomography/computed tomography (SPECT/CT) in the diagnosis of transthyretin amyloidosis (ATTR) cardiomyopathy using myocardium-to-blood ratio (MBR).</div></div><div><h3>Methods</h3><div>The final study population was 80 patients who underwent [<sup>99m</sup>Tc]Tc-HMDP SPECT/CT for suspected ATTR cardiomyopathy at Helsinki University Hospital or Jorvi Central Hospital in Finland. Patients were diagnosed according to the currently accepted European Society of Cardiology criteria as either non-ATTR (n = 48) or ATTR cardiomyopathy patients (n = 32). The left ventricular (LV) MBR was calculated by dividing LV maximal myocardial uptake with maximal left atrial uptake. Right ventricular (RV) uptake was calculated as the maximal uptake ratio on the RV-free wall and right atrium. Data are presented as mean ± standard deviation.</div></div><div><h3>Results</h3><div>The LV MBR was higher in ATTR patients than in non-ATTR patients (4.6 ± 1.2 vs .9 ± .2, <em>P</em> &lt; .001). The LV MBR of 1.5 identified ATTR cardiomyopathy with 100% accuracy. LV MBR was associated with LV wall thickness on echocardiography in univariable analysis but not with LV ejection fraction or E/e’. The RV MBR was higher in ATTR patients (2.9 ± 1.0 vs .8 ± .2, <em>P</em> &lt; .001). Neither LV nor RV MBR were associated with the clinical severity of ATTR cardiomyopathy in univariable analysis.</div></div><div><h3>Conclusions</h3><div>LV myocardium-to-blood ratio (MBR) greater than 1.5 was 100% accurate for detecting ATTR cardiomyopathy using [<sup>99m</sup>Tc]Tc-HMDP SPECT/CT. Left ventricular MBR was associated with wall thickness on echocardiography but not with the clinical severity of ATTR cardiomyopathy.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"47 ","pages":"Article 102199"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing risk in diabetes: Why myocardial flow reserve matters? 评估糖尿病的风险:为什么心肌血流储备很重要?
IF 3 4区 医学
Journal of Nuclear Cardiology Pub Date : 2025-05-01 DOI: 10.1016/j.nuclcard.2025.102220
John O. Prior MD , Andreas A. Giannopoulos MD, PhD
{"title":"Assessing risk in diabetes: Why myocardial flow reserve matters?","authors":"John O. Prior MD ,&nbsp;Andreas A. Giannopoulos MD, PhD","doi":"10.1016/j.nuclcard.2025.102220","DOIUrl":"10.1016/j.nuclcard.2025.102220","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"47 ","pages":"Article 102220"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144083686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of transmurality and location on the diagnostic performance of 13N-ammonia positron emission tomography in the detection of myocardial fibrosis – A hybrid positron emission tomography/magnetic resonance study 跨壁性和位置对13n -氨PET检测心肌纤维化诊断性能的影响——PET/MR混合研究
IF 3 4区 医学
Journal of Nuclear Cardiology Pub Date : 2025-05-01 DOI: 10.1016/j.nuclcard.2025.102172
Pascal S. Heiniger MD, Gian Diego Igual, Andrei Galafton MD, Tobia Albertini MD, Marko Gajic MD, Stjepan Jurisic MD, Rita Pingree MD, Dominik C. Benz MD, Aju P. Pazhenkottil MD, Andreas A. Giannopoulos MD, Philipp A. Kaufmann MD, Ronny R. Buechel MD
{"title":"Impact of transmurality and location on the diagnostic performance of 13N-ammonia positron emission tomography in the detection of myocardial fibrosis – A hybrid positron emission tomography/magnetic resonance study","authors":"Pascal S. Heiniger MD,&nbsp;Gian Diego Igual,&nbsp;Andrei Galafton MD,&nbsp;Tobia Albertini MD,&nbsp;Marko Gajic MD,&nbsp;Stjepan Jurisic MD,&nbsp;Rita Pingree MD,&nbsp;Dominik C. Benz MD,&nbsp;Aju P. Pazhenkottil MD,&nbsp;Andreas A. Giannopoulos MD,&nbsp;Philipp A. Kaufmann MD,&nbsp;Ronny R. Buechel MD","doi":"10.1016/j.nuclcard.2025.102172","DOIUrl":"10.1016/j.nuclcard.2025.102172","url":null,"abstract":"<div><h3>Background</h3><div>The influence of fibrosis transmurality and location on the diagnostic performance of positron emission tomography (PET) myocardial perfusion imaging (MPI) for detecting myocardial fibrosis remains unclear.