Total-Body PET: Investigating Mechanisms in Cardiovascular-Kidney-Metabolic Syndrome.

IF 3 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Nuclear Cardiology Pub Date : 2025-07-05 DOI:10.1016/j.nuclcard.2025.102299

Jenifer M Brown, Daniel M Huck

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引用次数: 0

Abstract

Total-body PET is an emerging tool whose potential is being actively explored to interrogate multisystem biologic processes. Cardiovascular-Kidney-Metabolic (CKM) syndrome is increasingly recognized as a multidimensional disease driving cardiovascular and renal morbidity and mortality, but the underlying pathologic mechanisms remain incompletely understood. As mechanistic investigation moves to understand systems physiology in CKM syndrome, the ability to simultaneously assess shared biologic processes and crosstalk between the cardiovascular and renal systems is a unique strength of total-body PET. Total-body PET-CT systems can leverage existing and novel radiotracers to evaluate perfusion, fibrosis, metabolism, inflammation, and body composition. This review summarizes evidence for the assessment of cardiovascular and renal tissues with PET and discusses potential future applications for understanding mechanistic interactions between these interrelated systems using total-body PET, which could ultimately be applied to the development of targeted therapies for the benefit of patients with CKM disorders.

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全身PET：研究心血管-肾-代谢综合征的机制。

全身PET是一种新兴的工具，其潜力正在被积极探索，以询问多系统的生物过程。心血管-肾-代谢综合征（CKM）越来越被认为是一种导致心血管和肾脏发病率和死亡率的多维疾病，但其潜在的病理机制仍不完全清楚。随着机制研究逐渐深入了解CKM综合征的系统生理学，同时评估心血管和肾脏系统之间共享的生物过程和串扰的能力是全身PET的独特优势。全身PET-CT系统可以利用现有的和新型的放射性示踪剂来评估灌注、纤维化、代谢、炎症和身体成分。这篇综述总结了用PET评估心血管和肾脏组织的证据，并讨论了利用全身PET了解这些相关系统之间的机制相互作用的潜在未来应用，这可能最终应用于CKM疾病患者的靶向治疗开发。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nuclear Cardiology 医学-核医学

CiteScore

5.30

自引率

20.80%

发文量

249

审稿时长

4-8 weeks

期刊介绍： Journal of Nuclear Cardiology is the only journal in the world devoted to this dynamic and growing subspecialty. Physicians and technologists value the Journal not only for its peer-reviewed articles, but also for its timely discussions about the current and future role of nuclear cardiology. Original articles address all aspects of nuclear cardiology, including interpretation, diagnosis, imaging equipment, and use of radiopharmaceuticals. As the official publication of the American Society of Nuclear Cardiology, the Journal also brings readers the latest information emerging from the Society''s task forces and publishes guidelines and position papers as they are adopted.