Journal of Nuclear Cardiology最新文献

{"title":"Incidentally detected diaphragmatic eventration as para-cardiac thoracic activity on myocardial perfusion imaging","authors":"Hardik Veerwal MD,&nbsp;Komal Preet MBBS,&nbsp;Ashwani Sood DNB,&nbsp;Harpreet Singh MD,&nbsp;Madan Parmar MSc,&nbsp;Bhagwant R. Mittal MD, DNB","doi":"10.1016/j.nuclcard.2024.101817","DOIUrl":"10.1016/j.nuclcard.2024.101817","url":null,"abstract":"<div><div>Diaphragmatic eventration<span><span> is the elevation of hemi-diaphragm without any disruption to diaphragmatic continuity which can be congenital or acquired. The most common acquired cause is phrenic nerve paralysis<span> due to traumatic causes and is usually incidentally diagnosed on chest radiograph or </span></span>computed tomography<span><span>. We hereby report a case of a patient who had road traffic accident with fracture of the left proximal femur<span>. Stress Myocardial Perfusion Imaging (MPI) done for pre-operative clearance showed an incidental </span></span>tracer<span><span> avidity adjoining to left myocardium in the </span>thorax. It was confirmed on anatomical imaging to be gastric cavity uptake due to diaphragm eventration.</span></span></span></div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"43 ","pages":"Article 101817"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139672026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"I can see clearly now the blur has gone: Deep learning efficiencies in single-photon emission computed tomography myocardial perfusion imaging","authors":"Manish Motwani MB ChB, PhD","doi":"10.1016/j.nuclcard.2024.102091","DOIUrl":"10.1016/j.nuclcard.2024.102091","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"43 ","pages":"Article 102091"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding best practices in nuclear cardiology: A blueprint for growth","authors":"Marcelo F. Di Carli MD, MASNC","doi":"10.1016/j.nuclcard.2025.102127","DOIUrl":"10.1016/j.nuclcard.2025.102127","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"43 ","pages":"Article 102127"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the effect of repeat positron emission tomography imaging on treatment response and cardiovascular outcomes among a homogenously treated cohort of patients with suspected cardiac sarcoidosis","authors":"Chaitanya Rojulpote MD ,&nbsp;Abhijit Bhattaru BA ,&nbsp;Shivaraj Patil MD ,&nbsp;Sarah L. Adams DO ,&nbsp;Jonathan A. Salas BS ,&nbsp;Mahesh K. Vidula MD ,&nbsp;Raul Porto Perez MD ,&nbsp;Wumesh Kc MD, PhD ,&nbsp;Karen Patterson MD ,&nbsp;Caitlin B. Clancy MD ,&nbsp;Milton Rossman MD ,&nbsp;Lee Goldberg MD ,&nbsp;Paco E. Bravo MD","doi":"10.1016/j.nuclcard.2024.102082","DOIUrl":"10.1016/j.nuclcard.2024.102082","url":null,"abstract":"<div><h3>Background</h3><div>Serial positron emission tomography (PET) imaging is routinely used to monitor treatment response in patients with suspected cardiac sarcoidosis (CS). Corticosteroids remain the mainstay of therapy in CS. However, there are no data available on the cardiovascular outcomes and optimal timing interval to obtain repeat PET while factoring in the influence of corticosteroid taper in relation to surveillance imaging.</div></div><div><h3>Methods</h3><div>We identified 81 patients with suspected CS (age: 56.3 ± 1.9, 67% male, left ventricle ejection fraction: 46.5 ± 3) who were not on immunosuppression treatment and demonstrated inflammation on baseline PET, subsequently started on moderate-dose prednisone monotherapy (i.e., 30-40 mg/day), and had a diagnostic follow-up PET. Treatment response was graded as complete treatment response (CTR) or partial treatment response (PTR) vs no response. Patients were divided into tertiles based on follow-up time between PET scans; tertile-1 (&lt;3.2 months; median: 3.1 months), tertile-2 (3.2-6.8 months; median: 5.9 months), and tertile-3 (&gt;6.8 months; median: 9.8 months). Corticosteroid taper was captured by measuring weekly changes in prednisone from the start of treatment to up to one-year follow-up. Major adverse cardiovascular events (MACEs), defined as sustained ventricular arrhythmias, were documented during the first year post baseline PET.</div></div><div><h3>Results</h3><div>Treatment response CTR/PTR rates were similar across tertiles: (tertile-1 [92%] vs tertile-2 [86.2%] vs tertile-3 [85.2%]; <em>P</em> = .76). Taper rates and one-year cumulative prednisone dose were similar between the three groups (<em>P</em> = .9). No significant difference was found in short-term MACEs between the tertile groups (<em>P</em> = .89). Similarly, MACEs did not differ significantly according to treatment response status (<em>P</em> = .39).</div></div><div><h3>Conclusions</h3><div>Surveillance time and taper rates do not seem to influence treatment response on PET scans among patients initiated on moderate-dose prednisone only. Similar MACE rates were observed despite variations in follow-up time and treatment response status.