Journal of Nuclear Cardiology最新文献

{"title":"Post-treatment bias and the prognostic utility of stress myocardial perfusion imaging","authors":"Alan Rozanski MD , Heidi Gransar MS , Robert JH. Miller MD , Donghee Han MD , Piotr Slomka PhD , Sean W. Hayes MD , John D. Friedman MD, MPH , Daniel S. Berman MD","doi":"10.1016/j.nuclcard.2025.102248","DOIUrl":"10.1016/j.nuclcard.2025.102248","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"51 ","pages":"Article 102248"},"PeriodicalIF":2.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of attenuation correction and prone positioning on stress-only imaging in cardiac SPECT: An observational study","authors":"Maria Alwan MD ,&nbsp;Ahmed Sayed MD ,&nbsp;Ahmed Ibrahim Ahmed MD ,&nbsp;Asim Shaikh MD ,&nbsp;Ahmad El Yaman MD ,&nbsp;Mahmoud Al Rifai MD, MPH ,&nbsp;Mouaz H. Al-Mallah MD, MSc","doi":"10.1016/j.nuclcard.2025.102249","DOIUrl":"10.1016/j.nuclcard.2025.102249","url":null,"abstract":"<div><h3>Background</h3><div><span>Current guidelines recommend stress-only single photon emission computed tomography </span>myocardial perfusion imaging (SPECT MPI) in select patients to reduce time, cost, and radiation. However, stress-only imaging remains underutilized.</div></div><div><h3>Objectives</h3><div>We assessed techniques to increase the adoption of stress-only SPECT MPI, specifically evaluating whether prone positioning and CT-based attenuation correction (AC) reduce the need for additional rest imaging.</div></div><div><h3>Methods</h3><div>Consecutive patients with normal stress SPECT MPI scans were included. The need for additional rest imaging was assessed according to the use of prone positioning and AC. Radiotracer dose was calculated per the institution's protocol and compared between groups. Survival analysis compared the safety of stress-only protocols to stress-rest protocols.</div></div><div><h3>Results</h3><div>Between 2018 and 2024, 14,274 patients with no stress perfusion defects were included. The use of stress-only imaging increased from 43.6% among patients with neither AC nor prone to 63.4% with AC and 65.7% with prone to 76 % with both techniques. Using multivariable logistic regression<span>, the simultaneous use of prone and AC techniques significantly increased stress-only imaging (OR: 5.0, 95% CI: 4.38-5.72). This was more pronounced among females, obese patients, patients &gt;65 years, and patients with an EF ≥ 55%. Radiotracer dose dropped by 35.6% when both AC and prone were used. Patients with normal stress-only SPECT scans had similar prognoses to those with normal SPECT scans using both stress and rest images, regardless of AC or prone imaging use.</span></div></div><div><h3>Conclusion</h3><div>Combined use of AC and prone reduces the need for rest imaging by nearly half and lowers radiotracer doses by a third. Benefits are more pronounced in women, the elderly, patients with obesity, non-diabetics, and those with preserved ejection fraction.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"51 ","pages":"Article 102249"},"PeriodicalIF":2.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-centered reporting: Should this become the new standard?","authors":"Krishna K. Patel MD, MSc ,&nbsp;John A. Spertus MD, MPH","doi":"10.1016/j.nuclcard.2025.102296","DOIUrl":"10.1016/j.nuclcard.2025.102296","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"51 ","pages":"Article 102296"},"PeriodicalIF":2.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to perform and interpret cardiac amyloidosis radionuclide imaging (CARI)","authors":"Dominik C. Benz MD ,&nbsp;Andreas J. Flammer MD ,&nbsp;Rahel Schwotzer MD ,&nbsp;Ronny R. Buechel MD","doi":"10.1016/j.nuclcard.2025.102448","DOIUrl":"10.1016/j.nuclcard.2025.102448","url":null,"abstract":"<div><div>Cardiac amyloidosis radionuclide imaging (CARI) has transformed the diagnostic approach to suspected transthyretin cardiomyopathy (ATTR-CM), enabling non-invasive diagnosis and reducing the need for biopsy. This review provides practical guidance for performing and interpreting CARI, illustrated by a clinical case. Exclusion of monoclonal gammopathy is essential to preserve specificity. When absent, Perugini grade 2–3 uptake on single-photon emission computed tomography (SPECT) is diagnostic; planar imaging or heart-to-contralateral ratios alone are insufficient. Optimal practice includes validated tracers (99mTc-DPD, -PYP, -HMDP), correct timing to avoid blood pool activity, and SPECT - preferably with CT - for accurate localization. Interpretation should account for pitfalls such as non-diffuse uptake, artifacts, and alternative causes (e.g., AL amyloidosis, infarction, drug toxicity). Emerging applications include quantitative SPECT/CT for staging, prognosis, and therapy monitoring, though standardization is needed. Adherence to expert consensus and technical standards maximizes diagnostic accuracy and safe integration of CARI into the management of cardiac amyloidosis.