Journal of Nuclear Cardiology最新文献

{"title":"18F-fluorodeoxyglucose positron emission tomography computed tomography in patients with prosthetic heart valves: Variations in imaging findings: A review of the literature","authors":"Eefje M. Dalebout MD ,&nbsp;Laurens E. Swart MD, PhD ,&nbsp;Jolanda Kluin MD, PhD ,&nbsp;Annick C. Weustink MD, PhD ,&nbsp;Ties A. Mulders MD, PhD ,&nbsp;Jolien W. Roos-Hesselink MD, PhD ,&nbsp;Alexander Hirsch MD, PhD ,&nbsp;Ricardo P.J. Budde MD, PhD","doi":"10.1016/j.nuclcard.2025.102247","DOIUrl":"10.1016/j.nuclcard.2025.102247","url":null,"abstract":"<div><div>Imaging is a cornerstone of the diagnosis of prosthetic valve endocarditis. An abnormal ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET-CT) was added as a major diagnostic criterion in the 2015 European Society of Cardiology guidelines for the management of endocarditis. However, interpretation of uptake around prosthetic heart valves (PHVs) can be difficult because physiological factors and confounders may result in false-positive or false-negative results. This review provides a comprehensive overview of “normal” uptake by reviewing the literature on uptake surrounding non-infected PHVs. We will elaborate on qualitative and quantitative measures of uptake. Then, differences in uptake between different valve types, implant positions, and the natural course of uptake over time following PHV implantation will be discussed. Finally, factors possibly hampering assessment or mimicking infection are reviewed. We aim to support clinical implementation of ¹⁸F-FDG PET-CT in suspected prosthetic valve endocarditis and to provide practical guidance to the differentiation between physiological, postoperative, and pathological uptake around PHVs.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"49 ","pages":"Article 102247"},"PeriodicalIF":3.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prognostic significance of rate pressure product corrected myocardial flow reserve","authors":"Mahmoud Al Rifai MD MPH ,&nbsp;Ahmed Ibrahim Ahmed MD MPH ,&nbsp;Malek Nayfeh MD ,&nbsp;Faisal Nabi MD ,&nbsp;Mouaz H. Al-Mallah MD MSc","doi":"10.1016/j.nuclcard.2025.102222","DOIUrl":"10.1016/j.nuclcard.2025.102222","url":null,"abstract":"<div><h3>Background</h3><div>It is unknown whether myocardial flow reserve (MFR) corrected for rate pressure product (RPP) can risk stratify events when added to uncorrected MFR. In this study, we evaluated the relationship between concordant vs discordant corrected and uncorrected MFR and incident outcomes.</div></div><div><h3>Methods</h3><div>Consecutive patients referred for clinically indicated positron emission tomography were enrolled in a prospective registry. MFR was calculated as the ratio of stress to rest myocardial blood flow and corrected for RPP (MFRcorr). Concordant MFR groups were defined as MFR ≥2-MFRcorr ≥2 and MFR &lt;2-MFRcorr &lt;2, while discordant MFR groups were defined as MFR ≥2-MFRcorr &lt;2 and MFR &lt;2-MFRcorr ≥2. The primary outcome was a composite of myocardial infarction, late revascularization and death.</div></div><div><h3>Results</h3><div>The study population included 4564 patients, mean (SD) age 66 (12) years, 56% females, 60% White and 24% Black. Compared with patients with MFR ≥2-MFRcorr ≥2, there was an increase in risk of the primary outcome in those with MFR ≥2-MFRcorr &lt;2 [hazard ratio (95% confidence interval)]: 1.59 (.98, 2.57; <em>P</em> = .061), MFR &lt;2-MFRcorr ≥2:2.16 (1.50, 3.11; <em>P</em> &lt; .001) and MFR &lt;2-MFRcorr &lt;2:2.91 (2.13, 3.98; <em>P</em> &lt; .001).</div></div><div><h3>Conclusions</h3><div>MFR &lt;2 is associated with a higher risk of cardiovascular outcomes and death even if corrected MFR is ≥2.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"49 ","pages":"Article 102222"},"PeriodicalIF":3.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning approaches for attenuation correction in myocardial perfusion imaging","authors":"Teemu Maaniitty MD, PhD","doi":"10.1016/j.nuclcard.2025.102277","DOIUrl":"10.1016/j.nuclcard.2025.102277","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"49 ","pages":"Article 102277"},"PeriodicalIF":3.