</div></div><div><h3>Methods and results</h3><div>One hundred patients with suspected or known coronary artery disease (n = 50) or with a history of myocarditis (n = 50) underwent simultaneous cardiac magnetic resonance (CMR) and 13N-ammonia PET imaging on a hybrid positron emission tomography/magnetic resonance (PET/MR) device. CMR served as the reference with late gadolinium enhancement defining fibrosis of the left ventricular myocardium. PET MPI was assessed for fibrosis qualitatively (i.e. visually), semiquantitatively, and quantitatively (both threshold-based). From CMR, for every segment, the transmurality and location (subendocardial, midmyocardial, or subepicardial) of fibrosis were recorded. The sensitivity and specificity of qualitatively analyzed PET to detect fibrosis were 83.6% and 84.9% per patient and 52.9% and 96.4% per segment, respectively, outperforming the threshold-based semiquantitative and quantitative analyses. On a per-segment basis, the sensitivity of PET was increasing with transmurality and was dependent on location with higher sensitivities for subendocardial than subepicardial or midmyocardial fibrosis (<em>P</em> &lt; .001). Overall median fibrosis extent, as depicted by PET, was significantly smaller than by CMR (2.0 [IQR 1.0-5.0] vs 3.0 [IQR 2.0-6.0] segments, <em>P</em> &lt; .001).</div></div><div><h3>Conclusions</h3><div>PET yields high sensitivity for the detection of left ventricular (LV) myocardial fibrosis of ischemic or inflammatory etiology on a per-patient basis. However, compared to CMR, the overall fibrosis extent is significantly underestimated because, on a segmental level, sensitivities are significantly lower for fibrosis with lower transmurality and those located subepicardial and midmyocardial, as compared to subendocardial.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"47 ","pages":"Article 102172"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Can ChatGPT answer patients’ questions about nuclear stress tests and 18F-Flurodeoxyglucose PET for myocardial inflammation? ChatGPT能否回答患者关于核应激试验和18f -氟脱氧葡萄糖PET检测心肌炎症的问题?
IF 3 4区 医学
Journal of Nuclear Cardiology Pub Date : 2025-05-01 DOI: 10.1016/j.nuclcard.2025.102174
Kaitlin Shinn MD , Cory S. Henderson MD , Aldo L. Schenone MD , Sascha N. Goonewardena MD , Supriya Shore MD , Venkatesh L. Murthy MD, PhD , Chaitanya Madamanchi MD
{"title":"Can ChatGPT answer patients’ questions about nuclear stress tests and 18F-Flurodeoxyglucose PET for myocardial inflammation?","authors":"Kaitlin Shinn MD ,&nbsp;Cory S. Henderson MD ,&nbsp;Aldo L. Schenone MD ,&nbsp;Sascha N. Goonewardena MD ,&nbsp;Supriya Shore MD ,&nbsp;Venkatesh L. Murthy MD, PhD ,&nbsp;Chaitanya Madamanchi MD","doi":"10.1016/j.nuclcard.2025.102174","DOIUrl":"10.1016/j.nuclcard.2025.102174","url":null,"abstract":"<div><h3>Background</h3><div>Several modalities are used for stress testing and require specific patient preparation. <sup>18</sup>F-Flurodeoxyglucose positron emission tomography (FDG PET) is an important tool in the diagnosis and risk stratification of patients suspected of cardiac sarcoidosis and endocarditis [1-3]. There is a need for improved patient access to questions regarding cardiac testing to ensure proper adherence to instructions. We sought to evaluate the effectiveness of ChatGPT in answering questions about stress testing and cardiac FDG PET inflammation scans.