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"51 ","pages":"Article 102448"},"PeriodicalIF":2.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From every corner of the map to ASNC2025: A global celebration of nuclear cardiology","authors":"Panithaya Chareonthaitawee MD","doi":"10.1016/j.nuclcard.2025.102471","DOIUrl":"10.1016/j.nuclcard.2025.102471","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"51 ","pages":"Article 102471"},"PeriodicalIF":2.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145098322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stenosis degree and plaque burden differ between the major epicardial coronary arteries supplying ischemic territories.","authors":"Tanja Kero, Juhani Knuuti, Sarah Bär, Jeroen J Bax, Antti Saraste, Teemu Maaniitty","doi":"10.1016/j.nuclcard.2025.102470","DOIUrl":"10.1016/j.nuclcard.2025.102470","url":null,"abstract":"<p><strong>Background: </strong>It is unclear whether coronary artery stenosis, plaque burden, and composition differ between major epicardial arteries supplying ischemic myocardial territories.</p><p><strong>Methods: </strong>We studied 837 symptomatic patients undergoing coronary computed tomography angiography (CTA) and ¹⁵O-water positron emission tomography (PET) myocardial perfusion imaging for suspected obstructive coronary artery disease. Coronary CTA was analyzed using artificial intelligence-guided quantitative computed tomography (AI-QCT) to assess stenosis and atherosclerotic plaque characteristics. Myocardial ischemia was defined by regional PET perfusion in the left anterior descending (LAD), left circumflex (LCX), and right coronary artery (RCA) territories.</p><p><strong>Results: </strong>Among arteries supplying ischemic territories, the LAD exhibited significantly higher stenosis and both absolute and normalized plaque volumes compared to LCX and RCA (P < .001 for all). Multivariable logistic regression showed diameter stenosis (P = .001-.015), percent atheroma volume (PAV; P < .001), and percent noncalcified plaque volume (NCPV) (P = .001-.017) were associated with ischemia across all three arteries. Percent calcified plaque volume (CPV) was associated with ischemia only in the RCA (P = .001).</p><p><strong>Conclusions: </strong>The degree of stenosis and atherosclerotic burden are significantly higher in the LAD as compared to LCX and RCA, both in epicardial coronary arteries supplying nonischemic or ischemic myocardial territories. In all the three main coronary arteries, both luminal narrowing and plaque burden are independent predictors of ischemia, where the plaque burden is mainly driven by noncalcified plaque. However, many vessels supplying ischemic territories have a relatively low degree of stenosis and plaque burden, especially in the LCX and RCA, limiting the ability of diameter stenosis and PAV to predict myocardial ischemia.</p>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":" ","pages":"102470"},"PeriodicalIF":2.7,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144821612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The REgistry of Flow and Perfusion Imaging for Artificial Intelligence with positron emission tomography (REFINE PET): Rationale and design.","authors":"Giselle Ramirez, Mark Lemley, Aakash Shanbhag, Jacek Kwiecinski, Robert J H Miller, Paul B Kavanagh, Joanna X Liang, Damini Dey, Leandro Slipczuk, Mark I Travin, Erick Alexanderson, Isabel Carvajal-Juarez, René R S Packard, Mouaz Al-Mallah, Andrew J Einstein, Attila Feher, Wanda Acampa, Stacey Knight, Viet T Le, Steve Mason, Rupa Sanghani, Samuel Wopperer, Panithaya Chareonthaitawee, Ronny R Buechel, Thomas L Rosamond, Robert A deKemp, Daniel S Berman, Marcelo F Di Carli, Piotr J Slomka","doi":"10.1016/j.nuclcard.2025.102449","DOIUrl":"10.1016/j.nuclcard.2025.102449","url":null,"abstract":"<p><strong>Background: </strong>The REgistry of Flow and Perfusion Imaging for Artificial Intelligence with positron emission tomography (REFINE PET) was established to collect multicenter PET and associated computed tomography (CT) images, together with clinical data and outcomes, into a comprehensive research resource. REFINE-PET will enable validation and development of both standard and novel cardiac PET/CT processing methods.</p><p><strong>Methods: </strong>REFINE-PET is a multicenter, international registry that contains both clinical and imaging data. The PET scans were processed using QPET software (Cedars-Sinai Medical Center, Los Angeles, CA), while the CT scans were processed using deep learning (DL) to detect coronary artery calcium (CAC). Patients were followed up for the occurrence of major adverse cardiovascular events (MACE), which include death, myocardial infarction, unstable angina, and late revascularization (>90 days from PET).