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144536064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leveraging stress testing as a risk modifier: Optimization of medical therapy after SPECT MPI","authors":"Catherine X. Wright MD,&nbsp;Erica S. Spatz MD, MHS","doi":"10.1016/j.nuclcard.2025.102282","DOIUrl":"10.1016/j.nuclcard.2025.102282","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"49 ","pages":"Article 102282"},"PeriodicalIF":3.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144536062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of medical therapies with survival according to SPECT MPI findings","authors":"Waseem Hijazi MD ,&nbsp;Yuanchao Feng MSc ,&nbsp;Danielle A. Southern MSc ,&nbsp;Derek Chew MD, MSC ,&nbsp;Neil Filipchuk MD ,&nbsp;Ilias Mylonas MD ,&nbsp;Mustapha Kazmi MD ,&nbsp;Hamid Banijamali MD ,&nbsp;Bryan Har MD, MSc ,&nbsp;Matthew James MD, PhD ,&nbsp;Stephen Wilton MD, MSc ,&nbsp;Piotr J. Slomka PhD ,&nbsp;Daniel Berman MD ,&nbsp;Robert JH. Miller MD","doi":"10.1016/j.nuclcard.2025.102229","DOIUrl":"10.1016/j.nuclcard.2025.102229","url":null,"abstract":"<div><h3>Background</h3><div>Myocardial perfusion imaging (MPI) results in downstream changes to medication prescription. While the benefits of medical therapy for coronary artery disease (CAD) are established, how this varies with MPI findings is unknown. Our goal was to evaluate the association of medical therapy with survival among patients undergoing MPI, including differential associations as a function of imaging findings.</div></div><div><h3>Methods</h3><div>Consecutive patients who underwent single-photon emission computed tomography MPI for suspected CAD between January 2015 and December 2021 were identified. Multivariable Cox regression modeling was used to assess the associations between medical therapy and all-cause mortality.</div></div><div><h3>Results</h3><div>In total, 7802 patients were included with a mean age of 66.1 ± 12.0 years and 3841 (49.2 %) male patients. Angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACE inhibitors/ARBs) were associated with lower mortality (adjusted hazard ratio [HR] .66, 95 % confidence interval [CI]: .57-.77, <em>P</em> &lt; .001). Beta-blockers were not associated with mortality overall (adjusted HR .95, 95 % CI: .83-1.10, <em>P</em> = .506) but were associated with lower mortality among patients with more ischemia (HR .94 per summed difference score point, 95 % CI: .90-.97, <em>P</em>-value &lt;.001). Statins were associated with greater survival in patients with coronary calcium (adjusted HR .67, 95 % CI .56-.81, <em>P</em> = &lt;0.001) but not in patients without assessment of coronary calcium (adjusted HR: 1.16, 95 % CI: .91–1.49 <em>P</em> = .236).</div></div><div><h3>Conclusion</h3><div>ACE/ARB prescription was significantly associated with improved survival. Beta-blocker prescription was associated with greater survival in patients with ischemia and statins were in patients with coronary calcification. Findings from MPI may identify patients more likely to benefit from specific therapies, suggesting a role for hybrid MPI in guiding medical therapy for CAD.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"49 ","pages":"Article 102229"},"PeriodicalIF":3.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of sestamibi CZT-SPECT reconstructed using deep-learning-based virtual attenuation correction maps according to coronary artery territory and with comparison to rubidium-PET","authors":"Telma Sprauel ,&nbsp;Laetitia Imbert ,&nbsp;Kaya Doyeux ,&nbsp;Mathieu Perrin ,&nbsp;Marine Claudin ,&nbsp;Véronique Roch ,&nbsp;Matthieu Doyen ,&nbsp;Nathaniel Roth ,&nbsp;Yechiel Lamash ,&nbsp;Renata Chequer ,&nbsp;François Rouzet ,&nbsp;Fabien Hyafil ,&nbsp;Pierre-Yves Marie","doi":"10.1016/j.nuclcard.2025.102226","DOIUrl":"10.1016/j.nuclcard.2025.102226","url":null,"abstract":"<div><h3>Background</h3><div>Attenuation