</div></div><div><h3>Methods and results</h3><div>We generated fifty-eight questions about stress testing and cardiac FDG PET inflammation scans. OpenAI ChatGPT-3.5 and -4o were used to answer the questions. The answers were graded by three nuclear cardiologists as the following categories: 1 = correct and complete, 2 = somewhat correct/somewhat complete, 3 = incorrect: no benefit, or 4 = incorrect: harmful/misleading information (Table I).</div><div>Of the 174 grades assigned to responses to the questions from ChatGPT-3.5, 62/174 (36%) were correct and complete, 93/174 (53%) were somewhat correct/somewhat complete, 12/174 (7%) were incorrect: no benefit, 7/174 (4%) were incorrect: harmful/misleading information. Of the grades assigned to responses to questions from ChatGPT-4o, 107/174 (61%) were correct and complete, 62/174 (36%) were somewhat correct/somewhat complete, 3/174 (2%) were incorrect: no benefit, and 2/174 (1%) were incorrect: harmful/misleading information.</div></div><div><h3>Conclusions</h3><div>ChatGPT can provide some accurate responses to patient questions regarding stress tests and cardiac FDG PET inflammation studies, and its accuracy has improved over time; however, it is not suitable as a primary resource for clinical care at this stage of development.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"47 ","pages":"Article 102174"},"PeriodicalIF":3.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143803563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of sestamibi CZT-SPECT reconstructed using deep-learning-based virtual attenuation correction maps according to coronary artery territory and with comparison to rubidium-PET. 基于深度学习的冠状动脉区域虚拟衰减校正图重建的sestamibi CZT-SPECT评估,并与铷- pet进行比较。
IF 3 4区 医学
Journal of Nuclear Cardiology Pub Date : 2025-04-19 DOI: 10.1016/j.nuclcard.2025.102226
Telma Sprauel, Laetitia Imbert, Kaya Doyeux, Mathieu Perrin, Marine Claudin, Véronique Roch, Matthieu Doyen, Nathaniel Roth, Yechiel Lamash, Renata Chequer, François Rouzet, Fabien Hyafil, Pierre-Yves Marie
{"title":"Assessment of sestamibi CZT-SPECT reconstructed using deep-learning-based virtual attenuation correction maps according to coronary artery territory and with comparison to rubidium-PET.","authors":"Telma Sprauel, Laetitia Imbert, Kaya Doyeux, Mathieu Perrin, Marine Claudin, Véronique Roch, Matthieu Doyen, Nathaniel Roth, Yechiel Lamash, Renata Chequer, François Rouzet, Fabien Hyafil, Pierre-Yves Marie","doi":"10.1016/j.nuclcard.2025.102226","DOIUrl":"https://doi.org/10.1016/j.nuclcard.2025.102226","url":null,"abstract":"<p><strong>Background: </strong>Attenuation artifacts affect the analysis of single-photon emission computed tomography (SPECT) myocardial perfusion imaging, especially in the right coronary artery (RCA) territory, although computed tomography (CT)-based attenuation corrections minimize this issue. This study aims to assess stress-rest [<sup>99m</sup>Tc]sestamibi cadmium zinc telluride (CZT)-SPECT reconstructed using deep-learning-based attenuation correction (DLAC) maps according to coronary artery territory and with comparison to [<sup>82</sup>Rb]rubidium-positron emission tomography (Rb-PET) conventionally reconstructed with CT-based attenuation correction.</p><p><strong>Methods: </strong>We compared stress-rest [<sup>99m</sup>Tc]sestamibi CZT-SPECT reconstructed without (i.e., standard (SD-SPECT)) and with DLAC (DLAC-SPECT) in 84 patients at risk of attenuation artifacts (overweight individuals and women) with no previous history of coronary artery disease (CAD), and who also had Rb-PET and, when indicated, coronary angiography.