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"43 ","pages":"Article 102082"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rubidium-82 dose effects on myocardial blood flow measurements using a digital positron emission tomography - computed tomography scanner","authors":"David Gao MD ,&nbsp;Mehmet Aykaç PhD ,&nbsp;Charles Hayden PhD ,&nbsp;Rob S.B. Beanlands MD ,&nbsp;Robert A. deKemp PhD","doi":"10.1016/j.nuclcard.2024.102073","DOIUrl":"10.1016/j.nuclcard.2024.102073","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"43 ","pages":"Article 102073"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142566991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Charting a responsible path to innovation: Embracing the next chapter in nuclear cardiology – The greatest adventures still lie ahead","authors":"Panithaya Chareonthaitawee MD","doi":"10.1016/j.nuclcard.2024.102107","DOIUrl":"10.1016/j.nuclcard.2024.102107","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"43 ","pages":"Article 102107"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143105325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prognostic utility of heart rate and blood pressure response to regadenoson stress","authors":"Andrea Torres MD ,&nbsp;Alex Yerkan BS ,&nbsp;Ayesha Abbasi MD ,&nbsp;Rami Doukky MD, MSc, MBA, FASNC","doi":"10.1016/j.nuclcard.2024.102050","DOIUrl":"10.1016/j.nuclcard.2024.102050","url":null,"abstract":"<div><h3>Background</h3><div>Although heart rate response (HRR) to regadenoson stress has been shown to be a strong predictor of outcome, it has not been investigated in a large all-comers cohort. The prognostic utility of systolic blood pressure response (SBPR) has not been investigated in comparison with HRR.</div></div><div><h3>Methods and results</h3><div>In a retrospective cohort of 10,227 patients undergoing regadenoson stress single-photon emission computed tomography myocardial perfusion imaging (MPI), HRR, and SBPR were calculated as 100×(peak hyperemia value–baseline value)/baseline value. During 35<!--> <!-->±<!--> <!-->21 months follow-up, 921 (8.8%) deaths were observed. The median HRR was 35% (interquartile range [IQR], 21% to 51%). The median SBPR was −9% (IQR, −17% to −2%). HRR and SBPR were independently associated with all-cause mortality with adjusted hazard ratio [HR] of .980 per 1% increment in HRR (CI, .977-.984) and .994 per 1% increment in SBPR (CI, .988-.999). Mortality rates increased with decreasing HRR quartile and SBPR tertile. HRR provided incremental prognostic value for all-cause mortality beyond clinical and imaging parameters (area under the curve [AUC] increase, .03; <em>P</em> <!-->&lt;<!--> <!-->.001) and SBPR data (AUC increase, .11; <em>P</em> <!-->&lt;<!--> <!-->0001). SBPR did not provide significant incremental prognostic value beyond clinical and imaging parameters or HRR data. We derived and validated HRR of &lt;20% as a cut-off that can improve risk stratification beyond clinical and MPI findings.</div></div><div><h3>Conclusion</h3><div>Among patients undergoing stress MPI, impaired HRR to regadenoson provided independent and incremental prognostic value for all-cause mortality beyond clinical, imaging, and SBPR data. SBPR positively correlates with HRR, but it does not provide incremental prognostic utility. HRR, but not SBPR, should be routinely reported and considered in assessing patients' overall risk. An abnormal HRR threshold of &lt;20% can improve risk stratification.</div></div>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"43 ","pages":"Article 102050"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142377973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The time is now: Identifying optimal imaging strategies to monitor cardiac sarcoidosis activity","authors":"Nisha A. Gilotra MD, FACC, FHFSA ,&nbsp;Sanjay Divakaran MD, MPH, FASNC","doi":"10.1016/j.nuclcard.2024.102081","DOIUrl":"10.1016/j.nuclcard.2024.102081","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":"43 ","pages":"Article 102081"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular positron emission tomography imaging of fibroblast activation: A review of the current literature.","authors":"Krithika Loganath, Neil Craig, Anna Barton, Shruti Joshi, Constantinos Anagnostopoulos, Paola Anna Erba, Andor W J M Glaudemans, Antti Saraste, Jan Bucerius, Mark Lubberink, Olivier Gheysens, Ronny R Buechel, Gilbert Habib, Oliver Gaemperli, Alessia Gimelli, Fabien Hyafil, David E Newby, Riemer H J A Slart, Marc R Dweck","doi":"10.1016/j.nuclcard.2024.102106","DOIUrl":"10.1016/j.nuclcard.2024.102106","url":null,"abstract":"<p><p>Fibrosis is one of the key healing responses to injury, especially within the heart, where it helps to maintain structural integrity following acute insults such as myocardial infarction. However, if it becomes dysregulated, then fibrosis can become maladaptive, leading to adverse remodelling, impaired cardiac function and heart failure. Fibroblast activation protein is exclusively expressed by activated fibroblasts, the key effector cells of fibrogenesis, and has a unique extracellular domain that is an ideal ligand for novel molecular imaging probes. Fibroblast activation protein inhibitor (FAPI) radiotracers have been developed for positron emission tomography (PET) imaging, demonstrating high selectivity for activated fibroblasts across a range of different pathologies and disparate organ systems. In this review, we will summarise the role of fibroblast activation protein in cardiovascular disease and how FAPI radiotracers might improve the assessment and treatment of patients with cardiovascular diseases.</p>","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":" ","pages":"102106"},"PeriodicalIF":3.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142822140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parametric FDG positron emission tomography K_i images using dual-time-point imaging data for cardiac sarcoidosis: A proof of concept study.","authors":"Jing Wu, Bryan D Young, Hui Liu, Mehran M Sadeghi, Edward J Miller, Chi Liu","doi":"10.1016/j.nuclcard.2024.102121","DOIUrl":"10.1016/j.nuclcard.2024.102121","url":null,"abstract":"","PeriodicalId":16476,"journal":{"name":"Journal of Nuclear Cardiology","volume":" ","pages":"102121"},"PeriodicalIF":3.0,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}