artifacts affect the analysis of single-photon emission computed tomography (SPECT) myocardial perfusion imaging, especially in the right coronary artery (RCA) territory, although computed tomography (CT)-based attenuation corrections minimize this issue. This study aims to assess stress-rest [^99mTc]sestamibi cadmium zinc telluride (CZT)-SPECT reconstructed using deep-learning-based attenuation correction (DLAC) maps according to coronary artery territory and with comparison to [⁸²Rb]rubidium-positron emission tomography (Rb-PET) conventionally reconstructed with CT-based attenuation correction.</div></div><div><h3>Methods</h3><div>We compared stress-rest [^99mTc]sestamibi CZT-SPECT reconstructed without (i.e., standard (SD-SPECT)) and with DLAC (DLAC-SPECT) in 84 patients at risk of attenuation artifacts (overweight individuals and women) with no previous history of coronary artery disease (CAD), and who also had Rb-PET and, when indicated, coronary angiography.</div></div><div><h3>Results</h3><div>In 74 very low CAD-risk patients: (i) the stress segmental activity values were homogeneous between the three coronary artery territories with DLAC-SPECT and Rb-PET but exhibited a marked reduction in the RCA territory with SD-SPECT (69.1% ± 8.2% vs 81.2% ± 7.1% and 77.7% ± 8.5% for DLAC-SPECT and Rb-PET, respectively, both <em>P</em> &lt; .001), and (ii) the absolute value of the difference between the rest and stress segmental activities was higher in the RCA territory with SD-SPECT (5.13% ± 4.04%) than with DLAC-SPECT (4.21% ± 3.24%) and Rb-PET (3.92% ± 3.08%, both <em>P</em> &lt; .001).</div></div><div><h3>Conclusions</h3><div>When utilizing DLAC maps for reconstruction of [^99mTc]sestamibi CZT-SPECT, there is no more drop in the RCA territory uptake with lower fluctuations in stress-to-rest activity, aligning closely with the results observed using Rb-PET in the same patients.</div></div><div><h3>Trial registration number</h3><div>NCT01679886 on clinicaltrials.gov.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"49 ","pages":"Article 102226"},"PeriodicalIF":3.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144000004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of complex prosthetic valve endocarditis: Unexpected embolic findings with clinical| implications.","authors":"Nayme L Calviño, Sonia Romero Acevedo, M Jesús Díez Castro, Azahara Palomar-Muñoz, Maria Nazarena Pizzi, Albert Roque Pérez","doi":"10.1016/j.nuclcard.2025.102276","DOIUrl":"10.1016/j.nuclcard.2025.102276","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":" ","pages":"102276"},"PeriodicalIF":3.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unexpected insight: Rubidium-82 PET/CT myocardial perfusion imaging uncovers malignant pleural mesothelioma.","authors":"William H S Spiller, Banu SathyaMurthi, Parthiban Arumugam","doi":"10.1016/j.nuclcard.2025.102264","DOIUrl":"10.1016/j.nuclcard.2025.102264","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":" ","pages":"102264"},"PeriodicalIF":3.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144326070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic performance of ¹⁸F-flurpiridaz PET myocardial perfusion imaging with total perfusion deficit quantification.","authors":"Jennifer M Renaud, Jonathan B Moody, Michael D Vanderver, Alexis Poitrasson-Rivière, Christopher J Buckley, Edward P Ficaro, Venkatesh L Murthy","doi":"10.1016/j.nuclcard.2025.102266","DOIUrl":"10.1016/j.nuclcard.2025.102266","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the diagnostic performance of ¹⁸F-flupiridaz positron emission tomography (PET) myocardial perfusion imaging (MPI) for coronary artery disease detection using total perfusion deficit (TPD), an automated metric of combined disease extent and severity.