</p><p><strong>Results: </strong>The REFINE-PET registry currently contains data for 35595 patients from 14 sites, with additional patient data and sites anticipated. Comprehensive clinical data (including demographics, medical history, and stress test results) were integrated with more than 2100 imaging variables across 34 categories. The registry is poised to address a broad range of clinical questions, supported by correlating invasive angiography (within 6 months of PET myocardial perfusion imaging [MPI]) in 5955 patients and a total of 9278 major adverse cardiovascular events during a median follow-up of 4.2 years.</p><p><strong>Conclusions: </strong>The REFINE-PET registry leverages the integration of clinical, multimodality imaging, and novel quantitative and AI tools to advance the role of PET/CT MPI in diagnosis and risk stratification.</p>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":" ","pages":"102449"},"PeriodicalIF":2.7,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redefining pericardial cyst prevalence: A large-scale contemporary analysis.","authors":"Huda El Mais, Kaitlyn Granstaff, Cameron Quick, Caleb Haverstick, Randall C Thompson","doi":"10.1016/j.nuclcard.2025.102453","DOIUrl":"10.1016/j.nuclcard.2025.102453","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":" ","pages":"102453"},"PeriodicalIF":2.7,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blunted hemodynamic response to pharmacological stress is predictive of mortality in liver transplant candidates.","authors":"Ibolya Csecs, Aakanksha Sharma, Vandana Khungar, Albert J Sinusas, Stephen Possick, Edward J Miller, Attila Feher","doi":"10.1016/j.nuclcard.2025.102454","DOIUrl":"10.1016/j.nuclcard.2025.102454","url":null,"abstract":"<p><strong>Background: </strong>The optimal method for evaluating coronary artery disease in liver transplant candidates (LTCs) remains controversial. To date no studies have compared the hemodynamic and symptomatic response to vasodilator stress between LTCs and patients without chronic liver disease.</p><p><strong>Methods: </strong>We conducted a retrospective study of LTCs who underwent regadenoson nuclear stress testing with either ^99mTc-tetrofosmin single-photon emission computed tomography (SPECT; N = 224) or ⁸²Rubidium positron emission tomography (N = 36). These patients were compared to controls matched for age, sex, body mass index, cardiovascular comorbidities, and imaging modality who underwent clinically indicated regadenoson stress test.</p><p><strong>Results: </strong>LTCs were less likely to experience symptoms in response to regadenoson than controls (65% vs 86 %, P < .001). Additionally, the increase in heart rate was blunted in LTCs (ΔHR: 13 beats per minute [bpm], interquartile range [IQR]: 11-15 vs 29 bpm, IQR: 27-31, P < .001). During the median follow-up period of 2.0 ± 1.5 years, 78 deaths occurred in LTCs. In the multivariable analysis, ΔHR (hazard ratio [HZR]: .975, 95% confidence interval [CI]: .951-.999, P = .042) and changes in diastolic blood pressure (ΔDBP, HZR: 1.037, 95% CI: 1.003-1.071, P = .031) were significantly associated with mortality regardless of Model for End-stage Liver Disease (MELD) score, age, cardiovascular comorbidities, and stress test results. In addition, LTCs with both high MELD score (≥15) and low ΔHR (≤10 bpm) had worse overall survival than patients with a low MELD score (<15) and high ΔHR (>10 bpm, HZR: 5.54, 95% CI: 3.21-9.53, P < .001), low MELD score and low ΔHR (HZR: 6.62, 95% CI: 3.25-13.49, P < .001), and high MELD score and low ΔHR (HZR: 2.91, 95% CI: 1.50-5.64, P = .002).</p><p><strong>Conclusions: </strong>In this retrospective cohort analysis, LTCs exhibited a reduced hemodynamic response detected as lower ΔHR as well as fewer symptoms in response to regadenoson during stress testing. Reduced hemodynamic response was significantly associated with mortality and provided incremental prognostic value in addition to MELD score. Further prospective studies are required to validate these findings.</p>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":" ","pages":"102454"},"PeriodicalIF":2.7,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144794739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serial assessment of diffusion-weighted whole-body magnetic resonance imaging with background body signal suppression and 18F-fluorodeoxyglcose positron emission tomography/computed tomography after corticosteroid therapy in Takayasu arteritis","authors":"Kazunori Omote MD, PhD ,&nbsp;Motoo Oi MD, PhD ,&nbsp;Tadao Aikawa MD, PhD","doi":"10.1016/j.nuclcard.2025.102171","DOIUrl":"10.1016/j.nuclcard.2025.102171","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"50 ","pages":"Article 102171"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}