</p><p><strong>Results: </strong>In 74 very low CAD-risk patients: (i) the stress segmental activity values were homogeneous between the three coronary artery territories with DLAC-SPECT and Rb-PET but exhibited a marked reduction in the RCA territory with SD-SPECT (69.1% ± 8.2% vs 81.2% ± 7.1% and 77.7% ± 8.5% for DLAC-SPECT and Rb-PET, respectively, both P < .001), and (ii) the absolute value of the difference between the rest and stress segmental activities was higher in the RCA territory with SD-SPECT (5.13% ± 4.04%) than with DLAC-SPECT (4.21% ± 3.24%) and Rb-PET (3.92% ± 3.08%, both P < .001).</p><p><strong>Conclusions: </strong>When utilizing DLAC maps for reconstruction of [<sup>99m</sup>Tc]sestamibi CZT-SPECT, there is no more drop in the RCA territory uptake with lower fluctuations in stress-to-rest activity, aligning closely with the results observed using Rb-PET in the same patients.</p><p><strong>Trial registration number: </strong>NCT01679886 on clinicaltrials.gov.</p>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":" ","pages":"102226"},"PeriodicalIF":3.0,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The prognostic significance of rate pressure product corrected myocardial flow reserve. 心率压积校正心肌血流储备的预后意义。
IF 3 4区 医学
Journal of Nuclear Cardiology Pub Date : 2025-04-17 DOI: 10.1016/j.nuclcard.2025.102222
Mahmoud Al Rifai, Ahmed Ibrahim Ahmed, Malek Nayfeh, Faisal Nabi, Mouaz H Al-Mallah
{"title":"The prognostic significance of rate pressure product corrected myocardial flow reserve.","authors":"Mahmoud Al Rifai, Ahmed Ibrahim Ahmed, Malek Nayfeh, Faisal Nabi, Mouaz H Al-Mallah","doi":"10.1016/j.nuclcard.2025.102222","DOIUrl":"https://doi.org/10.1016/j.nuclcard.2025.102222","url":null,"abstract":"<p><strong>Background: </strong>It is unknown whether myocardial flow reserve (MFR) corrected for rate pressure product (RPP) can risk stratify events when added to uncorrected MFR. In this study, we evaluated the relationship between concordant vs discordant corrected and uncorrected MFR and incident outcomes.</p><p><strong>Methods: </strong>Consecutive patients referred for clinically indicated positron emission tomography were enrolled in a prospective registry. MFR was calculated as the ratio of stress to rest myocardial blood flow and corrected for RPP (MFRcorr). Concordant MFR groups were defined as MFR ≥2-MFRcorr ≥2 and MFR <2-MFRcorr <2, while discordant MFR groups were defined as MFR ≥2-MFRcorr <2 and MFR <2-MFRcorr ≥2. The primary outcome was a composite of myocardial infarction, late revascularization and death.</p><p><strong>Results: </strong>The study population included 4564 patients, mean (SD) age 66 (12) years, 56% females, 60% White and 24% Black. Compared with patients with MFR ≥2-MFRcorr ≥2, there was an increase in risk of the primary outcome in those with MFR ≥2-MFRcorr <2 [hazard ratio (95% confidence interval)]: 1.59 (.98, 2.57; P = .061), MFR <2-MFRcorr ≥2:2.16 (1.50, 3.11; P < .001) and MFR <2-MFRcorr <2:2.91 (2.13, 3.98; P < .001).</p><p><strong>Conclusions: </strong>MFR <2 is associated with a higher risk of cardiovascular outcomes and death even if corrected MFR is ≥2.</p>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":" ","pages":"102222"},"PeriodicalIF":3.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coronary anatomy matters: Dual LAD presenting as atypical ischemia on myocardial perfusion imaging. 冠状动脉解剖学要点:双LAD在心肌灌注成像上表现为不典型缺血。
IF 3 4区 医学
Journal of Nuclear Cardiology Pub Date : 2025-04-06 DOI: 10.1016/j.nuclcard.2025.102205
Raza Abbas Mahdi, Harpreet Singh, Janarthanan Ilangovan, Neelam Dahiya, Bhagwant Rai Mittal
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