</p><p><strong>Methods: </strong>Flurpiridaz relative perfusion images and quantitative coronary angiography data from the initial phase III trial were evaluated using receiver operating characteristic analysis at separate endpoints of ≥70% stenosis and ≥50% stenosis, to determine the diagnostic performance of TPD at per-patient (global LV) and per-vessel levels. TPD results at both endpoints were compared with the performance of visual scores and defect extent values available from two previous publications.</p><p><strong>Results: </strong>Using a normal perfusion database that was created with the data of 25 patients from the flurpiridaz trial population, TPD was calculated in the remaining 729 trial patients. At the threshold of ≥70% stenosis, TPD was observed to have similar (P ≥ .05) per-patient diagnostic performance (74% accuracy) to visual scoring from previous publications (75%, 71%), as well as defect extent (72%). At the per-vessel level, the TPD achieved similar performance to defect extent in the left anterior descending artery (LAD) and left circumflex artery (LCx) (79%, 74% vs 80%, 72% accuracy) with slightly higher accuracy in the right coronary artery (RCA) (77% vs 72%, P = .03), and similar performance to visual scoring in the LAD and RCA (77, 79% vs 76%, 76% accuracy) with marginally lower performance in the LCx (74% vs 79%, P = .03). Similar results were observed at the ≥50% obstructive disease endpoint.</p><p><strong>Conclusions: </strong>Automated TPD demonstrated similar diagnostic performance for global and regional flurpiridaz PET MPI, respectively, to visual scoring and defect extent quantification.</p>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":" ","pages":"102266"},"PeriodicalIF":3.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of PET-CT and CZT-SPECT on myocardial blood flow and flow reserve measurement: A systematic review and meta-analysis.","authors":"Davi Shunji Yahiro, Luís Felipe Leite, Giovane L Azevedo, Mouaz H Al-Mallah, Claudio Tinoco Mesquita","doi":"10.1016/j.nuclcard.2025.102279","DOIUrl":"10.1016/j.nuclcard.2025.102279","url":null,"abstract":"<p><strong>Background: </strong>Myocardial blood flow (MBF) and myocardial flow reserve (MFR) measurement is crucial for diagnosing and managing coronary artery disease and microvascular dysfunction. While positron emission tomography (PET) is the gold standard, cadmium zinc telluride (CZT) is more accessible. This systematic review and meta-analysis aim to compare the accuracy, and the systematic bias of MBF and MFR measurement using CZT compared with PET.</p><p><strong>Methods: </strong>We conducted a systematic review across multiple databases up to April 2024. The main outcomes were mean difference between MBF and MFR values obtained from PET and CZT, limits of agreement, and diagnostic performance. Risk of bias was assessed using the Quality Assessment of Diagnostic Accuracy Studies 2 tool and statistical analysis was conducted using random effects models.</p><p><strong>Results: </strong>Eight studies, encompassing 268 patients, met the inclusion criteria. The mean difference for rest and stress myocardial blood flow between PET and CZT was .006 (95% confidence interval [CI]: -.088, .100) and .111 (95% CI: -.418, .195), respectively. The myocardial flow reserve mean difference was .0178 (95% CI: -.492, .135). Bland-Altman meta-analysis demonstrated a bias of .05 mL/min/g (95%CI: -1.08 to 1.24) for rest MBF, .13 mL/min/g for stress MBF (95%CI: -.969 to 1.228), and .03 mL/min/g (95%CI: -.999, 1.006) bias for MFR. The diagnostic performance for detecting significant reductions in MBF and MFR on single-photon emission computed tomography using PET as the gold standard demonstrated sensitivity and specificity of 80.8% and 87.0%, respectively.</p><p><strong>Conclusions: </strong>CZT MBF measurements demonstrated good agreement with PET, although they had a slight underestimation. While PET remains the preferred modality due to its superior performance, CZT represents a viable alternative when PET is unavailable. Future research should focus on standardizing CZT protocols.</p>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":" ","pages":"102279"},"PeriodicalIF":3.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}